scholarly journals An Improved L-Shaped Method for Solving Process Flexibility Design Problems

2016 ◽  
Vol 2016 ◽  
pp. 1-15
Author(s):  
Huasheng Yang ◽  
Jatinder N. D. Gupta ◽  
Lina Yu ◽  
Li Zheng
Keyword(s):  
Design Problem ◽  
Stochastic Program ◽  
Design Problems ◽  
Process Flexibility ◽  
Response Dimension ◽  
Flexibility Design ◽  
Different Types ◽  
Effectiveness And Efficiency ◽  
First Time ◽  
Long Chain

Process flexibility, where a plant is able to produce different types of products, is introduced to mitigate mismatch risk caused by demand uncertainties. Thelong chain designproposed by Jordan and Graves in 1995 has been shown to be able to reap most benefits of full-flexibility structure (where each plant is able to produce all products) in balanced systems (where the numbers of products and plants are equal). However, when systems are not balanced or asymmetric or when response dimension is taken into consideration, long chain design may not be the best configuration. Therefore, this paper models the process flexibility design problem in more general settings. The paper considers both balanced and unbalanced systems with asymmetric plants considering response dimension. The problem is formulated as a two-stage stochastic program which is solved by an adapted L-shaped method, combining it with several enhancements. To the best of our knowledge, this is the first time L-shaped method is used to solve the process flexibility design problem. The effectiveness and efficiency of the proposed method and enhancements are evaluated. Finally, the comparison between design methods proposed in this paper and in existing literature shows the superiority of the former.

Probabilistic Assessment of Reliability and Risk Values by Certification Results

2020 ◽  
pp. 52-67
Author(s):  
Vladimir A. Lapin ◽  
Erken S. Aldakhov ◽  
S. D. Aldakhov ◽  
A. B. Ali
Keyword(s):  
Seismic Risk ◽  
Housing Stock ◽  
Seismic Resistance ◽  
Probabilistic Assessment ◽  
Quantitative Estimates ◽  
Different Types ◽  
Reduce Risk ◽  
First Time ◽  
Structural Solutions ◽  
Practical Recommendations

For the first time in Almaty full passport of apartment stock of multiapartment building was carried out. The structure of the housing stock was revealed with the allocation of groups of buildings according to structural solutions and assessment of their seismic resistance. Based on the results of certification, quantitative estimates of failure probability values for different types of buildings were obtained. Formulas for estimation of quantitative value of seismic risk are obtained. The number of deaths in the estimated zem-shakes was estimated. The results of the assessments will be used for practical recommendations to reduce risk and expected losses in possible earthquakes.

The Small State Challenge

2018 ◽  
Author(s):  
Jack Corbett ◽  
Wouter Veenendaal
Keyword(s):  
Comparative Politics ◽  
Institutional Design ◽  
Small States ◽  
Small State ◽  
Informal Politics ◽  
Different Types ◽  
Approach Method ◽  
Key Terms ◽  
First Time

Chapter 1 introduces the main arguments of the book; outlines the approach, method, and data; defines key terms; and provides a chapter outline. Global theories of democratization have systematically excluded small states, which make up roughly 20 per cent of countries. These cases debunk mainstream theories of why democratization succeeds or fails. This book brings small states into the comparative politics fold for the first time. It is organized thematically, with each chapter tackling one of the main theories from the democratization literature. Different types of data are examined—case studies and other documentary evidence, interviews and observation. Following an abductive approach, in addition to examining the veracity of existing theory, each chapter is also used to build an explanation of how democracy is practiced in small states. Specifically, we highlight how small state politics is shaped by personalization and informal politics, rather than formal institutional design.

scholarly journals MiRNA Expression in Neuroendocrine Neoplasms of Frequent Localizations

2021 ◽  
Vol 7 (3) ◽  
pp. 38
Author(s):  
Alexandra Korotaeva ◽  
Danzan Mansorunov ◽  
Natalya Apanovich ◽  
Anna Kuzevanova ◽  
Alexander Karpukhin
Keyword(s):  
Mirna Expression ◽  
Malignant Tumors ◽  
Neuroendocrine Neoplasms ◽  
Specific Expression ◽  
Clinical Biomarkers ◽  
Different Types ◽  
Functional Features ◽  
First Time ◽  
Potential Biomarkers

Neuroendocrine neoplasms (NEN) are infrequent malignant tumors of a neuroendocrine nature that arise in various organs. They occur most frequently in the lungs, intestines, stomach and pancreas. Molecular diagnostics and prognosis of NEN development are highly relevant. The role of clinical biomarkers can be played by microRNAs (miRNAs). This work is devoted to the analysis of data on miRNA expression in NENs. For the first time, a search for specificity or a community of their functional characteristics in different types of NEN was carried out. Their properties as biomarkers were also analyzed. To date, more than 100 miRNAs have been characterized as differentially expressed and significant for the development of NEN tumors. Only about 10% of the studied miRNAs are expressed in several types of NEN; differential expression of the remaining 90% was found only in tumors of specific localizations. A significant number of miRNAs have been identified as potential biomarkers. However, only a few miRNAs have values that characterized their quality as markers. The analysis demonstrates the predominant specific expression of miRNA in each studied type of NEN. This indicates that miRNA’s functional features are predominantly influenced by the tissue in which they are formed.

