scholarly journals Cerebral Venous Thrombosis: A Mimic of Brain Metastases in Colorectal Cancer Associated with a Better Prognosis

2013 ◽  
Vol 2013 ◽  
pp. 1-3 ◽  
Author(s):  
Nida Iqbal ◽  
Atul Sharma
Keyword(s):  
Brain Metastases ◽  
Venous Thrombosis ◽  
Cerebral Venous Thrombosis ◽  
Brain Mri ◽  
Colon Adenocarcinoma ◽  
Rapid Diagnosis ◽  
Favourable Outcome ◽  
Neurological Dysfunction ◽  
Low Molecular Weight ◽  
Initiation Of Therapy

Malignancy is known to be one of the predisposing factors of cerebral venous thrombosis (CVT) due to its hypercoagulable state. CVT is a rare disorder which can lead to frequent misdiagnoses of brain metastases in such cases. We report here the case of a 35-year-old female with metastatic colon adenocarcinoma presenting with sudden neurological symptoms. Brain MRI and magnetic resonance venography confirmed the presence of CVT. She was treated with low molecular weight heparin followed by warfarin. She recovered and is doing well on warfarin after 5 months of diagnosis of CVT. CVT should be strongly suspected as a cause of neurological dysfunction in any case of disseminated malignancy including colon adenocarcinoma. Rapid diagnosis and initiation of therapy should be considered because of its favourable outcome.

scholarly journals Diagnostics of cerebral venous thrombosis associated with COVID-19 in young adults: clinical characteristics and imaging patterns

2021 ◽  
Vol 12 (3) ◽  
pp. 43-53
Author(s):  
F. Z. Olimova ◽  
Ye. G. Klocheva ◽  
V. N. Semich ◽  
V. V. Goldobin ◽  
S. V. Lobzin ◽  
...  
Keyword(s):  
Young Adults ◽  
Venous Thrombosis ◽  
Cerebral Venous Thrombosis ◽  
Clinical Laboratory ◽  
Brain Mri ◽  
Intravenous Contrast ◽  
Cerebrovascular Complications ◽  
Contrast Magnetic Resonance ◽  
Venous Infarcts ◽  
Initiation Of Therapy

Introduction. Cerebral venous thrombosis (CVT) is relatively rare, but leads to the development of cerebral venous infarction, intracranial hemorrhage, followed by severe disability and death. Due to the epidemiological situation caused by COVID-19, the incidence of CVT is increasing.Aims and objectives: to analyze clinical, laboratory instrumental and neuroimaging (multislice computed tomography (MSCT), MSCT — with intravenous contrast, magnetic resonance imaging of the brain (MRI) and MRI venography) data that confirmed the development of CVT in patients with COVID-19.Methods. Data of 5 young adults with cerebral venous thrombosis (CVT) associated with COVID-19 are presented.Results. Аmong 5 reported cases of COVID-19, two patients presented with venous infarcts (hemorrhagic and ischemic), 3 patients developed encephalopathy syndrome without acute cerebral infarction.Conclusion. Possibilities of modern imaging technologies permitted to timely diagnosis cerebral venous thrombosis associated with COVID-19, that can lead to immediate initiation of therapy and to prevent the development of cerebrovascular complications during the COVID-19 pandemic.

scholarly journals Unfractionated or Low–Molecular Weight Heparin for the Treatment of Cerebral Venous Thrombosis

Stroke ◽  
2010 ◽  
Vol 41 (11) ◽  
pp. 2575-2580 ◽  
Author(s):  
Jonathan M. Coutinho ◽  
José M. Ferro ◽  
Patrícia Canhão ◽  
Fernando Barinagarrementeria ◽  
Marie-Germaine Bousser ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Venous Thrombosis ◽  
Cerebral Venous Thrombosis ◽  
Low Molecular Weight Heparin ◽  
Low Molecular Weight

scholarly journals Risk factors and diagnosis of cerebral venous thrombosis: Data from a cohort of 45 Romanian patients

2014 ◽  
Vol 60 (5) ◽  
pp. 207-214
Author(s):  
Rodica Bălaşa ◽  
M Daboczi ◽  
Oana Costache ◽  
Smaranda Maier ◽  
Z Bajko ◽  
...  
Keyword(s):  
Risk Factors ◽  
Venous Thrombosis ◽  
Brain Imaging ◽  
Cerebral Venous Thrombosis ◽  
Sinus Thrombosis ◽  
Demographic Data ◽  
Brain Mri ◽  
Clinical Aspects ◽  
Initial Symptom ◽  
Clinical Criteria

