scholarly journals Physicochemical, Spectral, and Biological Studies of Mn(II), Cu(II), Cd(II), Zr(OH)2(IV), and UO2(VI) Compounds with Ligand Containing Thiazolidin-4-one Moiety

2014 ◽  
Vol 2014 ◽  
pp. 1-9
Author(s):  
Dinesh Kumar ◽  
Amit Kumar
Keyword(s):  
Antibacterial Activities ◽  
Molar Conductance ◽  
Mercaptoacetic Acid ◽  
Coordinate Structure ◽  
Donor Ligand ◽  
E Coli ◽  
Biological Studies ◽  
Elemental Analyses ◽  
Ir Reflectance ◽  
Bipyramidal Structure

The Schiff base (I) upon reacting with mercaptoacetic acid in dry benzene undergoes cyclization and forms N-(2-carbamoylthienyl)-C-(3′-carboxy-2′-hydroxyphenyl)thiazolidin-4-one, LH3(II). A MeOH solution ofIIreacts with Mn(II), Cu(II), Cd(II), Zr(OH)2(IV), and UO2(VI) ions and forms the coordination compounds, [Mn(LH)(MeOH)2], [Cu(LH)]2, [Cd(LH)], [Zr(OH)2(OAc)2(LH3)], and [UO2(NO3)(LH2)(MeOH)]. The compounds have been characterized on the basis of elemental analyses, molar conductance, molecular weight, spectral (IR, reflectance, and EPR) studies and magnetic susceptibility measurements. LH3behaves as a neutral tridentate ONS donor ligand in [Zr(OH)2(OAc)2(LH3)], monobasic tridentate ONS donor ligand in [UO2(NO3)(LH2)(MeOH)], dibasic tridentate OOS donor ligand in [Cu(LH)]2and dibasic tetradentate OONO donor ligand in [Mn(LH)(MeOH)2] and [Cd(LH)]. [Cu(LH)]2is dimer, while all other compounds are monomers in diphenyl. A square-planar structure for [Cu(LH)]2, a tetrahedral structure for [Cd(LH)], an octahedral structure for [Mn(LH)(MeOH)2], a pentagonal-bipyramidal structure for [Zr(OH)2(OAc)2(LH3)], and an eight-coordinate structure for [UO2(NO3)(LH2)(MeOH)] are proposed. The ligand (II) and its compounds show antibacterial activities towardsE. coli. (Gram negative) andS. aureus(Gram positive).

scholarly journals Syntheses, Magnetic, Spectral and Biological Studies on the Coordination Compounds of N-(2-Hydroxyphenyl)-C-(3′- Carboxy-2′-Hydroxyphenyl) Thiazolidin-4-One

2021 ◽  
Vol 23 (08) ◽  
pp. 135-142
Author(s):  
Praveen Kumar Gupta ◽  
◽  
Amit Kumar ◽  
Dinesh Kumar ◽  
◽  
...  
Keyword(s):  
Coordination Compounds ◽  
Benzene Solution ◽  
Antibacterial Activities ◽  
Molar Conductance ◽  
Mercaptoacetic Acid ◽  
Donor Ligand ◽  
Gram Positive Bacteria ◽  
Biological Studies ◽  
Elemental Analyses ◽  
Ir Reflectance

A dry benzene solution of the Schiff base, N-(2-hydroxyphenyl)-3′-carboxy-2′- hydroxybenzylideneimine upon reacting with mercaptoacetic acid undergoes cyclization and forms N- (2-hydroxyphenyl)-C-(3′-carboxy-2′-hydroxyphenyl)thiazolidin-4-one, LH3 (I). A MeOH solution of I reacts with Ni(II) and UO2(VI) ions and forms the monomeric coordination compounds, [Ni(LH)(MeOH)3] and [UO2(LH)(MeOH)]. The coordination compounds have been characterized on the basis of elemental analyses, molar conductance, molecular weight, spectral (IR, reflectance) studies and magnetic susceptibility measurements. I behaves as a dibasic tridentate OOS donor ligand in these compounds. The compounds are non-electrolytes (M = 4.3-6.4 mho cm2 mol-1) in DMF. Octahedral structure for Ni(II) and UO2(VI) compounds are suggested. LH3 (I) and its complexes while testing with E.Coli. (Gram Negative) and S. Aureus (Gram positive) bacteria show antibacterial activities.

scholarly journals Syntheses, Characterization, and Biological Activities of Metal Complexes of N-(2-Carbamoylthienyl)-C-(3′-carboxy-2′-hydroxyphenyl) Azetidin-2-one with Some Di-, Tetra-, and Hexavalent Metal Ions

