Giant Endometrial Polyp in a Postmenopausal Woman without Hormone/Drug Use and Vaginal Bleeding

The objective of this study is to determine and discuss the causes of a giant endometrial polyp in a postmenopausal woman without hormone/drug use and to submit interesting clinical presentation. Here we report a seventy-year-old female patient who was admitted to our hospital with lower back pain. There were no other complaints from her. Physical examination was normal. For further examination, computed tomography was performed and a heterogeneous mass, with a diameter of 10×9 centimeters, was detected in the uterine cavity. Hysterectomy because of suspected endometrial cancer was performed. Histopathological examination showed us a giant endometrial polyp with edematous and focal fibrotic stroma, large thick walled blood vessels between normal sized and cystically dilated endometrial glands. To the best of our knowledge, this is the first report of a giant endometrial polyp which is unrelated to use of drugs such as tamoxifen and raloxifene; however, based on the history of the patient it may be associated with long-term consumption of thyme, which is a kind of phytoestrogen.

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Multiple-System Atrophy in Long-Term Professional Painter: A Case Report

Case Reports in Pathology ◽

10.1155/2012/613180 ◽

2012 ◽

Vol 2012 ◽

pp. 1-5

Author(s):

Yusa Nagai ◽

Riko Kitazawa ◽

Miku Nakagawa ◽

Munenori Komoda ◽

Takeshi Kondo ◽

...

Keyword(s):

Multiple System Atrophy ◽

Medulla Oblongata ◽

Neurodegenerative Disorder ◽

Histopathological Examination ◽

Neuronal Loss ◽

Cytoplasmic Inclusion ◽

Multiple Organ ◽

Old Japanese ◽

History Of

Introduction. Multiple system atrophy (MSA) is a rare and severe adult-onset, sporadic, and progressive neurodegenerative disorder. Here, we describe an autopsy case of MSA in a long-term professional painter. Although typical glial cytoplasmic inclusion (GCI) was not observed in a routine histological examination, strong α-synuclein immunostaining in the nucleus confirmed the diagnosis of MSA.Case Presentation. A 48-year-old Japanese man with a long occupational history of professional painter was sent to the emergency room, where he died of multiple organ failure. The patient had suffered tremors and inarticulateness at age 28, developed diabetes at 42 and was diagnosed with spinocerebellar degeneration at 46. A histopathological examination showed severe neuronal loss, gliosis, and tissue rarefaction in the paleostriatum, striate body of the substantia nigra, the pons, and the olivary nucleus of the upper medulla oblongata, intermediolateral of the spinal gray matter (sacral region). α-synuclein-positive GCI in oligodendroglia was occurred in the cerebral cortex, the midbrain, the medulla oblongata, and the spinal cord. These findings confirmed the presence of multiple-system atrophy (OPCA+SDS).Conclusion. Although the pathogenesis of MSA is still unclear, prolonged, and extensive exposure to organic solvents, together with a hyperglycemic morbidity attributed to diabetes, may have contributed to the onset and clinical course of the present case.

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Variance in clinical presentation of Ectopic pregnancy

10.53350/pjmhs2115102845 ◽

2021 ◽

Vol 15 (10) ◽

pp. 2845-2847

Author(s):

Areeba Aftab ◽

Memoona Faiyaz ◽

Uzma Fahim ◽

Humaira Tabassum ◽

Saima Rafique ◽

...

Keyword(s):

Ectopic Pregnancy ◽

Key Words ◽

Acute Abdomen ◽

Vaginal Bleeding ◽

Clinical Presentation ◽

Uterine Cavity ◽

Cross Sectional ◽

Clinical Presentations ◽

Gestational Sac ◽

Labour Ward

Objective: To adjudge the prevalence of distinct presentations in ectopic pregnancy. Research Design: Descriptive cross-sectional. Place and Duration of Study: Emergency Labour Ward Department of Obstetrics & Gynecology, Nishtar Hospital Multan from 1.07.2017 to 31.12.2017. Methodology: Ninety five patients having positive pregnancy tests and uterine cavity with no intrauterine gestational sac on ultrasound were included. Clinical presentation like amenorrhea, vaginal bleeding, acute abdomen, shock or asymptomatic were assessed. Results: Amenorrhea observed in 73(76.8%) women, vaginal bleeding was seen in 32 (33.7%) women, 88 (92.6%) patients presented with acute abdomen and vitals instability was seen in 8 (8.4%) patients and 6(6.3%) patients were without symptoms. Conclusion: The two most common clinical presentations in patients included in study were amenorrhea and acute abdomen. Thorough evaluation of the patients with sub-acute or chronic presentation should be adopted to diagnose the cases of ectopic pregnancy. Key words: Ectopic pregnancy; Clinical presentation; Variations

