scholarly journals Syntheses, Magnetic, Spectral and Biological Studies on the Coordination Compounds of N-(2-Hydroxyphenyl)-C-(3′- Carboxy-2′-Hydroxyphenyl) Thiazolidin-4-One

2021 ◽  
Vol 23 (08) ◽  
pp. 135-142
Author(s):  
Praveen Kumar Gupta ◽  
◽  
Amit Kumar ◽  
Dinesh Kumar ◽  
◽  
...  
Keyword(s):  
Coordination Compounds ◽  
Benzene Solution ◽  
Antibacterial Activities ◽  
Molar Conductance ◽  
Mercaptoacetic Acid ◽  
Donor Ligand ◽  
Gram Positive Bacteria ◽  
Biological Studies ◽  
Elemental Analyses ◽  
Ir Reflectance

A dry benzene solution of the Schiff base, N-(2-hydroxyphenyl)-3′-carboxy-2′- hydroxybenzylideneimine upon reacting with mercaptoacetic acid undergoes cyclization and forms N- (2-hydroxyphenyl)-C-(3′-carboxy-2′-hydroxyphenyl)thiazolidin-4-one, LH3 (I). A MeOH solution of I reacts with Ni(II) and UO2(VI) ions and forms the monomeric coordination compounds, [Ni(LH)(MeOH)3] and [UO2(LH)(MeOH)]. The coordination compounds have been characterized on the basis of elemental analyses, molar conductance, molecular weight, spectral (IR, reflectance) studies and magnetic susceptibility measurements. I behaves as a dibasic tridentate OOS donor ligand in these compounds. The compounds are non-electrolytes (M = 4.3-6.4 mho cm2 mol-1) in DMF. Octahedral structure for Ni(II) and UO2(VI) compounds are suggested. LH3 (I) and its complexes while testing with E.Coli. (Gram Negative) and S. Aureus (Gram positive) bacteria show antibacterial activities.

scholarly journals Physico-Chemical Studies on the Coordination Compounds of Thiazolidin-4-One

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Dinesh Kumar ◽  
Amit Kumar ◽  
Jyoti Sharma
Keyword(s):  
Coordination Compounds ◽  
Benzene Solution ◽  
Molar Conductance ◽  
Mercaptoacetic Acid ◽  
Donor Ligand ◽  
Physico Chemical ◽  
Square Planar ◽  
Elemental Analyses ◽  
Ir Reflectance ◽  
Chemical Studies

A dry benzene solution of the Schiff base,N-(2-hydroxyphenyl)-3′-carboxy-2′-hydroxybenzylideneimine upon reacting with mercaptoacetic acid undergoes cyclization and formsN-(2-hydroxyphenyl)-C-(3′-carboxy-2′-hydroxyphenyl)thiazolidin-4-one, LH3(I). A MeOH solution ofIreacts with , , , and Mo ions and forms the monomeric coordination compounds, [Mn(LH)(MeOH)3] (II), [Cu(LH)(MeOH)] (III), [Zn(LH)(MeOH)] (IV), [FeCl(LH)(MeOH)2] (V), and [MoO2(LH)(MeOH)](VI). The coordination compounds have been characterized on the basis of elemental analyses, molar conductance, molecular weight, spectral (IR, reflectance, ESR) studies, and magnetic susceptibility measurements.Ibehaves as a dibasic tridentate OOS donor ligand in these compounds. The compounds are nonelectrolytes ( = 6.2–13.8 mho cm2 mol−1) in DMF. A square-planar structure forIII; a tetrahedral structure forIVand an octahedral structure forII,V, andVIare suggested.

scholarly journals Physicochemical, Spectral, and Biological Studies of Mn(II), Cu(II), Cd(II), Zr(OH)2(IV), and UO2(VI) Compounds with Ligand Containing Thiazolidin-4-one Moiety

2014 ◽  
Vol 2014 ◽  
pp. 1-9
Author(s):  
Dinesh Kumar ◽  
Amit Kumar
Keyword(s):  
Antibacterial Activities ◽  
Molar Conductance ◽  
Mercaptoacetic Acid ◽  
Coordinate Structure ◽  
Donor Ligand ◽  
E Coli ◽  
Biological Studies ◽  
Elemental Analyses ◽  
Ir Reflectance ◽  
Bipyramidal Structure

