scholarly journals Age- and Gender-Specific Components of the Metabolic Syndrome in 2228 First Graders: The PEP Family Heart Study

Scientifica ◽  
2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Peter Schwandt ◽  
Thomas Bertsch ◽  
Evelyn Liepold ◽  
Gerda-Maria Haas
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
First Graders ◽  
Growth Curves ◽  
Age And Gender ◽  
The Metabolic Syndrome ◽  
Family Heart Study ◽  
Heart Study ◽  
And Gender ◽  
Gender Specific

Because first graders are critical for excess weight gain, we assessed components of the metabolic syndrome (MetS) using the pediatric definition of the International Diabetes Federation (IDF). We compared four MetS components as defined by the IDF with age- and gender-specific components in 2228 first graders at the age of 6. The growth curves were derived from 22113 children and adolescents who participated in the PEP Family Heart Study. The aim was to determine in first graders precise values of waist circumference (WC), blood pressure (BP), triglycerides (TG), and HDL-Cholesterol (HDL-C) based on growth curves that were developed for a large German population of youths and to assess the prevalence in terms of both definitions at this critical age. The prevalence of high blood pressure for age was 13% compared with only 2% according to IDF. Because of this considerable divergence, we propose to define MetS components based on national growth curves.

scholarly journals Heritability of the metabolic syndrome and its components in the Tehran Lipid and Glucose Study (TLGS)

2012 ◽  
Vol 94 (6) ◽  
pp. 331-337 ◽  
Author(s):  
MARYAM ZARKESH ◽  
MARYAM SADAT DANESHPOUR ◽  
BITA FAAM ◽  
MOHAMMAD SADEGH FALLAH ◽  
NIMA HOSSEINZADEH ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Hdl Cholesterol ◽  
Age And Gender ◽  
The Metabolic Syndrome ◽  
Biological Parents ◽  
Heritability Estimation ◽  
Low Hdl ◽  
And Gender ◽  
Continuous Traits

SummaryGrowing evidence suggests that metabolic syndrome (MetS) has both genetic and environmental bases. We estimated the heritability of the MetS and its components in the families from the Tehran Lipid and Glucose Study (TLGS). We investigated 904 nuclear families in TLGS with two biological parents and at least one offspring (1565 parents and 2448 children), aged 3–90 years, for whom MetS information was available and had at least two members of family with MetS. Variance component methods were used to estimate age and sex adjusted heritability of metabolic syndrome score (MSS) and MetS components using SOLAR software. The heritability of waist circumference (WC), HDL-cholesterol (HDL-C), triglycerides (TGs), fasting blood sugar (FBS), systolic blood pressure (SBP) and diastolic blood pressure (DBP) as continuous traits after adjusting for age and gender were 27, 46, 36, 29, 25, 26 and 15%, respectively, and MSS had a heritability of 15%. When MetS components were analysed as discrete traits, the estimates of age and gender adjusted heritability for MetS, abdominal obesity, low HDL-C, high TG, high FBS and high blood pressure (BP) were 22, 40, 34, 38 and 23%, respectively (P < 0·05). Three factors were extracted from the six continuous traits of the MetS including factor I (BP), factor II (lipids) and factor III (obesity and FBS). Heritability estimation for these three factors were 7, 13 (P < 0·05) and 2%, respectively. The highest heritability was for HDL-C and TG. The results strongly encourage efforts to identify the underlying susceptibility genes.

scholarly journals Trends of Components of the Metabolic Syndrome in German First Graders Throughout 10 Years: The PEP Family Heart Study

Cholesterol ◽  
2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Gerda-Maria Haas ◽  
Thomas Bertsch ◽  
Peter Schwandt
Keyword(s):  
Metabolic Syndrome ◽  
First Graders ◽  
Hdl Cholesterol ◽  
Overweight And Obesity ◽  
Mean Values ◽  
The Metabolic Syndrome ◽  
Childhood Overweight And Obesity ◽  
Family Heart Study ◽  
Heart Study ◽  
Low Hdl

