scholarly journals Preparation and Characterization of Hyaluronic Acid-Polycaprolactone Copolymer Micelles for the Drug Delivery of Radioactive Iodine-131 Labeled Lipiodol

2017 ◽  
Vol 2017 ◽  
pp. 1-8
Author(s):  
Shih-Cheng Chen ◽  
Ming-Hui Yang ◽  
Tze-Wen Chung ◽  
Ting-Syuan Jhuang ◽  
Jean-Dean Yang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Radioactive Tracer ◽  
Cell Uptake ◽  
Hepatic Cells ◽  
Amphiphilic Molecules ◽  
Hydrophobic Tail ◽  
Uptake Activity ◽  
The Stability ◽  
Radioactive Iodine 131

Micelles, with the structure of amphiphilic molecules including a hydrophilic head and a hydrophobic tail, are recently developed as nanocarriers for the delivery of drugs with poor solubility. In addition, micelles have shown many advantages, such as enhanced permeation and retention (EPR) effects, prolonged circulation times, and increased endocytosis through surface modification. In this study, we measured the critical micelle concentrations, diameters, stability, and cytotoxicity and the cell uptake of micelles against hepatic cells with two kinds of hydrophilic materials: PEG-PCL and HA-g-PCL. We used 131I as a radioactive tracer to evaluate the stability, drug delivery, and cell uptake activity of the micelles. The results showed that HA-g-PCL micelles exhibited higher drug encapsulation efficiency and stability in aqueous solutions. In addition, the 131I-lipiodol loaded HA-g-PCL micelles had better affinity and higher cytotoxicity compared to HepG2 cells.

scholarly journals Synthesis and Characterization of New Biocompatible Amino Amphiphilic Compounds Derived from Oleic Acid as Nanovectors for Drug Delivery

Proceedings ◽  
2019 ◽  
Vol 41 (1) ◽  
pp. 1
Author(s):  
Victoria Valdivia ◽  
Chiara Paggiaro ◽  
Inmaculada Fernández
Keyword(s):  
Drug Delivery ◽  
Oleic Acid ◽  
Aqueous Medium ◽  
Self Assembly ◽  
Tetraethylene Glycol ◽  
Synthetic Approach ◽  
Polar Head ◽  
Amphiphilic Molecules ◽  
Amphiphilic Compounds

Amphiphilic molecules have been actively explored as promising materials in the field of bio and nanotechnology. These molecules are constituted by a polar head and a lipophilic tail and in an aqueous medium are self-assemble to form different types of macromolecular structures such as micelles, monolayer vesicles, bars, sheets and tubes. In this work, a convergent synthetic approach for the synthesis of two new amphiphilic compounds based on a versatile amino polar head, a tetraethylene glycol spacer and a lipophilic tail derived from oleic acid has been developed. Subsequently, after a self-assembly process in aqueous medium, nanostructures as micelles have been obtained and characterized. Finally, a procedure for the inclusion of the highly lipophilic drug Dexamethasone has been carried out in order to study the ability of these micelles to act as nanovectors for drug delivery.

scholarly journals Mesoscopic Modeling of Encapsulation of Capsaicin by Lecithin/Chitosan Liposomal Nanoparticles

2018 ◽  
Author(s):  
Ketzasmin A. Terrón-Mejía ◽  
Evelin Martínez-Benavidez ◽  
Inocencio Higuera-Ciapara ◽  
Claudia Virués ◽  
Javier Hernández ◽  
...  
Keyword(s):  
Synthesis Of Nanoparticles ◽  
Mesoscopic Modeling ◽  
Amphiphilic Molecules ◽  
Density Maps ◽  
Potentials Of Mean Force ◽  
Experimental Works ◽  
Liposomal Nanoparticles ◽  
The Stability ◽  
Low Solubility

Transport of hydrophobic drugs in the human body exhibits complications due to the low solubility of these compounds. With the purpose of enhancing the bioavailability and biodistribution of such drugs, recent studies have reported the use of amphiphilic molecules, such as phospholipids, for synthesis of nanoparticles or nanocapsules. Given that phospholipids can self–assemble in liposomes or micellar structures, they are ideal candidates to function as vehicles of hydrophobic molecules. In this work, we report mesoscopic simulations of nanoliposomes, constituted by lecithin and coated with a shell of chitosan. The stability of such structure and the efficiency of encapsulation of capsaicin, as well as the internal and superficial distribution of capsaicin and chitosan inside the nanoliposome were analyzed. The characterization of the system was carried out through density maps and the potentials of mean force for the lecithin–capsaicin, lecithin–chitosan and capsaicin–chitosan interactions. The results of these simulations show that chitosan is deposited on the surface of the nanoliposome, as has been reported in some experimental works. It was also observed that a nanoliposome of approximately 18 nm in diameter is stable during the simulation. The deposition behavior was found to be influenced by pattern of N-acetylation of chitosan.