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Myoepithelioma of the Skull

Neurosurgery ◽

10.1227/neu.0b013e318260ffb0 ◽

2012 ◽

Vol 71 (4) ◽

pp. E901-E904 ◽

Cited By ~ 7

Author(s):

Karen J. Fritchie ◽

Mitchel D. Bauman ◽

Quentin J. Durward

Keyword(s):

Clinical Presentation ◽

Histopathological Examination ◽

Bone Lesion ◽

Myoepithelial Cells ◽

The Past ◽

Lytic Bone Lesion ◽

Initial Biopsy

Abstract BACKGROUND AND IMPORTANCE: Myoepithelioma of bone is a rare osseous tumor thought to be related to myoepithelial lesions found at other anatomic sites such as the salivary gland and skin. These tumors are composed of varying proportions of epithelial and myoepithelial cells and exhibit a spectrum of biologic behavior ranging from benign to malignant. We present the first reported case of myoepithelioma of the skull. CLINICAL PRESENTATION: A 20-year-old white woman presented with a persistent right parieto-occipital skull nodule, relating its presence to a fall on the site 2 years previously. The nodule had become painful in the past 2 months. Her past medical history and workup were otherwise unremarkable. The initial biopsy was inconclusive for diagnosis. The lytic bone lesion was subsequently resected, and histopathological examination showed a proliferation of epithelioid cells in a myxochondroid background. Fluorescence in situ hybridization studies revealed a rearrangement of the EWSR1 locus. The morphologic and molecular findings were consistent with the diagnosis of myoepithelioma of bone. CONCLUSION: Six months after surgery, the patient is doing well with no evidence of recurrence. This case illustrates the clinical presentation, histopathology, and molecular findings of a myoepithelioma of the skull with successful surgical treatment. Because myoepitheliomas with benign morphological appearance may rarely act aggressively, long-term clinical follow-up is warranted.

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Tuberculosis of uterine cervix: a report of two cases with variable clinical presentation

Tropical Doctor ◽

10.1258/td.2009.090423 ◽

2010 ◽

Vol 40 (2) ◽

pp. 125-126 ◽

Cited By ~ 6

Author(s):

Sunita Singh ◽

Veena Gupta ◽

Shilpi Modi ◽

Praveen Rana ◽

Amrita Duhan ◽

...

Keyword(s):

Rare Disease ◽

Young Woman ◽

Uterine Cervix ◽

Vaginal Bleeding ◽

Clinical Presentation ◽

Histopathological Examination ◽

The Other ◽

Perimenopausal Woman ◽

Cervical Biopsy ◽

Variable Clinical Presentation

Tuberculosis (TB) of the cervix is a rare disease. We describe two cases of tuberculous cervicitis with variable clinical presentation. In one case, a young woman presented with primary infertility and secondary amenorrhoea. The other is a perimenopausal woman with irregular vaginal bleeding and postcoital blood-stained discharge. The diagnosis was confirmed on histopathological examination of the endocervical curettings and a cervical biopsy. The patients were given six months of anti-tuberculous therapy and responded well.

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Primary medulla oblongata teratomas

Journal of Neurosurgery Pediatrics ◽

10.3171/2014.6.peds1423 ◽

2014 ◽

Vol 14 (3) ◽

pp. 296-300 ◽

Cited By ~ 1

Author(s):

Da Li ◽

Shu-Yu Hao ◽

Zhen Wu ◽

Li-Wei Zhang ◽

Jun-Ting Zhang

Keyword(s):