Although childhood overweight and obesity are increasing worldwide, some countries report trends for stabilization. However, the trend for the potentially atherogenic components of the metabolic syndrome (MetS) in children and adolescents is not well understood. Therefore, the purpose of this study was to analyze the trend of the five components of over 10 years in 2228 first graders aged 6 years. Waist circumference (WC) remained mainly unchanged between 1994 and 2003 whereas the other four components continuously decreased. In boys and girls mean values of triglycerides (−25.9% and −28.6%, resp.), HDL cholesterol (−19.8% and −23.4%, resp.), fasting glucose (−7.3% and −9%, resp.), systolic (−3.8% and −4.1%, resp.), and diastolic (−10.2% and −9.7%, resp.) blood pressure significantly decreased. Whereas the prevalence of abdominal adiposity was stable at baseline and after 10 years (−1% in boys and +2% in girls), the prevalence of hypertension, hypertriglyceridemia, low HDL-C, and glucose was very low without any trend.

Using height-corrected definition of metabolic syndrome in children and adolescents

2019 ◽  
Vol 32 (5) ◽  
pp. 429-438
Author(s):  
Chunming Ma ◽  
Qiang Lu ◽  
Rui Wang ◽  
Fuzai Yin
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Waist Circumference ◽  
Children And Adolescents ◽  
Age And Gender ◽  
Anthropometric Indexes ◽  
And Gender ◽  
Definition Of ◽  
Hypertension In Children ◽  
Gender Specific

Abstract Metabolic syndrome (MS) is common among children and adolescents. Age- and gender-specific references or age-, gender- and height-specific references were used in pediatric MS definitions. More recently, an increasing number of studies documented that the ratio of waist circumference (WC) to height (WHtR) and blood pressure to height (BPHR) were easy anthropometric indexes for detection of obesity and hypertension in children and adolescents. For these reasons, height-corrected MS definition was proposed. WHtR and BPHR were used as alternatives to WC and BP in the definition of MS. In the present review, we discuss the possibility of the height-corrected MS definition for identifying MS in children.

scholarly journals Impact of Age and Gender on the Prevalence and Prognostic Importance of the Metabolic Syndrome and Its Components in Europeans. The MORGAM Prospective Cohort Project

PLoS ONE ◽  
2014 ◽  
Vol 9 (9) ◽  
pp. e107294 ◽  
Author(s):  
Julie K. K. Vishram ◽  
Anders Borglykke ◽  
Anne H. Andreasen ◽  
Jørgen Jeppesen ◽  
Hans Ibsen ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Prospective Cohort ◽  
Age And Gender ◽  
The Metabolic Syndrome ◽  
Prognostic Importance ◽  
And Gender

scholarly journals Association of Apolipoprotein A5 Gene  −1131T>C Polymorphism with the Risk of Metabolic Syndrome in Korean Subjects

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Kwang Hoon Song ◽  
Seongwon Cha ◽  
Sung-Gon Yu ◽  
Hyunjoo Yu ◽  
Soo A. Oh ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Genetic Model ◽  
Serum Triglyceride ◽  
Control Group ◽  
Total Study Population ◽  
Age And Gender ◽  
Apolipoprotein A5 ◽  
Remarkable Effect ◽  
The Metabolic Syndrome ◽  
And Gender

We assessed the associations between theAPOA5  −1131T>C polymorphism and lipid parameters and other risk factors of the metabolic syndrome in Korean subjects. A total of 2,901 participants from 20 oriental medical hospitals in Korea were enrolled between 2006 and 2011. According to the modified National Cholesterol Education Program Adult Treatment Panel III definitions, subjects were classified into the metabolic syndrome group and control group. TheAPOA5  −1131T>C genotype was significantly associated with serum high-density lipoprotein cholesterol levels (effect = − 1.700 mg/dL,P=6.550-E07) in the total study population after adjustment for differences in age and gender. The association of theAPOA5  −1131T>C genotype with serum log-transformed triglyceride was also significant in an additive genetic model (effect = 0.056 mg/dL,P=2.286E-19). After adjustment for age and gender, we determined that the odds ratio for the occurrence of the metabolic syndrome was 1.322 for C-allele carriers in the additive model (95% CI = [1.165 − 1.501],P=1.48E-05). In the current study, we demonstrated that theAPOA5  −1131T>C polymorphism is associated with the metabolic syndrome because of its remarkable effect on serum triglyceride levels in Korean subjects.

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