The Schiff base (I) upon reacting with mercaptoacetic acid in dry benzene undergoes cyclization and forms N-(2-carbamoylthienyl)-C-(3′-carboxy-2′-hydroxyphenyl)thiazolidin-4-one, LH3(II). A MeOH solution ofIIreacts with Mn(II), Cu(II), Cd(II), Zr(OH)2(IV), and UO2(VI) ions and forms the coordination compounds, [Mn(LH)(MeOH)2], [Cu(LH)]2, [Cd(LH)], [Zr(OH)2(OAc)2(LH3)], and [UO2(NO3)(LH2)(MeOH)]. The compounds have been characterized on the basis of elemental analyses, molar conductance, molecular weight, spectral (IR, reflectance, and EPR) studies and magnetic susceptibility measurements. LH3behaves as a neutral tridentate ONS donor ligand in [Zr(OH)2(OAc)2(LH3)], monobasic tridentate ONS donor ligand in [UO2(NO3)(LH2)(MeOH)], dibasic tridentate OOS donor ligand in [Cu(LH)]2and dibasic tetradentate OONO donor ligand in [Mn(LH)(MeOH)2] and [Cd(LH)]. [Cu(LH)]2is dimer, while all other compounds are monomers in diphenyl. A square-planar structure for [Cu(LH)]2, a tetrahedral structure for [Cd(LH)], an octahedral structure for [Mn(LH)(MeOH)2], a pentagonal-bipyramidal structure for [Zr(OH)2(OAc)2(LH3)], and an eight-coordinate structure for [UO2(NO3)(LH2)(MeOH)] are proposed. The ligand (II) and its compounds show antibacterial activities towardsE. coli. (Gram negative) andS. aureus(Gram positive).

scholarly journals Syntheses and Characterization of the Coordination Compounds of N-(2-hydroxymethylphenyl)-C-(3′-carboxy-2′-hydroxyphenyl)thiazolidin-4-one

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Dinesh Kumar ◽  
Amit Kumar ◽  
Durga Dass
Keyword(s):  
Molecular Weight ◽  
Coordination Compounds ◽  
Benzene Solution ◽  
Molar Conductance ◽  
Mercaptoacetic Acid ◽  
Octahedral Structure ◽  
Donor Ligand ◽  
Tetrahedral Structure ◽  
Elemental Analyses

A dry benzene solution of the Schiff base N-(2-hydroxymethylphenyl)-3′-carboxy-2′-hydroxybenzylideneimine upon reacting with mercaptoacetic acid undergoes cyclization and forms N-(2-hydroxymethylphenyl)-C-(3′-carboxy-2′-hydroxyphenyl)thiazolidin-4-one, LH3 (I). A MeOH solution of I reacts with Co(II), Ni(II), Cd(II), Zr(OH)2(IV), and UO2(VI) ions and forms the monomeric coordination compounds, [M(LH)(MeOH)3] [where M = Co(II), Ni(II)], [M′(LH)(MeOH)] [here M′ = Cd(II), UO2(VI)] and [Zr(OH)2(LH)(MeOH)]. The coordination compounds have been characterized on the bases of elemental analyses, molar conductance, molecular weight, spectral (IR, NMR, and reflectance) studies, and magnetic susceptibility measurements. I behaves as a dibasic tridentate OOS donor ligand in these compounds. The compounds are nonelectrolytes (ΛM = 3.8–8.9 mho cm2 mol−1) in DMF. A tetrahedral structure for [Cd(LH)(MeOH)] and an octahedral structure for the remaining compounds are suggested.

scholarly journals Syntheses, Magnetic and Spectral Studies on the Coordination Compounds of the Polystyrene-anchored Thiazolidin-4-one

2012 ◽  
Vol 9 (4) ◽  
pp. 2532-2539 ◽  
Author(s):  
Dinesh Kumar ◽  
Amit Kumar
Keyword(s):  
Coordination Compounds ◽  
Acid Hydrazide ◽  
Mercaptoacetic Acid ◽  
Spectral Studies ◽  
Donor Ligand ◽  
Square Planar ◽  
Elemental Analyses ◽  
Ir Reflectance ◽  
Bipyramidal Structure ◽  
Monodentate Ligands

