Diagnostic Accuracy of Preoperative Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in Detecting Occult Papillary Thyroid Microcarcinomas in Benign Multinodular Goitres

Objective. To investigate the diagnostic accuracy of neutrophil-to-lymphocyte (NLR) and platelet-to-lymphocyte (PLR) ratios in detecting occult papillary thyroid microcarcinomas in benign, multinodular goitres. Methods. 397 total thyroidectomy patients were identified from the institutional thyroid surgery database between 2007 and 2016 (94 males, 303 females, mean age 53 ± 14.5 years). NLR and PLR were calculated as the absolute neutrophil and absolute platelet counts divided by the absolute lymphocyte count, respectively, based on the preoperative complete blood cell count. Results. NLR was significantly higher in carcinomas and microcarcinomas compared to benign pathology (p=0.026), whereas a direct association could not be established for PLR. Both NLR and PLR scored low in all parameters of diagnostic accuracy, with overall accuracy ranging between 45 and 50%. Conclusions. As surrogate indices of the systemic inflammatory response, NLR and PLR are inexpensive and universally available from routine blood tests. Although we found higher NLR values in cases of malignancy, NLR and PLR cannot effectively predict the presence of occult papillary microcarcinomas in otherwise benign, multinodular goitres.

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The Role of Complete Blood Cell Count in Prognosis—Watch this Space!

Oncology & Hematology Review (US) ◽

10.17925/ohr.2012.08.1.76 ◽

2012 ◽

Vol 08 (01) ◽

pp. 76 ◽

Cited By ~ 3

Author(s):

Nicole M Rochet ◽

Svetomir N Markovic ◽

Luis F Porrata ◽

◽

...

Keyword(s):

Blood Cell ◽

Cell Count ◽

Clinical Outcomes ◽

Absolute Lymphocyte Count ◽

Risk Groups ◽

Monocyte Count ◽

Complete Blood Cell Count ◽

Blood Cell Count ◽

Treatment Plans

Prognostic factors in cancer patients provide information about possible clinical outcomes and help classify patients into different risk groups. Treatment and clinical management decisions are often challenging, thus the availability of reliable and accessible prognostic markers is vital when designing treatment plans and discussing them with patients. This article discusses the prognostic value of the complete blood cell count components (i.e., white blood cell count, absolute neutrophil count, absolute lymphocyte count, absolute monocyte count, hemoglobin level, and platelet count) in regard to clinical outcomes in patients with malignant disorders.

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A Quantitative Ultrastructural Study of Peripheral Blood Lymphocytes Containing Parallel Tubular Arrays in Epstein-Barr Virus and Cytomegalo-Virus Mononucleosis

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100098769 ◽

1981 ◽

Vol 39 ◽

pp. 454-455

Author(s):

C. M. Payne ◽

P. M. Tennican

Keyword(s):

Peripheral Blood ◽

Lymphocyte Count ◽

Epstein Barr Virus ◽

Absolute Lymphocyte Count ◽

Peripheral Blood Lymphocytes ◽

Clinical State ◽

Barr Virus ◽

The Absolute ◽

Epstein Barr ◽

Tubular Arrays

In the normal peripheral circulation there exists a sub-population of lymphocytes which is ultrastructurally distinct. This lymphocyte is identified under the electron microscope by the presence of cytoplasmic microtubular-like inclusions called parallel tubular arrays (PTA) (Figure 1), and contains Fc-receptors for cytophilic antibody. In this study, lymphocytes containing PTA (PTA-lymphocytes) were quantitated from serial peripheral blood specimens obtained from two patients with Epstein -Barr Virus mononucleosis and two patients with cytomegalovirus mononucleosis. This data was then correlated with the clinical state of the patient.It was determined that both the percentage and absolute number of PTA- lymphocytes was highest during the acute phase of the illness. In follow-up specimens, three of the four patients' absolute lymphocyte count fell to within normal limits before the absolute PTA-lymphocyte count.In one patient who was followed for almost a year, the absolute PTA- lymphocyte count was consistently elevated (Figure 2). The estimation of absolute PTA-lymphocyte counts was determined to be valid after a morphometric analysis of the cellular areas occupied by PTA during the acute and convalescent phases of the disease revealed no statistical differences.

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Diagnostic Accuracy of Follicular Variant of Papillary Thyroid Carcinoma in Fine-Needle Aspirates Processed by Ultrafast Papanicolaou Stain: Histologic Follow-up of 125 Cases

Yearbook of Pathology and Laboratory Medicine ◽

10.1016/s1077-9108(08)70415-8 ◽

2007 ◽

Vol 2007 ◽

pp. 258-260

Author(s):

M.F. Vazquez

Keyword(s):

Papillary Thyroid Carcinoma ◽

Thyroid Carcinoma ◽

Diagnostic Accuracy ◽

Papillary Thyroid ◽

Follicular Variant ◽

Fine Needle ◽

Fine Needle Aspirates

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Complete blood cell count risk score as a predictor of in-hospital mortality and morbidity among patients undergoing cardiac surgery with cardiopulmonary bypass

International Journal of Cardiology ◽

10.1016/j.ijcard.2015.03.227 ◽

2015 ◽

Vol 187 ◽

pp. 60-62 ◽

Cited By ~ 1

Author(s):

Ana Paula Porto Rödel ◽

Manuela Borges Sangoi ◽

Larissa Garcia de Paiva ◽

Jossana Parcianello ◽

José Edson Paz da Silva ◽

...

