scholarly journals Evaluation of analgesic and anti-inflammatory activity of ethanolic extract of Enhydra fluctuans on male wistar rats

2021 ◽  
Vol 9 (1) ◽  
pp. 1-7
Author(s):  
Kishor Kumar Roy ◽  
Md. Kabirul Islam Mollah ◽  
Md. Masud Reja ◽  
Dibyendu Shil ◽  
Ranjan Kumar Maji
Keyword(s):  
Wistar Rats ◽  
Pain Threshold ◽  
Ethanolic Extract ◽  
Inflammatory Activity ◽  
Paw Edema ◽  
Hot Plate ◽  
Plate Method ◽  
Traditional System ◽  
Male Wistar Rats ◽  
Anti Inflammatory

Enhydra fluctuations an edible semi-aquatic vegetable plant are widely used in the traditional system of medicine. Ethanolic extract of Enhydra fluctuans was screened for analgesic & anti-inflammatory activity. Analgesic activity was evaluated by the hot plate method and anti-inflammatory activity was evaluated by formalin induce paw edema in Wistar rats (male). Ethanolic extract dose of 300 mg/kg reduce formalin induce paw inflammation and also increased the pain threshold in rats evidenced by hot plate method. The experimental results concluded that Enhydra fluctuans have significant analgesic and anti-inflammatory activity may due to flavonoid and phenolic compound content.

Analgesic and Anti-inflammatory Activity of Ficus glomerata in Experimental Animal Models

2011 ◽  
Vol 4 (3) ◽  
pp. 1501-1505
Author(s):  
Cylma Menezes ◽  
Kunal G ◽  
Reema N ◽  
Satyanarayana D ◽  
Jagadish K
Keyword(s):  
Analgesic Activity ◽  
Inflammatory Activity ◽  
Significant Activity ◽  
Paw Edema ◽  
Hot Plate ◽  
Plate Method ◽  
Swiss Albino Mice ◽  
Albino Mice ◽  
Anti Inflammatory ◽  
Ficus Glomerata

The anti-inflammatory and analgesic activity of various extracts of Ficus glomerata Roxb. were evaluated in experimental animals. We have determined the anti-inflammatory and analgesic activity of various extracts of the dried fruits of Ficus glomerata by oral administration at doses of 200 and 400 mg/kg of body weight to healthy animals. The extracts were studied for their anti-inflammatory activity in carageenan induced hind paw edema in rats and the paw volume was measured plethysmometrically after 3 hours of injection. The extracts were also evaluated for analgesic activity using Eddy’s hot plate method in Swiss albino mice. The extracts of Ficus glomerata significantly reduced carageenan induced hind paw edema in rats and analgesic activity evidenced by increase in the reaction time by Eddy’s hot plate method in Swiss albino mice. The extracts showed a similar anti-inflammatory and analgesic effect comparative to the standard drugs indomethacin and diclofenac sodium respectively. The present results indicated the ethanolic extract of Ficus glomerata exhibited more significant activity than other extracts in the treatment of pain and inflammation.

scholarly journals Anti-Inflammatory Activity ofLactobacilluson Carrageenan-Induced Paw Edema in Male Wistar Rats

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Sarika Amdekar ◽  
Purabi Roy ◽  
Vinod Singh ◽  
Avnish Kumar ◽  
Rambir Singh ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Inflammatory Activity ◽  
Paw Edema ◽  
Male Wistar Rats ◽  
Anti Inflammatory

Water Mediated One-Pot, Stepwise Green Synthesis, Anti-Inflammatory and Analgesic Activities of (3-Amino-1-Phenyl-1H-Benzo[f]Chromen-2-yl) (1H-Indol-3-yl) Methanone Catalysed by L-Proline

2021 ◽  
Vol 18 ◽  
Author(s):  
G. Ganga Reddy ◽  
Ch Venkata Ramana Reddy ◽  
B. Srinivasa Reddy
Keyword(s):  
Analgesic Activity ◽  
Inflammatory Activity ◽  
Paw Edema ◽  
Hot Plate ◽  
Plate Method ◽  
One Pot ◽  
Standard Drug ◽  
Edema Model ◽  
Anti Inflammatory ◽  
Analgesic Activities

