scholarly journals Premalignant and Malignant Skin Lesions in Two Recipients of Vascularized Composite Tissue Allografts (Face, Hands)

2015 ◽  
Vol 2015 ◽  
pp. 1-4 ◽  
Author(s):  
Jean Kanitakis ◽  
Palmina Petruzzo ◽  
Aram Gazarian ◽  
Sylvie Testelin ◽  
Bernard Devauchelle ◽  
...  
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Immunosuppressive Treatment ◽  
Premalignant Lesions ◽  
Solid Organ ◽  
Composite Tissue ◽  
Disseminated Superficial Actinic Porokeratosis ◽  
Increased Risk ◽  
Malignant Lesions

Recipients of solid organ transplants (RSOT) have a highly increased risk for developing cutaneous premalignant and malignant lesions, favored by the lifelong immunosuppression. Vascularized composite tissue allografts (VCA) have been introduced recently, and relevant data are sparse. Two patients with skin cancers (one with basal cell carcinoma and one with squamous cell carcinomas) have been so far reported in this patient group. Since 2000 we have been following 9 recipients of VCA (3 face, 6 bilateral hands) for the development of rejection and complications of the immunosuppressive treatment. Among the 9 patients, one face-grafted recipient was diagnosed with nodular-pigmented basal cell carcinoma of her own facial skin 6 years after graft, and one patient with double hand allografts developed disseminated superficial actinic porokeratosis, a potentially premalignant dermatosis, on her skin of the arm and legs. Similar to RSOT, recipients of VCA are prone to develop cutaneous premalignant and malignant lesions. Prevention should be applied through sun-protective measures, regular skin examination, and early treatment of premalignant lesions.

A case-control study ofMC1Rvariants in Greek patients with basal cell carcinoma: increased risk independently of pigmentary characteristics

2015 ◽  
Vol 24 (6) ◽  
pp. 476-478 ◽  
Author(s):  
Clio Dessinioti ◽  
Vana Sypsa ◽  
Katerina Kypreou ◽  
Gerasimos Dimisianos ◽  
Elisavet Kodela ◽  
...  
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Case Control Study ◽  
Case Control ◽  
Increased Risk ◽  
Control Study

scholarly journals Increased Risk of Cutaneous Squamous Cell Carcinoma After Vismodegib Therapy for Basal Cell Carcinoma

2016 ◽  
Vol 152 (5) ◽  
pp. 527 ◽  
Author(s):  
Shalini V. Mohan ◽  
Julia Chang ◽  
Shufeng Li ◽  
A. Solomon Henry ◽  
Douglas J. Wood ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Basal Cell ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Increased Risk

scholarly journals Ultrastructural peculiarities in basal cell carcinoma

2019 ◽  
Vol 1 (1) ◽  
pp. 36-38
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Tumor Cells ◽  
Basal Cell ◽  
Membrane Vesicles ◽  
Premalignant Lesions ◽  
Elastic Fibers ◽  
Cell Phenotype ◽  
Electron Microscopic ◽  
Peritumoral Stroma

The last decade was marked by a statistically significant increase in the incidence of skin cancers, which motivated the development of new studies to later understand the behavior of these pathologies developing new therapeutic approaches. Also, the multitude of premalignant lesions as well as the complex classification of the carcinomas required a more accurate differentiation of the differential diagnosis, and in this regard the present electron microscopic study contributes significantly. A tumor is a very complex ecosystem represented in particular by (1) genetically modified neoplastic cells and (2) tumor stroma represented by (a) various other cell types (fibroblasts, fibrocytes, mast cells, inflammatory cells, endothelial cells, myelinated or non-myelinated nerves, etc.), and (b) extracellular matrix (basal lamina, elastic fibers and collagen, but also soluble molecules) [1]. The purpose of this study was to discover new aspects of ultrastructure that occur in basal cell carcinoma cases investigated by us, related to the capacity of invasiveness of these tumors. Fresh tumor fragments were obtained with the informed consent of the patients. Here we present some peculiar aspects concerning infrastructure of tumor cells involved in invasive process, especially desmosomal and hemidesmosomal junctions, invadopodia and shedding membrane vesicles. Moreover, here we report about new described cell phenotype termed telocytes involved in cell signaling by their homo- and heterocellular contacts. Telocytes from basal cell carcinoma stroma exhibit a reduced number of heterocellular contacts, which suggests a possible perturbation of tissue homeostasis modulation. Electron microscopic investigations revealed that in invasive basal cell carcinoma intercellular junctions, namely desmosomes are severely altered and that the tumor cells generate and disseminate membrane vesicles, including exosomes inside of the peritumoral stroma. Using transmission electron microscopy to investigate invasive basal cell carcinoma, we have managed to determine the relevance of all these changes for the purpose of evaluation of the invasive capacity of tumor cells within the peritumoral stroma.

