scholarly journals Corrigendum to “Ferulic Acid, anAngelica sinensis-Derived Polyphenol, Slows the Progression of Membranous Nephropathy in a Mouse Model”

2016 ◽  
Vol 2016 ◽  
pp. 1-1
Author(s):  
Chao-Wen Cheng ◽  
Wen-Liang Chang ◽  
Li-Cheng Chang ◽  
Chia-Chao Wu ◽  
Yuh-Feng Lin ◽  
...  
Keyword(s):  
Mouse Model ◽  
Ferulic Acid ◽  
Membranous Nephropathy

scholarly journals Ferulic Acid, anAngelica sinensis-Derived Polyphenol, Slows the Progression of Membranous Nephropathy in a Mouse Model

2012 ◽  
Vol 2012 ◽  
pp. 1-12 ◽  
Author(s):  
Chao-Wen Cheng ◽  
Wen-Liang Chang ◽  
Li-Cheng Chang ◽  
Chia-Chao Wu ◽  
Yuh-Feng Lin ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Mouse Model ◽  
Ferulic Acid ◽  
Membranous Nephropathy ◽  
Angelica Sinensis ◽  
Therapeutic Effects ◽  
Th2 Response ◽  
Adequate Treatment ◽  
Oxidative Stresses ◽  
Antiangiogenic Factors

Membranous nephropathy (MN) is a leading cause of adult nephrotic syndrome but lacks adequate treatment. Different extracts ofAngelica sinensis(AS) and one of its active compounds, ferulic acid (FA), were used to evaluate the therapeutic effects in a MN mouse model. The MN model was grouped into three subgroups: no treatment (N-T), treatment at induction of MN (Pre-T), and treatment after full-blown MN (Post-T). The results showed that the methanol (ME) layer of AS extract exhibited a therapeutic effect on MN-induced proteinuria. The ME layer-enriched compound, FA, improved the hypoalbuminemia, hyperlipidemia, and proteinuria in both Pre-T and Post-T groups. Ferulic acid also reduced the formation of oxidative protein products and increased the synthesis of antioxidant enzymes in groups Pre-T and Post-T. Regarding angiogenesis factors, the antiangiogenic factors in renal glomeruli were increased in group N-T, but, after FA treatment, only one of the antiangiogenic factors, thrombospondin-1, showed a significant decrease. Furthermore, the expression of Th2 predominant showed significant decrease in both Pre-T and Post-T groups when compared to that of N-T group. In summary, FA retarded the progression of MN, and the mechanisms involved the regulation of oxidative stresses, angiogenic and antiangiogenic factors, and attenuation of Th2 response.

Ferulic acid through mitigation of NMDA receptor pathway exerts anxiolytic-like effect in mouse model of maternal separation stress

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Zahra Lorigooini ◽  
Ali Nouri ◽  
Faezeh mottaghinia ◽  
Shima Balali-Dehkordi ◽  
Elham Bijad ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Mouse Model ◽  
Ferulic Acid ◽  
Nmda Receptors ◽  
Effective Dose ◽  
Life Stress ◽  
Receptor Agonist ◽  
Maternal Separation ◽  
Early Life Stress ◽  
Central Zone

AbstractBackgroundExperiencing early-life stress plays an important role in the pathophysiology of anxiety disorders. Ferulic acid is a phenolic compound found in some plants which has several pharmacological properties. N-methyl-D-aspartate (NMDA) receptors are involved in the pathophysiology of mood disorders. In this study we aimed to assess the anxiolytic-like effect of ferulic acid in a mouse model of maternal separation (MS) stress by focusing on the possible involvement of NMDA receptors.MethodsMice were treated with ferulic acid (5 and 40 mg/kg) alone and in combination with NMDA receptor agonist/antagonist. Valid behavioral tests were performed, including open field test (OFT) and elevated plus maze test (EPM), while quantitative real time polymerase chain reaction (qRT-PCR) was used to evaluate gene expression of NMDA subunits (GluN2A and GluN2B) in the hippocampus.ResultsFindings showed that treatment of MS mice with ferulic acid increased the time spent in the central zone of the OFT and increased both open arm time and the percent of open arm entries in the EPM. Ferulic acid reduced the expression of NMDA receptor subunit genes. We showed that administration of NMDA receptor agonist (NMDA) and antagonist (ketamine) exerted anxiogenic and anxiolytic-like effects, correspondingly. Results showed that co-administration of a sub-effective dose of ferulic acid plus ketamine potentiated the anxiolytic-like effect of ferulic acid. Furthermore, co-administration of an effective dose of ferulic acid plus NMDA receptor agonist (NMDA) attenuated the anxiolytic-like effect of ferulic acid.ConclusionsIn deduction, our findings showed that NMDA, partially at least, is involved in the anxiolytic-like effect of ferulic acid in the OFT and EPM tests.

