scholarly journals Mistaken Diabetic Ulcers: A Case of Bilateral Foot Verrucous Carcinoma

2018 ◽  
Vol 2018 ◽  
pp. 1-3 ◽  
Author(s):  
Vanessa Di Palma ◽  
Jill P. Stone ◽  
Andrew Schell ◽  
Jeffrey C. Dawes
Keyword(s):  
Verrucous Carcinoma ◽  
Low Grade ◽  
Mohs Micrographic Surgery ◽  
Micrographic Surgery ◽  
Delay In Diagnosis ◽  
Plantar Surface ◽  
Complete Surgical Resection ◽  
Well Differentiated ◽  
Slow Growing

Verrucous carcinoma (VC) is a rare, low-grade, and well-differentiated variant of squamous cell carcinoma. These tumors are slow-growing and exophytic and have a negligible incidence of metastasis. Treatment is complete surgical resection, ideally by Mohs micrographic surgery, to ensure adequate clear margins. Cutaneous VC predominantly occurs on the plantar surface of the foot and rarely occurs in multiple sites. This case study describes the fourth reported occurrence of bilateral VC of the feet in a woman with chronic diabetic foot ulcers. The case provides further support for persistent wounds contributing to the development of this lesion and describes their role in the characteristic delay in diagnosis of VC.

scholarly journals Verrucous Carcinoma of the Foot Arising on a Muscle Flap and Skin Graft Site in a 74-year-old Filipino Female: A Case Report

2020 ◽  
Vol 54 (3) ◽  
Author(s):  
Eileen Liesl A. Cubillan ◽  
Monica Felise J. Sabal
Keyword(s):  
Skin Graft ◽  
Slow Growth ◽  
Verrucous Carcinoma ◽  
Malignant Neoplasm ◽  
Muscle Flap ◽  
Limb Amputation ◽  
Low Grade ◽  
Delay In Diagnosis ◽  
Local Destruction ◽  
Well Differentiated

Verrucous carcinoma is an uncommon low-grade well-differentiated malignant neoplasm that commonly arises on acral and mucosal sites. It is often both clinically and histologically misdiagnosed because of its slow growth and low cytologic atypia, respectively. We describe the case of a 74-year-old female with a papillomatous mass arising on a muscle flap and skin graft site on the left foot that had delay in diagnosis for more than 30 years. This case highlights verrucous carcinoma as consideration for both clinical and histologic differential diagnoses in chronic non-healing fungating tumor on the foot. Though non-aggressive in its course, the tumor can cause extensive local destruction of contiguous structures, hence, timely diagnosis and excision is paramount to prevent limb amputation.

scholarly journals Optimal treatment for penile verrucous carcinoma: a systematic literature review

BMC Urology ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Dong In Jo ◽  
Song Hyun Han ◽  
Soon Heum Kim ◽  
Hye Young Kim ◽  
Hong Chung ◽  
...  
Keyword(s):  
Local Excision ◽  
Verrucous Carcinoma ◽  
Surgical Excision ◽  
Metastatic Potential ◽  
Biological Behavior ◽  
Publication Date ◽  
Low Grade ◽  
Clinical Prognosis ◽  
Impact Function ◽  
Well Differentiated

Abstract Background Verrucous carcinoma, a rare low-grade well-differentiated squamous cell carcinoma, is known for its favorable biological behavior and lack of metastatic potential. However, aggressive resection is problematic in terms of compromised function and aesthetics. Hence, more conservative treatments are needed. Methods: To identify the up-to-date general biological behavior, diagnosis, and treatment trends, we searched PubMed using the keyword “penile verrucous carcinoma” without restrictions on publication date. Results: Current treatments for penile verrucous carcinoma include wide surgical excision, seldom preventive lymphadenectomy, and conservative chemotherapy without surgery or local excision with safe margins. Despite the advent of partial penectomy to minimally impact function and aesthetics, affected patients experience psychosexual problems. Local excision can be used to save the penile shaft and glans penis without preventive lymphadenectomy or adjuvant therapy and can achieve good clinical prognosis with rare recurrence. Conclusions: To preserve the functional and cosmetic aspects, we recommend local excision, especially for tumors measuring < 3 cm and classified as stage T1 according to the 2016 tumor node metastasis clinical and pathological classification for penile cancer.