scholarly journals THE INFLUENCE OF DESIGN BRIEF INFORMATION ON CREATIVE OUTCOMES BY NOVICE AND ADVANCED STUDENTS

2021 ◽  
Vol 1 ◽  
pp. 3041-3050
Author(s):  
Georgios Koronis ◽  
Hernan Casakin ◽  
Arlindo Silva ◽  
Jacob Kai Siang Kang
Keyword(s):  
Design Education ◽  
Design Problems ◽  
Frame Design ◽  
Design Creativity ◽  
Abstract Representations ◽  
Advanced Students ◽  
Different Types ◽  
Fishbone Diagram ◽  
Design Expertise ◽  
Novel Design

AbstractThis study centers on using different types of brief information to support creative outcomes in architectural and engineering design and its relation to design expertise. We explore the influence of design briefs characterized by abstract representations and/or instructions to frame design problems on the creativity of concept sketches produced by novice and advanced students. Abstract representations of problem requirements served as stimuli to encourage associative thinking and knowledge transfer. The Ishikawa/Fishbone Diagram was used to foster design restructuring and to modify viewpoints about the main design drives and goals. The design outcomes generated by novice and advanced engineering/architecture students were assessed for their creativity using a pairwise experimental design. Results indicated that advanced students generated more novel design solutions while also contributing the most useful solutions overall. Implications for creativity in design education and professional practice are presented. Educational programs aimed at promoting creativity in the design studio may find it helpful to consider that the way design briefs are constructed can either promote or inhibit different aspects of design creativity.

scholarly journals Second-order neutrosophic boundary-value problem

2021 ◽  
Author(s):  
Sandip Moi ◽  
Suvankar Biswas ◽  
Smita Pal(Sarkar)
Keyword(s):  
Differential Equation ◽  
Boundary Value Problem ◽  
Differential Calculus ◽  
Boundary Value ◽  
Second Order ◽  
Numerical Examples ◽  
Different Types ◽  
First Time

AbstractIn this article, some properties of neutrosophic derivative and neutrosophic numbers have been presented. This properties have been used to develop the neutrosophic differential calculus. By considering different types of first- and second-order derivatives, different kind of systems of derivatives have been developed. This is the first time where a second-order neutrosophic boundary-value problem has been introduced with different types of first- and second-order derivatives. Some numerical examples have been examined to explain different systems of neutrosophic differential equation.

scholarly journals Interactions between an Associative Amphiphilic Block Polyelectrolyte and Surfactants in Water: Effect of Charge Type on Solution Properties and Aggregation

Polymers ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 1729
Author(s):  
Patrizio Raffa
Keyword(s):  
Surface Tension ◽  
Self Assembly ◽  
Interaction Model ◽  
Industrial Applications ◽  
Molecular Organization ◽  
Different Types ◽  
Solution Rheology ◽  
Interesting Class ◽  
First Time

The study of interactions between polyelectrolytes (PE) and surfactants is of great interest for both fundamental and applied research. These mixtures can represent, for example, models of self-assembly and molecular organization in biological systems, but they are also relevant in industrial applications. Amphiphilic block polyelectrolytes represent an interesting class of PE, but their interactions with surfactants have not been extensively explored so far, most studies being restricted to non-associating PE. In this work, interactions between an anionic amphiphilic triblock polyelectrolyte and different types of surfactants bearing respectively negative, positive and no charge, are investigated via surface tension and solution rheology measurements for the first time. It is evidenced that the surfactants have different effects on viscosity and surface tension, depending on their charge type. Micellization of the surfactant is affected by the presence of the polymer in all cases; shear viscosity of polymer solutions decreases in presence of the same charge or nonionic surfactants, while the opposite charge surfactant causes precipitation. This study highlights the importance of the charge type, and the role of the associating hydrophobic block in the PE structure, on the solution behavior of the mixtures. Moreover, a possible interaction model is proposed, based on the obtained data.

scholarly journals How detection ranges and usage stops impact digital contact tracing effectiveness for COVID-19

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Konstantin D. Pandl ◽  
Scott Thiebes ◽  
Manuel Schmidt-Kraepelin ◽  
Ali Sunyaev
Keyword(s):  
Disease Spread ◽  
Contact Tracing ◽  
Behavioral Characteristics ◽  
Policy Makers ◽  
Detection Range ◽  
Proximity Detection ◽  
Effective Technology ◽  
Different Types ◽  
Effectiveness And Efficiency ◽  
The Impact

