scholarly journals Korean Red Ginseng Saponin Fraction Rich in Ginsenoside-Rb1, Rc and Rb2 Attenuates the Severity of Mouse Collagen-Induced Arthritis

2014 ◽  
Vol 2014 ◽  
pp. 1-14 ◽  
Author(s):  
Mehari Endale ◽  
Eun Ju Im ◽  
Joo Young Lee ◽  
Sung Dae Kim ◽  
Taddesse Yayeh ◽  
...  
Keyword(s):  
Inflammatory Responses ◽  
Combined Therapy ◽  
Cartilage Damage ◽  
Serum Antibody ◽  
Ginsenoside Rb1 ◽  
Red Ginseng ◽  
Korean Red Ginseng ◽  
Ginseng Saponin ◽  
Anti Inflammatory ◽  
Saponin Fraction

Despite a multitude of reports on anti-inflammatory properties of ginseng extracts or individual ginsenosides, data on antiarthritic effect of ginseng saponin preparation with mixed ginsenosides is limited. On the other hand, a combined therapy of safe and inexpensive plant-derived natural products such as ginsenosides can be considered as an alternative to treat arthritis. Our previousin vitrodata displayed a strong anti-inflammatory action of red ginseng saponin fraction-A (RGSF-A). We, herein, report a marked antiarthritic property of RGSF-A rich in ginsenoside Rb1, Rc, and Rb2. Collagen-induced arthritic (CIA) mice were treated with RGSF-A or methotrexate (MTX) for 5 weeks. Joint pathology, serum antibody production and leukocye activation, cytokine production in the circulation, lymph nodes, and joints were examined. RGSF-A markedly reduced severity of arthritis, cellular infiltration, and cartilage damage. It suppressed CD3+/CD69+, CD4+/CD25+, CD8+T-cell, CD19+, B220/CD23+B-cell, MHCII+/CD11c+, and Gr-1+/CD11b+cell activations. It further suppressed anti-CII- or anti-RF-IgG/IgM, TNF-α, IL-1β, IL-17, and IL-6 secretions but stimulated IL-10 levels in the serum, joint, or splenocyte. RGSF-A attenuated arthritis severity, modified leukocyte activations, and restored cytokine imbalances, suggesting that it can be considered as an antiarthritic agent with the capacity to ameliorate the immune and inflammatory responses in CIA mice.

scholarly journals Red Ginseng Saponin Fraction A Isolated from Korean Red Ginseng by Ultrafiltration on the Porcine Coronary Artery

2011 ◽  
Vol 35 (3) ◽  
pp. 325-330 ◽  
Author(s):  
Young-Hyun Jung ◽  
Kwang-Yeol Park ◽  
Jin-Hong Jeon ◽  
Yi-Seong Kwak ◽  
Yong-Bum Song ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Red Ginseng ◽  
Korean Red Ginseng ◽  
Porcine Coronary Artery ◽  
Ginseng Saponin ◽  
Saponin Fraction

Ginsenoside Rc from Korean Red Ginseng (Panax ginseng C.A. Meyer) Attenuates Inflammatory Symptoms of Gastritis, Hepatitis and Arthritis

2016 ◽  
Vol 44 (03) ◽  
pp. 595-615 ◽  
Author(s):  
Tao Yu ◽  
Man Hee Rhee ◽  
Jongsung Lee ◽  
Seung Hyung Kim ◽  
Yanyan Yang ◽  
...  
Keyword(s):  
Panax Ginseng ◽  
Molecular Mechanisms ◽  
Red Ginseng ◽  
Korean Red Ginseng ◽  
Inhibitory Mechanisms ◽  
Inflammatory Processes ◽  
Anti Inflammatory ◽  
Ginsenoside Rc