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Dinesh Kumar ◽  
Amit Kumar
Keyword(s):  
Coordination Compounds ◽  
Biological Activities ◽  
Antibacterial Activities ◽  
Molar Conductance ◽  
Octahedral Structure ◽  
Coordinate Structure ◽  
Donor Ligand ◽  
E Coli ◽  
Elemental Analyses ◽  
Subnormal Magnetic Moment

The cyclization of the Schiff base, N-(2-carbamoylthienyl)-3′-carboxy-2′-hydroxybenzylideneimine with ClCH2COCl in dioxane, in the presence of triethylamine (Et3N) forms N-(2-carbamoylthienyl)-C-(3′-carboxy-2′-hydroxyphenyl) azetidin-2-one, LH3(I). A methanolic solution ofIreacts with Co(II), Cu(II), Zn(II), Zr(OH)2(IV), and MoO2(VI) ions and forms the coordination compounds, [Co(LH)(MeOH)]2(II), [Cu(LH)]2(III), [Zn(LH)(MeOH)2] (IV), [Zr(OH)2(LH)(MeOH)] (V), and [MoO2(LH)(MeOH)2] (VI). The compounds have been characterized on the basis of elemental analyses, molar conductance, molecular weight, spectral (IR, NMR, reflectance, and ESR) studies, and magnetic susceptibility measurements. All the coordination compounds are nonelectrolytes (ΛM=3.1-9.2 mho cm2mol−1) in DMF.Ibehaves as a dibasic tridentate OON donor ligand inV; a dibasic tetradentate OONO donor ligand inII,III, andVI; and a dibasic tetradentate OONS donor ligand inIV.IIandIIIare dimers, while others are monomers in diphenyl.IIIexhibits subnormal magnetic moment (1.55 B.M.) and is involved in antiferromagnetic exchange, while the other complexes are magnetically dilute. A square-pyramidal structure forIIIand an octahedral structure forII,IV, andVare suggested.VIexhibits an eight-coordinate structure. The ligand (I) and its compounds show antibacterial activities towardsE. coli(gram negative) andS. aureus(gram positive).

scholarly journals Syntheses, Magnetic and Spectral Studies on the Coordination Compounds of the Polystyrene-anchored Thiazolidin-4-one

2012 ◽  
Vol 9 (4) ◽  
pp. 2532-2539 ◽  
Author(s):  
Dinesh Kumar ◽  
Amit Kumar
Keyword(s):  
Coordination Compounds ◽  
Acid Hydrazide ◽  
Mercaptoacetic Acid ◽  
Spectral Studies ◽  
Donor Ligand ◽  
Square Planar ◽  
Elemental Analyses ◽  
Ir Reflectance ◽  
Bipyramidal Structure ◽  
Monodentate Ligands

The reaction between polystyrene 3-formylsalicylate and thiophene-2-carboxylic acid hydrazide in DMF in the presence of ethyl acetate results in the formation of polystyrene N-(2-carbamoylthienyl)-3'-carboxy-2'-hydroxybenzylideneimine (I). A benzene suspension of I reacts with mercaptoacetic acid and forms the polystyrene N-(2-carbamoylthienyl)-C-(3'-carboxy-2'-hydroxyphenyl) thiazolidin-4-one, PSCH2–LH2(II). A DMF suspension of II reacts with Zn(II), Co(II), Cu(II), Zr(OH)2(IV) and MoO2(VI) ions and forms the corresponding polystyrene-anchored coordination compounds, [PSCH2–LZn(DMF)] (III), [PSCH2–LCo(DMF)3] (IV), [PSCH2–LHCu(OAc)] (V), [PSCH2–LH2Zr(OH)2(OAc)2] (VI) and [PSCH2–LHMoO2(acac)] (VII) respectively. The polystyrene-anchored coordination compounds have been characterized on the basis of elemental analyses, spectral (IR, reflectance, ESR) studies and magnetic susceptibility measurements. II acts as a neutral tridentate ONS donor ligand in VI, a monobasic bidentate OS donor ligand in VII, a monobasic tridentate ONS donor ligand in V and a dibasic tridentate ONO donor ligand in III and IV. The acetato groups behave as monodentate ligands in V and VI. A square-planar structure for V, a tetrahedral structure for III, an octahedral structure for IV and VII and a pentagonal-bipyramidal structure for VI are suggested.

