Synthesis and Selfassambling of Amphiphilic Oligoesters Based on Pyromellitic Acid

2016 ◽  
Vol 10 (2) ◽  
pp. 159-172 ◽  
Author(s):  
Ihor Tarnavchyk ◽  
◽  
Andriy Voronov ◽  
Volodymyr Donchak ◽  
Olga Budishevska ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Polyethylene Glycol ◽  
Size Distribution ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Fatty Alcohols ◽  
Polyethylene Glycols ◽  
Pyromellitic Acid ◽  
New Class ◽  
Solubilization Capacity

The method for synthesis of a new class of amphiphilic oligoesters of pyromellitic acid is developed. As hydrophilic fragments polyethylene glycols or polyethylene glycol mono methyl ethers were used, as lipophilic ones – primary fatty alcohols or cholesterol. The structure of the synthesized oligoesters was confirmed by IR- and PMR-spectroscopy. The oligoesters could solubilize water-insoluble substances, for example such effective antitumor lipophilic drug as curcumin. The high solubilization capacity of the OEPA assemblies and their biodegradability, as well as other properties (size distribution, ζ-potential) make the oligoesters considered as promising materials for the design of drug delivery systems.

scholarly journals Aptamers Chemistry: Chemical Modifications and Conjugation Strategies

Molecules ◽  
2019 ◽  
Vol 25 (1) ◽  
pp. 3 ◽  
Author(s):  
Fadwa Odeh ◽  
Hamdi Nsairat ◽  
Walhan Alshaer ◽  
Mohammad A. Ismail ◽  
Ezaldeen Esawi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Pharmacological Properties ◽  
Chemical Modifications ◽  
New Class ◽  
Advantages And Disadvantages ◽  
Dna Oligonucleotides ◽  
Low Toxicity ◽  
Group Diversity

Soon after they were first described in 1990, aptamers were largely recognized as a new class of biological ligands that can rival antibodies in various analytical, diagnostic, and therapeutic applications. Aptamers are short single-stranded RNA or DNA oligonucleotides capable of folding into complex 3D structures, enabling them to bind to a large variety of targets ranging from small ions to an entire organism. Their high binding specificity and affinity make them comparable to antibodies, but they are superior regarding a longer shelf life, simple production and chemical modification, in addition to low toxicity and immunogenicity. In the past three decades, aptamers have been used in a plethora of therapeutics and drug delivery systems that involve innovative delivery mechanisms and carrying various types of drug cargos. However, the successful translation of aptamer research from bench to bedside has been challenged by several limitations that slow down the realization of promising aptamer applications as therapeutics at the clinical level. The main limitations include the susceptibility to degradation by nucleases, fast renal clearance, low thermal stability, and the limited functional group diversity. The solution to overcome such limitations lies in the chemistry of aptamers. The current review will focus on the recent arts of aptamer chemistry that have been evolved to refine the pharmacological properties of aptamers. Moreover, this review will analyze the advantages and disadvantages of such chemical modifications and how they impact the pharmacological properties of aptamers. Finally, this review will summarize the conjugation strategies of aptamers to nanocarriers for developing targeted drug delivery systems.

Microfluidic-mediated nano-drug delivery systems: from fundamentals to fabrication for advanced therapeutic applications

Nanoscale ◽  
2020 ◽  
Vol 12 (29) ◽  
pp. 15512-15527 ◽  
Author(s):  
Qingming Ma ◽  
Jie Cao ◽  
Yang Gao ◽  
Shangcong Han ◽  
Yan Liang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Size Distribution ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Therapeutic Applications ◽  
Nano Drug Delivery

Microfluidics-mediated NDDS show uniform morphology, size and size distribution, reduced batch-to-batch variations and controllable drug delivering capacity.

