scholarly journals Drug Hypersensitivity due to Azathioprine with Elevated Procalcitonin

2018 ◽  
Vol 2018 ◽  
pp. 1-4
Author(s):  
Tania Ahuja ◽  
Frank R. Chung ◽  
Tania Ruiz-Maya
Keyword(s):  
Skin Biopsy ◽  
Myasthenia Gravis ◽  
Acute Phase ◽  
Drug Hypersensitivity ◽  
C Reactive Protein ◽  
Acute Phase Reactants ◽  
Reactive Protein ◽  
Microbial Cultures

We present a case of azathioprine hypersensitivity presenting as sepsis with elevated procalcitonin in a 68-year-old man with myasthenia gravis. The patient presented with fever, chills, nausea, vomiting, and headache. He developed numerous 1 cm erythematous papules over his upper torso. Infectious workup including bacteriological tests and microbial cultures was negative and a skin biopsy was performed which revealed suppurative folliculitis with eosinophils, consistent with drug hypersensitivity. Notably, acute phase reactants including C-reactive protein and procalcitonin were elevated upon presentation, likely secondary to drug hypersensitivity.

scholarly journals Combined C-Reactive Protein and Novel Inflammatory Parameters as a Predictor in Cancer—What Can We Learn from the Hematological Experience?

Cancers ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 1966 ◽  
Author(s):  
Øystein Bruserud ◽  
Helene Hersvik Aarstad ◽  
Tor Henrik Anderson Tvedt
Keyword(s):  
Acute Phase ◽  
Hematological Malignancies ◽  
Phase Reaction ◽  
C Reactive Protein ◽  
Acute Phase Reactants ◽  
Reactive Protein ◽  
Inflammatory Parameters ◽  
Cell Counts ◽  
Blood Cell Counts ◽  
White Blood Cell Counts

The acute phase reaction is a systemic response to acute or chronic inflammation. The serum level of C-reactive protein (CRP) is the only acute phase biomarker widely used in routine clinical practice, including its uses for prognostics and therapy monitoring in cancer patients. Although Interleukin 6 (IL6) is a main trigger of the acute phase reactions, a series of acute phase reactants can contribute (e.g., other members in IL6 family or IL1 subfamily, and tumor necrosis factor α). However, the experience from patients receiving intensive chemotherapy for hematological malignancies has shown that, besides CRP, other biomarkers (e.g., cytokines, soluble cytokine receptors, soluble adhesion molecules) also have altered systemic levels as a part of the acute phase reaction in these immunocompromised patients. Furthermore, CRP and white blood cell counts can serve as a dual prognostic predictor in solid tumors and hematological malignancies. Recent studies also suggest that biomarker profiles as well as alternative inflammatory mediators should be further developed to optimize the predictive utility in cancer patients. Finally, the experience from allogeneic stem cell transplantation suggests that selected acute phase reactants together with specific markers of organ damages are useful for predicting or diagnosing graft versus host disease. Acute phase proteins may also be useful to identify patients (at risk of) developing severe immune-mediated toxicity after anticancer immunotherapy. To conclude, future studies of acute phase predictors in human malignancies should not only investigate the conventional inflammatory mediators (e.g., CRP, white blood cell counts) but also combinations of novel inflammatory parameters with specific markers of organ damages.

scholarly journals Relationship of Acute Phase Reactants and Fat Accumulation during Treatment for Tuberculosis

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Alejandro Sanchez ◽  
Colleen Azen ◽  
Brenda Jones ◽  
Stan Louie ◽  
Fred Sattler
Keyword(s):  
Acute Phase ◽  
Muscle Wasting ◽  
Cell Mass ◽  
Fat Free Mass ◽  
C Reactive Protein ◽  
Acute Phase Reactants ◽  
Reactive Protein ◽  
Low Levels ◽  
Beta 2 Microglobulin ◽  
Relationship Of

Background. Tuberculosis causes inflammation and muscle wasting. We investigated how attenuation of inflammation relates to repletion of body composition during treatment in an underserved population.Design. Twenty-four patients (23 to 79 years old) with pulmonary tuberculosis and inflammation (pretreatment albumin  g/dL, C-reactive protein [CRP]  μg/dL, and beta-2-microglobulin  μg/L) were evaluated and had BIA over 24 weeks.Results. Weight increased by  kg (5.5%; ) at week 4 and by  kg (15.6%; ) at week 24. Repletion of body mass was primarily fat, which increased by  kg at week 4 and  kg at week 24 ( and versus baseline). Fat-free mass (FFM), body cell mass (BCM), and phase angle did not increase until study week 8. Albumin rose to  g/dL by week 4 () and slowly increased thereafter. CRP levels declined by~50% at each interval visit.Conclusions. During the initial treatment, acute phase reactants returned towards normal. The predominant accrual of fat mass probably reflects ongoing, low levels of inflammation.

