Avocado Oil Supplementation Modifies Cardiovascular Risk Profile Markers in a Rat Model of Sucrose-Induced Metabolic Changes

The purpose of this study was to evaluate the effects of avocado oil administration on biochemical markers of cardiovascular risk profile in rats with metabolic changes induced by sucrose ingestion. Twenty-five rats were divided into five groups: a control group (CG; basic diet), a sick group (MC; basic diet plus 30% sucrose solution), and three other groups (MCao, MCac, and MCas; basic diet plus 30% sucrose solution plus olive oil and avocado oil extracted by centrifugation or using solvent, resp.). Glucose, total cholesterol, triglycerides, phospholipids, low- and high-density lipoproteins (LDL, HDL), very low-density lipoprotein (VLDL), lactic dehydrogenase, creatine kinase, and high sensitivity C-reactive protein concentration were analyzed. Avocado oil reduces TG, VLDL, and LDL levels, in the LDL case significantly so, without affecting HDL levels. An effect was exhibited by avocado oil similar to olive oil, with no significant difference between avocado oil extracted either by centrifugation or solvent in myocardial injury biochemical indicators. Avocado oil decreased hs-CRP levels, indicating that inflammatory processes were partially reversed. These findings suggested that avocado oil supplementation has a positive health outcome because it reduces inflammatory events and produces positive changes in the biochemical indicators studied, related to the development of metabolic syndrome.

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Effects of an olive oil by-product on the cardiovascular risk profile: results of a randomized controlled clinical trial

Nutrition Metabolism and Cardiovascular Diseases ◽

10.1016/j.numecd.2019.12.025 ◽

2020 ◽

Vol 30 (3) ◽

pp. 537

Author(s):

M. Dinu ◽

G. Pagliai ◽

F. Scavone ◽

B. Colombini ◽

L. Bellumori ◽

...

Keyword(s):

Clinical Trial ◽

Cardiovascular Risk ◽

Olive Oil ◽

Risk Profile ◽

Controlled Clinical Trial ◽

Cardiovascular Risk Profile ◽

Randomized Controlled Clinical Trial ◽

Randomized Controlled

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Effects of a rapeseed oil-enriched hypoenergetic diet with a high content of α-linolenic acid on body weight and cardiovascular risk profile in patients with the metabolic syndrome

British Journal Of Nutrition ◽

10.1017/s0007114512002875 ◽

2012 ◽

Vol 108 (4) ◽

pp. 682-691 ◽

Cited By ~ 48

Author(s):

Andrea Baxheinrich ◽

Bernd Stratmann ◽

Young Hee Lee-Barkey ◽

Diethelm Tschoepe ◽

Ursel Wahrburg

Keyword(s):

Blood Pressure ◽

Metabolic Syndrome ◽

Body Weight ◽

Cardiovascular Risk ◽

Olive Oil ◽

Linolenic Acid ◽

Rapeseed Oil ◽

Risk Profile ◽

Cardiovascular Risk Profile ◽

The Metabolic Syndrome

In therapy of the metabolic syndrome, the optimal dietary approach with regard to its macronutrient composition and metabolically favourable food components, such as the plant-derived n-3 fatty acid α-linolenic acid (ALA), is still a matter of debate. We investigated the effects of a hypoenergetic diet with low energy density (ED) enriched in rapeseed oil, resulting in high MUFA content and an ALA intake of 3·5 g/d on body weight and cardiovascular risk profile in eighty-one patients with the metabolic syndrome in comparison with an olive oil diet rich in MUFA, but with a low ALA content. After a 6-month dietary intervention, body weight was significantly reduced in the rapeseed oil and olive oil groups ( − 7·8 v. − 6·0 kg; P < 0·05). There were significant decreases in systolic blood pressure, total cholesterol and LDL-cholesterol, and insulin levels in both groups (P < 0·05). For all of these changes, no inter-group differences were observed. After the rapeseed oil diet, diastolic blood pressure declined more than after the olive oil diet (P < 0·05 for time × group interaction). Furthermore, concentrations of serum TAG were significantly reduced after the high ALA intake, but not in the low ALA group (P < 0·05 for time × group interaction). In conclusion, our dietary food pattern with a low ED and high intakes of MUFA and ALA may be a practical approach for long-term dietary treatment in patients with the metabolic syndrome, leading to weight reduction and an improvement in the overall cardiovascular risk profile.

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