scholarly journals The Association between NOS3 Gene Polymorphisms and Hypoxic-Ischemic Encephalopathy Susceptibility and Symptoms in Chinese Han Population

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Yongqin Wu ◽  
Zhiling Zhu ◽  
Xiaoxia Fang ◽  
Ling Yin ◽  
Yuxia Liu ◽  
...  
Keyword(s):  
Gene Polymorphisms ◽  
Clinical Characteristics ◽  
Chinese Han Population ◽  
Hypoxic Ischemic Encephalopathy ◽  
Genotype Distribution ◽  
Chinese Han ◽  
Apgar Scores ◽  
Han Population ◽  
Nos3 Gene ◽  
Ischemic Encephalopathy

Endothelial NOS (NOS3) has a potential role in the prevention of neuronal injury in hypoxic-ischemic encephalopathy (HIE). Thus, we aimed to explore the association between NOS3 gene polymorphisms and HIE susceptibility and symptoms in a Chinese Han population. Three single nucleotide polymorphisms (SNPs) in the NOS3 gene, rs1800783, rs1800779, and rs2070744, were detected in 226 children with HIE and 212 healthy children in a Chinese Han population. Apgar scores and magnetic resonance image scans were used to estimate the symptoms and brain damage. The association analyses were conducted by using SNPStats and SPSS 18.0 software. The genotype and allele distributions of rs1800779 and rs1799983 displayed no significant differences between the patients and the controls, while the rs2070744 allele distribution was significantly different (correctedP=0.009). For clinical characteristics, the rs2070744 genotype distribution was significantly different in patients with different Apgar scores (≤5, TT/TC/CC = 6/7/5; 6~7, TT/TC/CC = 17/0/0; 8~9, TT/TC/CC = 6/2/0; 10, TT/TC/CC = 7/1/0; correctedP=0.006) in the 1001 to 1449 g birth weight subgroup. The haplotype test did not show any associations with the risk and clinical characteristics of HIE. The results suggest that NOS3 gene SNP rs2070744 was significantly associated with HIE susceptibility and symptom expression in Chinese Han population.

scholarly journals Impact of diabetes-related gene polymorphisms on the clinical characteristics of type 2 diabetes Chinese Han population

Oncotarget ◽  
2016 ◽  
Vol 7 (51) ◽  
pp. 85464-85471 ◽  
Author(s):  
Jing Li ◽  
Jiachen Wei ◽  
Pengcheng Xu ◽  
Mengdan Yan ◽  
Jingjie Li ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Gene Polymorphisms ◽  
Clinical Characteristics ◽  
Chinese Han Population ◽  
Related Gene ◽  
Chinese Han ◽  
Han Population

scholarly journals Association of interleukin-18 gene polymorphisms with Takayasu arteritis in a Chinese Han population

2020 ◽  
Vol 133 (19) ◽  
pp. 2315-2320
Author(s):  
Dan Wen ◽  
Xian-Liang Zhou ◽  
Xin Du ◽  
Jian-Zeng Dong ◽  
Chang-Sheng Ma
Keyword(s):  
Takayasu Arteritis ◽  
Gene Polymorphisms ◽  
Chinese Han Population ◽  
Interleukin 18 ◽  
Chinese Han ◽  
Han Population

scholarly journals Association between BMP4 gene polymorphisms and eyelid traits in Chinese Han population

2017 ◽  
Vol 6 ◽  
pp. e355-e356 ◽  
Author(s):  
Qian Wang ◽  
Bo Jin ◽  
Xiaoying Luo ◽  
Tao Feng ◽  
Yu Xia ◽  
...  
Keyword(s):  
Gene Polymorphisms ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population

scholarly journals Impact of polymorphisms in DNA repair genes XPD, hOGG1 and XRCC4 on colorectal cancer risk in a Chinese Han Population

2019 ◽  
Vol 39 (1) ◽  
Author(s):  
Dexi Jin ◽  
Min Zhang ◽  
Hongjun Hua
Keyword(s):  
Colorectal Cancer ◽  
Gene Polymorphisms ◽  
Colorectal Carcinogenesis ◽  
Chinese Han Population ◽  
Control Group ◽  
Chinese Han ◽  
Han Population ◽  
Increased Risk ◽  
Hogg1 Gene ◽  
Repair Genes

Abstract Background: This research aimed to study the associations between XPD (G751A, rs13181), hOGG1 (C326G, rs1052133) and XRCC4 (G1394T, rs6869366) gene polymorphisms and the risk of colorectal cancer (CRC) in a Chinese Han population. Method: A total of 225 Chinese Han patients with CRC were selected as the study group, and 200 healthy subjects were recruited as the control group. The polymorphisms of XPD G751A, hOGG1 C326G and XRCC4 G1394T loci were detected by the RFLP-PCR technique in the peripheral blood of all subjects. Results: Compared with individuals carrying the XPD751 GG allele, the A allele carriers (GA/AA) had a significantly increased risk of CRC (adjusted OR = 2.109, 95%CI = 1.352–3.287, P=0.003). Similarly, the G allele (CG/GG) of hOGG1 C326G locus conferred increased susceptibility to CRC (adjusted OR = 2.654, 95%CI = 1.915–3.685, P<0.001). In addition, the T allele carriers (GT/TT) of the XRCC4 G1394T locus have an increased risk of developing CRC (adjusted OR = 4.512, 95%CI = 2.785–7.402, P<0.001). The risk of CRC was significantly increased in individuals with both the XPD locus A allele and the hOGG1 locus G allele (adjusted OR = 1.543, 95%CI = 1.302–2.542, P=0.002). Furthermore, individuals with both the hOGG1 locus G allele and the XRCC4 locus T allele were predisposed to CRC development (adjusted OR = 3.854, 95%CI = 1.924–7.123, P<0.001). The risks of CRC in XPD gene A allele carriers (GA/AA) (adjusted OR = 1.570, 95%CI = 1.201–1.976, P=0.001), hOGG1 gene G allele carriers (CG/GG) (adjusted OR = 3.031, 95%CI = 2.184–4.225, P<0.001) and XRCC4 gene T allele carriers (GT/TT) (adjusted OR = 2.793, 95%CI = 2.235–3.222, P<0.001) were significantly higher in patients who smoked ≥16 packs/year. Conclusion: Our results suggest that XPD G751A, hOGG1 C326G and XRCC4 G1394T gene polymorphisms might play an important role in colorectal carcinogenesis and increase the risk of developing CRC in the Chinese Han population. The interaction between smoking and these gene polymorphisms would increase the risk of CRC.

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