scholarly journals Sinonasal Melanoma: A Case Report and Literature Review

2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
I. S. S. Alves ◽  
L. G. S. Berriel ◽  
R. T. Alves ◽  
M. B. Pinto ◽  
C. F. P. Oliveira ◽  
...  
Keyword(s):  
Case Report ◽  
Nasal Obstruction ◽  
Complete Response ◽  
Undifferentiated Carcinoma ◽  
Human Melanoma ◽  
Mucosal Melanoma ◽  
Response To Treatment ◽  
Incisional Biopsy ◽  
Response To Chemotherapy ◽  
The Right

Purpose. Sinonasal malignant mucosal melanoma is a rare, aggressive tumour. Nasal obstruction and epistaxis are the most commonly reported symptoms, although symptomatology may develop late and be nonspecific, which tends to delay diagnosis, resulting in a poorer prognosis.Case Report. This report describes a 64-year-old male patient with nasal obstruction and epistaxis. Computed tomography of the facial sinuses revealed a large lesion in the right nasal cavity, with infiltration into the left cavity, ethmoidal cells, and erosion of the cribriform plate. Initial incisional biopsy revealed an undifferentiated carcinoma of the right maxillary sinus, staged as T4aN0M0. Induction chemotherapy was initiated with cisplatin and etoposide. Response to treatment was complete. The patient was then submitted to radiotherapy with concomitant cisplatin. Immunochemical analysis revealed positivity for vimentin, S100, and HMB-45 (human melanoma black 45), a result compatible with a diagnosis of malignant melanoma.Discussion. Due to the rarity of the tumour and the patient’s complete response to chemotherapy and since no blackened lesion had been found at the previous exam, treatment was continued as planned. The patient remains healthy, with no metastasis or recurrence. He is currently being monitored by the clinical oncology team.

Complete Response to Chemotherapy in Intra-Abdominal Desmoplastic Small round Cell Carcinoma. A Case Report

1998 ◽  
Vol 84 (3) ◽  
pp. 412-416 ◽  
Author(s):  
Mario De Lena ◽  
Maria Lucia Caruso ◽  
Franco Marzullo ◽  
Sergio Mancarella ◽  
Raffaele Armentano ◽  
...  
Keyword(s):  
Good Health ◽  
Complete Response ◽  
Complete Disappearance ◽  
Round Cell ◽  
Small Round Cell ◽  
Response To Chemotherapy ◽  
Lower Abdominal Quadrant ◽  
Antineoplastic Treatment ◽  
Multiagent Chemotherapy ◽  
The Right

Aims and background The authors report the case of a 23-year-old woman affected by intra-abdominal desmoplastic small round cell tumor (DSRCT) who obtained a complete response to multiagent chemotherapy. DSRCT is a rare, highly aggressive neoplasm generally arising in young people and seldom in females (about 20 cases described in the literature). Methods The patient underwent surgical resection of a large 15 × 15 cm mass located in the right lower abdominal quadrant, but after only 2 months later, two liver metastasis were noted. Thus, she was subjected to an aggressive antineoplastic treatment consisting of three groups of alternating non-cross resistant multiagent regimens administered every 21 days (cis-platin-etoposide-adriamycin-bleomicin; gemcitabine-ifosfamide-dacarbazine; methotrexate-5-fluorouracilfolinic acid) for a total of 9 administrations. Results After one cycle of treatment including the administration of all the three alternated schemes of chemotherapy, a complete disappearance of liver disease was noted. The treatment was relatively well-tolerated and the toxicity was acceptable. At present, after 15 months from diagnosis and 12 months after starting chemotherapy, the patient is disease-free and in good health. Conclusions Even though this study regards only a single patient, it is noteworthy because of the rarity of this neoplasm and because of the infrequent complete responses reported in the literature. The efficacy and manageability of the treatment, suggests that both the timing and schedule used could constitute an important therapeutical option for this aggressive and poorly chemo-responsive tumor.

scholarly journals Recurrent Pindborg Tumor of the Maxilla: A Case Report and Review of the Literature

2013 ◽  
Vol 92 (2) ◽  
pp. 84-87 ◽  
Author(s):  
Gangadhara Somayaji ◽  
Aroor Rajeshwary ◽  
Sullia Ramesh ◽  
Sullia Dinesh
Keyword(s):  
Case Report ◽  
Nasal Cavity ◽  
Nasal Obstruction ◽  
Radical Surgery ◽  
Odontogenic Tumor ◽  
Review Of The Literature ◽  
Calcifying Epithelial Odontogenic Tumor ◽  
Pindborg Tumor ◽  
The Right ◽  
Epithelial Odontogenic Tumor