Korean Red Ginseng (KRG) is an herbal medicine prescribed worldwide that is prepared from Panax ginseng C.A. Meyer (Araliaceae). Out of ginseng’s various components, ginsenosides are regarded as the major ingredients, exhibiting anticancer and anti-inflammatory activities. Although recent studies have focused on understanding the anti-inflammatory activities of KRG, compounds that are major anti-inflammatory components, precisely how these can suppress various inflammatory processes has not been fully elucidated yet. In this study, we aimed to identify inhibitory saponins, to evaluate the in vivo efficacy of the saponins, and to understand the inhibitory mechanisms. To do this, we employed in vitro lipopolysaccharide-treated macrophages and in vivo inflammatory mouse conditions, such as collagen (type II)-induced arthritis (CIA), EtOH/HCl-induced gastritis, and lipopolysaccharide (LPS)/D-galactosamine (D-GalN)-triggered hepatitis. Molecular mechanisms were also verified by real-time PCR, immunoblotting analysis, and reporter gene assays. Out of all the ginsenosides, ginsenoside Rc (G-Rc) showed the highest inhibitory activity against the expression of tumor necrosis factor (TNF)-[Formula: see text], interleukin (IL)-1[Formula: see text], and interferons (IFNs). Similarly, this compound attenuated inflammatory symptoms in CIA, EtOH/HCl-mediated gastritis, and LPS/D-galactosamine (D-GalN)-triggered hepatitis without altering toxicological parameters, and without inducing gastric irritation. These anti-inflammatory effects were accompanied by the suppression of TNF-[Formula: see text] and IL-6 production and the induction of anti-inflammatory cytokine IL-10 in mice with CIA. G-Rc also attenuated the increased levels of luciferase activity by IRF-3 and AP-1 but not NF-[Formula: see text]B. In support of this phenomenon, G-Rc reduced TBK1, IRF-3, and ATF2 phosphorylation in the joint and liver tissues of mice with hepatitis. Therefore, our results strongly suggest that G-Rc may be a major component of KRG with useful anti-inflammatory properties due to its suppression of IRF-3 and AP-1 pathways.

Beneficial Effects of Korean Red Ginseng in the Progression of Non-Alcoholic Steatohepatitis via FABP4 Modulation

2018 ◽  
Vol 46 (07) ◽  
pp. 1581-1607 ◽  
Author(s):  
Hyeneui Jeong ◽  
Jong-Won Kim ◽  
Myeon-Sik Yang ◽  
Chul Park ◽  
Jong Hoon Kim ◽  
...  
Keyword(s):  
Inflammatory Responses ◽  
Alternative Therapy ◽  
Diet Group ◽  
Therapeutic Effects ◽  
Red Ginseng ◽  
High Fat ◽  
Korean Red Ginseng ◽  
Safe Alternative ◽  
Expression Levels

Korean red ginseng (KRG) is a traditional herbal medicine used to prevent several geriatric diseases due to its therapeutic effects on metabolic disorder, including type 2 diabetes and fatty liver disease. In this study, we investigated the effects of KRG on the progression of nonalcoholic steatohepatitis (NASH) in mice. NASH was induced by feeding a methionine- and choline-deficient high-fat or high-fat/high-sucrose diet for 6 or 13 weeks, respectively. Each diet group was also orally administered saline (group G0) or KRG extract (100, 200, or 400 mg/kg/day; groups G1, G2, and G4, respectively). KRG showed anti-inflammatory and antifibrogenic effects in the diet-induced NASH models. Furthermore, the expression levels of lipid metabolism-related genes were markedly decreased with KRG treatment in both diet-induced NASH groups. We next confirmed the expression levels of FABP4 in the liver and its ability to regulate inflammation and/or oxidative stress. We observed decreased levels of FABP4 mRNA and protein in the KRG-treated groups indicating that KRG affects the pathogenesis of NASH-related inflammatory responses by modulating FABP4 expression. Results of in vitro experiments showed similar patterns in cells treated with KRG, indicating that KRG treatment regulates the expression of FABP4 and subsequently reduces NASH related inflammation. Our findings suggest a novel role of KRG in NASH-related inflammatory responses via modulation of FABP4 expression in the liver. KRG may be a safe alternative therapy to prevent NASH progression.

ATF-2/CREB/IRF-3-targeted anti-inflammatory activity of Korean red ginseng water extract

2014 ◽  
Vol 154 (1) ◽  
pp. 218-228 ◽  
Author(s):  
Yanyan Yang ◽  
Woo Seok Yang ◽  
Tao Yu ◽  
Gi-Ho Sung ◽  
Kye Won Park ◽  
...  
Keyword(s):  
Water Extract ◽  
Inflammatory Activity ◽  
Red Ginseng ◽  
Korean Red Ginseng ◽  
Anti Inflammatory

scholarly journals Anti-inflammatory and antifatigue effect of Korean Red Ginseng in patients with nonalcoholic fatty liver disease

2016 ◽  
Vol 40 (3) ◽  
pp. 203-210 ◽  
Author(s):  
Meegun Hong ◽  
Yoon Hyeong Lee ◽  
Seungwoo Kim ◽  
Ki Tae Suk ◽  
Chang Seok Bang ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Red Ginseng ◽  
Korean Red Ginseng ◽  
Nonalcoholic Fatty Liver ◽  
Anti Inflammatory
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