scholarly journals Carboxymethyl Cellulose Acetate Butyrate: A Review of the Preparations, Properties, and Applications

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Mohamed El-Sakhawy ◽  
Samir Kamel ◽  
Ahmed Salama ◽  
Hebat-Allah Sarhan
Keyword(s):  
Cellulose Acetate ◽  
Carboxymethyl Cellulose ◽  
Solid Dispersions ◽  
Pharmaceutical Research ◽  
Amorphous Solid ◽  
Water Soluble ◽  
Cellulose Acetate Butyrate ◽  
Wide Range ◽  
Poorly Soluble ◽  
Acetate Butyrate

Carboxymethyl cellulose acetate butyrate (CMCAB) has gained increasing importance in several fields, particularly in coating technologies and pharmaceutical research. CMCAB is synthesized by esterification of CMC sodium salt with acetic and butyric anhydrides. CMCAB mixed esters are relatively high molecular weight (MW) thermoplastic polymers with high glass transition temperatures (Tg). CMCAB ester is dispersible in water and soluble in a wide range of organic solvents, allowing varied opportunity to the solvent choice. It makes application of coatings more consistent and defect-free. Its ability to slow down the release rate of highly water-soluble compounds and to increase the dissolution of poorly soluble compounds makes CMCAB a unique and potentially valuable tool in pharmaceutical and amorphous solid dispersions (ASD) formulations.

scholarly journals Preparation and characterization of nanoparticles of carboxymethyl cellulose acetate butyrate containing acyclovir

2015 ◽  
Vol 6 (2) ◽  
pp. 197-208 ◽  
Author(s):  
Venkata Bharadwaz Vedula ◽  
Maulick Chopra ◽  
Emil Joseph ◽  
Sonal Mazumder
Keyword(s):  
Cellulose Acetate ◽  
Carboxymethyl Cellulose ◽  
Cellulose Acetate Butyrate ◽  
Acetate Butyrate

Electrospun carboxymethyl cellulose acetate butyrate (CMCAB) nanofiber for high rate lithium-ion battery

2013 ◽  
Vol 96 (1) ◽  
pp. 240-245 ◽  
Author(s):  
Lei Qiu ◽  
Ziqiang Shao ◽  
Mingshan Yang ◽  
Wenjun Wang ◽  
Feijun Wang ◽  
...  
Keyword(s):  
Lithium Ion Battery ◽  
Cellulose Acetate ◽  
Carboxymethyl Cellulose ◽  
Lithium Ion ◽  
Cellulose Acetate Butyrate ◽  
High Rate ◽  
Acetate Butyrate

scholarly journals The Self-Assembly Phenomenon of Poloxamers and Its Effect on the Dissolution of a Poorly Soluble Drug from Solid Dispersions Obtained by Solvent Methods

Pharmaceutics ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 130 ◽  
Author(s):  
Joanna Szafraniec ◽  
Agata Antosik ◽  
Justyna Knapik-Kowalczuk ◽  
Krzysztof Chmiel ◽  
Mateusz Kurek ◽  
...  
Keyword(s):  
Spray Drying ◽  
Self Assembly ◽  
Binary Systems ◽  
Solid Dispersions ◽  
Water Soluble ◽  
The Self ◽  
Drug Dissolution ◽  
Reduced Pressure ◽  
Wide Range ◽  
Poorly Soluble

The self-assembly phenomenon of amphiphiles has attracted particular attention in recent years due to its wide range of applications. The formation of nanoassemblies able to solubilize sparingly water-soluble drugs was found to be a strategy to solve the problem of poor solubility of active pharmaceutical ingredients. Binary and ternary solid dispersions containing Biopharmaceutics Classification System (BCS) class II drug bicalutamide and either Poloxamer®188 or Poloxamer®407 as the surface active agents were obtained by either spray drying or solvent evaporation under reduced pressure. Both processes led to morphological changes and a reduction of particle size, as confirmed by scanning electron microscopy and laser diffraction measurements. The increase in powder wettability was confirmed by means of contact angle measurements. The effect of an alteration of the crystal structure was followed by powder X-ray diffractometry while thermal properties were determined using differential scanning calorimetry. Interestingly, bicalutamide exhibited a polymorph transition after spray drying with the poloxamer and polyvinylpyrrolidone (PVP), while the poloxamer underwent partial amorphization. Moreover, due to the surface activity of the carrier, the solid dispersions formed nanoaggregates in water, as confirmed using dynamic light scattering measurements. The aggregates measuring 200–300 nm in diameter were able to solubilize bicalutamide inside the hydrophobic inner parts. The self-assembly of binary systems was found to improve the amount of dissolved bicalutamide by 4- to 8-fold in comparison to untreated drug. The improvement in drug dissolution was correlated with the solubilization of poorly soluble molecules by macromolecules, as assessed using emission spectroscopy.

