scholarly journals Synthesis, Spectral Characterization, and Biological Evaluation of Transition Metal Complexes of Bidentate N, O Donor Schiff Bases

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Sajjad Hussain Sumrra ◽  
Muhammad Ibrahim ◽  
Sabahat Ambreen ◽  
Muhammad Imran ◽  
Muhammad Danish ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Metal Complexes ◽  
Schiff Bases ◽  
Transition Metal Complexes ◽  
Metal Ion ◽  
Analytical Data ◽  
Biological Evaluation ◽  
Equimolar Ratio ◽  
Donor Type ◽  
Good Agreement

New series of three bidentate N, O donor type Schiff bases(L1)–(L3)were prepared by using ethylene-1,2-diamine with 5-methyl furfural, 2-anisaldehyde, and 2-hydroxybenzaldehyde in an equimolar ratio. These ligands were further complexed with Co(II), Cu(II), Ni(II), and Zn(II) metals to produce their new metal complexes having an octahedral geometry. These compounds were characterized on the basis of their physical, spectral, and analytical data. Elemental analysis and spectral data of the uncomplexed ligands and their metal(II) complexes were found to be in good agreement with their structures, indicating high purity of all the compounds. All ligands and their metal complexes were screened for antimicrobial activity. The results of antimicrobial activity indicated that metal complexes have significantly higher activity than corresponding ligands. This higher activity might be due to chelation process which reduces the polarity of metal ion by coordinating with ligands.

scholarly journals Synthesis, Characterization and Antimicrobial Activity of Ni(II), Zn(II), and Cd(II) Complexes of 3/4-Bromo-Benzoic Acid (Phenyl-Pyridine-2-yl-Methylene)-Hydrazide Ligand

2020 ◽  
Vol 9 (4) ◽  
pp. 1529-1537
Keyword(s):  
Antimicrobial Activity ◽  
Benzoic Acid ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Metal Ion ◽  
Trichophyton Rubrum ◽  
Salmonella Typhi ◽  
Spectral Studies ◽  
Mass Analysis ◽  
Uv Visible

New transition metal complexes [Ni(L)2], [Zn(L)Cl], [Zn(L)2] and [Cd(L)2] were synthesized from 3-bromo-benzoic acid (phenyl-pyridin-2-yl-methylene)-hydrazide (3Bbpph) and 4-bromo-benzoic acid (phenyl-pyridin-2-yl-methylene)-hydrazide (4Bbpph) ligands and were characterized by different physicochemical and spectral studies - IR, elemental, UV Visible, 1H NMR spectra and mass analysis. The data revealed the presence of tetra-coordinate [Zn (L)Cl], whereas [Ni(L)2], [Zn(L)2], and [Cd(L)2] complexes consist of metal ion coordinated with two molecules of ligand to form octahedral geometry. The ligands act as monobasic, tridentate, and coordinated through enolate-O, azomethine-N, and pyridyl-N atoms. The antimicrobial activity of the ligands and metal complexes was investigated against Staphylococcus Aureus, Streptococcus Pyogenes, Escherichia coli, Salmonella typhi, Candida Albicans and Trichophyton Rubrum which revealed that the metal complexes exhibit greater activity than the parent ligands.

scholarly journals Biologically Important Schiff Bases and Their Transition Metal Complexes

2012 ◽  
Vol 11 (2) ◽  
pp. 57-72 ◽  
Author(s):  
Riya Datta ◽  
Ramya V
Keyword(s):  
Amino Acids ◽  
Antimicrobial Activity ◽  
Transition Metal ◽  
Metal Complexes ◽  
Schiff Bases ◽  
Transition Metal Complexes ◽  
Fungal Infections ◽  
Biological Systems ◽  
Aromatic Aldehydes

Transition metal complexes with different ligand systems have been developed. Majority of them are derived from heteroaromatic cycles and Schiff bases of variety of aromatic aldehydes, diketones with amino acids, polyamines, N-aromatic cycles and ethylenediamines. Metal complexes of Schiff bases are used as polymers, dyes and in various biological systems. They show antimicrobial activity and can be used as suitable drug to treat bacterial and fungal infections. Most of the Cu, Ni and Co complexes are also capable of binding and cleaving DNA.

scholarly journals Synthesis, Characterization and Antimicrobial Activity of Transition Metal Complexes of [NN] Donor Benzenesulfonamide Based Schiff Bases

