scholarly journals Effect of Acarbose on Long-Term Prognosis in Acute Coronary Syndromes Patients with Newly Diagnosed Impaired Glucose Tolerance

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
Peng Yun ◽  
Ai-ming Du ◽  
Xue-jun Chen ◽  
Jing-cheng Liu ◽  
Hu Xiao

Objective. To investigate the effect of acarbose therapy on the long-term prognosis of patients with acute coronary syndromes (ACS) complicating newly diagnosed impaired glucose tolerance (IGT).Methodology. 135 patients hospitalized for ACS who had been newly diagnosed with IGT were randomly assigned to acarbose group (150 mg/day,n=67) or control group (no acarbose,n=68). All cases in each group were given the same elementary treatment. Mean follow-up was 2.3 years. The incidence of major adverse cardiovascular event (MACE) and carotid intima-middle thickness (CIMT) were statistically analyzed.Results. During the mean follow-up of 2.3 years, the risk of recurrent MACE in acarbose group was decreased significantly compared with that in control group (26.67% versus 46.88%,P<0.05); at the same time, thickening of the CIMT was significantly slower than the control group ((1.28 ± 0.42) mm versus (1.51 ± 0.64) mm,P<0.05).Conclusions. Acarbose can effectively reduce the risk of MACE in ACS patients with newly diagnosed IGT, simultaneously retarding the progression of carotid intima-media thickness.

2018 ◽  
Vol 270 ◽  
pp. 36-41 ◽  
Author(s):  
Alberto Cordero ◽  
Jose M. García-Acuña ◽  
Moisés Rodríguez-Mañero ◽  
Rosa Agra-Bermejo ◽  
Belen Cid ◽  
...  

2007 ◽  
Vol 71 (6) ◽  
pp. 834-841 ◽  
Author(s):  
Koichi Tamita ◽  
Minako Katayama ◽  
Tsutomu Takagi ◽  
Takashi Akasaka ◽  
Atsushi Yamamuro ◽  
...  

2014 ◽  
Vol 63 (12) ◽  
pp. A121
Author(s):  
Jose C. Nicolau ◽  
Andre Franci ◽  
Carlos Barbosa ◽  
Luciano Baracioli ◽  
Remo Furtado ◽  
...  

1970 ◽  
Vol 110 (4) ◽  
pp. 77-80
Author(s):  
M. R. Babarskiene ◽  
J. Vencloviene ◽  
D. Luksiene ◽  
I. Milvidaite

Ischemic heart disease is the leading cause of death in Europe among males over 45 years of age and females older than 65. The aim of the study: to evaluate the informative value of the models in ACS patients using GRACE (GR) risk score, to identify additional informative indicators for short-term and long-term prognosis following ACS, and to evaluate the prognostic reliability of the integrated model. The study included 1491 patients who in 2005 were treated for ACS in the Department of Cardiology, the Hospital of Kaunas University of Medicine. We devised an adjusted prognostic index for making short and long-term prognosis in patients with acute coronary syndromes (STEMI and NSETMI). Following adjustment of the GR scores, the prognostic value improved for STEMI patients. Ill. 2, bibl. 12, tabl. 3 (in English; abstracts in English and Lithuanian).http://dx.doi.org/10.5755/j01.eee.110.4.292


1973 ◽  
Vol 122 (567) ◽  
pp. 125-139 ◽  
Author(s):  
Arne Sund

The aim of this social-psychiatric and personal follow-up examination has been to illustrate the long-term prognosis of Norwegian youth suffering from psychiatric disorders which initially presented during peacetime compulsory military service. The follow-up examinations were conducted personally, and a control group of presumed healthy men was also followed. Sund (1968, 1970) has made a systematic comparison between the patient group and the control group concerning prognosis. Here, therefore, the main emphasis will be on a comparison of the courses followed by clinically different diagnostic sub-group. Eitinger (1950) showed the necessity of undertaking personal follow-up examinations in order to map out the prognosis for this kind of patient. Prognostic studies outside Scandinavia have been reported by Ginzberg et al. (1959), by Glass et al. (1956) and by Plag and Arthur (1965). However, the periods of observation in these studies have been short; moreover, adjustment to the military system was the objective, and the cases were not personally examined in a follow-up. It has been difficult to find prognostic studies with sufficiently long observation periods and with personal follow-up to serve as an adequate basis of comparison with our material. To a large extent, therefore, we have chosen to see the development of our patients in relation to our knowledge of psychiatric reactions in the rest of the population.


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