scholarly journals PROCALCITONIN, C-REACTIVE PROTEIN AND FIBRINOGEN LEVELS IN CASES WITH MECHANIC BOWEL OBSTRUCTION AND THEIR CHANGE IN RELATION TO THE DURATION OF OBSTRUCTION: AN EXPERIMENTAL STUDY

2017 ◽  
Author(s):  
Hakan Guzel ◽  
Sahin Kahramanca ◽  
Oskay Kaya ◽  
Gulay Ozgehan ◽  
Demet Yilmazer ◽  
...  
Keyword(s):  
Acute Phase ◽  
Bowel Obstruction ◽  
Surgical Intervention ◽  
Late Phase ◽  
Study Groups ◽  
Control Group ◽  
C Reactive Protein ◽  
Acute Phase Reactants ◽  
Reactive Protein ◽  
Mechanical Bowel Obstruction

The need and timing of surgical intervention in patients with adhesive bowel obstruction is a dilemma. We aimed to investigate the role of three acute-phase reactants, namely procalcitonin (PCT), fibrinogen and C-reactive protein (CRP) in this clinical condition We chose a rat model whose mechanical bowel obstruction was created with caecum ligation. There were two study groups and one control group. Each group contained ten subjects. The study groups had and six-hour obstruction samples. Blood PCT, fibrinogen and CRP levels were measured before and after the surgical procedure. These parameters were compared between the groups and they were also evaluated with the degree of histopathological changes occurred in terminal ileal tissue samples. Compared with the control group, PCT measurements showed a mild decrease in the early phase of obstruction but a significant elevation in the late phase (p: 0,977 and p: 0,001). Unlike PCT, fibrinogen levels increased at first but decreased later (p: 0,978 and p: 0,326). We observed an increase in CRP levels parallel to the prolonged duration of obstruction (p: 0,987 and p: 0,134). With regard to mucosal injury, PCT levels increased at first, and then decreased (p: 0,003). On the other hand, fibrinogen and CRP levels decreased at first, and then increased (p: 0,139 and p: 0,102). The acute-phase reactants PCT, fibrinogen and CRP associated with the duration of obstruction may help to determine the time of surgical intervention in patients with adhesive mechanical bowel obstruction.

DETERMINATION OF SOME STREPTOCOCCAL ANTIBODY TITERS AND ACUTE PHASE REACTANTS IN PATIENTS WITH CHOREA

PEDIATRICS ◽  
1958 ◽  
Vol 21 (1) ◽  
pp. 13-21
Author(s):  
T. N. Harris ◽  
Sidney Friedman ◽  
David C. McLean
Keyword(s):  
Rheumatic Fever ◽  
Acute Phase ◽  
Clinical Evidence ◽  
C Reactive Protein ◽  
Acute Phase Reactants ◽  
Reactive Protein ◽  
Erythrocyte Sedimentation ◽  
Distribution Of Values ◽  
Antibody Titers

Forty-three patients with chorea were examined by a number of laboratory tests: These consisted of two streptococcal serologic titrations, antistreptolysin-O and antihyaluronidase, and three acute phase tests, the erythrocyte sedimentation rate, and the concentrations of C-reactive protein and mucoproteins in the serum. The patients were divided into two groups, those with apparently "pure" chorea, who did not show any other clinical evidence of rheumatic fever in conjunction with an episode of chorea, or at any other time to our knowledge, and those with some other evidence of rheumatic fever. In the case of each of these tests the frequency distribution of values found in the rheumatic chorea group was different from that of the "pure" chorea group, the former having a higher center and range of distribution. Also, the results of both the acute phase tests and the streptococcal serologic tests gave evidence of contamination of the "pure" chorea group with rheumatic subjects. The data suggest that there are, in fact, two such clinical groups of patients with chorea, and that laboratory aid toward the differential diagnosis between them would be applied in the same way as in other differential diagnoses involving rheumatic fever.

scholarly journals Compartmentalization of acute phase reactants Interleukin-6, C-Reactive Protein and Procalcitonin as biomarkers of intra-amniotic infection and chorioamnionitis

Cytokine ◽  
2015 ◽  
Vol 76 (2) ◽  
pp. 236-243 ◽  
Author(s):  
Antonette T. Dulay ◽  
Irina A. Buhimschi ◽  
Guomao Zhao ◽  
Mert O. Bahtiyar ◽  
Stephen F. Thung ◽  
...  
Keyword(s):  
Acute Phase ◽  
Interleukin 6 ◽  
C Reactive Protein ◽  
Acute Phase Reactants ◽  
Reactive Protein
Sign in / Sign up

Export Citation Format

Share Document