Plasma-Polymerized Polyethylene Glycol Hydrogel Films as Reservoirs for Drug Delivery Systems in Chemical and Biological Sensor Applications

Electroconductive hydrogels are composed of 3-dimensionally structured hydrogels and conducting molecules with electrical, optical, and reversible redox properties.

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Synthesis and Selfassambling of Amphiphilic Oligoesters Based on Pyromellitic Acid

Chemistry & Chemical Technology ◽

10.23939/chcht10.02.159 ◽

2016 ◽

Vol 10 (2) ◽

pp. 159-172 ◽

Cited By ~ 2

Author(s):

Ihor Tarnavchyk ◽

◽

Andriy Voronov ◽

Volodymyr Donchak ◽

Olga Budishevska ◽

...

Keyword(s):

Drug Delivery ◽

Polyethylene Glycol ◽

Size Distribution ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Fatty Alcohols ◽

Polyethylene Glycols ◽

Pyromellitic Acid ◽

New Class ◽

Solubilization Capacity

The method for synthesis of a new class of amphiphilic oligoesters of pyromellitic acid is developed. As hydrophilic fragments polyethylene glycols or polyethylene glycol mono methyl ethers were used, as lipophilic ones – primary fatty alcohols or cholesterol. The structure of the synthesized oligoesters was confirmed by IR- and PMR-spectroscopy. The oligoesters could solubilize water-insoluble substances, for example such effective antitumor lipophilic drug as curcumin. The high solubilization capacity of the OEPA assemblies and their biodegradability, as well as other properties (size distribution, ζ-potential) make the oligoesters considered as promising materials for the design of drug delivery systems.

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Polyethylene Glycol-Coated Gold Nanoparticles as DNA and Atorvastatin Delivery Systems and Cytotoxicity Evaluation

Journal of Nanomaterials ◽

10.1155/2019/5982047 ◽

2019 ◽

Vol 2019 ◽

pp. 1-11 ◽

Cited By ~ 1

Author(s):

José Alberto Zamora-Justo ◽

Paulina Abrica-González ◽

Guillermo Rocael Vázquez-Martínez ◽

Alejandro Muñoz-Diosdado ◽

José Abraham Balderas-López ◽

...

Keyword(s):

Drug Delivery ◽

Gold Nanoparticles ◽

Polyethylene Glycol ◽

Drug Delivery Systems ◽

Transfection Efficiency ◽

Delivery Systems ◽

Cell Uptake ◽

Imaging Studies ◽

Human Embryonic Kidney Cell ◽

Hek 293

The application of nanoscience and nanotechnology in medicine has been useful in the diagnosis, monitoring, and treatment of many diseases. Gold nanoparticles are commonly used for medical imaging studies, biosensors, drug delivery systems, and gene therapy. It has been reported that nanoparticles coated with specific polymers improve the biocompatibility and stability and decrease the cytotoxicity of the nanoparticles. In this work, we performed transfection studies of gold nanoparticles coated with polyethylene glycol, synthetized by two different methods, in a human embryonic kidney cell culture (HEK 293), by using plasmids pSV-β-Gal and pIRES2-EGFP. In addition, we also evaluated the cell uptake of a fluorescent drug (atorvastatin) using the synthetized gold nanoparticles as carriers. Furthermore, the study of cell viability after the interaction between these cells and the nanoparticles was performed. It was shown that the polyethylene glycol-coated gold nanoparticles presented transfection efficiency and cell uptake greater than 45% in each case. These results suggest that the synthetized gold nanoparticles coated with polyethylene glycol could be used successfully and safely as DNA and drug delivery systems.

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Fully Supramolecular Polyrotaxanes as Biphase Drug Delivery Systems

International Journal of Polymer Science ◽

10.1155/2014/829474 ◽

2014 ◽

Vol 2014 ◽

pp. 1-9 ◽

Cited By ~ 3

Author(s):

Abdolhossien Massoudi ◽

Mohsen Adeli ◽

Leila Khosravi far

Keyword(s):

Drug Delivery ◽

Polyethylene Glycol ◽

Citric Acid ◽

Hydrogen Bonds ◽

Drug Delivery Systems ◽

Noncovalent Interactions ◽

Delivery Systems ◽

End Groups ◽

Model Drug ◽

Primary Drug

Pseudopolyrotaxanes (PPR) consisting ofα-cyclodextrin rings and polyethylene glycol axes with end thymine groups have been synthesized and characterized successfully. Fluorescein (Fl) as a model drug was conjugated to the hydroxyl functional groups of cyclodextrin rings of PPR via ester bonds and PPR-Fl as the primary drug delivery system was obtained. Finally PPR-Fl was capped by hydrogen bonds between end thymine groups and a suitable complementary molecule such as polycitric acid, citric acid, or adenine. The aim of this work was to control the release of the fluorescein-cyclodextrin (Fl-CD) conjugates, as the secondary drug delivery systems, from PPR-Fl by controlling the noncovalent interactions between stoppers and thymine end groups. It was found that the rate of release of the Fl-CD from PPR-Fl could be controlled by pH and the ratio of citric acid or adenine to the PPR-Fl.

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Techniques For The Preparation of Tissue Samples Containing Injectable Polymer Microcapsules

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100120242 ◽

1985 ◽

Vol 43 ◽

pp. 710-711

Author(s):

G.E. Visscher ◽

R. L. Robison ◽

G. J. Argentieri

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Gastrocnemius Muscle ◽

Degradation Process ◽

Delivery Systems ◽

Tissue Reaction ◽

Electron Microscopic ◽

Tissue Samples ◽

Injectable Polymer ◽

Microscopic Techniques

The use of various bioerodable polymers as drug delivery systems has gained considerable interest in recent years. Among some of the shapes used as delivery systems are films, rods and microcapsules. The work presented here will deal with the techniques we have utilized for the analysis of the tissue reaction to and actual biodegradation of injectable microcapsules. This work has utilized light microscopic (LM), transmission (TEM) and scanning (SEM) electron microscopic techniques. The design of our studies has utilized methodology that would; 1. best characterize the actual degradation process without artifacts introduced by fixation procedures and 2. allow for reproducible results.In our studies, the gastrocnemius muscle of the rat was chosen as the injection site. Prior to the injection of microcapsules the skin above the sites was shaved and tattooed for later recognition and recovery. 1.0 cc syringes were loaded with the desired quantity of microcapsules and the vehicle (0.5% hydroxypropylmethycellulose) drawn up. The syringes were agitated to suspend the microcapsules in the injection vehicle.

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