scholarly journals Prevalence of Bacteriuria and Antimicrobial Susceptibility Patterns among Diabetic and Nondiabetic Patients Attending at Debre Tabor Hospital, Northwest Ethiopia

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Seble Worku ◽  
Awoke Derbie ◽  
Mulusew Alemneh Sinishaw ◽  
Yesuf Adem ◽  
Fantahun Biadglegne
Keyword(s):  
Urinary Tract Infection ◽  
Multidrug Resistance ◽  
Urinary Tract ◽  
Tract Infection ◽  
Antimicrobial Susceptibility ◽  
Bacterial Pathogens ◽  
Diabetic Patients ◽  
Gram Positive ◽  
Debre Tabor ◽  
Susceptibility Patterns

Background. Urinary tract infection is a major health problem especially in developing countries. Information about bacterial pathogens isolated from urinary tract infection in diabetic patients and their antimicrobial susceptibility patterns is limited in Ethiopia. Therefore, this study aimed at isolating bacterial pathogens and their antimicrobial susceptibility patterns.Methods. A hospital based comparative cross-sectional study was conducted at Debre Tabor. Urine sample was inoculated onto cysteine lysine electrolyte deficient (CLED) medium. Bacterial pathogens were identified using standard bacteriological methods. The data were cleaned and entered into SPSS version 20.Pvalue less than 0.05 is considered statistically significant.Result. A total of 384 study participants were included in the study. Of them, 21 (10.9%) were from diabetics and 9 (4.7%) of them were from nondiabetics. Large proportion of gram positive bacteria at 18 (58.1%) were isolated compared to gram negatives at 13 (41.9%). Gram positive isolates were resistant to cotrimoxazole 10 (58.8%).Conclusion. The isolation rates of bacterial pathogens were higher in diabetic than nondiabetic patients. Bacteriuria was significantly associated with sex and type of diabetes. Multidrug resistance to two or more antibiotics was observed in 56.7% of bacterial isolates. Rational use of antimicrobial agent should be thought of to prevent the emergence of multidrug resistance.

scholarly journals Prevalence Of Bacterial Urinary Tract Infection And Antimicrobial Susceptibility Patterns Among Diabetes Mellitus Patients Attending Zewditu Memorial Hospital, Addis Ababa, Ethiopia

2020 ◽  
Author(s):  
Gebremedhin Yenehun Worku ◽  
Yerega alamneh belete ◽  
Woldaregay Erku Abegaz
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Antimicrobial Susceptibility ◽  
Bacterial Isolates ◽  
Gram Positive ◽  
Gram Negative ◽  
High Level ◽  
Susceptibility Patterns ◽  
Diabetes Patients

Abstract Background: Urinary tract infection (UTI) is caused by colonization and growth of microorganisms within the urinary system. Diabetic patients are more prone to bacterial urinary tract infections due to impaired host defense and high glucose concentration in urine. Surveillance of urinary tract pathogens and their antibiogram is a key to patient management. The aim of this study was to determine the prevalence of bacterial UTI and antimicrobial susceptibility patterns (AST) among diabetes patients. Methods: Hospital-based cross-sectional study was conducted from May to July, 2018. Two hundred twenty-five mid-stream urine samples were collected for culture and identification based on the standard protocol. Antimicrobial susceptibility test was done for all positive urine cultures by Kirby Bauer's disk diffusion method based on CLSI guidelines. Data were entered into Epi-data version 3.2.1 and exported to the Statistical Package for the Social Science (SPSS) version 20 statistical software. Binary and multiple logistic regression test results were used.Results: The study result revealed 9.8% overall UTI prevalence. Five species of bacterial uropathogens were isolated. Among these, E. coli (63.6%) was the leading followed by K. pneumoniae (13.6%). In this study, significant bacteriuria was strongly associated with duration of diabetics, previous UTI and symptomatic UTI. Gram-negative bacterial isolates showed high level of sensitivity (100%) to nitrofurantoin and meropenem. On the contrary, high level of resistance (100 %) for ampicillin, doxycycline, cefuroxime, and (94.4 %) amoxacillin-clavulanate were observed. No resistance was observed among gram positive bacterial isolates except penicillin (100 % resistance). Over all prevalence of MDR was 100 % For Gram-negative bacteria.Conclusion: Presence of previous urinary tract infection and duration of diabetes were found as important factors that increase the prevalence of UTI among diabetes patients. This study also showed high prevalence of drug resistance to doxycycline, amoxacillin-clavulanate, cefuroxime and penicillin for both Gram- negative and Gram- positive bacteria. Therefore, since therapeutic selection for empirical treatment and management should be based on the knowledge of the local bacterial profile and antimicrobial response, we suggest physicians take this high resistance profile in to consideration when prescribing antimicrobials against the pathogens in question.

scholarly journals Prevalence, Antimicrobial Susceptibility Pattern, and Associated Factors of Urinary Tract Infections among Adult Diabetic Patients at Metu Karl Heinz Referral Hospital, Southwest Ethiopia

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Tesfaye Gutema ◽  
Fitsum Weldegebreal ◽  
Dadi Marami ◽  
Zelalem Teklemariam
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Urinary Tract Infections ◽  
Antimicrobial Susceptibility ◽  
Diabetic Patients ◽  
Susceptibility Pattern ◽  
Southwest Ethiopia ◽  
Antimicrobial Susceptibility Pattern ◽  
Tract Infections

Urinary tract infection causes considerable morbidity in diabetic patients and if complicated, can cause severe renal damage and life-threatening infections. The escalating antimicrobial resistance rate among bacteria over the past years is another concern in the treatment of urinary tract infections. This study investigated the prevalence, antimicrobial susceptibility pattern of the isolates and associated factors of urinary tract infection among adult diabetic patients attending Metu Karl Heinz Referral Hospital, Southwest Ethiopia. An institutional-based cross-sectional study was conducted among 233 adult diabetic patients selected using simple random sampling technique. Data were collected using a structured questionnaire. Clean-catch midstream urine samples were investigated for the presence of pathogenic bacteria and their antimicrobial susceptibility pattern using recommended culture methods. Data were entered, cleaned, and analyzed using the Statistical Program for Social Sciences version 21.0. Statistical significance was set at ap-value < 0.05. The prevalence of urinary tract infection was 16.7% (95%, CI: 12.0, 21.5). The predominant isolates wereEscherichia coli(25.6%) andKlebsiellaspp. (20.5%).E. coliisolates showed higher sensitivity to ceftriaxone (80%), ciprofloxacin (70%), and gentamycin (70%), but resistant to tetracycline (60%).Staphylococcus aureuswas sensitive to amoxicillin-clavulanic acid (85.7%), and gentamycin (57.1%), while resistant to tetracycline (85.7%), nitrofurantoin (85.7%), and ampicillin (71.4%). The odds of developing urinary tract infections were significantly higher in diabetic females (AOR: 3.56, 95% CI: 1.44, 8.76), those who were not able to read and write (AOR: 2.55, 95% CI: 1.19, 5.49) and those with a history of urinary tract infection (AOR: 2.31, 95% CI: 1.09, 4.90) compared with their counterparts. In this study, the prevalence of urinary tract infection among diabetic patients was relatively comparable with the previous studies conducted in Ethiopia. Management of urinary tract infection in diabetic patients should be supported with culture and antimicrobial susceptibility testing.

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