scholarly journals Clinico-Histological study of Basosquamous Carcinoma of the Skin

2012 ◽  
Vol 6 (2) ◽  
pp. 3-8
Author(s):  
Rafal Abdulrazak Al-Rawi
Keyword(s):  
Squamous Cell Carcinoma ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Basal Cell ◽  
Epithelial Membrane Antigen ◽  
Histological Study ◽  
Low Molecular Weight ◽  
Increased Risk ◽  
Clinical Records

asosquamous carcinoma is one of skin malignant tumor with features of both basal cell carcinoma and squamous cell carcinoma. It may behave more aggressively with an increased risk of recurrence and metastases. Investigations on the incidence, clinical, histological and immunohistochemical findings of basosquamous cell carcinoma in comparison with basal and squamous cell carcinoma were carried out. The clinical records of 3000 patients were reviewed from Razgary teaching hospital in Erbil from the period of 1-1-2008 to 1-1-2009 for the diagnosis of basosquamous carcinoma, basal and squamous cell carcinoma and an immunohistochemistry study was done to the basosquamous cell carcinoma.The incidence of basosquamous carcinoma is 8.82% among basal 63.24% and squamous cell carcinoma 27.94%. The commonest site is the nose and mostly occurs in patient over 50 years. Regarding immunohistochemical study of both epithelial membrane antigen (EMA) and low molecular weight keratin (LMWK) showed 5 positive cases out of 6 Basosquamous carcinoma cases. It was concluded that Basosquamous carcinoma incidence is less than that of basal and squamous cell carcinoma. The histological diagnosis of basosquamous carcinoma is confirmed by the use of LMWK and EMA immunohistochemical staining of the areas of both basal cell carcinoma area and squamous cell carcinoma area, respectively

scholarly journals Clinico-Histological presentation of Head and Neck Lesions in a Tertiary Care Hospital

2021 ◽  
Vol 25 (1) ◽  
pp. 21-25
Author(s):  
Mohammad Sajjad Kattak ◽  
Abdul Ghafoor ◽  
Rafi Ullah ◽  
Asif Mehmmod ◽  
Mohammad Iqbal ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Basal Cell Carcinoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Basal Cell ◽  
Histopathological Diagnosis ◽  
Care Hospital ◽  
Malignant Lesions

Objective: This study aimed to see the clinical presentation and histological pattern of various head and neck lesions.Materials and Methods: This descriptive study was conducted in the Department of Pathology, Bannu Medical College in association with the Department of Surgery and ENT, Khalifa Gul Nawaz Teaching Hospital, Bannu. A total of 184 cases of head and neck lesions biopsy were subjected to histopathological diagnosis. Patients' age, gender, anatomical location, and other relevant necessary clinical findings were recorded on an already designed proforma. All biopsies were received in 10% buffered formalin, fixed overnight, and processed for histopathological examination and diagnosis. Inclusion criteria were patients with head and neck lesions including skin, salivary gland, lymph node, and oral cavity of any age and gender. Exclusion criteria were thyroid, nasal cavity lesions, autolysed, and insufficient biopsy specimen. Results: In this study, the mean age was 28.58 ± 17.34 years, and the age range was from 10 to 80 years. The male-to-female ratio was 1.3:1. The most common age group was 36-45 years followed by 46-55 years and 26-35 years etc. The most common inflammatory lesion was granulomatous lymphadenitis 14.67% followed by reactive lymphoid hyperplasia 9.23%. Common benign lesions were pleomorphic adenoma 5.97% followed by lipoma and hemangioma 3.80% and 3.26% respectively. Amongst malignant lesions basal cell carcinoma 23.91% of the face was the commonest lesion followed by squamous cell carcinoma 22.28% of the oral cavity. Conclusion: This study show spectrum of lesions from inflammatory to benign and malignant, occurring in the head and neck region. Malignant lesions are more common as compared to benign and inflammatory lesions, basal cell carcinoma of the skin is the commonest malignant lesion followed by squamous cell carcinoma of the skin and oral cavity.

scholarly journals Sex-Stratified Polygenic Risk Score Identifies Individuals at Increased Risk of Basal Cell Carcinoma

2020 ◽  
Vol 140 (5) ◽  
pp. 971-975
Author(s):  
Michelle R. Roberts ◽  
Joanne E. Sordillo ◽  
Peter Kraft ◽  
Maryam M. Asgari
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Risk Score ◽  
Basal Cell ◽  
Polygenic Risk Score ◽  
Polygenic Risk ◽  
Increased Risk

A rare presentation of multiple scrotal basal cell carcinomas secondary to Gorlin’s syndrome

2019 ◽  
pp. 205141581987292
Author(s):  
Pat Rohan ◽  
Christine Shilling ◽  
Nigam Shah ◽  
Padraig Daly ◽  
Ivor Cullen
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Locally Advanced ◽  
The Body ◽  
High Rate ◽  
De Novo Mutation ◽  
Gorlin Syndrome ◽  
Increased Risk ◽  
Basal Cell Carcinomas