The reaction between polystyrene 3-formylsalicylate and thiophene-2-carboxylic acid hydrazide in DMF in the presence of ethyl acetate results in the formation of polystyrene N-(2-carbamoylthienyl)-3'-carboxy-2'-hydroxybenzylideneimine (I). A benzene suspension of I reacts with mercaptoacetic acid and forms the polystyrene N-(2-carbamoylthienyl)-C-(3'-carboxy-2'-hydroxyphenyl) thiazolidin-4-one, PSCH2–LH2(II). A DMF suspension of II reacts with Zn(II), Co(II), Cu(II), Zr(OH)2(IV) and MoO2(VI) ions and forms the corresponding polystyrene-anchored coordination compounds, [PSCH2–LZn(DMF)] (III), [PSCH2–LCo(DMF)3] (IV), [PSCH2–LHCu(OAc)] (V), [PSCH2–LH2Zr(OH)2(OAc)2] (VI) and [PSCH2–LHMoO2(acac)] (VII) respectively. The polystyrene-anchored coordination compounds have been characterized on the basis of elemental analyses, spectral (IR, reflectance, ESR) studies and magnetic susceptibility measurements. II acts as a neutral tridentate ONS donor ligand in VI, a monobasic bidentate OS donor ligand in VII, a monobasic tridentate ONS donor ligand in V and a dibasic tridentate ONO donor ligand in III and IV. The acetato groups behave as monodentate ligands in V and VI. A square-planar structure for V, a tetrahedral structure for III, an octahedral structure for IV and VII and a pentagonal-bipyramidal structure for VI are suggested.

scholarly journals Syntheses, Characterization, and Biological Activities of Metal Complexes of N-(2-Carbamoylthienyl)-C-(3′-carboxy-2′-hydroxyphenyl) Azetidin-2-one with Some Di-, Tetra-, and Hexavalent Metal Ions

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Dinesh Kumar ◽  
Amit Kumar
Keyword(s):  
Coordination Compounds ◽  
Biological Activities ◽  
Antibacterial Activities ◽  
Molar Conductance ◽  
Octahedral Structure ◽  
Coordinate Structure ◽  
Donor Ligand ◽  
E Coli ◽  
Elemental Analyses ◽  
Subnormal Magnetic Moment

The cyclization of the Schiff base, N-(2-carbamoylthienyl)-3′-carboxy-2′-hydroxybenzylideneimine with ClCH2COCl in dioxane, in the presence of triethylamine (Et3N) forms N-(2-carbamoylthienyl)-C-(3′-carboxy-2′-hydroxyphenyl) azetidin-2-one, LH3(I). A methanolic solution ofIreacts with Co(II), Cu(II), Zn(II), Zr(OH)2(IV), and MoO2(VI) ions and forms the coordination compounds, [Co(LH)(MeOH)]2(II), [Cu(LH)]2(III), [Zn(LH)(MeOH)2] (IV), [Zr(OH)2(LH)(MeOH)] (V), and [MoO2(LH)(MeOH)2] (VI). The compounds have been characterized on the basis of elemental analyses, molar conductance, molecular weight, spectral (IR, NMR, reflectance, and ESR) studies, and magnetic susceptibility measurements. All the coordination compounds are nonelectrolytes (ΛM=3.1-9.2 mho cm2mol−1) in DMF.Ibehaves as a dibasic tridentate OON donor ligand inV; a dibasic tetradentate OONO donor ligand inII,III, andVI; and a dibasic tetradentate OONS donor ligand inIV.IIandIIIare dimers, while others are monomers in diphenyl.IIIexhibits subnormal magnetic moment (1.55 B.M.) and is involved in antiferromagnetic exchange, while the other complexes are magnetically dilute. A square-pyramidal structure forIIIand an octahedral structure forII,IV, andVare suggested.VIexhibits an eight-coordinate structure. The ligand (I) and its compounds show antibacterial activities towardsE. coli(gram negative) andS. aureus(gram positive).

scholarly journals Syntheses, Spectral Characterization, and Antimicrobial Studies on the Coordination Compounds of Metal Ions with Schiff Base Containing Both Aliphatic and Aromatic Hydrazide Moieties

2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
Dinesh Kumar ◽  
Silky Chadda ◽  
Jyoti Sharma ◽  
Parveen Surain
Keyword(s):  
Schiff Base ◽  
Coordination Compounds ◽  
Molar Conductance ◽  
Equimolar Ratio ◽  
Gram Positive Bacteria ◽  
H Nmr ◽  
Antimicrobial Studies ◽  
Elemental Analyses ◽  
Ir Reflectance ◽  
Bipyramidal Structure

