Sythesis, Modification, and Biosensing Characteristics of Au2S/AuAgS-Coated Gold Nanorods

The Au2S/AuAgS-coated gold nanorods (Au2S/AuAgS/GNRs) are prepared by a facile synthesis method and functionally modified for their biosensing application. In the preparation process, the longitudinal plasmon resonance (LPR) bands of Au2S/AuAgS/GNRs can be changed by controlling the thickness of the chalcogenide layer coated on GNRs. Especially, the LPR band located at 800 nm is obtained for biosensing application in the near-infrared region. Furthermore, mercaptoundecanoic acid (MUA) and poly(styrenesulfonate) (PSS) are, respectively, used to modify Au2S/AuAgS/GNRs to acquire the functional nanoprobes; that is, MUA-modified and PSS-modified Au2S/AuAgS/GNRs and their different chemical reaction mechanisms are studied by the absorption spectrum andξ-potential measurement. Then, the functional nanoprobes are incubated with anti-prostate-specific antigen (PSA) antibody to detect PSA. The experimental results demonstrate that the functional nanoprobes are sensitive to the target binding of PSA. Therefore, Au2S/AuAgS/GNRs are suitable to form the bioprobes for detection of PSA in early-phase prostate cancer.

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Synthesis of Colloidal Gold Nanorods with Plasmon Absorbance Wavelength in the Near Infrared Region

MRS Advances ◽

10.1557/adv.2016.486 ◽

2016 ◽

Vol 1 (30) ◽

pp. 2181-2186 ◽

Cited By ~ 1

Author(s):

Luis M. Angelats-Silva ◽

David Asmat-Campos ◽

Henry León-León ◽

Kevin A. Wilkinson ◽

Daniel A. Sánchez-Vaca ◽

...

Keyword(s):

Silver Nitrate ◽

Gold Nanorods ◽

Colloidal Gold ◽

Near Infrared ◽

Infrared Region ◽

X Ray Diffraction ◽

Transmission Electron ◽

Scanning Transmission ◽

Absorbance Peak ◽

Silver Nitrate Concentration

ABSTRACTWe report preparation and characterization of colloidal gold nanorods (AuNR) with plasmon absorbance over 950 nm and an aspect ratio of 7.2 by tuning silver nitrate concentration and the CTAB/BDAC ratio during growth. Samples were analyzed by scanning transmission electron microscopy, X-ray diffraction, UV-vis absorption spectroscopy and measurement of zeta potential. Addition of 170 μM silver nitrate to the CTAB-containing reaction mixture allowed preparation of AuNRs with a maximum absorbance peak at 941.8 nm and a yield around 96%. Optimization of the BDAC/CTAB ratio allowed for a further redshift of the absorbance maximum to 954.0 nm, but with poorer yields.

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Cancer Cell Growth in the Near Infrared Region by Using Silica Coated Gold Nanorods

NANO ◽

10.1142/s1793292020500010 ◽

2020 ◽

Vol 15 (01) ◽

pp. 2050001 ◽

Cited By ~ 1

Author(s):

Tuntun Wang ◽

Kwi Seok Yeom ◽

Sitansu Sekhar Nanda ◽

Seong Soo A. An ◽

Dong Kee Yi

Keyword(s):

Protein Folding ◽

Cell Growth ◽

Cancer Cells ◽

Cancer Cell ◽

Gold Nanorods ◽

Near Infrared ◽

Infrared Region ◽

Cancer Cell Growth ◽

Growth And Survival ◽

Cell Behaviors

Gold nanorods (AuNRs) have been considered as suitable materials for diverse biomedical applications in controlling cell behaviors. The nanoisland system with well-dispersed silica coated Au nanorods (Si-AuNRs) was used to demonstrate the enhanced cell growth of normal and cancer cells (MDA-MB-231 mammalian breast cancer cells) from the induced expressions of the heat shock proteins (HSPs). The over-expressions of HSP could help in protein folding in cell proliferations and growths of both the normal and cancer cells. In the current study, interesting mechanisms of cancer cell growth with Si-AuNRs than the conventional systems, such as incubator, would be presented. We believe that the growth of cancer cells in near infrared (NIR) region using Si-AuNRs induced the activities of HSPs, which could help the protein folding in cell growth and survival in comparison to the cells grown in the incubator only. The cell growth enhancing technology could be expanded in diverse applications in cell culture systems.

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Photothermal therapy of acute leukemia cells in the near-infrared region using gold nanorods CD-33 conjugates

10.1117/12.878802 ◽

2011 ◽

Cited By ~ 2

Author(s):

Anton Liopo ◽

André Conjusteau ◽

Marina Konopleva ◽

Michael Andreeff ◽

Alexander Oraevsky

Keyword(s):

Acute Leukemia ◽

Gold Nanorods ◽

Photothermal Therapy ◽

Near Infrared ◽

Infrared Region ◽

Leukemia Cells ◽

Near Infrared Region

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Spectrum-based and color-selective electrochemiluminescence immunoassay for determining human prostate specific antigen in near-infrared region

Talanta ◽

10.1016/j.talanta.2016.12.045 ◽

2017 ◽

Vol 165 ◽

pp. 117-121 ◽

Cited By ~ 12

Author(s):

Jie Zhou ◽

Yupeng He ◽

Bin Zhang ◽

Qiaoling Sun ◽

Guizheng Zou

Keyword(s):