AbstractTo combat the COVID-19 pandemic, many countries around the globe have adopted digital contact tracing apps. Various technologies exist to trace contacts that are potentially prone to different types of tracing errors. Here, we study the impact of different proximity detection ranges on the effectiveness and efficiency of digital contact tracing apps. Furthermore, we study a usage stop effect induced by a false positive quarantine. Our results reveal that policy makers should adjust digital contact tracing apps to the behavioral characteristics of a society. Based on this, the proximity detection range should at least cover the range of a disease spread, and be much wider in certain cases. The widely used Bluetooth Low Energy protocol may not necessarily be the most effective technology for contact tracing.

scholarly journals AB0243 CONSIDERING THE COMBINATION OF TWO BIOLOGICS IN CASE OF FAILURE OF THE MONOTHERAPY IN JUVENILE ONSET RHEUMATOID ARTHRITIS

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 1147.1-1147
Author(s):  
A. Haddouche ◽  
K. Ait Bellabas ◽  
W. F. Hamrani ◽  
S. Sahraoui ◽  
R. Fatma ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Alternative Therapy ◽  
Biologic Therapies ◽  
Disease Modifying Antirheumatic Drugs ◽  
Antirheumatic Drugs ◽  
Juvenile Onset ◽  
Multiple Treatment ◽  
Tnf Blocker ◽  
Different Types ◽  
First Time

Background:The management of rheumatoid arthritis refractory to conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) is currently well codified and includes different types of biologics and even targeted sDMARDs. A rotation of biologic therapies is recommended in order to better control the disease.Methods:We report the case of a 20-year-old patient followed in our hospital for the management of a deforming and erosive seropositive rheumatoid arthritis (FR +, ACPA +) with a juvenile onset at the age of 8 years. The diagnosis of an immunopositive polyarticular form of JIA was retained in 2010 (9 years old); the patient was treated with methotrexate (MTX) at a dose of 10 mg per week and methylprednisolone at doses varying between 4 and 10 mg per day. Following the failure of MTX, etanercept was introduced for 6 months without success, followed by tocilizumab in 2012 at a dose of 8mg/kg/month for a year, without good response. In 2014, a course of rituximab (RTX) at a dose of 2 shots of 500mg, 2 weeks apart was prescribed followed 9 months later by etanercept at a dose of 50 mg a week for 3 years then by adalimumab (40mg/ week) because of the multiple treatment failures.In 2018, the repetition of RTX at a dose of 1g, renewed 15 days later, improved the patient for only 3 months. Then, a combination of two biologics, namely RTX (2 x 1g, 15 days apart) and adalimumab 1 month later (40mg / week) was received by the patient with a good response at 3 months. The latter was maintained for 7 months even after stopping the adalimumab following confinement for COVID-19. In September 2020, flares occurred and the adalimumab (ADA) has been delivered but without success during 3 months, stopped later for a benign form of COVID-19 (15 months after RTX). In January 2021, the association RTX + ADA was given again and we hope that it will be as effective as the first prescription.Results:The clinical and biological severity of our patient’s rheumatoid arthritis led us to give a combination of two biological treatments. Indeed, we do not have other therapeutic classes to deliver to her, that encouraged us to rotate between all the available biological therapies in our country. The combination of a CD20 inhibitor (RTX) with a TNF blocker (ADA) was safe and made possible, for the first time, the achievement of clinical and biological remission during 7 months, even after stopping the TNF blocker. Greenwald et al. reported the safety of the combination of RTX + TNF inhibitors in a randomized clinical trial in 51 patients. Its efficacy, a secondary goal of the study, was suggested at 24 weeks by the percentage of ACR 20 and ACR 50 responses that was greater than in the RTX placebo group.Conclusion:The combination of RTX with a TNF blocker can be a real alternative therapy in rheumatoid arthritis with failure to a biological monotherapy.Disclosure of Interests:None declared

The habits and habitats of the opisthobranch molluscs of the British Solomon Islands

1969 ◽  
Vol 255 (800) ◽  
pp. 541-548 ◽  
Keyword(s):  
Natural History ◽  
Solomon Islands ◽  
Gut Contents ◽  
Numerical Evidence ◽  
Large Numbers ◽  
Different Types ◽  
Opisthobranch Molluscs ◽  
First Time ◽  
Reef Formation

Often bizarre in shape and gaudily coloured, the opisthobranchs of the tropical IndoPacific have always been attractive subjects for the specialist worker and for writers of popular natural history. There is certainly no lack of papers describing their anatomy and systematics (Marcus & Burch (1965) give a fairly full bibliography), but only in those by Risbec (1928 a, b , 1951, 1953) are there descriptions of where or how they live and his statements are brief and rather vague. I collected opisthobranchs so as to record them for the British Solomon Islands for the first time and, whenever possible, I noted their habits and habitats. My observations on gut contents are rather scanty as I did not wish to damage any of the few specimens of each species collected. From an examination of ten different types of reef formation I discovered that opisthobranchs are common in only two places; (1) the crest of a semi-exposed reef where algae occur in pools, and (2) the flat of a sheltered or semi-sheltered reef. At each of these sites several distinct habitats can be distinguished. Unfortunately my recognition of these habitats is not supported by strong numerical evidence as none of the 55 species occurred in large numbers.

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