Keyword(s):

Cardiac Surgery ◽

Cardiopulmonary Bypass ◽

Blood Cell ◽

Hospital Mortality ◽

Cell Count ◽

Risk Score ◽

Complete Blood Cell Count ◽

Blood Cell Count ◽

Mortality And Morbidity

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Myelodysplastic Syndrome Clinically Presenting with the “Classic TTP Pentad”

Case Reports in Hematology ◽

10.1155/2017/4619406 ◽

2017 ◽

Vol 2017 ◽

pp. 1-6 ◽

Cited By ~ 1

Author(s):

Santiago Fabián Moscoso Martínez ◽

Evelyn Carolina Polanco Jácome ◽

Elizabeth Guevara ◽

Vijay Mattoo

Keyword(s):

Myelodysplastic Syndrome ◽

Clinical Presentation ◽

Renal Involvement ◽

Medical Emergency ◽

Complete Blood Cell Count ◽

Blood Cell Count ◽

Thrombocytopenic Purpura ◽

Life Saving ◽

Threatening Condition ◽

Life Threatening

The clinical presentation of myelodysplastic syndrome (MDS) is not specific. Many patients can be asymptomatic and can be detected only due to an abnormal complete blood cell count (CBC) on routine exam or for other reasons while others can be symptomatic as a consequence of underlying cytopenias. Thrombotic thrombocytopenic purpura (TTP) usually is suspected under the evidence of microangiopathic hemolytic anemia (MAHA) and thrombocytopenia and because it is a life-threatening condition (medical emergency) immediate initiation of plasmapheresis could be life-saving. The following case illustrates an unusual presentation of MDS in a patient who came in to the emergency room with the classic TTP “pentad” of fever, renal involvement, MAHA, mental status changes, and thrombocytopenia. We will focus our discussion in the clinical presentation of this case.

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Prognostic Value of Complete Blood Cell Count-Derived Inflammatory Markers in Hepatitis B Virus-Related Acute-on-Chronic Liver Failure

Clinical Laboratory ◽

10.7754/clin.lab.2021.210217 ◽

2021 ◽

Vol 67 (10/2021) ◽

Author(s):

Xiao-Yun Liu ◽

Xia He ◽

Ming Cai ◽

Song-Qing Peng

Keyword(s):

Hepatitis B Virus ◽

Hepatitis B ◽

Blood Cell ◽

Liver Failure ◽

Inflammatory Markers ◽

Prognostic Value ◽

Complete Blood Cell Count ◽

Blood Cell Count ◽

Chronic Liver Failure ◽

B Virus

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Protective Effect of Citrulline on the Hearts of Rats with Sepsis Induced by Cecal Ligation and Puncture

BioMed Research International ◽

10.1155/2018/2574501 ◽

2018 ◽

Vol 2018 ◽

pp. 1-10

Author(s):

Ji-qiu Zhou ◽

Xiong Xu ◽

Wei-wei Zhen ◽

Yu-long Luo ◽

Bin Cai ◽

...

Keyword(s):

Protective Effect ◽

Inflammatory Cell ◽

Cecal Ligation ◽

Blood Cell Count ◽

Sod Activity ◽

Cardiac Tissues ◽

Blood Tests ◽

Blood Biochemical ◽

Neutrophil Percentage ◽

Myocardial Fibers

Purpose. To investigate the protective effect of citrulline (Cit) on the hearts of rats with sepsis. Methods. Wistar rats were divided into the normal, sham-operated, CLP, Cit, and CLP+Cit groups. Routine blood tests were performed, and the blood biochemical indexes were measured. Pathological changes in the cardiac tissues were observed. The levels of NO and iNOS in blood and SOD activity and MDA levels in the heart were measured. Results. Less inflammatory cell infiltration of the myocardial fibers and significantly decreased white blood cell count, absolute neutrophil count, neutrophil percentage, CK, HBDH, and NO (all P<0.05) were detected in the CLP+Cit group compared with the CLP group. In addition, SOD activity and MDA levels in heart tissues were, respectively, higher and lower in the CLP+Cit group than in the CLP group (both P<0.05). Conclusions. Cit reduces pathological damage in the heart and enhances the heart’s antioxidant capacity, thereby protecting cardiomyocytes.

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