Prostate Specific Antigen ◽

Near Infrared ◽

Specific Antigen ◽

Infrared Region ◽

Human Prostate ◽

Electrochemiluminescence Immunoassay ◽

Near Infrared Region

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Cancer Cell Imaging and Photothermal Therapy in the Near-Infrared Region by Using Gold Nanorods

Journal of the American Chemical Society ◽

10.1021/ja057254a ◽

2006 ◽

Vol 128 (6) ◽

pp. 2115-2120 ◽

Cited By ~ 3765

Author(s):

Xiaohua Huang ◽

Ivan H. El-Sayed ◽

Wei Qian ◽

Mostafa A. El-Sayed

Keyword(s):

Cancer Cell ◽

Gold Nanorods ◽

Photothermal Therapy ◽

Near Infrared ◽

Cell Imaging ◽

Infrared Region ◽

Cancer Cell Imaging ◽

Near Infrared Region

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Zwitterionic AIEgens: Rational Molecular Design for NIR-II Fluorescence Imaging-Guided Synergistic Phototherapy

10.26434/chemrxiv.12464120 ◽

2020 ◽

Author(s):

wei zhu ◽

Miaomiao Kang ◽

qian wu ◽

Zhijun Zhang ◽

yi wu ◽

...

Keyword(s):

Fluorescence Imaging ◽

Rational Design ◽

Near Infrared ◽

Molecular Design ◽

Infrared Region ◽

High Fidelity ◽

Facile Synthesis ◽

Rational Molecular Design ◽

Near Infrared Region ◽

Synthesis Protocol

Fluorescence imaging in the second near-infrared region (NIR-II) can penetrate tissue at centimeter depths and obtain high fidelity of images. However, facile synthesis of small-molecule fluorescent photosensitizers for efficient NIR-II fluorescence imaging as well as photodynamic and photothermal combinatorial therapies (PDT-PTT) is still a challenging task. Herein, we reported a rational design and facile synthesis protocol for a series of novel NIR-emissive zwitterionic luminogens with aggregation-induced emission (AIE) features for cancer phototheranostics.

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Facile Synthesis of Conical Arrays with Broadband Antireflective Property

Applied Mechanics and Materials ◽

10.4028/www.scientific.net/amm.614.79 ◽

2014 ◽

Vol 614 ◽

pp. 79-83

Author(s):

Wen Yan Zhang ◽

Ling Yun Hao ◽

Chun Hua Lu ◽

Chun Hua Feng ◽

Qin Lin ◽

...

Keyword(s):

Mass Production ◽

Smooth Surface ◽

Near Infrared ◽

Low Cost ◽

Infrared Region ◽

Polydimethyl Siloxane ◽

Facile Synthesis ◽

Specular Reflectance ◽

Regular Shape ◽

Reflective Property

Conical arrays of polydimethyl siloxane were fabricated by duplicating the morphology of needle tips. The prepared cones have periodic order and regular shape, with the bottom diameter of about 80 μm and height of about 250 μm. Due to their special structure, the conical arrays of polydimethyl siloxane exhibited broadband anti-reflective property. Compared with smooth surface, they could reduce the reflection of incident electromagnetic wave at ultraviolet, visible and near-infrared region. The specular reflectance was lower than 0.75% in the range of 250-2600 nm. The prepared PDMS cones have potential to be applied for antireflective devices. The method was simple for mass production of PDMS cones at low cost.

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Synthesis and Bioevaluation of Iodine-131 Directly Labeled Cyclic RGD-PEGylated Gold Nanorods for Tumor-Targeted Imaging

Contrast Media & Molecular Imaging ◽

10.1155/2017/6081724 ◽

2017 ◽

Vol 2017 ◽

pp. 1-10 ◽

Cited By ~ 8

Author(s):

Yingying Zhang ◽

Yongxue Zhang ◽

Lianglan Yin ◽

Xiaotian Xia ◽

Fan Hu ◽

...

Keyword(s):

Gold Nanorods ◽

Near Infrared ◽

Biomedical Application ◽

Infrared Region ◽

Ct Imaging ◽

Targeted Imaging ◽

Coupling Reactions ◽

Theranostic Agent ◽

Iodine 131

Introduction.Radiolabeled gold nanoparticles play an important role in biomedical application. The aim of this study was to prepare iodine-131 (131I)-labeled gold nanorods (GNRs) conjugated with cyclic RGD and evaluate its biological characteristics for targeted imaging of integrinαvβ3-expressing tumors.Methods.HS-PEG(5000)-COOH molecules were applied to replace CTAB covering the surface of bare GNRs for better biocompatibility, and c(RGDfK) peptides were conjugated onto the carboxyl terminal of GNR-PEG-COOH via EDC/NHS coupling reactions. The nanoconjugate was characterized, and131I was directly tagged on the surface of GNRs via AuI bonds for SPECT/CT imaging. We preliminarily studied the characteristics of the probe and its feasibility for tumor-targeting SPECT/CT imaging.Results.The[131I]GNR-PEG-cRGD probe was prepared in a simple and rapid manner and was stable in both PBS and fetal bovine serum. It targeted selectively and could be taken up by tumor cells mainly via integrinαvβ3-receptor-mediated endocytosis. In vivo imaging, biodistribution, and autoradiography results showed evident tumor uptake in integrinαvβ3-expressing tumors.Conclusions.These promising results showed that this smart nanoprobe can be used for angiogenesis-targeted SPECT/CT imaging. Furthermore, the nanoprobe possesses a remarkable capacity for highly efficient photothermal conversion in the near-infrared region, suggesting its potential as a multifunctional theranostic agent.

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