scholarly journals Physico-Chemical Studies on the Coordination Compounds of Thiazolidin-4-One

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Dinesh Kumar ◽  
Amit Kumar ◽  
Jyoti Sharma
Keyword(s):  
Coordination Compounds ◽  
Benzene Solution ◽  
Molar Conductance ◽  
Mercaptoacetic Acid ◽  
Donor Ligand ◽  
Physico Chemical ◽  
Square Planar ◽  
Elemental Analyses ◽  
Ir Reflectance ◽  
Chemical Studies

A dry benzene solution of the Schiff base,N-(2-hydroxyphenyl)-3′-carboxy-2′-hydroxybenzylideneimine upon reacting with mercaptoacetic acid undergoes cyclization and formsN-(2-hydroxyphenyl)-C-(3′-carboxy-2′-hydroxyphenyl)thiazolidin-4-one, LH3(I). A MeOH solution ofIreacts with , , , and Mo ions and forms the monomeric coordination compounds, [Mn(LH)(MeOH)3] (II), [Cu(LH)(MeOH)] (III), [Zn(LH)(MeOH)] (IV), [FeCl(LH)(MeOH)2] (V), and [MoO2(LH)(MeOH)](VI). The coordination compounds have been characterized on the basis of elemental analyses, molar conductance, molecular weight, spectral (IR, reflectance, ESR) studies, and magnetic susceptibility measurements.Ibehaves as a dibasic tridentate OOS donor ligand in these compounds. The compounds are nonelectrolytes ( = 6.2–13.8 mho cm2 mol−1) in DMF. A square-planar structure forIII; a tetrahedral structure forIVand an octahedral structure forII,V, andVIare suggested.

Synthesis, Structural Chemistry, and Biological Studies on Various Divalent Copper Chelates of Novel Ligands Derived from Food Preservative, Dehydroacetic Acid, with Anilines

2019 ◽  
Vol 41 (6) ◽  
pp. 1055-1055
Author(s):  
Ahmed Hassan Abdel Salam Ahmed Hassan Abdel Salam
Keyword(s):  
Magnetic Susceptibility ◽  
Schiff Base ◽  
Copper Ions ◽  
Antibacterial Activities ◽  
Molar Conductance ◽  
Thermal Stabilities ◽  
Dehydroacetic Acid ◽  
Biological Studies ◽  
Water Of Hydration ◽  
Elemental Analyses

Various six coordinated copper(II) complexes of novel (E)-4-hydroxy-6-methyl-3-(1-(p-tolylimino) ethyl-2H-pyran-2-one (HL1) and (E)-3-(1-(4-chlorophenylimino) ethyl-4-hydroxy-6-methyl-2H-pyran-2-one (HL2) derived from 3-Acetyl-2-hydroxy-6-methyl-4H-pyran-4-one (dehydroacetic acid, DHA) and aniline derivatives (p-chloroaniline and p-toluidine) were fabricated. The coordination mode of Schiff base donor atoms with copper ions was well investigated by thermal and elemental analyses, FTIR, UV-vis, 1H, 13C-NMR spectral tools and measurements of magnetic susceptibility as well as molar conductance at ambient temperature. The novel neutral bidentate Schiff base ligands (HL1 and HL2) linked to Cu(II) cation via the azomethine-N and hydroxyl-O atoms and to acetate and nitrate anions in bidentate bridging mode to form polymeric octahedral complexes. The thermal study showed the stepwise removal of water of hydration and anions and decomposition of these chelates. The decomposition products were examined and the relative thermal stabilities of these chelates were evaluated. Different parameters of activation were derived from the thermal curves by Coats–Redfern methodology. The degradation steps of the metal complexes had positive free energy values indicating their non-spontaneous nature. The antifungal and antibacterial activities of all investigated compounds were also studied. The magnetic susceptibility measurements and conductance data were investigated and provided evidence for the non-electrolytic character of the complexes.

scholarly journals Syntheses, Spectral Characterization, and Antimicrobial Studies on the Coordination Compounds of Metal Ions with Schiff Base Containing Both Aliphatic and Aromatic Hydrazide Moieties

2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
Dinesh Kumar ◽  
Silky Chadda ◽  
Jyoti Sharma ◽  
Parveen Surain
Keyword(s):  
Schiff Base ◽  
Coordination Compounds ◽  
Molar Conductance ◽  
Equimolar Ratio ◽  
Gram Positive Bacteria ◽  
H Nmr ◽  
Antimicrobial Studies ◽  
Elemental Analyses ◽  
Ir Reflectance ◽  
Bipyramidal Structure