A novel mouse model of phospholipase A2 receptor 1-associated membranous nephropathy mimics podocyte injury in patients

2020 ◽  
Vol 97 (5) ◽  
pp. 913-919 ◽  
Author(s):  
Catherine Meyer-Schwesinger ◽  
Nicola M. Tomas ◽  
Silke Dehde ◽  
Larissa Seifert ◽  
Irm Hermans-Borgmeyer ◽  
...  
Keyword(s):  
Mouse Model ◽  
Phospholipase A2 ◽  
Membranous Nephropathy ◽  
Podocyte Injury ◽  
Phospholipase A2 Receptor

Ferulic acid ameliorates memory impairment in d-galactose-induced aging mouse model

2016 ◽  
Vol 67 (7) ◽  
pp. 806-817 ◽  
Author(s):  
Honggai Yang ◽  
Zhuo Qu ◽  
Jingze Zhang ◽  
Liqin Huo ◽  
Jing Gao ◽  
...  
Keyword(s):  
Mouse Model ◽  
Ferulic Acid ◽  
Memory Impairment ◽  
Aging Mouse

Effects of Danggui and Its Component Ferulic Acid On Hematopoiesis and Platelet Production.

Blood ◽  
2009 ◽  
Vol 114 (22) ◽  
pp. 3509-3509
Author(s):  
Rui Xia Deng ◽  
Jie Yu Ye ◽  
Chang Charlie Liu ◽  
Godfrey ChiFung Chan ◽  
Jian Liang Chen ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Mouse Model ◽  
Ferulic Acid ◽  
Chinese Herbs ◽  
Astragaloside Iv ◽  
Platelet Production ◽  
Apoptotic Effect ◽  
Radiation Induced ◽  
Cell Series ◽  
Vitro Effect

Abstract Abstract 3509 Poster Board III-446 Chinese herbs have been used for the treatment of myelosuppression and thrombocytopenia for centuries and some herb mixtures have been shown to have favorable effects in cancer patients with myelosuppression. Our recent publication has shown that Danggui Buxue Tong, a traditional Chinese medicine decoction containing Radix Angelicae Sinensis (Danggui) and Radix Astragali (Huangqi), promotes hematopoiesis and thrombopoiesis in mouse model (Yang et al, J Ethnopharm, 2009). However, reports about the pharmacological effects of each herb ingredient have been scanty. The root of Danggui is an important ingredient of many commonly used prescriptions in Chinese herbs for promoting blood production. The chemical constituents and the pharmacological action of Danggui have been investigated using modern scientific methods at the beginning of this century. The objective of this study was to compare the effect of Danggui and TPO on hematopoiesis and platelet production in radiation-induced hematocytopenic mouse model. Danggui extracts (10 mg/kg/day) and TPO (10 ug/kg/day) were given by injection daily for 21 days starting from the day after radiotherapy. Peripheral blood platelet, WBC and RBC from Danggui, TPO and water control groups were analyzed at different time-points. On day 21, the mouse was sacrificed and bone marrow cells were harvested for CFU-MK and CFU-GM assays using the plasma clot and methylcellulose methods. The results showed that both Danggui and TPO significantly enhanced the recovery of platelet and WBC count, as well as CFU-MK and CFU-GM formation (n=6). Morphological examination of bone marrow also showed that Danggui treatment significantly increased the recovery of hematopoietic progenitor cells and megakaryocytic cell series. In addition, Danggui also increased the recovery of the body weight and organ weight (liver and spleen) in mouse model. We further analyzed the in vitro effect of Ferulic acid (major component of Danggui) and Astragaloside IV (major component of Huangqi) on hematopoiesis using CFU assay. Ferulic acid plus Astragaloside IV significantly promoted mouse CFU-GEMM formation (n=4). Ferulic acid together with Astragaloside IV also significantly reduced serum free-induced apoptosis in K562 cells by annexin V assay using flow cytometry (n=3). This anti-apoptotic effect can be mediated by reducing the activation of Caspase-3 pathway. In summary, our studies showed that Danggui extracts as well as TPO enhances hematopoiesis and thrombopoiesis in a radiation-induced hematocytopenic mouse model. Ferulic acid, in combination with Astragaloside IV, also has promoting effect on hematopoiesis and anti-apoptotic effect on hematopoietic cells. Disclosures: No relevant conflicts of interest to declare.

scholarly journals P04 A NOVEL MOUSE MODEL OF MEMBRANOUS NEPHROPATHY INDUCED WITH HETEROLOGOUS RABBIT ANTI-THSD7A ANTIBODIES

2016 ◽  
Vol 1 (4) ◽  
pp. S2
Author(s):  
N. Tomas ◽  
C. Meyer-Schwesinger ◽  
H. von Spiegel ◽  
G. Zahner ◽  
E. Hoxha ◽  
...  
Keyword(s):  
Mouse Model ◽  
Membranous Nephropathy
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