An EtOH solution of 3-ketobutanehydrazide and salicylhydrazide on refluxing in equimolar ratio forms the corresponding Schiff base, LH3(1). The latter reacts with Mn(II), Co(II), Ni(II), Cu(II), Zn(II), Cd(II), Zr(OH)2(IV), MoO2(VI), and UO2(VI) ions in equimolar ratio and forms the corresponding coordination compounds, [M(LH)(MeOH)3] (2, M = Mn, Co, Ni), [Cu(LH)]2(3), [M′(LH)(MeOH)] (4, M′ = Zn, Cd), [Zr(OH)2(LH)(MeOH)2] (5), [MoO2(LH)(MeOH)] (6), and [UO2(LH)(MeOH)] (7). The coordination compounds have been characterized on the basis of elemental analyses, molar conductance, spectral (IR, reflectance,1H NMR, ESR) studies, and magnetic susceptibility measurements. They are nonelectrolytes in DMSO. The coordination compounds, except3, are monomers in diphenyl. They are active against gram-positive bacteria (S. aureus, B. subtilis), gram-negative bacteria (E. coli, P. aeruginosa), and yeast (S. cerevisiae, C. albicans).1acts as a dibasic tridentate ONO donor ligand in2–7coordinating through its both enolic O and azomethine N atoms. The coordination compounds2and3are paramagnetic, while rest of the compounds are diamagnetic. A square-planar structure to3, a tetrahedral structure to4, an octahedral structure to2,6, and7, and a pentagonal bipyramidal structure to5are proposed.

Synthesis, Structural Chemistry, and Biological Studies on Various Divalent Copper Chelates of Novel Ligands Derived from Food Preservative, Dehydroacetic Acid, with Anilines

2019 ◽  
Vol 41 (6) ◽  
pp. 1055-1055
Author(s):  
Ahmed Hassan Abdel Salam Ahmed Hassan Abdel Salam
Keyword(s):  
Magnetic Susceptibility ◽  
Schiff Base ◽  
Copper Ions ◽  
Antibacterial Activities ◽  
Molar Conductance ◽  
Thermal Stabilities ◽  
Dehydroacetic Acid ◽  
Biological Studies ◽  
Water Of Hydration ◽  
Elemental Analyses

Various six coordinated copper(II) complexes of novel (E)-4-hydroxy-6-methyl-3-(1-(p-tolylimino) ethyl-2H-pyran-2-one (HL1) and (E)-3-(1-(4-chlorophenylimino) ethyl-4-hydroxy-6-methyl-2H-pyran-2-one (HL2) derived from 3-Acetyl-2-hydroxy-6-methyl-4H-pyran-4-one (dehydroacetic acid, DHA) and aniline derivatives (p-chloroaniline and p-toluidine) were fabricated. The coordination mode of Schiff base donor atoms with copper ions was well investigated by thermal and elemental analyses, FTIR, UV-vis, 1H, 13C-NMR spectral tools and measurements of magnetic susceptibility as well as molar conductance at ambient temperature. The novel neutral bidentate Schiff base ligands (HL1 and HL2) linked to Cu(II) cation via the azomethine-N and hydroxyl-O atoms and to acetate and nitrate anions in bidentate bridging mode to form polymeric octahedral complexes. The thermal study showed the stepwise removal of water of hydration and anions and decomposition of these chelates. The decomposition products were examined and the relative thermal stabilities of these chelates were evaluated. Different parameters of activation were derived from the thermal curves by Coats–Redfern methodology. The degradation steps of the metal complexes had positive free energy values indicating their non-spontaneous nature. The antifungal and antibacterial activities of all investigated compounds were also studied. The magnetic susceptibility measurements and conductance data were investigated and provided evidence for the non-electrolytic character of the complexes.