Abstract Cerebral venous thrombosis (CVT) represents 1% of the total stroke pathology but is a real challenge both regarding the diagnosis and the treatment. Objective: Evaluate different etiological, demographical, clinical, imaging and therapeutic aspects of CVT. Material: Prospective study during 4 years. From the total 3658 patients hospitalized with acute stroke, 45 (1.23%) had CVT. For each patient, were recorded: demographic data, symptom of onset, type of onset, daily habits, medical history, neurological examination, brain imaging (CT and MRI with venography). Statistical analysis: data are presented as mean and SD and Student t test was applied. Results: Mean age was 44.07± 23,12 years; female: male ratio 2.21:1. The most frequent type of onset was acute (77.78%). Headache was found in 80% of cases as initial symptom, followed by neurological focal deficits. As risk factors, thrombophilia was found most often (59.5%), followed by local infections. No risk factors were found in 17.8% of cases. The brain imaging was positive in 29 patients. In 16 cases, the imaging workout was negative and the diagnosis consisted of clinical criteria, risk factors, response to heparin treatment. Conclusions: CVT is a rare pathology that affects mainly young women and that needs a complex diagnostic evaluation. The patient prototype diagnosed with CVT in our region: female of 44 years old, with an intense acute headache, with MRI showing direct signs of transverse sinus thrombosis, with a thrombophilic state and good response to anticoagulants. Brain MRI is the imaging investigation required but clinical aspects play a decisive role.

scholarly journals Cerebral venous thrombosis as a rare thromboembolic complication of celiac disease: a case report

2020 ◽  
Vol 4 (5) ◽  
pp. 1-5
Author(s):  
Maha Bouziane ◽  
Salim Arous ◽  
Rachida Habbal
Keyword(s):  
Celiac Disease ◽  
Venous Thrombosis ◽  
Cerebral Venous Thrombosis ◽  
Sinus Thrombosis ◽  
Anticoagulation Therapy ◽  
Thromboembolic Complication ◽  
Favourable Outcome ◽  
Complete Regression ◽  
Thromboembolic Events ◽  
Cerebral Magnetic Resonance Imaging

Abstract Background  Celiac disease is a digestive inflammatory syndrome with several complications. It is associated with coagulation and platelets abnormalities leading to thromboembolic events. Cerebral venous thrombosis is an exceptional localization of thrombosis in celiac disease and could be life-threatening. Case summary  A 17-year-old female patient with history of celiac disease and not following a gluten-free diet, checked in to the emergency department for a sudden, 2-week-old, and deteriorating, onset of intense headache and muscle weakness. The cerebral computed tomography-scan showed bilateral fronto-parietal hypodensity with micro-bleeds. We investigated using a cerebral magnetic resonance imaging that revealed superior longitudinal sinus thrombosis and right transverse and sigmoid sinuses thrombosis, along with right haematoma and ischaemic areas. The patient was prescribed anticoagulation therapy. Follow-ups over a 2-year period confirmed a favourable outcome and a complete regression of symptoms. Discussion  Evolution of celiac disease could be associated with several complications. Eighty-five percent of patients is potentially exposed to thromboembolic events due to the hypercoagulability state of the disease and different coagulation and fibrinolysis abnormalities (e.g. hyperhomocysteinaemia, protein C and S deficiencies, vitamin K and B deficiencies). Cerebral venous thrombosis is a rare thromboembolic localization. Anticoagulation is efficient in most cases though endovascular treatment might be required.

scholarly journals Cerebral Venous Thrombosis after a Cesarean Delivery

2010 ◽  
Vol 53 (2) ◽  
pp. 109-113 ◽  
Author(s):  
Edvard Ehler ◽  
Aleš Kopal ◽  
Milan Mrklovský ◽  
Milan Košťál
Keyword(s):  
Risk Factors ◽  
Molecular Weight ◽  
Venous Thrombosis ◽  
Cesarean Delivery ◽  
Cerebral Venous Thrombosis ◽  
Low Molecular Weight Heparin ◽  
Methylenetetrahydrofolate Reductase ◽  
Low Molecular Weight ◽  
Viii Level ◽  
Risk Patients