Preparation and Pharmacokinetics of Candesartan Cilexetil with Polymer Materials in Self-Microemulsifying Drug Delivery Systems

2013 ◽  
Vol 661 ◽  
pp. 104-107
Author(s):  
Rong Rong Li ◽  
Zhi Fei Xie ◽  
Ming Xing Liu ◽  
Hong Da Zhu
Keyword(s):  
Drug Delivery ◽  
Size Distribution ◽  
Drug Delivery Systems ◽  
Candesartan Cilexetil ◽  
Delivery Systems ◽  
Polydispersity Index ◽  
Polymer Materials ◽  
Narrow Size Distribution ◽  
Good Agreement

The candesartan cilexetil SMEDDS with PEG-PLA as long-circulating materials were successfully prepared and characterized by appearance, size and size distribution, morphology of emulsion and stability. The emulsion showed a narrow size distribution, well-proportioned in good agreement with polydispersity index of 0.005 and 3.6 nm diameter. The candesartan cilexetil SMEDDS were precipitated for 30 days at 25 °C or 37 °C. Meanwhile, Pharmacokinetics experiments illuminated that the candesartan cilexetil SMEDDS in rats had a larger drug curve concentration (AUC) compared to the tablets in the experiments.

scholarly journals Polyethylene Glycol-Coated Gold Nanoparticles as DNA and Atorvastatin Delivery Systems and Cytotoxicity Evaluation

2019 ◽  
Vol 2019 ◽  
pp. 1-11 ◽  
Author(s):  
José Alberto Zamora-Justo ◽  
Paulina Abrica-González ◽  
Guillermo Rocael Vázquez-Martínez ◽  
Alejandro Muñoz-Diosdado ◽  
José Abraham Balderas-López ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Gold Nanoparticles ◽  
Polyethylene Glycol ◽  
Drug Delivery Systems ◽  
Transfection Efficiency ◽  
Delivery Systems ◽  
Cell Uptake ◽  
Imaging Studies ◽  
Human Embryonic Kidney Cell ◽  
Hek 293

The application of nanoscience and nanotechnology in medicine has been useful in the diagnosis, monitoring, and treatment of many diseases. Gold nanoparticles are commonly used for medical imaging studies, biosensors, drug delivery systems, and gene therapy. It has been reported that nanoparticles coated with specific polymers improve the biocompatibility and stability and decrease the cytotoxicity of the nanoparticles. In this work, we performed transfection studies of gold nanoparticles coated with polyethylene glycol, synthetized by two different methods, in a human embryonic kidney cell culture (HEK 293), by using plasmids pSV-β-Gal and pIRES2-EGFP. In addition, we also evaluated the cell uptake of a fluorescent drug (atorvastatin) using the synthetized gold nanoparticles as carriers. Furthermore, the study of cell viability after the interaction between these cells and the nanoparticles was performed. It was shown that the polyethylene glycol-coated gold nanoparticles presented transfection efficiency and cell uptake greater than 45% in each case. These results suggest that the synthetized gold nanoparticles coated with polyethylene glycol could be used successfully and safely as DNA and drug delivery systems.

scholarly journals Fully Supramolecular Polyrotaxanes as Biphase Drug Delivery Systems

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Abdolhossien Massoudi ◽  
Mohsen Adeli ◽  
Leila Khosravi far
Keyword(s):  
Drug Delivery ◽  
Polyethylene Glycol ◽  
Citric Acid ◽  
Hydrogen Bonds ◽  
Drug Delivery Systems ◽  
Noncovalent Interactions ◽  
Delivery Systems ◽  
End Groups ◽  
Model Drug ◽  
Primary Drug

Pseudopolyrotaxanes (PPR) consisting ofα-cyclodextrin rings and polyethylene glycol axes with end thymine groups have been synthesized and characterized successfully. Fluorescein (Fl) as a model drug was conjugated to the hydroxyl functional groups of cyclodextrin rings of PPR via ester bonds and PPR-Fl as the primary drug delivery system was obtained. Finally PPR-Fl was capped by hydrogen bonds between end thymine groups and a suitable complementary molecule such as polycitric acid, citric acid, or adenine. The aim of this work was to control the release of the fluorescein-cyclodextrin (Fl-CD) conjugates, as the secondary drug delivery systems, from PPR-Fl by controlling the noncovalent interactions between stoppers and thymine end groups. It was found that the rate of release of the Fl-CD from PPR-Fl could be controlled by pH and the ratio of citric acid or adenine to the PPR-Fl.

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