STRUCTURAL FEATURES, COMPUTATIONAL STUDIES AND BIOLOGICAL ANALYSIS: SCHIFF’S BASE LIGAND AND ITS COORDINATION COMPOUNDS

INDIAN DRUGS ◽  
2021 ◽  
Vol 58 (07) ◽  
pp. 22-31
Author(s):  
Seema Gautam ◽  
Sulekh Chandra ◽  
Jugmendra Singh ◽  
Navneet Manav ◽  
Vinod K Paliwal ◽  
...  
Keyword(s):  
Metal Ions ◽  
Coordination Compounds ◽  
Computational Study ◽  
Inhibition Zone ◽  
Antibacterial Activities ◽  
Structural Features ◽  
Schiff’S Base ◽  
H Nmr ◽  
Diffusion Technique ◽  
Elemental Analyses

Structure and biological application based analysis has been carried out for Schiff’s base ligand containing nitrogen and sulphur donor atoms and also for a series of its coordination compounds. Ligand benzil-bis(5-amino-1,3,4-thiadiazole-2-thiol) (L) has been prepared and structural features of ligand investigated by elemental analyses, IR, 1 H-NMR, mass spectra and molecular modeling studies. The chemical reaction of the prepared ligand with metal ions afforded mononuclear coordination compounds of Mn(II) and Co(II) metal ions. The characterization of the coordination compounds is being based on the techniques i.e. elemental analysis, infra-red, UV-visible as well as melting point, molar conductivity and magnetic moment measurement. A computational study has been done to understand the miscellaneous coordination modes of ligand to metal ions. Characterization result shows that coordination compounds exhibit a six coordinated geometrical arrangement i.e. octahedral geometry. The biological inhibition zone (antifungal and antibacterial activities) of synthesized compounds, i.e. ligand and its coordination compounds, has been monitored using well diffusion technique

scholarly journals Ferrocene Derivatives Carrying Urea, Thiourea, and Sulfonamide Moieties: Synthesis and Evaluation of Antibacterial and Antifungal Activities

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Serkan Yavuz ◽  
Hilal Yıldırım
Keyword(s):  
Inhibitory Concentration ◽  
Antibacterial Activities ◽  
Klebsiella Pneumonia ◽  
Gram Negative Bacteria ◽  
Ferrocene Derivatives ◽  
Antifungal Activities ◽  
Gram Positive Bacteria ◽  
Antibacterial And Antifungal Activities ◽  
Elemental Analyses ◽  
Antibacterial And Antifungal

In the present study, some novel ferrocene derivatives carrying urea, thiourea, and sulfonamide groups were synthesized, and all compounds were characterized by spectral and elemental analyses. These compounds were screened for their antibacterial activities and also their minimum inhibitory concentration (MIC) against Gram-positive bacteria (Staphylococcus aureusandBacillus subtilis) and Gram-negative bacteria (Klebsiella pneumoniaandEscherichia coli) and antifungal activities againstSaccharomyces cerevisiaeandCandida albicans. Amongst the tested compounds,4b,4c,5b, and6bdisplayed excellent antimicrobial activity.

scholarly journals Synthesis, Characterization and Antibacterial Activities of New Bivalent Complexes of Transition Metals

2019 ◽  
Vol 31 (9) ◽  
pp. 1926-1930
Author(s):  
Veenu Chugh ◽  
Sangeeta Sharma ◽  
Rimpi Mehani Ne'e Chopra
Keyword(s):  
Magnetic Measurements ◽  
Antimicrobial Properties ◽  
Antibacterial Activities ◽  
Molar Conductance ◽  
Spectral Studies ◽  
X Ray Diffraction ◽  
Gram Positive Bacteria ◽  
Diffusion Technique ◽  
Complexes Of Transition Metals ◽  
Thermal Stability Of

This paper describes the synthesis, spectral studies and antimicrobial properties of the complexes with the formula [M(C30H24N4O2)Cl2], where M = Fe(II), Co(II), Ni(II), Zn(II) and Cu(II). These complexes were prepared by yield effective template condensation of hexamethylenediamine and 2,2-dihydroxyindane-1,3-dione(ninhydrin). The synthesized complexes were characterized by elemental analysis, infrared spectra, thermogravimetric analysis, Mass spectrum, 13C NMR, molar conductance, electronic spectra, magnetic measurements. TGA and X-ray diffraction studies were used to ascertain the crystal structure and thermal stability of the complexes. The antimicrobial properties of complexes against two Gram-positive bacteria and two Gram-negative bacteria were evaluated by Agar well diffusion technique. Streptomycin and chloramphenicol were taken as standard antibiotics. The results shows that some of the complexes have potential to act as antibacterial agents.

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