Medulla Oblongata ◽

Histopathological Examination ◽

Mature Teratoma ◽

Radiographic Findings ◽

First Case ◽

Cystic Component ◽

Long Term Follow Up ◽

History Of

Medulla oblongata teratomas are rare. The authors report 2 new cases of teratomas that occurred exclusively in the medulla oblongata. The first case was in a 9-year-old boy who presented with a 6-month history of neck pain and repeated paroxysmal vomiting. Based on preoperative radiographic findings, the initial diagnosis was of an intraaxial medulla oblongata hemangioblastoma. Intraoperatively, the cystic component of the tumor was gray, gelatinous, and soft in consistency. The solid component was light pink, rubbery, and nodular in appearance, with an identifiable boundary. The lesion was completely removed. Histopathological investigation revealed a mature teratoma. Postoperatively, the patient was supported with ventilator assistance and received a tracheotomy, but died of intracranial infection. The second case was in a 10-year-old boy with intermittent headache for 1 month. Radiographs revealed an exophytic cystic and solid lesion with dorsal involvement of the medulla oblongata. The lesion was predominantly solid, pinkish gray, tenacious, and moderately vascularized, with clearly delineated surgical dissection planes. The histopathological examination confirmed a diagnosis of immature teratoma. Total resection was achieved, followed by postoperative chemotherapy. He was alive without recurrence of the lesion or symptoms at 59 months after surgery. Resection of medulla oblongata teratoma is challenging, with inherent surgical risks that are contingent on the tumor growth pattern. Teratomas should be considered in the differential diagnosis of brainstem lesions. Chemotherapy has been suggested for immature teratomas. Long-term follow-up and larger studies of teratomas in unusual locations are required to improve practitioners' understanding of this disease's treatment and outcomes.

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V. Zhemchuzhnikov. A case of long-term retention of the fetal head in the uterine cavity after decapitation. (Protocol of the meeting of the obstetric-gynecological society in Kiev; year 5, volume 5. Issues 9 and 10)

Journal of obstetrics and women s diseases ◽

10.17816/jowd75429 ◽

2020 ◽

Vol 7 (5) ◽

pp. 429

Author(s):

F. Krasnopolskiy

Keyword(s):

Uterine Cavity ◽

Fetal Head ◽

Detailed History ◽

Term Retention ◽

History Of ◽

Long Term Retention ◽

Sacral Bone ◽

Anterior Posterior

The author gives a detailed history of a patient suffering from a tumor emanating from the region of the sacral bone, the size of a child's head, dense fibrous consistency, so much narrowed the anterior-posterior size of the pelvis that the last one was barely 2 - ctm. Due to such a contraction, at the 6th birth, the subsequent head could not be removed, and, after decapitation, was left in the uterine cavity; three months later, the patient was admitted to the clinic of prof. Rake, and in the continuation of this time the bones of the skull of the detained head were arbitrarily protruded, which was accompanied by a feverish state.

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Grinspan’s Syndrome: A Rare Case with Malignant Transformation

Case Reports in Otolaryngology ◽

10.1155/2018/9427650 ◽

2018 ◽

Vol 2018 ◽

pp. 1-4 ◽

Cited By ~ 1

Author(s):

Numan Kökten ◽

Lokman Uzun ◽

Ayşe Serap Karadağ ◽

Tülay Zenginkinet ◽

M. Tayyar Kalcıoğlu

Keyword(s):

Malignant Transformation ◽

Lichen Planus ◽

Buccal Mucosa ◽

Histopathological Examination ◽

Split Thickness Skin Graft ◽

Thickness Skin ◽

Exophytic Tumor ◽

History Of ◽

Stratified Squamous Epithelium

Aim. Oral lichen planus (OLP) is one of the common chronic inflammatory, noninfectious, and precancerous oral mucosal diseases that affect the stratified squamous epithelium in adults. Grinspan et al. reported an association of OLP with diabetes mellitus and vascular hypertension and called that Grinspan’s syndrome in 1966. We aim to present a case of Grinspan’s syndrome with malignant transformation. Case Presentation. A 60-year-old man who presented with a ten-year history of OLP diagnosed clinically and histologically was referred to our otolaryngology department with a painless swallowing in the left buccal mucosa for 3 months. Clinical examination revealed several plaques, striated white lesions in the buccal mucosa bilaterally, and an exophytic tumor in the left buccal mucosa. Histopathological examination showed lichen planus bilaterally and oral squamous cell carcinoma in the left buccal mucosa. The tumor had been developed on the preexisting areas of lichen planus which had been histologically proven before. The tumor was removed completely, and the tissue defect on the buccal mucosa was repaired with a split-thickness skin graft. Conclusion. Patients with OLP should be followed up periodically in a long term at close intervals for early diagnosis of malignant transformation.

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MPC-16 RAPID PROGRESSIVE SPINAL DIFFUSE MIDLINE GLIOMA, A CASE REPORT

Neuro-Oncology Advances ◽

10.1093/noajnl/vdz039.111 ◽

2019 ◽

Vol 1 (Supplement_2) ◽

pp. ii24-ii25

Author(s):

Tatsuya Takezaki ◽

Naoki Shinojima ◽

Junichiro Kuroda ◽

Takahiro Yamamoto ◽

Keishi Makino ◽

...

