scholarly journals Radial Retinotomies with Endodiathermy for Severe Proliferative Vitreoretinopathy: Short-Term Results

2016 ◽  
Vol 2016 ◽  
pp. 1-9
Author(s):  
Zhaoxin Jiang ◽  
Suo Qiu ◽  
Bingsheng Lou ◽  
Miaoli Lin ◽  
Junlian Tan ◽  
...  
Keyword(s):  
Silicone Oil ◽  
Fundus Photography ◽  
Oil Removal ◽  
Efficacy And Safety ◽  
Slit Lamp ◽  
Less Invasive Surgery ◽  
Short Term ◽  
Noncomparative Trial ◽  
Slit Lamp Microscopy ◽  
Observation Period

Purpose.Retinal redetachment of silicone oil-filled eyes continues to be a frustrating condition that typically requires retinectomy. We proposed radial retinotomy as a potentially less invasive surgery. Here, we preliminarily explored its feasibility, efficacy, and safety.Methods.Totally 9 eyes of 9 consecutive patients were included in a prospective noncomparative trial. A series of retinotomies were created by endodiathermy in a radial pattern to relax the foreshortened retina. The eye was refilled with fresh silicone oil. The treated eyes were examined via visual acuity (VA) tests, tonometry, slit-lamp microscopy, and fundus photography during a 6-month observation period.Results.The procedure was completed in an average of 28 minutes from silicone oil removal to fresh silicone oil placement. Fundus photography demonstrated that 7 of the 9 eyes (78%) exhibited retinal reattachment. On average, VA was significantly improved within the first 2 weeks (P=0.02) and remained stable for the following 6 months. The change in intraocular pressure was not significant (P=0.76), and no adverse event was observed (0%).Conclusion.Radial retinotomies with endodiathermy were shown to be feasible, effective, and safe in selected cases of inferior contracted retina without vitreous base fibrosis over a 6-month observation period. This trial is registered withNCT02201706.

scholarly journals Passive Removal of Silicone Oil with Temporal Head Position through Two 23-Gauge Cannulas

2016 ◽  
Vol 2016 ◽  
pp. 1-4 ◽  
Author(s):  
Zhong Lin ◽  
Zhi Sheng Ke ◽  
Qian Zheng ◽  
Zhen Quan Zhao ◽  
Zong Ming Song
Keyword(s):  
Silicone Oil ◽  
Fast Method ◽  
Oil Removal ◽  
Slit Lamp ◽  
New Approach ◽  
The Mean ◽  
23 Gauge ◽  
Mean Time ◽  
Vitrectomy System ◽  
Air Exchange

Purpose. To report a new approach for removal of silicone oil. Methods. All surgeries were performed using 23-gauge vitrectomy system with two transconjunctival sutureless cannulas. At the beginning, most of the silicone oil was removed by traditional microinvasive vitrectomy system through inferior-temporal cannula. Then, the blood transfusion tube is removed from the inferior-temporal cannula, and the fluid-air exchange is performed. A passive fluid-air exchange was performed to aspirate the residual silicone oil after gradually turning the patient’s head temporally by approximately 90° gradually. Results. After the surgery, all patients had a clear anterior chamber and vitreous cavity on slit lamp and B scan examination, respectively. The mean time taken for silicone oil removal and total surgery was 8.0±1.4 minutes and 12.4±2.5 minutes, respectively. The mean intraocular pressure 1 day, 3 days, 1 week, 1 month, and 3 months after surgery was 9.0±5.8 mmHg, 11.3±7.6 mmHg, 16.1±6.9 mmHg, 17.7±4.8 mmHg, and 17.1±3.5 mmHg, respectively. Conclusion. This new approach may provide a safe and fast method to remove the silicone oil.

scholarly journals The role of high-dose steroid therapy in Covid-19 pneumonia

2021 ◽  
Author(s):  
Ayperi Ozturk ◽  
Figen Ozturk Ergur ◽  
Suna Kavurgacı ◽  
Melahat Uzel Şener ◽  
Murat Yıldız
Keyword(s):  
Mortality Rate ◽  
Low Dose ◽  
High Dose ◽  
Efficacy And Safety ◽  
Short Term ◽  
High Dose Steroid ◽  
Younger Age ◽  
Observation Period

