scholarly journals Preparation and Optimization of 10-Hydroxycamptothecin Nanocolloidal Particles Using Antisolvent Method Combined with High Pressure Homogenization

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Bolin Lian ◽  
Yong Li ◽  
Xiuhua Zhao ◽  
Yuangang Zu ◽  
Ying Wang ◽  
...  
Keyword(s):  
High Pressure ◽  
Aqueous Suspension ◽  
Volume Ratio ◽  
Small Range ◽  
High Pressure Homogenization ◽  
Optimum Conditions ◽  
Short Term ◽  
Antisolvent Precipitation ◽  
Primary Particles ◽  
The Stability

The aim of this study was to prepare 10-hydroxycamptothecin nanocolloidal particles (HCPTNPs) to increase the solubility of drugs, reduce the toxicity, improve the stability of the drug, and so forth. HCPTNPs was prepared by antisolvent precipitation (AP) method combined with high pressure homogenization (HPH), followed by lyophilization. The main parameters during antisolvent process including volume ratio of dimethyl sulfoxide (DMSO) and H2O and dripping speed were optimized and their effects on mean particle size (MPS) and yield of HCPT primary particles were investigated. In the high pressure homogeneous procedure, types of surfactants, amount of surfactants, and homogenization pressure (HP) were optimized and their influences on MPS, zeta potential (ZP), and morphology were analyzed. The optimum conditions of HCPTNPs were as follows: 0.2 mg/mL HCPT aqueous suspension, 1% of ASS, 1000 bar of HP, and 20 passes. Finally, the HCPTNPs via lyophilization using glucose as lyoprotectant under optimum conditions had an MPS of 179.6 nm and a ZP of 28.79 ± 1.97 mV. The short-term stability of HCPTNPs indicated that the MPS changed in a small range.

scholarly journals Stability Aspects of Non-Dairy Milk Alternatives

2021 ◽  
Author(s):  
Jyotika Dhankhar ◽  
Preeti Kundu
Keyword(s):  
High Pressure ◽  
Physical Stability ◽  
Bovine Milk ◽  
Processing Parameters ◽  
High Pressure Homogenization ◽  
Antibiotic Residues ◽  
Plant Materials ◽  
Milk Products ◽  
The Stability ◽  
Dairy Milk

In recent years, plant-based milk products, commonly called as non-dairy milk alternatives have gained high popularity due to concerns associated with bovine milk like lactose intolerance, allergies, hypercholesterolemia, and pesticide and antibiotic residues. Important strategies for manufacture of non-dairy milk alternatives involve disintegration of plant materials in aqueous medium; its homogenization and addition of some additives to attain a consistency and appearance similar to that of bovine milk. Different range of ingredients are added to non-dairy milk alternatives such as oils, emulsifiers, thickeners, antioxidants, minerals etc. The main problem associated with non-dairy milk alternatives is generally linked with its stability. Stability is a crucial factor that governs the sensory properties and overall acceptance of non-dairy milk alternatives. Differences in processing parameters and molecular interaction mechanisms affect the stability of emulsions as well as the stability of non-dairy milk manufactured thereof. Various treatments like thermal treatment, non-thermal processing (ultra high pressure homogenization, pulsed electric field, ultrasonication), addition of emulsifiers are effective in achieving the stability of non-dairy milks. The present chapter aims to summarize the various factors contributing to the physical stability of non-dairy milk alternatives like appearance, consistency, emulsion stability, and the approaches required to maintain it.

scholarly journals Effects of high pressure homogenization on the stability of cloudy apple juice

2019 ◽  
Vol 358 ◽  
pp. 022059
Author(s):  
Danshi Zhu ◽  
Chengcheng Kou ◽  
Liwei Wei ◽  
Pushun Xi ◽  
LV Changxin ◽  
...  
Keyword(s):  
High Pressure ◽  
Apple Juice ◽  
High Pressure Homogenization ◽  
The Stability

Lycopene Nanoparticles Coated with Microemulsions to Improve Stability

2015 ◽  
Vol 1120-1121 ◽  
pp. 897-902 ◽  
Author(s):  
Zhu Fen Lu ◽  
Yan Zhong Chen ◽  
Jun Feng Ban ◽  
Guang Han Deng ◽  
Huang Xin ◽  
...  
Keyword(s):  
High Pressure ◽  
Zeta Potential ◽  
Drug Loading ◽  
Drug Efficacy ◽  
Tween 20 ◽  
Microemulsion System ◽  
Loading Capacity ◽  
High Pressure Homogenization ◽  
The Stability ◽  
Improve Stability

Delivery systems play important roles in improving drug efficacy. In particular, insoluble functional pigments must be handled carefully when increasing their solubility, in order to ensure that they remain active. In this study, the nanoparticles were coated by the oil phase in the microemulsion system (NPs-SEs), and this system was found to both increase the stability of the drug and improve drug loading. NPs-SEs containing lycopene, soybean oil, Span-40, Tween-20, stabilizer and glycerol were prepared by high pressure homogenization technology. It was characterized and its droplet size, and Zeta potential were 181±15 nm ( PDI 0.092±0.01), -70.83±1.64mV, respectively. The drug loading capacity of NPs-SEs was 1.02±0.16mg/ml and was nearly 4 times more than the highest concentration of lycopene O/W emulsion.

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