scholarly journals Surface-Based Regional Homogeneity in First-Episode, Drug-Naïve Major Depression: A Resting-State fMRI Study

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Hui-Jie Li ◽  
Xiao-Hua Cao ◽  
Xing-Ting Zhu ◽  
Ai-Xia Zhang ◽  
Xiao-Hui Hou ◽  
...  
Keyword(s):  
Resting State ◽  
Rating Scale ◽  
Resting State Fmri ◽  
Regional Homogeneity ◽  
First Episode ◽  
Pathophysiological Mechanism ◽  
Healthy Controls ◽  
Intersubject Variability ◽  
Drug Naïve ◽  
Left Insula

Background.Previous volume-based regional homogeneity (ReHo) studies neglected the intersubject variability in cortical folding patterns. Recently, surface-based ReHo was developed to reduce the intersubject variability and to increase statistical power. The present study used this novel surface-based ReHo approach to explore the brain functional activity differences between first-episode, drug-naïve MDD patients and healthy controls.Methods.Thirty-three first-episode, drug-naïve MDD patients and 32 healthy controls participated in structural and resting-state fMRI scans. MDD patients were rated with a 17-item Hamilton Rating Scale for Depression prior to the scan.Results.In comparison with the healthy controls, MDD patients showed reduced surface-based ReHo in the left insula. There was no increase in surface-based ReHo in MDD patients. The surface-based ReHo value in the left insula was not significantly correlated with the clinical information or the depressive scores in the MDD group.Conclusions.The decreased surface-based ReHo in the left insula in MDD may lead to the abnormal top-down cortical-limbic regulation of emotional and cognitive information. The surface-based ReHo may be a useful index to explore the pathophysiological mechanism of MDD.

scholarly journals Antipsychotic drugs increase Neuregulin1b1 serum levels in first-episode drug-naïve patients and chronic schizophrenia with suggestions for improving the treatment of psychotic symptoms

2021 ◽  
Author(s):  
Haidong Yang ◽  
Wen Pan ◽  
Wenhuan Xiao ◽  
Man Yang ◽  
Jianchun Xu ◽  
...  
Keyword(s):  
Antipsychotic Drugs ◽  
Chronic Schizophrenia ◽  
Serum Levels ◽  
Psychotic Symptoms ◽  
First Episode ◽  
Antipsychotic Treatment ◽  
Therapeutic Effects ◽  
Pathophysiological Mechanism ◽  
Healthy Controls ◽  
Drug Naïve

Abstract Background: Neuregulin1 (NRG1) plays a role in neuronal migration, regulation of synaptic plasticity, and neural survival, and has been considered to be among the candidate genes for schizophrenia. This study focused on the variations in serum NRG1b1 levels following antipsychotic treatment and the relationship between NRG1b1 level and improvements in psychotic symptoms in first-episode drug-naïve (FEDN) patients and chronic schizophrenia.Methods: A total of 100 patients with schizophrenia were recruited and compared with 79 matched healthy controls. All patients had been drug-naïve for at least four weeks. Serum NRG1b1 levels and positive and negative syndrome scale (PANSS) scores were measured at the baseline and after four weeks. Serum NRG1b1 levels were measured using sandwich enzyme-linked immunosorbent assays (ELISA).Results: Baseline NRG1b1 levels were significantly lower in the patients with schizophrenia compared with the healthy controls. NRG1b1 levels increased significantly following antipsychotic treatment. NRG1b1 levels gradually increased with declining PANSS scores and its three subscales during antipsychotic therapy. The levels of NRG1b1 increased significantly in responders after four weeks of treatment, although non-responders showed no such effect. Correlation analyses showed that the levels of NRG1b1 were negatively correlated with the duration of illness and positively correlated with improvement in symptoms.Conclusion: The levels of serum NRG1b1 and the therapeutic effects gradually increased following treatment, indicating that NRG1b1 may be an indicator of therapy, and that it may also be associated with the pathophysiological mechanism causing schizophrenia, although this possible pathway requires further investigation. Antipsychotic drugs increase Neuregulin1b1 serum levels in first-episode drug-naïve patients and chronic schizophrenia with suggestions for improving the treatment of psychotic symptoms

Increased coherence-based regional homogeneity in resting-state patients with first-episode, drug-naive somatization disorder

2018 ◽  
Vol 235 ◽  
pp. 150-154 ◽  
Author(s):  
Yangpan Ou ◽  
Feng Liu ◽  
Jindong Chen ◽  
Pan Pan ◽  
Renrong Wu ◽  
...  
Keyword(s):  
Resting State ◽  
Regional Homogeneity ◽  
Somatization Disorder ◽  
First Episode ◽  
Drug Naïve

scholarly journals Identify changes of brain regional homogeneity in early and later adult onset patients with first-episode depression using resting-state fMRI

PLoS ONE ◽  
2017 ◽  
Vol 12 (9) ◽  
pp. e0184712 ◽  
Author(s):  
Zonglin Shen ◽  
Linling Jiang ◽  
Shuran Yang ◽  
Jing Ye ◽  
Nan Dai ◽  
...  
Keyword(s):  
Resting State ◽  
Resting State Fmri ◽  
Regional Homogeneity ◽  
First Episode ◽  
Adult Onset

Distinguishing hypochondriasis and schizophrenia using regional homogeneity: a resting-state fMRI study and support vector machine analysis

2021 ◽  
pp. 1-29
Author(s):  
Kangyu Jin ◽  
Zhe Shen ◽  
Guoxun Feng ◽  
Zhiyong Zhao ◽  
Jing Lu ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Resting State ◽  
Parietal Lobe ◽  
Brain Activity ◽  
Resting State Fmri ◽  
Brain Regions ◽  
Regional Homogeneity ◽  
Middle Temporal Gyrus ◽  
Support Vector ◽  
Fmri Study

Abstract Objective: A few former studies suggested there are partial overlaps in abnormal brain structure and cognitive function between Hypochondriasis (HS) and schizophrenia (SZ). But their differences in brain activity and cognitive function were unclear. Methods: 21 HS patients, 23 SZ patients, and 24 healthy controls (HC) underwent Resting-state functional magnetic resonance imaging (rs-fMRI) with the regional homogeneity analysis (ReHo), subsequently exploring the relationship between ReHo value and cognitive functions. The support vector machines (SVM) were used on effectiveness evaluation of ReHo for differentiating HS from SZ. Results: Compared with HC, HS showed significantly increased ReHo values in right middle temporal gyrus (MTG), left inferior parietal lobe (IPL) and right fusiform gyrus (FG), while SZ showed increased ReHo in left insula, decreased ReHo values in right paracentral lobule. Additionally, HS showed significantly higher ReHo values in FG, MTG and left paracentral lobule but lower in insula than SZ. The higher ReHo values in insula were associated with worse performance in MCCB in HS group. SVM analysis showed a combination of the ReHo values in insula and FG was able to satisfactorily distinguish the HS and SZ patients. Conclusion: our results suggested the altered default mode network (DMN), of which abnormal spontaneous neural activity occurs in multiple brain regions, might play a key role in the pathogenesis of HS, and the resting-state alterations of insula closely related to cognitive dysfunction in HS. Furthermore, the combination of the ReHo in FG and insula was a relatively ideal indicator to distinguish HS from SZ.

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