Cerebral venous thrombosis (CVT) is a serious condition affecting mostly women. This report concerns two cases of women who developed CVT within 14 days of cesarean delivery. Magnetic resonance angiography of the brain (venous phase) is the best modality to diagnose the condition, and parenteral application of low-molecular-weight heparin is the most beneficial treatment. The first patient was found to have an elevated factor VIII level. In the second patient, homozygosity of the C677T mutation in the 5,10-methylenetetrahydrofolate reductase gene was found. The puerperal period and Cesarean Section (CS) are risk factors for thrombotic complications, including CVT. It is necessary to search for risk factors in a patient’s history and within the group of at-risk patients to prolong preventive administration of low molecular weight heparin (LMWH). CVT (including puerperium related) is not a detrimental to future pregnancies.

scholarly journals Cerebral venous thrombosis: An experience with anticoagulation with low molecular weight heparin

2005 ◽  
Vol 9 (1) ◽  
pp. 14-18 ◽  
Author(s):  
Lalitha V. Pillai ◽  
Dhananjay P. Ambike ◽  
Satish Nirhale ◽  
S. M. K. Husainy ◽  
Satish Pataskar
Keyword(s):  
Molecular Weight ◽  
Venous Thrombosis ◽  
Cerebral Venous Thrombosis ◽  
Low Molecular Weight Heparin ◽  
Low Molecular Weight

scholarly journals Unusual Case of Cerebral Venous Thrombosis in Patient with Crohn's Disease

2015 ◽  
Vol 7 (2) ◽  
pp. 115-120 ◽  
Author(s):  
Inha Kim ◽  
Kyung-Hyun Min ◽  
Minju Yeo ◽  
Ji Seon Kim ◽  
Sung Hyun Lee ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Venous Thrombosis ◽  
Disease Activity ◽  
Cerebral Venous Thrombosis ◽  
Brain Mri ◽  
Active Phase ◽  
Filling Defect ◽  
Sudden Onset ◽  
Acute Infarction

The development of cerebral venous thrombosis (CVT) as a secondary complication of Crohn's disease (CD) seems to be rare, but it is generally accepted that the disease activity of CD contributes to the establishment of a hypercoagulable state. Here, we describe a case of CVT that developed outside the active phase of CD. A 17-year-old male visited the emergency room because of a sudden onset of right-sided weakness and right-sided hypesthesia. He had been diagnosed with CD 1 year before and was on a maintenance regimen of mesalazine and azathioprine. He did not exhibit any symptoms indicating a CD flare-up (bloody stools, abdominal pain, complications, or weight loss). A brain MRI scan revealed an acute infarction of the left frontal cortex and a cortical subarachnoid hemorrhage. Additionally, a magnetic resonance venography revealed a segmental filling defect in the superior sagittal sinus and also the non-visualizability of some bilateral cortical veins. The characteristics of the present case suggest that the risk of CVT is most likely related to CD per se rather than disease activity associated with CD.

scholarly journals Antithrombotic Strategy in Cerebral Venous Thrombosis: Differences Between Neurologist and Hematologist Respondents in a Canadian Survey

2016 ◽  
Vol 44 (1) ◽  
pp. 116-119 ◽  
Author(s):  
Thalia S. Field ◽  
Marie-Christine Camden ◽  
Sohaila Al-Shimemeri ◽  
Gary Lui ◽  
Agnes Y.Y. Lee
Keyword(s):  
Molecular Weight ◽  
Venous Thrombosis ◽  
Unfractionated Heparin ◽  
Cerebral Venous Thrombosis ◽  
Low Molecular Weight Heparin ◽  
Response Rate ◽  
Low Molecular Weight ◽  
Clinical Equipoise ◽  
First Line ◽  
Patterns Of Practice

AbstractPatterns of practice for management of cerebral venous thrombosis in Canada are unknown. We surveyed Canadian neurologists and hematologists regarding anticoagulation in cerebral venous thrombosis. The response rate was 28%, with 27 neurologists and 20 hematologists responding. We found that choice of first-line initial anticoagulation differed significantly between neurologists and hematologists, with 89% of neurologists favouring unfractionated heparin and hematologists’ preference split between unfractionated heparin (50%) and low-molecular-weight heparin (50%). Differences in patterns of practice likely reflect clinical equipoise.

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