Bioinspired Nanomaterials

2021 ◽  
Keyword(s):  
Drug Delivery ◽  
Electrochemical Sensors ◽  
Low Cost ◽  
Nanocomposite Materials ◽  
Biological Synthesis ◽  
Oxide Nanostructures ◽  
Metal Oxide Nanostructures ◽  
Bioinspired Nanomaterials ◽  
The Stability

Biological synthesis employing microorganisms, fungi or plants is an alternative method to produce nanoparticles in low-cost and eco-friendly ways. The book covers the synthesis of metal nanoparticles, metal oxide nanostructures and nanocomposite materials, as well as the stability and characterization of bioinspired nanomaterials. Applications include optical and electrochemical sensors, packaging, SERS and drug delivery processes.

TEM characterization of Au/Polysilicon interactions

1990 ◽  
Vol 48 (4) ◽  
pp. 650-651
Author(s):  
N. David Theodore ◽  
Leslie H. Allen ◽  
C. Barry Carter ◽  
James W. Mayer
Keyword(s):  
Solid Phase ◽  
Single Crystal Silicon ◽  
Chemical Vapor ◽  
Electrical Contacts ◽  
Silicon Substrates ◽  
Crystal Silicon ◽  
Transmission Electron ◽  
Polysilicon Films ◽  
The Stability

Metal/polysilicon investigations contribute to an understanding of issues relevant to the stability of electrical contacts in semiconductor devices. These investigations also contribute to an understanding of Si lateral solid-phase epitactic growth. Metals such as Au, Al and Ag form eutectics with Si. reactions in these metal/polysilicon systems lead to the formation of large-grain silicon. Of these systems, the Al/polysilicon system has been most extensively studied. In this study, the behavior upon thermal annealing of Au/polysilicon bilayers is investigated using cross-section transmission electron microscopy (XTEM). The unique feature of this system is that silicon grain-growth occurs at particularly low temperatures ∽300°C).Gold/polysilicon bilayers were fabricated on thermally oxidized single-crystal silicon substrates. Lowpressure chemical vapor deposition (LPCVD) at 620°C was used to obtain 100 to 400 nm polysilicon films. The surface of the polysilicon was cleaned with a buffered hydrofluoric acid solution. Gold was then thermally evaporated onto the samples.

Biopolymers with Medical Applications Optimized method for obtaining chitosan-based delivery systems

2018 ◽  
Vol 69 (7) ◽  
pp. 1756-1759 ◽  
Author(s):  
Luminita Confederat ◽  
Iuliana Motrescu ◽  
Sandra Constantin ◽  
Florentina Lupascu ◽  
Lenuta Profire
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Average Diameter ◽  
Delivery Systems ◽  
Cross Linking ◽  
Low Molecular Weight ◽  
Polymeric Systems ◽  
Chitosan Microparticles ◽  
Degree Of Swelling

The aim of this study was to optimize the method used for obtaining microparticles based on chitosan � a biocompatible, biodegradable, and nontoxic polymer, and to characterize the developed systems. Chitosan microparticles, as drug delivery systems were obtained by inotropic gelation method using pentasodiumtripolyphosphate (TPP) as cross-linking agent. Chitosan with low molecular weight (CSLMW) in concentration which ranged between 0.5 and 5 %, was used while the concentration of cross-linking agent ranged between 1 and 5%. The characterization of the microparticles in terms of shape, uniformity and adhesion was performed in solution and dried state. The size of the microparticles and the degree of swelling were also determined. The structure and the morphology of the developed polymeric systems were analyzed by Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM).The average diameter of the chitosan microparticles was around 522 �m. The most stable microparticles were obtained using CSLMW 1% and TPP 2% or CSLMW 0.75%and TPP 1%. The micropaticles were spherical, uniform and without flattening. Using CSLMW in concentration of 0.5 % poorly cross-linked and crushed microparticles have been obtained at all TPP concentrations. By optimization of the method, stable chitosan-based micropaticles were obtained which will be used to develop controlled release systems for drug delivery.

Hydrogel-clay Nanocomposites as Carriers for Controlled Release

2020 ◽  
Vol 27 (6) ◽  
pp. 919-954 ◽  
Author(s):  
Raluca Ianchis ◽  
Claudia Mihaela Ninciuleanu ◽  
Ioana Catalina Gifu ◽  
Elvira Alexandrescu ◽  
Cristina Lavinia Nistor ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Hybrid Materials ◽  
Pharmaceutical Formulations ◽  
Tree Of Life ◽  
Present Review ◽  
Clay Nanocomposites ◽  
Delivery Platform ◽  
Complex Hybrid

The present review aims to summarize the research efforts undertaken in the last few years in the development and testing of hydrogel-clay nanocomposites proposed as carriers for controlled release of diverse drugs. Their advantages, disadvantages and different compositions of polymers/biopolymers with diverse types of clays, as well as their interactions are discussed. Illustrative examples of studies regarding hydrogel-clay nanocomposites are detailed in order to underline the progressive researches on hydrogel-clay-drug pharmaceutical formulations able to respond to a series of demands for the most diverse applications. Brief descriptions of the different techniques used for the characterization of the obtained complex hybrid materials such as: swelling, TGA, DSC, FTIR, XRD, mechanical, SEM, TEM and biology tests, are also included. Enlightened by the presented data, we can suppose that hydrogel-clay nanocomposites will still be a challenging subject of global assiduous researches. We can dare to dream to an efficient drug delivery platform for the treatment of multiple affection concomitantly, these being undoubtedly like ”a tree of life” bearing different kinds of fruits and leaves proper for human healing.

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