An EtOH solution of 3-ketobutanehydrazide and salicylhydrazide on refluxing in equimolar ratio forms the corresponding Schiff base, LH3(1). The latter reacts with Mn(II), Co(II), Ni(II), Cu(II), Zn(II), Cd(II), Zr(OH)2(IV), MoO2(VI), and UO2(VI) ions in equimolar ratio and forms the corresponding coordination compounds, [M(LH)(MeOH)3] (2, M = Mn, Co, Ni), [Cu(LH)]2(3), [M′(LH)(MeOH)] (4, M′ = Zn, Cd), [Zr(OH)2(LH)(MeOH)2] (5), [MoO2(LH)(MeOH)] (6), and [UO2(LH)(MeOH)] (7). The coordination compounds have been characterized on the basis of elemental analyses, molar conductance, spectral (IR, reflectance,1H NMR, ESR) studies, and magnetic susceptibility measurements. They are nonelectrolytes in DMSO. The coordination compounds, except3, are monomers in diphenyl. They are active against gram-positive bacteria (S. aureus, B. subtilis), gram-negative bacteria (E. coli, P. aeruginosa), and yeast (S. cerevisiae, C. albicans).1acts as a dibasic tridentate ONO donor ligand in2–7coordinating through its both enolic O and azomethine N atoms. The coordination compounds2and3are paramagnetic, while rest of the compounds are diamagnetic. A square-planar structure to3, a tetrahedral structure to4, an octahedral structure to2,6, and7, and a pentagonal bipyramidal structure to5are proposed.

scholarly journals Syntheses and Characterization of the Coordination Compounds of N-(2-hydroxymethylphenyl)-C-(3′-carboxy-2′-hydroxyphenyl)thiazolidin-4-one

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Dinesh Kumar ◽  
Amit Kumar ◽  
Durga Dass
Keyword(s):  
Molecular Weight ◽  
Coordination Compounds ◽  
Benzene Solution ◽  
Molar Conductance ◽  
Mercaptoacetic Acid ◽  
Octahedral Structure ◽  
Donor Ligand ◽  
Tetrahedral Structure ◽  
Elemental Analyses

A dry benzene solution of the Schiff base N-(2-hydroxymethylphenyl)-3′-carboxy-2′-hydroxybenzylideneimine upon reacting with mercaptoacetic acid undergoes cyclization and forms N-(2-hydroxymethylphenyl)-C-(3′-carboxy-2′-hydroxyphenyl)thiazolidin-4-one, LH3 (I). A MeOH solution of I reacts with Co(II), Ni(II), Cd(II), Zr(OH)2(IV), and UO2(VI) ions and forms the monomeric coordination compounds, [M(LH)(MeOH)3] [where M = Co(II), Ni(II)], [M′(LH)(MeOH)] [here M′ = Cd(II), UO2(VI)] and [Zr(OH)2(LH)(MeOH)]. The coordination compounds have been characterized on the bases of elemental analyses, molar conductance, molecular weight, spectral (IR, NMR, and reflectance) studies, and magnetic susceptibility measurements. I behaves as a dibasic tridentate OOS donor ligand in these compounds. The compounds are nonelectrolytes (ΛM = 3.8–8.9 mho cm2 mol−1) in DMF. A tetrahedral structure for [Cd(LH)(MeOH)] and an octahedral structure for the remaining compounds are suggested.

scholarly journals Spectral, Theoretical and Biological Studies of 3-((4-Mercaptophenyl)imino)- 1-phenylindolin-2-one Schiff Base and Its Organotellurium(IV) Complexes

2021 ◽  
Vol 33 (8) ◽  
pp. 1749-1756
Author(s):  
Manish Kumar ◽  
Poonam Jangra Darolia ◽  
Nidhi Antil ◽  
Mahak Dalal ◽  
Jitender Narwal ◽  
...  
Keyword(s):  
Schiff Base ◽  
Schiff Base Ligand ◽  
Molar Conductance ◽  
Spectral Studies ◽  
Receptor Proteins ◽  
E Coli ◽  
Biological Studies ◽  
Elemental Analyses ◽  
Ft Ir ◽  
Bacteria And Fungi