We report a case of recurrent Pindborg tumor (calcifying epithelial odontogenic tumor) of the maxilla. The patient was a 34-year-old woman who had been previously diagnosed with Pindborg tumor and treated with curettage. She was subsequently referred to us for evaluation of nasal obstruction. Examination revealed the presence of a mass lesion in the right nasal cavity and right maxilla, which was identified as a recurrence of her earlier Pindborg tumor. The patient was treated with maxillectomy with orbital preservation. Pindborg tumor is a rare odontogenic tumor; when it does occur, it is more often seen in the mandible than in the maxilla. While this tumor is often treated with curettage alone, the aggressive nature of the recurrence in our patient necessitated radical surgery. We report this case to highlight the need to be suitably aggressive in treating these types of tumors in order to avoid recurrence.

scholarly journals Vogt-Koyanagi-Harada with Unilateral Clinical Presentation: A Case Report

2020 ◽  
Author(s):  
Seyedeh Maryam Hosseini ◽  
Maryam Dourandish ◽  
Marjan Mazouchi
Keyword(s):  
Case Report ◽  
Clinical Manifestations ◽  
Oral Prednisolone ◽  
Response To Treatment ◽  
Systemic Involvement ◽  
Optic Disc Swelling ◽  
Characteristic Features ◽  
The Right ◽  
Visual Blurring ◽  
Vkh Disease

Purpose: To report a case of acute Vogt-Koyanagi-Harada (VKH) disease with unilateral clinical manifestations followed by late fellow eye involvement. Case Report: This case report reviews the 12-month follow-up observation of a 44-year old woman who presented to the emergency department with unilateral progressive and painless visual blurring. Ophthalmoscopic findings, best-corrected visual acuity (BCVA), fluorescein angiography (FAG), enhanced-depth optical coherence tomography (EDIOCT), indocyanine green angiography, and response to treatment were evaluated. Her BCVA was 20/50 (logMAR: 0.4) in the right eye and 20/20 (logMAR: 0) in the left eye. Eye examination revealed optic disc swelling and multiple serous retinal detachments in the right eye and a normal left eye. She had headache, dysacusia, and mild hearing problems. Her past ocular and drug histories were unremarkable. Retinal imaging revealed characteristic features of VKH in the right eye. All laboratory testing results were inconclusive. VA and OCT findings significantly improved following the treatment with methylprednisolone 1 g/day continued by tapering dose of oral prednisolone. Two months after the presentation and during prednisolone tapering, VA of the left eye decreased and fundus examination revealed multiple serous retinal detachments in this eye. Conclusion: Ophthalmologists should recognize unilateral and asymmetrical VKH disease with subtle systemic involvement.

scholarly journals Sinonasal undifferentiated carcinoma: Case report and short literature review

2021 ◽  
Vol 11 (42) ◽  
pp. 74-80
Author(s):  
Ionut Tanase ◽  
Andra Virlan
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Ct Scan ◽  
Nasal Septum ◽  
Posterior Wall ◽  
Undifferentiated Carcinoma ◽  
Tumor Formation ◽  
Endoscopic Control ◽  
The Right ◽  
Middle Nasal Meatus

Abstract We present a case of a 48-year-old male patient who was admitted in our clinic for right nasal obstruction, antero-posterior mucopurulent rhinorrhea, recurrent right micro-epistaxis, hyposmia, cacosmia and right hemicrania. ENT findings and CT scan detects proliferative, polylobate, vascularized tumor formation occupying the right nasal nostril, with muco-purulent secretions lining the tumor formation. The tumor pushes the intersinusal wall to the side and the nasal septum to the contralateral nostril. The apparent origin is at the level of the right middle nasal meatus, but we could not identify a clear limit from the nasopharynx lateral and posterior wall. Resection of the entire tumor formation was performed under endoscopic control. The histopathological outcome revealed undifferentiated carcinoma; immunohistochemical tests were performed and support the myoepithelial origins.

scholarly journals P.012 Treatment and long-term follow-up of primary CNS classical Hodgkin’s Lymphoma – a case report and review of the literature

2017 ◽  
Vol 44 (S2) ◽  
pp. S17-S17
Author(s):  
PA Szelemej ◽  
M Bigder ◽  
J Krcek
Keyword(s):  
Case Report ◽  
Hodgkin’S Lymphoma ◽  
Central Nervous System Involvement ◽  
Complete Response ◽  
Hodgkin's Lymphoma ◽  
Response To Treatment ◽  
Term Survival ◽  
Whole Brain Radiation ◽  
Long Term Follow Up