Aim: The reactions were carried out by one pot three-component synthesis, 3-cyanoacetylindole (1) on reaction with aromatic aldehydes (2) and β-naphthol (3) in an aqueous medium in presence of L-proline as a catalyst under reflux for 30 min, resulted (3-amino-1-phenyl-1H-benzo[f]chromen-2-yl) (1H-indol-3-yl)methanone (4). The method has many advantages like short reaction times, good yields and simple workup procedure besides being green in nature. Pharmacological evaluation of title compounds was done for anti-inflammatory and analgesic activities. Anti-inflammatory activity was carried carrageenan-induced paw edema model in which indomethacin was used as standard and analgesic activity was evaluated by eddy's hot plate method using diclofenac as standard drug. Background: Benzopyrans or chromenes are an important class of heterocyclic compounds due to their broad spectrum of biological activity and a wide range of applications in medicinal chemistry. The chromene moiety is found in various natural products with interesting biological properties. Chromenes constitute the basic backbone of various types of polyphenols and are widely found in alkaloids, tocopherols, flavonoids and anthocyanins. Indoles are omnipresent in various bioactive compounds like alkaloids, agrochemicals and pharmaceuticals. Objective: To synthesize one-pot stepwise Green synthesis, anti-inflammatory and analgesic activities of 3-amino-1-phenyl-1H-benzo[f]chromen-2-yl) (1H-indol-3-yl)methanones Methods: The acute anti-inflammatory effect was evaluated by carrageenan-induced mice paw edema (Ma Rachchh et al., 2011). Edema was induced by injecting carrageenan (1% w/v, 0.1 ml) in the right hind paw of mice. The test compounds 1-12, indomethacin (10 mg/kg) and the vehicle were administered orally one hour before injection of carrageenan. Paw volume was measured with digital plethysmometer at 0, 30, 60, 90, 120 min after injection. Percentage increase =A-B/ A *100 Results: Carrageenan Induced paw edema model was used for Anti-inflammatory activity in which animals treated with standard (indomethacin) and test compounds showed a significant decrease in the paw edema. Analgesic activity was estimated by using Eddy’s hot plate method; animals were treated with standard (diclofenac) and test compounds showed a significant increase in the reaction time. Conclusion: A green, One-pot, step-wise and three-component synthesis of 3-amino-1-phenyl-1H-benzo[f]chromen-2-yl) (1H-indol-3-yl) methanone was achieved by using water as a solvent, L-proline as catalyst under reflux conditions. The reactions were carried out in eco-friendly conditions with shorter reaction times, easier workup and high yields. Anti-inflammatory activity was evaluated by carrageenan-induced paw edema model where significant anti-inflammatory activity is shown by all the test compounds (4a-l) when compared to standard drug. Analgesic activity was studied by Eddy’s Hot plate method and Test compounds 4e, 4f, 4h, 4i, 4j, 4k, 4l showed significant activities when compared to the reference drug.

scholarly journals Evaluation of Analgesic and Anti-Inflamatory Activity of Ventilago calyculata

2015 ◽  
Vol 9 (1) ◽  
pp. 43-47
Author(s):  
G. Pranaya ◽  
P. Venkata Smitha ◽  
N. Srinivasa Reddy ◽  
R. Vinay ◽  
Ch. Murali Mohan ◽  
...  
Keyword(s):  
Formalin Test ◽  
Methanolic Extract ◽  
Life Sciences ◽  
Inflammatory Activity ◽  
Tail Flick ◽  
Paw Edema ◽  
Hot Plate ◽  
Plate Method ◽  
Ear Edema ◽  
Anti Inflammatory

Ventilago calyculata was traditionally used to treat sprains and pain. The purpose of this study was to evaluate the analgesic and anti-inflammatory activity of methanolic extract of bark of Ventilago calyculata (MVC). For evaluating analgesic activity, Hot plate method, Tail-flick method, Formalin test and Writhing methods were used. For evaluating anti-inflammatory activity Carrageenan induced paw edema and Xylene induced ear edema methods were used. Administration of MVC (100 and 200mg/kg) significantly reduced the total number of writhings in Acetic acid induced writhing method. In Hot plate and Tail-Flick methods there was a significant increase in baseline. There was a significant reduction in ear edema in Xylene induced ear edema method. The results suggest that the methanolic extract of bark of Ventilago calyculata might have analgesic and anti-inflammatory activity.DOI: http://dx.doi.org/10.3126/ijls.v9i1.11925 International Journal of Life Sciences Vol.9(1) 2015 43-47

scholarly journals Evaluation of analgesic and anti-inflammatory activity of alcoholic extract of leaves of Malachra Capitata in male Wistar rats

2014 ◽  
Vol 01 (03) ◽  
pp. 85-90
Author(s):  
Premalatha Sundararajan ◽  
Ranjith K Rajendranb ◽  
Suresh Arumugamc ◽  
Varalakshmi Jayaramdoss
Keyword(s):  
Wistar Rats ◽  
Inflammatory Activity ◽  
Alcoholic Extract ◽  
Male Wistar Rats ◽  
Anti Inflammatory

Pharmacological Evaluation of Antipyretic, Analgesic and Anti-inflammatory Activities of Ethanolic Extract of Cassia fistula

2021 ◽  
Author(s):  
D.K. Sharma ◽  
S.K. Sharma ◽  
M.K. Lonare ◽  
Rajdeep Kaur ◽  
V.K. Dumka
Keyword(s):  
Analgesic Activity ◽  
Ethanolic Extract ◽  
Inflammatory Activity ◽  
Bark Extract ◽  
Control Group ◽  
Albino Rats ◽  
Hot Plate ◽  
Antipyretic Activity ◽  
Tail Immersion ◽  
Anti Inflammatory