Basal cell carcinoma is the most commonly occurring cancer worldwide but it is rarely seen in non-sun-exposed areas of the body such as the scrotum.1 Basal cell carcinomas account for 5–10% of all scrotal tumours.2,3 Scrotal basal cell carcinoma is considered more aggressive with higher rates of metastasis versus non-scrotal basal cell carcinoma.1 Gorlin syndrome or nevoid basal cell carcinoma syndrome is an autosomal dominant condition characterised by the development of multiple basal cell carcinomas at a young age.4,5 Prevalence of nevoid basal cell carcinoma syndrome is reported to range from 1 in 57,000 to 1 in 164,000.5 We present the case of a 58-year-old gentleman with a 3-month history of bleeding scrotal and penile lesions. These lesions were excised with 2 cm margins and without complication. Histology showed surface ulceration with basaloid infiltrating tumour extending into the dermis. Given the potential for a very high rate of tumour occurrence within individuals, surgical management of basal cell carcinomas can result in significant, lifestyle-limiting disfigurement.5 As understanding of the pathogenesis of nevoid basal cell carcinoma syndrome has advanced, a number of targeted therapies have been developed.5 Vismodegib targets the Hedgehog signalling pathway and is used in the treatment of locally advanced and metastatic basal cell carcinomas. This represents a rare case of basal cell carcinoma of the scrotum associated with nevoid basal cell carcinoma syndrome caused by a de novo mutation. It is not clear from the literature whether incidence of scrotal tumours is increased in Gorlin syndrome but given the increased risk of basal cell carcinoma elsewhere, it may be prudent for those with known Gorlin syndrome to regularly examine the scrotal skin along with recommended frequent dermatologic surveillance. Level of evidence: 5.

High-ceiling diuretics are associated with an increased risk of basal cell carcinoma in a population-based follow-up study

2010 ◽  
Vol 46 (13) ◽  
pp. 2467-2472 ◽  
Author(s):  
Rikje Ruiter ◽  
Loes E. Visser ◽  
Mark Eijgelsheim ◽  
Eline M. Rodenburg ◽  
Albert Hofman ◽  
...  
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Population Based ◽  
Follow Up Study ◽  
Increased Risk

scholarly journals A STUDY OF MALIGNANT LESIONS OF VULVA

2020 ◽  
pp. 1-2
Author(s):  
Mareeswari. M ◽  
Anitha Catherine Preethima.T
Keyword(s):  
Squamous Cell Carcinoma ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Basal Cell ◽  
Genital Tract ◽  
Vulvar Cancer ◽  
Malignant Lesion ◽  
Clinical Staging ◽  
Malignant Lesions

INTRODUCTION: Vulvar cancer is uncommon and relatively rare. Vulvar cancers do not always go through the preinvasive stages before developing into invasive cancer. It represents 1-4% of malignancies of female genital tract. Most common among the valvar cancer is squamous cell carcinoma (90%). Less common is melanoma, basal cell carcinoma, Adenocarcinoma and sarcoma which account for 10%. AIM: To determine the prevalence among genital tract malignancies, histopathological pattern, Staging, modality of treatment and post operative complications of malignant lesion of vulva. METHODS: It is a Cross sectional study carried out in Madurai medical college. The medical records of all women with malignant lesion of vulve between January 2009 to September 2011 were reviewed. From the case record, the patient profile, complaints, associated medical complications were noted. The record of investigations, treatment modalities and postoperative complications were studied. The diagnosis was confirmed by biopsy and clinical staging was done and planned for treatment. RESULTS: 10 cases of malignant lesions of vulva were noted during the period. Prevalence is about 0.8% of all genital tract malignancies. Age wise distribution reveals 60 % of our cases were above 60 years of age. 80% of our prevalence observed in postmenopausal women. Most patient had complaints of pruritis (100%), ulcer(70%), swelling(30%). Had associated medical complication of diabetic (40%), hypertensive (20%). Histopathologically the most predominant type is squamous cell carcinoma (60%), malignant melanoma (10%), basal cell carcinoma(10%), Baseloid squamous cell carcinoma(10%), Vulvar intraepithelial neoplasia (10%). Stage wise classification of squamous cell carcinoma –stage 0-12.5%, stage2- 37.5%, stage 3- 37.5%, stage 4 – 12.5%. CONCLUSION: Most cases above 60 yrs of age and 80% of our cases shows squamous cell carcinoma. Prevalence is about 0.8% of all genital tract malignancies. Most of the cases reported in the advanced stage of vulvar cancer. Biopsy is the method to confirm the diagnosis, Early diagnosis has a good prognosis . five year survival in stage 1 is 90%.

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