scholarly journals Prevalence of HLA-B27 in Patients with Ankylosing Spondylitis in Qatar

2012 ◽  
Vol 2012 ◽  
pp. 1-3 ◽  
Author(s):  
M. H. Abdelrahman ◽  
S. Mahdy ◽  
I. A. Khanjar ◽  
A. M. Siam ◽  
H. A. Malallah ◽  
...  
Keyword(s):  
New York ◽  
Major Histocompatibility Complex ◽  
Ankylosing Spondylitis ◽  
Human Leukocyte Antigen ◽  
Human Leukocyte ◽  
Hla B27 ◽  
Cross Sectional ◽  
Leukocyte Antigen ◽  
Histocompatibility Complex ◽  
Class 1

Background and Objectives. The human leukocyte antigen HLA-B27 is a class 1 antigen of the major histocompatibility complex and is strongly associated with ankylosing spondylitis (AS). The purpose of the present study is to investigate the distribution of HLA-B27 in patients with AS of different ethnic groups in Qatar.Design and Setting. Study design was cross-sectional and the setting was rheumatology clinics of Hamad General Hospital in Qatar where most of ankylosing spondylitis patients are followed up.Patients and Methods. Patients with diagnosis of AS who met the New York modified criteria for AS were tested for HLA-B27. 119 patients were tested for HLA-B27: 66 Arabs, 52 Asians (Indians, Pakistanis, Bengalis, and Iranians), and one Western (Irish).Results. Of all the individuals, 82 were positive (69%) for HLA-B27. Among the Arabs, 49/66 were positive (74%). Among the Asians, 32/52 were positive (61%). Furthermore, Qatari patients (10 males and one female) 9 were positive (82%), 14/19 Jordanians/Palestinians were positive, and 9/10 (90%) Egyptians were positive. Among the Asians, 19/26 Indians were positive (73%), which was similar to the Arabs.Conclusion. HLA-B27 in our small group of Arabs is present in 74%. Comparison with other data will be presented in detail.

scholarly journals Prevalence of Human Leukocyte Antigen B27 Positivity and Microbiological Profiles of Patients with Reactive Arthritis – A Cross Sectional Study

2021 ◽  
Vol 15 (1) ◽  
pp. 382-389
Author(s):  
T. Jayaprakash ◽  
K.V. Leela ◽  
A. Sundaram ◽  
C. Panchapakesa Rajendran ◽  
R. Aparna
Keyword(s):  
Human Leukocyte Antigen ◽  
Reactive Arthritis ◽  
Human Leukocyte ◽  
Cross Sectional Study ◽  
Hla B27 ◽  
Klebsiella Species ◽  
Cross Sectional ◽  
Culture Techniques ◽  
Leukocyte Antigen ◽  
Etiological Agents

The present study aims to determine the spectrum of etiological agents and to screen HLA-B27 and, related inflammatory markers in patients presenting with symptoms of Spondyloarthritis(SpA) post diarrhea, which can aid in prompt diagnosis of reactive arthritis (ReA). A total of 903 stool samples of patients presenting with diarrhea were collected and screened with microscopic and culture techniques to identify the etiological agents. Blood samples of patients presenting with both diarrhea and arthritis were collected and subjected to C- reactive protein(CRP), Erythrocyte sedimentation rate(ESR) and Human Leukocyte Antigen B27(HLA-B27) detection tests.Among the total of 903 patients, 20 Salmonella species were isolated. Othergut microbes identified included Escherichia coli 572(63%), Klebsiella species 126(14%), Proteus vulgaris 43(5%), Proteus mirabilis 27(3%), Citrobacter species and Enterococcus species 8(1%), while some of these organisms(3.2%) caused inflammation resulting in ReA. Parasitic etiology was found in 99 patients, among which the most common parasites include Entamoeba histolytica and hookworm, identified through microscopy. Among the total, 29 patients were found to have symptoms of joint pain with articular and extra articular manifestations, and some associated with HLA-B27.

scholarly journals Genomic Diversity of the Major Histocompatibility Complex in Health and Disease

Cells ◽  
2019 ◽  
Vol 8 (10) ◽  
pp. 1270 ◽  
Author(s):  
Kulski ◽  
Shiina ◽  
Dijkstra
Keyword(s):  
Major Histocompatibility Complex ◽  
Human Leukocyte Antigen ◽  
Human Leukocyte ◽  
Genomic Diversity ◽  
Major Histocompatibility ◽  
Human Major Histocompatibility Complex ◽  
Leukocyte Antigen ◽  
Mhc Genes ◽  
Histocompatibility Complex ◽  
Health And Disease

The human Major Histocompatibility Complex (MHC) genes are part of the supra‐locus onchromosome 6p21 known as the human leukocyte antigen (HLA) system [...]

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