Background: The antipyretic, analgesic and anti-inflammatory activities of two concentrations (100 and 200 mg/kg) of ethanolic extract of leaf, bark, flower and fruit pulp of C. fistula were determined in male wistar albino rats. Methods: Antipyretic activity was assessed by E. coli endotoxin induced pyrexia. Analgesic activity was assessed by hot plate, tail immersion and acetic acid induced writhing test. Anti-inflammatory activity was evaluated by carrageenan-induced rat paw edema assay. Result: Significant (p less than 0.05) antipyretic activity was exhibited from 2h onwards by bark extract @ 200 mg/kg and from 3h onwards by bark extract @100 mg/kg and leaves extract @ 200mg/kg as compared to control group. Significant (p less than 0.05) analgesic activity was shown by extract of bark @ 200 mg/kg as it is evident by increase in reflex time in hot plate (90,120,180 min), tail immersion test (120,180 min) and inhibition of writhing (32.12%). Significant (p less than 0.05) anti-inflammatory activity was exhibited from 3h post administration by bark @ 200 and leaves @ 100 and 200 mg/kg.

Anti-Inflammatory activity of seeds extract of datura stramonium against carrageenan induced paw edema on albino wistar rats

2019 ◽  
Vol 7 (1) ◽  
pp. 41-46
Author(s):  
Vivek Asati ◽  
Rishika Agarwal ◽  
Ravi Gupta ◽  
Rajesh Yadav ◽  
Jagdish Chandra Rathi
Keyword(s):  
Wistar Rats ◽  
Datura Stramonium ◽  
Inflammatory Activity ◽  
Paw Edema ◽  
Anti Inflammatory

scholarly journals Analgesic and anti-inflammatory effect of Clausena suffruticosa root extract in animal model

2011 ◽  
Vol 3 (3) ◽  
pp. 631-639 ◽  
Author(s):  
M. A. Rahman ◽  
J. S. Chakma ◽  
S. Islam ◽  
M. S. Rana ◽  
N. U. Ahmed
Keyword(s):  
Animal Model ◽  
Analgesic Activity ◽  
Root Extract ◽  
Paw Edema ◽  
Hot Plate ◽  
Plate Method ◽  
Albino Rat ◽  
Chemical Models ◽  
Anti Inflammatory ◽  
Inflammatory Effect

The aim of the study was to evaluate the analgesic and anti-inflammatory effects of Clausena suffruticosa root extract. The effect of different concentrations of ethanolic root extract were studied in animal model using acetic acid induced writhing response, formalin induced pain, hot plate method for analgesic activity in Swiss Albino mice and carrageenan induced paw edema for anti-inflammatory action in Wister Albino rat. The extract reduced writhing response 20% by 0.5g/kg, 57.6% by 1.5g/kg and 78% by 2 g/kg and showed significant analgesic activity as determined by formalin induced pain and hot plate method. In the carrageenan induced paw edema, the extract at a dose of 0.5, 1.0 and 2.0 g/kg showed the highest inhibition 17.23%, 26.30% and 42.46%, respectively, at the 4th hour of administration. The results indicate that the extract shows promising analgesic effect in chemical models of nociception (not related to the opioid system) and anti-inflammatory effect.

scholarly journals ANTI-INFLAMMATORY PROPERTIES OF ZANTHOXYLUM OVALIFOLIUM WEIGHT METHANOLIC EXTRACT ON ALBINO WISTAR RATS

2019 ◽  
pp. 274-277 ◽  
Author(s):  
PAVANI P ◽  
RAJA NAIKA
Keyword(s):  
Wistar Rats ◽  
Leaf Extract ◽  
Statistical Significance ◽  
Saline Group ◽  
Negative Control ◽  
Inflammatory Activity ◽  
Paw Edema ◽  
Standard Drug ◽  
Group I ◽  
Anti Inflammatory

Objective: The object of the present study, the methanolic leaf extract of Zanthoxylum ovalifolium was examined for anti-inflammatory activity and tested using carrageenan-induced paw edema in albino Wistar rats. Materials and Methods: The rats were grouped into five, each group consisting of six animals, Group I (negative control) received 1 ml of saline, Group II (standard) received 10 mg/kg p. o. of indomethacin, and remaining three groups received three different doses (100, 200, and 400 mg/kg p. o.) of the methanolic leaf extract after 1 h 0.1 ml of 1% carrageenan injection. The result of anti-inflammatory activity was set up to be dose-dependent in the carrageenan-induced paw edema model. Results: The methanolic leaf extract has shown significant (p<0.001) inhibition of paw edema, 66%, 66.03%, and 69.29% on the 3rd h at the doses of 100, 200, and 400 mg/kg, p. o., respectively. The results were expressed as the Mean±standard error of mean and statistical significance was analyzed by ANOVA followed by Dunnett’s test. The methanolic leaf of Z. ovalifolium extract showed significant anti-inflammatory activity compared with the standard drug indomethacin. Conclusion: Methanolic leaf extract of Z.ovalifolium showed excellent results in the anti-inflammatory experiment so, the plant can be explored as a potential medicine in suppressing inflammation.

Sign in / Sign up

Export Citation Format

Share Document