2016 ◽  
Vol 28 (11) ◽  
pp. 2388-2392
Author(s):  
Ali Athar ◽  
Azim Khan Khattak ◽  
Wajeha Batool ◽  
Farman Ullah ◽  
Zia ul Haq ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Transition Metal ◽  
Metal Complexes ◽  
Schiff Bases ◽  
Transition Metal Complexes

scholarly journals Study of Metal Complexes with Schiff Base Derived from 2-Amino-4, 6-dimethylbenzothiazole and Pyrrole-2- aldehyde

2021 ◽  
Vol 9 (VIII) ◽  
pp. 931-936
Author(s):  
Dr. Vilas G. Deshpande
Keyword(s):  
Metal Complexes ◽  
Spectral Data ◽  
Schiff Bases ◽  
Metal Ion ◽  
Thermal Studies ◽  
Analytical Data ◽  
Conductivity Measurement ◽  
Planar Geometry ◽  
Central Metal

As it is proved that the transition metal complexes have drug activities, hence we have synthesized heterocyclic Schiff bases. Six complexes of Co(II), Ni(II), Fe(III), Mn(II), Cr(II) and Cu(II) Schiff bases have been prepared. All ligands and its metal complexes the structures of the complexes have been proposed by analytical data, conductivity measurement, magnetic moment, IR, 1H NMR spectra and thermal studies. Analytical data confirmed 1:2 (metal:ligand) stoichiometry and the spectral data suggest that all Fe(III), Mn(II), Cr(II), Ni(II) and Co(II) complexes have octahedral geometry where as the Cu(II) metal complex shows the square planar geometry. The molar conductance values of metal complexes suggest their non electrolytic nature. The IR spectral data reveals that the ligand behaves as bidentate with O,N donor atoms sequence towards central metal ion. Antibacterial and antifungal activities of ligands and its metal complexes were performed in vitro against E.coli, S. typhi, S. aureus, B. subtilis and against various fungi like P.chrysogenum, A. niger, F. moniliformae, and A.Flavus. The complexes show more activity compare to the ligand.

SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF 3-FORMYL INDOLE BASED SCHIFF BASES

2018 ◽  
Vol 7 (6) ◽  
Author(s):  
Singh Gurvinder ◽  
Singh Prabhsimran ◽  
Dhawan R. K.
Keyword(s):  
Antimicrobial Activity ◽  
Spectral Analysis ◽  
Schiff Bases ◽  
Antimicrobial Agents ◽  
Biological Evaluation ◽  
Fungal Strain ◽  
Bacterial Strains ◽  
Standard Drug ◽  
Gram Negative ◽  
E Coli

In order to develop new antimicrobial agents, a series of 3-formyl indole based Schiff bases were synthesized by reacting 3-formyl indole(indole-3-carboxaldehyde) with substituted aniline taking ethanol as solvent. The reaction was carried in the presence of small amount of p-toluene sulphonic acid as catalyst.All the synthesized compounds were characterized by IR, 1H-NMR spectral analysis. All the synthesized compounds were evaluated for antimicrobial activity against two gram positive bacterial strains (B. subtilisand S. aureus) and two gram negative bacterial strains (P. aeruginosaand E. coli) and one fungal strain (C. albicans). All the synthesized compounds were found to have moderate to good antimicrobial activity. The  standard drug amoxicillin, fluconazole were used for antimicrobial activity. Among the synthesized compounds, the maximum antimicrobial activity was shown by compounds GS04, GS07, GS08 and GS10.

Synthesis, Characterization and in vitro Biological Evaluation of a New Schiff Base Derived from Drug and its Complexes with Transition Metal Ions

2018 ◽  
Vol 69 (7) ◽  
pp. 1678-1681
Author(s):  
Amina Mumtaz ◽  
Tariq Mahmud ◽  
M. R. J. Elsegood ◽  
G. W. Weaver
Keyword(s):  
Schiff Base ◽  
Transition Metal ◽  
Metal Ions ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Free Ligand ◽  
Transition Metal Ions ◽  
Biological Evaluation ◽  
Pyridoxal Hydrochloride

New series of copper (II), cobalt (II), zinc (II), nickel (II), manganese (II), iron (II) complexes of a novel Schiff base were prepared by the condensation of sulphadizine and pyridoxal hydrochloride. The ligand and metal complexes were characterized by utilizing different instrumental procedures like microanalysis, thermogravimetric examination and spectroscopy. The integrated ligand and transition metal complexes were screened against various bacteria and fungus. The studies demonstrated the enhanced activity of metal complexes against reported microbes when compared with free ligand.

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