Mohs micrographic surgery for verrucous carcinoma of the anogenital area: report of two cases

2012 ◽  
Vol 51 (6) ◽  
pp. 722-725 ◽  
Author(s):  
Beatriz Casado-Verrier ◽  
Rosa Feltes-Ochoa ◽  
Cristina Gómez-Fernández ◽  
Marta Feito-Rodríguez ◽  
María Beato-Merino ◽  
...  
Keyword(s):  
Verrucous Carcinoma ◽  
Mohs Micrographic Surgery ◽  
Micrographic Surgery ◽  
Anogenital Area

scholarly journals RARE TUMOUR OF UPPER LIP: MUCOEPIDERMOID CARCINOMA

2020 ◽  
pp. 1-2
Author(s):  
Kanhaiya Lal Kishnani ◽  
Ashwini Choudhary ◽  
Satyajeet Singh
Keyword(s):  
Mucoepidermoid Carcinoma ◽  
Histological Grade ◽  
Clinical Stage ◽  
Wide Resection ◽  
Low Grade ◽  
Upper Lip ◽  
Rare Tumour ◽  
Delay In Diagnosis ◽  
Rare Tumours ◽  
Slow Growing

Mucoepidermoid carcinoma tumours are less common and approximately 5% of tumours of salivary glands. They are slow growing usually asymptomatic at beginning which cause delay in diagnosis. Mucoepidermoid carcinoma tumours commonly occur predominantly in women in fourth to fifth decades of age and their occurrence in the upper lip area is extremely rare. Tumours of upper lip pose difficulty to airway management team due to their proximity to airway, wide resection surgery and repair. Care should be taken to avoid any kind of pressure on swelling during intubation to avoid tumour rupture or tumour bleed. The prognosis of low-grade Mucoepidermoid carcinoma depends upon its clinical stage and histological grade. Low-grade MEC has better 5-year survival rate in comparison to intermediate and high grade tumours. Cure rate of MEC is excellent after wide local resection.

scholarly journals ORAL VERRUCOUS CARCINOMA: A REPORT OF THREE CASES

2014 ◽  
Vol 4 ◽  
Author(s):  
Smit Singla ◽  
Raghavendra Kini ◽  
Vathsala Naik ◽  
Anjali Shetty
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Buccal Mucosa ◽  
Verrucous Carcinoma ◽  
Metastatic Potential ◽  
Epidermoid Carcinoma ◽  
Low Grade ◽  
Pathological Features ◽  
Slow Growing

Ackerman’s tumor is a low grade variant of oral Verrucous carcinoma (VC) or squamous cell carcinoma (OSCC). Although it occurs in other anatomic sites, most intraoral cases involve buccal mucosa, alveolar mucosa and gingiva. The typical features of VC that differ from the usual oral epidermoid carcinoma is it generally slow growing, chiefly exophytic and superficially invasive at until late in the course of the disease and have low metastatic potential. This paper presents three variable cases of oral VC along with their clinical and histo-pathological features.

scholarly journals When tumefactive demyelination is truly a tumor: case report of a radiographic misdiagnosis

CNS Oncology ◽  
2021 ◽  
pp. CNS69
Author(s):  
Breanna Taylor ◽  
Mallika P Patel ◽  
Katherine B Peters
Keyword(s):  
Multiple Sclerosis ◽  
Case Report ◽  
Brain Tumors ◽  
Disease Progression ◽  
Symptom Management ◽  
Low Grade ◽  
Appropriate Therapy ◽  
Well Differentiated ◽  
Adult Male Patient ◽  
Slow Growing

Oligodendrogliomas are slow-growing tumors that account for 15–20% of gliomas. This case report describes the case of an adult male patient diagnosed initially with tumefactive demyelination and multiple sclerosis, which was subsequently found to be a well-differentiated low-grade oligodendroglioma. This case emphasizes the importance of timely diagnosis in oligodendrogliomas and other brain tumors for the prompt initiation of appropriate therapy, to minimize the likelihood of disease progression, ensure symptom management and escalation of unnecessary treatments for multiple sclerosis.

Zygomatic Arch Parosteal Osteosarcoma in Dogs and a Cat

2018 ◽  
Vol 56 (2) ◽  
pp. 274-276 ◽  
Author(s):  
Randi Gold ◽  
Fabiano Oliveira ◽  
Roy Pool
Keyword(s):  
Zygomatic Arch ◽  
Low Grade ◽  
Parosteal Osteosarcoma ◽  
Cellular Atypia ◽  
Clinical Presentations ◽  
Facial Swelling ◽  
Well Differentiated ◽  
Mitotic Figures ◽  
The Masses ◽  
Slow Growing

Parosteal osteosarcoma is a rare, slow-growing tumor most commonly arising from the surface of long bones. Tissue or histological sections from 5 dogs and 1 cat with zygomatic arch masses were examined. Clinical presentations varied from chronic sneezing to facial swelling. Imaging consistently demonstrated osseous proliferation in the area of the zygomatic arch. Histologically, the masses were characterized by well-differentiated fibro-osseous and chondroid components that radiated outward from the periosteum of the zygomatic bone. Cellular atypia and mitotic figures were uncommon. Parosteal osteosarcomas have previously been reported in the skulls of dogs and cats, but only 1 has been reported on the zygomatic arch. Initially, these tumors are of low histologic low grade, but with time, they can show more aggressive behavior and invade the underlying bone.