Formulation and Evaluation of Atorvastatin Solid Dispersions using Entada scandens seed starch as Superdisintegrant

2021 ◽  
pp. 5141-5149
Author(s):  
Sandeep Doppalapudi ◽  
Vidyadhara Suryadevara ◽  
Sailaja Yallam ◽  
Sowjanya Lakshmi Battula ◽  
Vanya Nayudu
Keyword(s):  
Solid Dispersions ◽  
Pharmaceutical Research ◽  
Surface Characteristics ◽  
Water Soluble ◽  
Physical Parameters ◽  
Poorly Soluble Drugs ◽  
Scanning Calorimetry ◽  
Dsc Studies ◽  
Poorly Soluble ◽  
Evaporation Technique

The present work mainly focuses on solubility enhancement of poorly soluble drugs using superdisintegrants. One of such poorly soluble drugs is Atorvastatin, which belongs to the category of statins. Atorvastatin belongs to BCS class – II, which is poorly water soluble and highly permeable. Natural sources are now-a-days playing a key role in pharmaceutical research. They have several pharmaceutical applications. Starches obtained from plants are pharmaceutically useful as binders, diluents, disintegrants and lubricants. Various physical parameters were evaluated. Solid dispersions were prepared using solvent evaporation technique. Where as in solid dispersions, formulations F2 and F5 showed better dissolution rate compared with other formulations. Fourier Transform Infra red spectroscopy (FTIR) and Differential Scanning Calorimetry (DSC) studies for optimized formulations revealed that there were no major interactions between the drug and excipients. X-Ray Diffraction (XRD) studies revealed the crystalline and amorphous nature of formulations. Scanning Electron Microscopy (SEM) revealed the surface characteristics. Thus from the present study, it was concluded that Entada scandens seed starch posses superdisintegrant property.

scholarly journals THERMAL PROPERTIES OF CARBOXYMETHYL CELLULOSE ACETATE BUTYRATE

2019 ◽  
Vol 53 (7-8) ◽  
pp. 667-675 ◽  
Author(s):  
MOHAMED EL-SAKHAWY ◽  
◽  
HEBAT-ALLAH S. TOHAMY ◽  
AHMED SALAMA ◽  
SAMIR KAMEL ◽  
...  
Keyword(s):  
Thermal Properties ◽  
Cellulose Acetate ◽  
Carboxymethyl Cellulose ◽  
Cellulose Acetate Butyrate ◽  
Acetate Butyrate

scholarly journals Solid Dispersions of Anthelmintics and Plant Protection Preparations

Solids ◽  
2021 ◽  
Vol 2 (1) ◽  
pp. 60-75
Author(s):  
Salavat S. Khalikov
Keyword(s):  
Plant Protection ◽  
Rapid Development ◽  
Solid Dispersions ◽  
Animal Health ◽  
Water Soluble ◽  
Biologically Active ◽  
Cultivated Plants ◽  
Industrial Complex ◽  
Scientific Papers ◽  
Poorly Soluble

Because of the rapid development of nanotechnologies, materials, in particular, solid dispersions (SDs), which are actively introduced into the life of modern man, have been obtained. Special progress in this area is observed in industry and medicine. The use of SDs in agriculture is lagging far behind, despite the growing number of scientific papers on this topic. At the same time, the prospects for the introduction of SDs in the agro-industrial complex are obvious. The review presents the results of research on the development of innovative preparations based on SD to protect plants from diseases and pests of cultivated plants, as well as parasiticides to protect animal health based on modern achievements of nanotechnology. One of these technologies is the methods of mechanochemistry, which improve the properties of poorly soluble biologically active substances by their joint mechanical treatment with water-soluble polymers and auxiliary substances.

scholarly journals Relative Contributions of Solubility and Mobility to the Stability of Amorphous Solid Dispersions of Poorly Soluble Drugs: A Molecular Dynamics Simulation Study

Pharmaceutics ◽  
2018 ◽  
Vol 10 (3) ◽  
pp. 101 ◽  
Author(s):  
Michael Brunsteiner ◽  
Johannes Khinast ◽  
Amrit Paudel
Keyword(s):  
Molecular Dynamics ◽  
Oral Delivery ◽  
Solid Dispersions ◽  
Amorphous Solid ◽  
Dynamics Simulation ◽  
Limiting Factor ◽  
Poorly Soluble Drugs ◽  
Formulation Development ◽  
Amorphous Solid Dispersions ◽  
Poorly Soluble

Amorphous solid dispersions are considered a promising formulation strategy for the oral delivery of poorly soluble drugs. The limiting factor for the applicability of this approach is the physical (in)stability of the amorphous phase in solid samples. Minimizing the risk of reduced shelf life for a new drug by establishing a suitable excipient/polymer-type from first principles would be desirable to accelerate formulation development. Here, we perform Molecular Dynamics simulations to determine properties of blends of eight different polymer–small molecule drug combinations for which stability data are available from a consistent set of literature data. We calculate thermodynamic factors (mixing energies) as well as mobilities (diffusion rates and roto-vibrational fluctuations). We find that either of the two factors, mobility and energetics, can determine the relative stability of the amorphous form for a given drug. Which factor is rate limiting depends on physico-chemical properties of the drug and the excipients/polymers. The methods outlined here can be readily employed for an in silico pre-screening of different excipients for a given drug to establish a qualitative ranking of the expected relative stabilities, thereby accelerating and streamlining formulation development.

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