Introduction: Today, whereas hypoxemia and respiratory failure is the major challenging problem in the course of severe COVID-19 pneumonia, to control the disease at a mild-moderate stage or to stop the inflammation by recognizing the cytokine storm early should be the most prominent goal. We aimed to reveal the clinical efficacy and safety of short-term high-dose corticosteroids in severe COVID-19. Material and Methods: This retrospective observational study consisted of 54 patients who were given high-dose steroid (HDS (>250 mg/day methylprednisolone, 3 days.). Low-dose steroid (LDS) therapy (dexamethasone 8 mg ) was applied to all patients. HDS group was reviewed in terms of decreasing hospital mortality and preventing fibrosis development in follow-up. Results: During the observation period, out of 317 severe COVID-19 pneumonia hospitalized, HDS and LDS were administered to 54 and 216 patients, respectively. Higher body mass index, younger age, more oxygen need of patients at admission, and more need for advanced oxygen therapy during hospitalization were found in the HDS group (p<0.001). Furthermore, 18.5% of patients in the HDS group had need transfer to the intensive care unit whereas it was 3.8% in LDS (p<0.001). Additionally, the mortality rate was determined higher in the HDS group (25. 9% vs 9.9%, p<0.001). The HDS group had lower saturated O2 [IQR, 85% (76-89), p <0.001], and higher ferritin at admission. It was found that HDS was given simultaneously with the increased ferritin with deepening lymphopenia on the third and fifth days. There was no difference in fibrosis development between HDS patients receive and not (15.4% vs 26.2%, p=0.11) Conclusion: The use of HDS in hospitalized COVID-19 patients remains unclear. Along with this, our study demonstrated the use of high-dose corticosteroids might not be associated with a lower mortality rate among hospitalized severe COVID-19 patients.

Silicone oil removal options after cataract phacoemulsification

2020 ◽  
pp. 98-99
Author(s):  
A.M. Danilov ◽  
◽  
A.G. Grinev ◽  
M.B. Sviridova ◽  
◽  
...  
Keyword(s):  
Silicone Oil ◽  
Oil Removal ◽  
Silicone Oil Removal

Актуальность. Тампонада витреальной полости силиконовым маслом (СМ) или наличие остатков СМ при авитрии являются показаниями к их удалению, которое может быть выполнено различными методиками, нередко после факоэмульсификации катаракты. Цель. Изучить результаты удаления СМ через задний капсулорексис (ЗК) различными методами. 1. Изучить возможность удаления остатков СМ через задний капсулорексис при авитрии. 2. Провести апробацию удаления СМ через ЗК методом эффузии. 3. Провести апробацию удаления СМ через ЗК методом аспирации. Материал и методы. Под наблюдением находилось 18 пациентов, проходивших лечение в СОКБ №1. Результаты. Операции выполнены без осложнений в ближайшем и отдаленном послеоперационном периоде с улучшением зрительных функций. Выводы. 1. Изучены результаты удаления СМ через задний капсулорексис. 2. Удаление остатков СМ через ЗК при авитрии после факоэмульсификации позволяет повысить степень удовлетворенности пациентов результатами хирургического лечения. 3. Проведена апробация удаления СМ через ЗК методом эффузии, что позволяет качественнее удалять СМ, в том числе эмульгированные фрагменты. 4. Проведена апробация удаления СМ через ЗК методом аспирации, что сокращает время операции, позволяет в большем объеме удалять остатки эмульгированного СМ.

Proposal to Eliminate Urethane-Treated Positive Control Dose Groups in 26-Week Tg.rasH2 Carcinogenicity Studies

2021 ◽  
pp. 109158182110033
Author(s):  
Madhav G. Paranjpe ◽  
Daniel Rudmann ◽  
Aaron Sargeant ◽  
Mark Morse ◽  
Rossalin Yonpiam ◽  
...  
Keyword(s):  
Alternative Model ◽  
Positive Control ◽  
Short Term ◽  
Control Material ◽  
Pilot Studies ◽  
Cumulative Experience ◽  
Observation Period

Short-term (26 weeks) Tg.rasH2 mouse carcinogenicity studies have been conducted as an alternative model to the conventional 2-year mouse carcinogenicity studies, using urethane as a positive control material. In these studies, urethane was used at a dose of 1,000 mg/kg/dose, administered intraperitoneally on days 1, 3, and 5. Urethane consistently produces lung adenomas and carcinomas and hemangiosarcomas of the spleen, proving validity of the assay. We conducted 3 pilot studies at 3 different sites of Charles River Laboratories using a lower dose of urethane (500 mg/kg/dose), administered on days 1, 3, and 5, followed by a 12-week observation period. Our results demonstrate that a lower dose can be used successfully with fewer number of animals per sex to prove the validity of the assay. However, based on our cumulative experience with this model, we propose to eliminate positive control dose groups in future Tg.rasH2 carcinogenicity studies.

SILICONE OIL REMOVAL: A SIMPLE TECHNIQUE

Retina ◽  
1997 ◽  
Vol 17 (3) ◽  
pp. 266-267 ◽  
Author(s):  
LINGAM GOPAL ◽  
SALIL MEHTA
Keyword(s):  
Simple Technique ◽  
Silicone Oil ◽  
Oil Removal ◽  
Silicone Oil Removal
Sign in / Sign up

Export Citation Format

Share Document