Background: Unlike non-Hodgkin’s lymphoma, central nervous system involvement with classical Hodgkin’s lymphoma is exceedingly rare, thus information regarding treatment and prognostication of the disease is lacking. Methods: This case report was prepared using hospital charts, and PubMed for the literature search. Our case was compared and contrasted against similar cases in the literature. Results: We present the case of a 47 year old female who presented with a left parietal dural-based lesion which proved to be Stage IE primary CNS classical Hodgkin’s lymphoma. After surgery and whole brain radiation therapy, the patient has remained in complete remission over nine years. Conclusions: Despite the dearth of information available regarding CNS Hodgkin’s lymphoma, our case is consistent with the findings in the literature that long-term survival is possible in patients achieving a complete response to treatment, especially in those patients who present with sole CNS involvement. To our knowledge, this represents the longest reported survival in the literature and contributes to our understanding of prognosis in patients with CNS Hodgkin’s lymphoma.

Metastatic small cell carcinoma of the endometrium: prolonged remission and possible cure following chemotherapy

1994 ◽  
Vol 4 (2) ◽  
pp. 127-130 ◽  
Author(s):  
R. W. Hunter ◽  
M. Buck ◽  
I. G. Hammond ◽  
K. E. Williams
Keyword(s):  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Advanced Disease ◽  
Neuron Specific Enolase ◽  
Complete Response ◽  
Small Cell ◽  
Response To Treatment ◽  
Short Survival ◽  
Response To Chemotherapy ◽  
Serum Neuron Specific Enolase

A 54-year-old woman with inoperable metastatic small cell carcinoma (SCC) of the endometrium was treated with cisplatin and etoposide chemotherapy on the basis of the histologic similarity to pulmonary SCC. The response to treatment was monitored using serum neuron specific enolase (NSE) levels. A complete remission was obtained with resolution of symptoms and disappearance of the mass. The patient is alive and well 4½ years later. Considering the aggressive behavior and short survival usually associated with this tumor and the presence of such advanced disease, a complete response to chemotherapy was unexpected. It would appear that chemotherapy should always be considered in the management of metastatic endometrial SCC, even in the presence of large-volume disease.

scholarly journals Rhinolith in the concha bullosa as a rare location: a case report

2020 ◽  
Vol 48 (8) ◽  
pp. 030006052095101
Author(s):  
Tolga Ersözlü ◽  
Erdogan Gültekin
Keyword(s):  
Case Report ◽  
Nasal Obstruction ◽  
Clinical Examination ◽  
Rare Condition ◽  
Concha Bullosa ◽  
Computed Tomographic ◽  
The Third ◽  
Computed Tomographic Scan ◽  
Rare Location ◽  
The Right

The presence of a rhinolith is a rare condition, which can cause long-standing symptoms, such as rhinorrhea, foul-smelling discharge, nasal obstruction, and headache. A rhinolith is usually easily diagnosed by a clinical examination and a paranasal computed tomographic scan. Rhinoliths are usually found in nasal cavities, but rare locations are also possible. We report a patient who was evaluated in our clinic for nasal obstruction, headache, and snoring symptoms. A clinical examination showed no major findings, but a paranasal computed tomographic scan of coronal sections showed a hyperdense mass within the right concha bullosa. A rhinolith in the concha bullosa is a rare condition. Our case is the third case of a rhinolith in the concha bullosa to be reported in the literature.

scholarly journals Metastatic Jaw Swelling as the Manifestation of Leiomyosarcoma of Uterus- A Case Report

1970 ◽  
Vol 29 (2) ◽  
pp. 96-98
Author(s):  
MM Hassan ◽  
M Ahmed ◽  
RA Bhuiyan ◽  
MM Rahman ◽  
ME Mahmud
Keyword(s):  
Case Report ◽  
Poor Prognosis ◽  
Hard Palate ◽  
Soft Tissues ◽  
Palliative Chemotherapy ◽  
Metastatic Tumor ◽  
Incisional Biopsy ◽  
The Right ◽  
Molar Region ◽  
Oral Metastasis

Metastatic tumor in oral region is uncommon and may occur in the oral soft tissues or in the Jaw bone. Because of their rarity, metastasis in oral cavity are challenging to diagnose and treat. Oral metastasis is associated with poor prognosis. This case report is of a 45 year old female with a small pedunculated swelling on the left side of the hard palate in the molar region for 30 days. Incisional biopsy revealed metastatic leiomyosarcoma with possible primaries in the uterus. Metastasis in the right lung and liver was also diagnosed. Palliative chemotherapy was started but the patient died after two weeks of diagnosis after receiving the first cycle of chemotherapy. DOI: http://dx.doi.org/10.3329/jbcps.v29i2.7954 (J Bangladesh Coll Phys Surg 2011; 29: 96-98)

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