The Clinical Values of Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein-3 Levels in Blood and Thyroid Nodules

Aim.Insulin-like growth factor-1 (IGF-1) is a potent mitogen for many cells. IGF-1 plays a role in the pathogenesis of various tumors with its mutagenic and antiapoptotic properties. The aim of this study was to determine both the serum and intranodular levels of IGF-1 and insulin-like growth factor binding protein-3 (IGFBP-3) in patients with nodular thyroid diseases.Materials and Methods.In this study, 80 subjects who performed fine-needle aspiration biopsy (FNAB) were required in order to investigate the effects of serum and intranodular IGF-1 and IGFBP-3 in the pathogenesis of nodules. After performing FNAB, IGF-1 and IGFBP-3 levels were determined in blood and aspiration samples.Results.The serum levels of IGF-1 (232.8 ± 12.9 ng/ml) and IGFBP-3 (4.8 μg/ml) were found significantly higher than that of the intranodular IGF-1 (39.1 ng/ml) and intranodular IGFBP-3 levels (0.173 μg/ml) (p<0.01). Intranodular levels of IGF-1 and IGFBP-3 were higher in subjects with multinodular thyroid gland than those of subjects with solitary nodules (p=0.043). A positive correlation between the nodule size and the serum IGFBP-3 levels was detected (p=0.042,r=0.23).Conclusion.This study demonstrated the possible role of both IGF-1 and IGFBP-3 in the growth and the formation of multinodularity of thyroid nodules.

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Dietary Fat and Carbohydrates Are Independently Associated With Circulating Insulin-Like Growth Factor 1 and Insulin-Like Growth Factor–Binding Protein 3 Concentrations in Healthy Adults

Journal of Clinical Oncology ◽

10.1200/jco.1999.17.10.3291 ◽

1999 ◽

Vol 17 (10) ◽

pp. 3291-3298 ◽

Cited By ~ 83

Author(s):

Virginia G. Kaklamani ◽

Athena Linos ◽

Evangelia Kaklamani ◽

Ioanna Markaki ◽

Yvonni Koumantaki ◽

...

Keyword(s):

Growth Factor ◽

Energy Intake ◽

Binding Protein ◽

Serum Insulin ◽

Serum Levels ◽

Dietary Factors ◽

Insulin Like Growth Factor ◽

Negatively Associated ◽

Factor Binding ◽

Igfbp 3

PURPOSE: To evaluate and quantify the association between consumption of specific food groups/macronutrients and concentrations of serum insulin-like growth factor 1 (IGF-1) and insulin-like growth factor–binding protein 3 (IGFBP-3). SUBJECTS AND METHODS: Data from a comprehensive food-frequency questionnaire administered to 115 healthy subjects were used to study cross-sectionally the relationship between nutritional factors and circulating IGF-1 and IGFBP-3 concentrations. Adjustment for the effect of total energy intake and a series of epidemiologic parameters (age, sex, height, body mass index, smoking, alcohol consumption, and coffee drinking) was implemented through multivariate linear regression. RESULTS: We observed that serum levels of IGF-1 are positively associated with consumption of redmeats, fats, and oils. In addition, serum levels of IGF-1 are independently and positively associated with energy intake from lipids and negatively associated with energy intake from carbohydrates. Finally, serum levels of IGFBP-3 are independently and negatively associated with energy intake from saturated fat. CONCLUSION: Serum IGF-1 and/or IGFBP-3 concentrations are associated with red meat, carbohydrate intake, and fat intake and, thus, may mediate the effect of these dietary factors on the pathogenesis of several disease states. Additional studies are needed to further quantify these associations and elucidate the underlying mechanisms.

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PO4-4: Cerebrospinal fluid and serum levels of growth hormone (GH), insulin-like-growth factor-I (IGF-1), insulin-like growth factor binding protein -3 (IGFBP-3) and ghrelin in patients with bacterial and tuberculous meningitis

Growth Hormone & IGF Research ◽

10.1016/s1096-6374(14)50138-4 ◽

2014 ◽

Vol 24 ◽

pp. S50

Author(s):

A. Akinci ◽

S. Gungor ◽

G. Yucel ◽

S. Gungor ◽

H.I. Ozerol

Keyword(s):

Growth Hormone ◽

Cerebrospinal Fluid ◽

Growth Factor ◽

Tuberculous Meningitis ◽

Binding Protein ◽

Serum Levels ◽

Insulin Like Growth Factor ◽

Factor Binding ◽

Factor I ◽

Igfbp 3

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Role of insulin-like growth factor binding protein (IGFBP)-3 in TGF-?- and GDF-8 (myostatin)-induced suppression of proliferation in porcine embryonic myogenic cell cultures

Journal of Cellular Physiology ◽

10.1002/jcp.10362 ◽

2003 ◽

Vol 197 (2) ◽

pp. 225-231 ◽

Cited By ~ 22

Author(s):

E. Kamanga-Sollo ◽

M.S. Pampusch ◽

M.E. White ◽

W.R. Dayton

Keyword(s):

Growth Factor ◽

Cell Cultures ◽

Binding Protein ◽

Myogenic Cell ◽

Insulin Like Growth Factor ◽

Factor Binding ◽

Igfbp 3

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The phosphorylation status of insulin-like growth factor-binding protein-1 in prepubertal obese children

Acta Endocrinologica ◽

10.1530/eje.0.1410585 ◽

1999 ◽

pp. 585-589 ◽

Cited By ~ 2

Author(s):

T Kamoda ◽

H Saitoh ◽

S Nakahara ◽

M Inudoh ◽

T Hirano ◽

...

Keyword(s):

Growth Factor ◽

Binding Protein ◽

Serum Levels ◽

Insulin Like Growth Factor ◽

Obese Children ◽

Factor Binding ◽

Igf I ◽

The Status ◽

And Control ◽

Igfbp 3

OBJECTIVE: We measured the total and nonphosphorylated insulin-like growth factor-binding protein (IGFBP)-1 concentrations in obese children to determine the effect of obesity on the status of IGFBP-1 phosphorylation. We also measured the serum levels of insulin, total and free IGF-I, and IGFBP-3 to investigate their relationships to the IGFBP-1 phosphorylation status in obese subjects. SUBJECTS AND METHODS: Nineteen prepubertal obese and 15 age-matched control children were included in the study. The serum levels of total and nonphosphorylated IGFBP-1 were determined by noncompetitive RIAs. RESULTS: The serum levels of total and nonphosphorylated IGFBP-1 were significantly lower in the obese group (48.7+/-5.6 microgram/l, P<0.001 and 11.1+/-1.9 microgram/l, P<0.01 respectively) than in the controls (86.7+/-9.0 microgram/l and 28.8+/-6.2 microgram/l respectively). However, the ratio of nonphosphorylated IGFBP-1 to total IGFBP-1 did not differ significantly between the obese and control groups. The circulating free IGF-I level was significantly higher in the obese children than in the controls (P<0.05), while the serum levels of insulin, total IGF-I and IGFBP-3 were not significantly different between the two groups. A stepwise regression analysis of the combined group revealed that only the total IGFBP-1 level was an independent predictor of the free IGF-I concentration (P<0.001). CONCLUSION: The present study shows that both total and nonphosphorylated IGFBP-1 concentrations are decreased in obese children and the increased free IGF-I level in obese children is related to the reduced total IGFBP-1 level, but unrelated to the change in the IGFBP-1 phosphorylation status.

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