Schiff base ligand (3-((4-mercaptophenyl)imino)-1-phenylindolin-2-one) of 1-phenylindoline-2,3-dione and 4-aminothiophenol was synthesized by refluxing. Organotellurium(IV) complexes of type (RTeCl3.NPhIATP and R2TeCl2.NPhIATP, where R = 4-hydroxyphenyl, 4-methoxyphenyl and 3-methyl-4-hydroxyphenyl, NPhIATP = Schiff base ligand). The ligand and its organotellurium(IV) complexes (9a-f) were characterized by FT-IR, molar conductance, elemental analyses, UV-vis, mass, 1H & 13C NMR spectral studies. Geometry of all the compounds were optimized and octahedral geometry have been proposed for all the tellurium(IV) complexes. Molecular docking was studied to find the binding interactions between ligand (NPhIATP) and receptor proteins: E. coli (3t88) and S. aureus (3ty7). The antimicrobial activity of ligand and its tellurium(IV) complexes have been screened against bacteria and fungi. All the organotellurium(IV) complexes complexes showed good activity to ligand towards different studied microorganisms.

scholarly journals Synthesis, Spectroscopic, Molecular Structure, and Antibacterial Studies of Dibutyltin(IV) Schiff Base Complexes Derived from Phenylalanine, Isoleucine, and Glycine

2014 ◽  
Vol 2014 ◽  
pp. 1-12 ◽  
Author(s):  
Har Lal Singh ◽  
Jangbhadur Singh
Keyword(s):  
Amino Acids ◽  
Schiff Base ◽  
Schiff Bases ◽  
Molar Conductance ◽  
Schiff Base Complexes ◽  
Spectral Studies ◽  
E Coli ◽  
Elemental Analyses ◽  
In Vitro Antibacterial Activity

New series of organotin(IV) complexes and Schiff bases derived from amino acids have been designed and synthesized from condensation of1H-indole-2,3-dione, 5-chloro-1H-indole-2,3-dione, andα-amino acids (phenylalanine, isoleucine, and glycine). All compounds are characterized by elemental analyses, molar conductance measurements, and molecular weight determinations. Bonding of these complexes is discussed in terms of their UV-visible, infrared, and nuclear magnetic resonance (1H,13C, and119Sn NMR) spectral studies. The results suggest that Schiff bases behave as monobasic bidentate ligands and coordinate with dibutyltin(IV) in octahedral geometry according to the general formula [Bu2Sn(L)2]. Elemental analyses and NMR spectral data of the ligands with their dibutyltin(IV) complexes agree with their proposed distorted octahedral structures. Few representative compounds are tested for their in vitro antibacterial activity against Gram-positive (B. cereus,Staphylococcusspp.) and Gram-negative (E. coli,Klebsiellaspp.) bacteria. The results show that the dibutyltin complexes are more reactive with respect to their corresponding Schiff base ligands.

scholarly journals Synthesis, Characterization and Crystal Structures of Zinc(II) and Cobalt(III) Complexes Derived from Tridentate NNO- and NON- Schiff Bases with Antibacterial Activities

2021 ◽  
Vol 68 (3) ◽  
pp. 700-708
Author(s):  
Heng-Yu Qian
Keyword(s):  
Antibacterial Activities ◽  
Bacterial Strains ◽  
X Ray Diffraction ◽  
X Ray ◽  
E Coli ◽  
Mtt Method ◽  
Trigonal Bipyramidal ◽  
Mononuclear Cobalt ◽  
Elemental Analyses ◽  
Distorted Trigonal Bipyramidal Coordination

Two new polynuclear zinc complexes [Zn2Br2(L1)2] (1) and [Zn(μ1,5-dca)L2]n (2), and two new mononuclear cobalt(III) complexes [CoL1N3(Brsal)] (3) and [CoL2(HL2)] (4), where L1 = 5-bromo-2-(((2-dimethylamino)ethyl)imino)methyl)phenolate, L2 = 5-bromo-2-(((2-hydroxyethyl)imino)methyl)phenolate, dca = dicyanoamide, Brsal = 5-bromo-2-formylphenolate, have been synthesized and characterized. The complexes were characterized by elemental analyses, IR, UVVis spectra, molar conductivity, and single crystal X-ray diffraction. X-ray analysis indicates that the Zn atoms in complex 1 are in distorted square pyramidal coordination, the Zn atoms in complex 2 are in distorted trigonal bipyramidal coordination, and the Co atoms in complexes 3 and 4 are in octahedral coordination. The molecules of the complexes are stacked through π···π interactions and hydrogen bonds. The complexes were assayed for antibacterial activities against three Gram-positive bacterial strains (B. subtilis, S. aureus, and St. faecalis) and three Gram-negative bacterial strains (E. coli, P. aeruginosa, and E. cloacae) by MTT method.

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