Keyword(s):

Histopathological Examination ◽

Lower Limbs ◽

Intramedullary Tumor ◽

Resonance Imaging ◽

Lower Back ◽

Nuchal Rigidity ◽

Atypical Cells ◽

History Of ◽

Diffuse Midline Glioma ◽

Spinal Gliomas

Abstract A 17-year-old boy presented with a 2-week history of lower back pain, progressive gait difficulty and sensory deficit of bilateral lower limbs. Magnetic resonance imaging of neuroaxis showed intramedullary tumor with spinal cord expansion from Th12 to L2 and irregular areas of enhancement. Emergent laminoplasty and biopsy was performed. Histopathological examination showed small atypical cells, but most cells had too much degeneration and necrosis to confirm the diagnosis definitively. Leptomeningeal dissemination caused conscious disturbance, nuchal rigidity and epilepsy. 2 weeks after decompression, we performed cordotomy again for advanced diagnosis, to be found diffuse midline glioma, H3K27M mutant by immunohistopathological examination and DAN sequence. He was treated with combination of whole brain and spine radiation therapy and chemotherapy with temozolomide and bevacizumab. He is still alive over 6 months. The clinical significance of H3K27M mutant in spinal gliomas is unclear. Further examinations are needed.

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Massive juvenile ossifying fibroma arising from the middle turbinate

BMJ Case Reports ◽

10.1136/bcr-2020-234432 ◽

2020 ◽

Vol 13 (4) ◽

pp. e234432

Author(s):

Valentinos Sofokleous ◽

Konstantina Chrysouli ◽

Efthymios Kyrodimos ◽

Evangelos Giotakis

Keyword(s):

Histopathological Examination ◽

Therapeutic Option ◽

Correct Diagnosis ◽

Middle Turbinate ◽

Ossifying Fibroma ◽

Endoscopic Endonasal ◽

Juvenile Ossifying Fibroma ◽

History Of

A 19-year-old man presented with a long-standing history of nasal obstruction, which gradually became worse over the past 2 years. Nasal endoscopy revealed a sizeable rounded mass covered by a normal-looking mucosa. Imaging studies showed a mass arising from the left middle turbinate that extended throughout the expanse of the anterior skull base. The tumour was resected via an endoscopic endonasal approach. Histopathological examination revealed a psammomatoid juvenile ossifying fibroma. The patient remains free of recurrence after almost 3 years of follow-up. Only four cases of ossifying fibroma with middle turbinate localisation have been reported in the literature so far, with our case representing the fifth and most extensive case. Clinical, radiological and histological findings should all be considered for establishing the correct diagnosis. An endoscopic approach represents an excellent therapeutic option. Long-term clinical and radiological surveillance is required due to the risk of recurrence.

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Multifocal polypoid endometriosis in a young woman simulating vaginal and pelvic neoplasm

Journal of Clinical Pathology ◽

10.1136/jcp.2009.073312 ◽

2010 ◽

Vol 63 (5) ◽

pp. 452-454 ◽

Cited By ~ 3

Author(s):

Seema Kaushal ◽

Vatsla Dadhwal ◽

Sandeep R Mathur ◽

Ruma Ray ◽

Prashant Durgapal ◽

...

Keyword(s):

Young Women ◽

Vaginal Bleeding ◽

Oestrogen Receptor ◽

Clinical Presentation ◽

History Of ◽

Pouch Of Douglas ◽

Age Range ◽

Pelvic Neoplasm ◽

Unopposed Oestrogen ◽

Polypoid Endometriosis

A 27-year-old nulliparous woman presented with large finger-like projections protruding from her vagina. Intraoperatively there were deposits in the pouch of Douglas. Clinical presentation and history of vaginal bleeding suggested malignancy. Histopathology of both the vaginal and pouch of Douglas masses showed endometrial glands and stroma. There was no architectural complexity or cytological atypia of glands or stroma. Immunohistochemistry for oestrogen receptor, progesterone receptor and CD10 was positive. Based on morphological and immunohistochemical findings, multifocal polypoid endometriosis was diagnosed; this is a recently described entity having a clinical presentation and age range completely different from conventional or non-polypoid endometriosis. Although an association between tamoxifen use, unopposed oestrogen therapy and polypoid endometriosis has been suggested, the patient had no history of tamoxifen or oestrogen intake. Polypoid endometriosis should be part of the differential diagnosis in young women presenting with vaginal growth.

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