scholarly journals Detection of Micro-invasion in Sudanese Oral Verrucous Carcinoma Samples Using Syndecan-1 Stain

2019 ◽  
Vol 11 ◽  
pp. 1179299X1986195
Author(s):  
AKB Elhassan ◽  
AM Suleiman ◽  
NIA El Dawi ◽  
Sofia B Mohamed
Keyword(s):  
Reference Group ◽  
Verrucous Carcinoma ◽  
Low Grade ◽  
Oral Epithelial Dysplasia ◽  
Normal Oral Mucosa ◽  
Cell Matrix ◽  
Paraffin Block ◽  
Hematoxylin And Eosin ◽  
Well Differentiated ◽  
Cell To Cell Adhesion

Aim: Verrucous carcinoma (VC) is a low-grade rare variant of squamous cell carcinoma (SCC). Syndecan-1 (CD138) is a heparan sulfate proteoglycan which participates in cell-to-cell adhesion and cell-matrix interaction. Being misled by the apparent non-aggressive nature of VC, some clinicians and pathologists believe that this tumor is not an aggressive tumor, not realizing the fact that some of these lesions may contain nests or foci of well-differentiated SCC. This study aimed to assess syndecan-1 expression of VC and detection of micro-invasion in VC using syndecan-1 immunohistochemical (IHC) stain. Methods: Observational analytical study of 34 paraffin block of VC cases and 24 cases of variable grades of oral epithelial dysplasia. Cases were stained by hematoxylin and eosin (H&E) and then IHC stain for syndecan-1 was applied. Nine paraffin blocks from specimens of normal oral mucosa were used as the reference group for syndecan-1 stain positivity. Results: In this study, we found that 32 (94.1%) out of 34 of verrucous carcinoma cases showed loss of syndecan-1 expression. Moreover, highly statistically significant association was found between the presence of suggestive micro-invasion in H&E and loss of syndecan-1 expression in micro-invasive area in the same case. Conclusions: In conclusion, syndecan-1 stain can be used as a biomarker in detection of micro-invasion in verrucous carcinoma.

scholarly journals Verrucous Carcinoma of the Foot - Report of Two Cases

2016 ◽  
Vol 8 (3) ◽  
pp. 155-160
Author(s):  
Jovan Lalošević ◽  
Branislav Lekić ◽  
Mirjana Gajić-Veljić ◽  
Dušan Škiljević ◽  
Katarina Đukić ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Verrucous Carcinoma ◽  
Histopathological Diagnosis ◽  
Low Grade ◽  
X Rays ◽  
Clinical Center ◽  
Partial Amputation ◽  
Well Differentiated

Abstract Verrucous carcinoma (VC) is a rare variant of a well-differentiated squamous cell carcinoma (SCC) with a low grade of malignancy. Epithelioma cuniculatum (EC) is a subtype of VC, usually found on the sole of the foot. Two patients, a 55-year-old female, and a 77-year-old male, with VC were treated at the Clinic of Dermatology and Venereology, Clinical Center of Serbia, from 2002 to 2011. Both patients presented with a tumor on the foot. Incisional biopsies showed a well differentiated squamous cell carcinoma. Foot x-rays showed bone involvement in one case. One patient underwent surgical amputation of the lower extremity, while the other had a partial amputation of the affected foot. In the initial stage of the disease, it is difficult to distinguish pseudoepitheliomatous hyperplasia from verrucous carcinoma. The superficial biopsy of EC lesion may mislead to a histopathological diagnosis of warts or condylomas. Multiple deep biopsies are necessary for accurate and timely diagnosis of verrucous carcinoma.

Verrucous carcinoma of the tongue — a rare case study

Open Medicine ◽  
2012 ◽  
Vol 7 (2) ◽  
pp. 145-148 ◽  
Author(s):  
Jadwiga Waskowska ◽  
Rafal Koszowski ◽  
Agnieszka Raczkowska-Siostrzonek ◽  
Katarzyna Stemplewska
Keyword(s):  
Oral Cavity ◽  
Rare Case ◽  
Clinical Course ◽  
Verrucous Carcinoma ◽  
Hpv Infection ◽  
Good Prognosis ◽  
Rare Tumour ◽  
Slow Growing ◽  
Carcinoma Of The Tongue

AbstractVerrucous carcinoma is a slow growing, well demarcated, exophytic variant of squamosus cell carcinoma with a characteristic verrucous presentation. It is a rare tumour and in 75% of cases it is localised in the oral cavity, and sporadically within the tongue. HPV infection is identified in 40% of patients. Good prognosis is characteristic for this tumour, since the 5-year survival is 93%. The authors describe a case of verrucous carcinoma localised in the tongue of a 62-year old patient. The clinical course, diagnostics and proposed treatment was described and discussed with the existing literature data.

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