scholarly journals Desired Turbulence? Gut-Lung Axis, Immunity, and Lung Cancer

2017 ◽  
Vol 2017 ◽  
pp. 1-15 ◽  
Author(s):  
Rea Bingula ◽  
Marc Filaire ◽  
Nina Radosevic-Robin ◽  
Mathieu Bey ◽  
Jean-Yves Berthon ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Immune System ◽  
Innate Immune ◽  
The Other ◽  
Microbial Composition ◽  
Central Nervous Systems ◽  
Altered Immune Response ◽  
Insight Into ◽  
Antitumour Response ◽  
Stimulation Of

The microbiota includes different microorganisms consisting of bacteria, fungi, viruses, and protozoa distributed over many human body surfaces including the skin, vagina, gut, and airways, with the highest density found in the intestine. The gut microbiota strongly influences our metabolic, endocrine, and immune systems, as well as both the peripheral and central nervous systems. Recently, a dialogue between the gut and lung microbiota has been discovered, suggesting that changes in one compartment could impact the other compartment, whether in relation to microbial composition or function. Further, this bidirectional axis is evidenced in an, either beneficial or malignant, altered immune response in one compartment following changes in the other compartment. Stimulation of the immune system arises from the microbial cells themselves, but also from their metabolites. It can be either direct or mediated by stimulated immune cells in one site impacting the other site. Additionally, this interaction may lead to immunological boost, assisting the innate immune system in its antitumour response. Thus, this review offers an insight into the composition of these sites, the gut and the lung, their role in shaping the immune system, and, finally, their role in the response to lung cancer.

scholarly journals Insights into Sensing of Murine Retroviruses

Viruses ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 836
Author(s):  
Eileen A. Moran ◽  
Susan R. Ross
Keyword(s):  
Immune Response ◽  
Immune System ◽  
Nucleic Acid ◽  
Adaptive Immunity ◽  
Innate Immune System ◽  
Innate Immune ◽  
Genetic Tool ◽  
Causes Of Disease ◽  
Retrovirus Infection ◽  
Insight Into

Retroviruses are major causes of disease in animals and human. Better understanding of the initial host immune response to these viruses could provide insight into how to limit infection. Mouse retroviruses that are endemic in their hosts provide an important genetic tool to dissect the different arms of the innate immune system that recognize retroviruses as foreign. Here, we review what is known about the major branches of the innate immune system that respond to mouse retrovirus infection, Toll-like receptors and nucleic acid sensors, and discuss the importance of these responses in activating adaptive immunity and controlling infection.

In VivoRadioprotection by 5-Androstenediol: Stimulation of the Innate Immune System

2001 ◽  
Vol 156 (3) ◽  
pp. 283-293 ◽  
Author(s):  
M. H. Whitnall ◽  
C. E. Inal ◽  
W. E. Jackson III ◽  
V. L. Miner ◽  
V. Villa ◽  
...  
Keyword(s):  
Immune System ◽  
Innate Immune System ◽  
Innate Immune ◽  
Stimulation Of

scholarly journals SARS-COV-2 acts as a test of Air Pollution, Lifestyle Disorders and Immune Tolerance dysregulation in human body

2021 ◽  
Author(s):  
bose Karthik
Keyword(s):  
Immune System ◽  
Immune Tolerance ◽  
Adaptive Immune System ◽  
Innate Immune ◽  
Human Immune System ◽  
Adaptive Immune ◽  
Human Immune ◽  
Humoral Responses ◽  
Skeletal Mechanism ◽  
Insight Into

SARS-COV-2 is reported to be associated with severe immune dysregulation, delayed humoral responses and accelerated innate immune response mediated damages. As the pandemic is turning the world upside down, In order to address this disease we should first get an insight into the mechanism of action through which SARS-COV-2 is achieving the above said dysregulating or modulating effects on human immune system. T his article presents the basic or skeletal mechanism through which SARS-COV-2 dysregulates immune system by targeting innate immune system, adaptive immune system and different immune tolerance check points by dysregulating different miRNA’s and the preexisting conditions or comorbidities of the patients. This article comprises of the comparative and comprehensive literature review targeting all topics with the data available/reported till date in the scientific community.

scholarly journals Targeting and stimulation of the zebrafish (Danio rerio) innate immune system with LPS/dsRNA-loaded nanoliposomes

Vaccine ◽  
2014 ◽  
Vol 32 (31) ◽  
pp. 3955-3962 ◽  
Author(s):  
Angels Ruyra ◽  
Mary Cano-Sarabia ◽  
Pablo García-Valtanen ◽  
Daniel Yero ◽  
Isidre Gibert ◽  
...  
Keyword(s):  
Immune System ◽  
Danio Rerio ◽  
Innate Immune System ◽  
Innate Immune ◽  
Stimulation Of

scholarly journals Neuroinflammation and disruption in working memory in aged mice after acute stimulation of the peripheral innate immune system

2008 ◽  
Vol 22 (3) ◽  
pp. 301-311 ◽  
Author(s):  
Jing Chen ◽  
Jessica B. Buchanan ◽  
Nathan L. Sparkman ◽  
Jonathan P. Godbout ◽  
Gregory G. Freund ◽  
...  
Keyword(s):  
Working Memory ◽  
Immune System ◽  
Innate Immune System ◽  
Innate Immune ◽  
Aged Mice ◽  
Stimulation Of

scholarly journals High-content screening of coronavirus genes for innate immune suppression reveals enhanced potency of SARS-CoV-2 proteins

2021 ◽  
Author(s):  
Erika J. Olson ◽  
David M. Brown ◽  
Timothy Z. Chang ◽  
Lin Ding ◽  
Tai L. Ng ◽  
...  
Keyword(s):  
Immune System ◽  
Immune Suppression ◽  
Innate Immune System ◽  
Innate Immune ◽  
The Other ◽  
High Content Screening ◽  
Sequence Information ◽  
Spike Gene ◽  
Immune Pathways

SummarySuppression of the host intracellular innate immune system is an essential aspect of viral replication. Here, we developed a suite of medium-throughput high-content cell-based assays to reveal the effect of individual coronavirus proteins on antiviral innate immune pathways. Using these assays, we screened the 196 protein products of seven coronaviruses (SARS-CoV-2, SARS-CoV-1, 229E, NL63, OC43, HKU1 and MERS). This includes a previously unidentified gene in SARS-CoV-2 encoded within the Spike gene. We observe immune-suppressing activity in both known host-suppressing genes (e.g., NSP1, Orf6, NSP3, and NSP5) as well as other coronavirus genes, including the newly identified SARS-CoV-2 protein. Moreover, the genes encoded by SARS-CoV-2 are generally more potent immune suppressors than their homologues from the other coronaviruses. This suite of pathway-based and mechanism-agnostic assays could serve as the basis for rapid in vitro prediction of the pathogenicity of novel viruses based on provision of sequence information alone.

Sign in / Sign up

Export Citation Format

Share Document