scholarly journals Verrucous Carcinoma of the Foot Arising on a Muscle Flap and Skin Graft Site in a 74-year-old Filipino Female: A Case Report

2020 ◽  
Vol 54 (3) ◽  
Author(s):  
Eileen Liesl A. Cubillan ◽  
Monica Felise J. Sabal
Keyword(s):  
Skin Graft ◽  
Slow Growth ◽  
Verrucous Carcinoma ◽  
Malignant Neoplasm ◽  
Muscle Flap ◽  
Limb Amputation ◽  
Low Grade ◽  
Delay In Diagnosis ◽  
Local Destruction ◽  
Well Differentiated

Verrucous carcinoma is an uncommon low-grade well-differentiated malignant neoplasm that commonly arises on acral and mucosal sites. It is often both clinically and histologically misdiagnosed because of its slow growth and low cytologic atypia, respectively. We describe the case of a 74-year-old female with a papillomatous mass arising on a muscle flap and skin graft site on the left foot that had delay in diagnosis for more than 30 years. This case highlights verrucous carcinoma as consideration for both clinical and histologic differential diagnoses in chronic non-healing fungating tumor on the foot. Though non-aggressive in its course, the tumor can cause extensive local destruction of contiguous structures, hence, timely diagnosis and excision is paramount to prevent limb amputation.

scholarly journals Mistaken Diabetic Ulcers: A Case of Bilateral Foot Verrucous Carcinoma

2018 ◽  
Vol 2018 ◽  
pp. 1-3 ◽  
Author(s):  
Vanessa Di Palma ◽  
Jill P. Stone ◽  
Andrew Schell ◽  
Jeffrey C. Dawes
Keyword(s):  
Verrucous Carcinoma ◽  
Low Grade ◽  
Mohs Micrographic Surgery ◽  
Micrographic Surgery ◽  
Delay In Diagnosis ◽  
Plantar Surface ◽  
Complete Surgical Resection ◽  
Well Differentiated ◽  
Slow Growing

Verrucous carcinoma (VC) is a rare, low-grade, and well-differentiated variant of squamous cell carcinoma. These tumors are slow-growing and exophytic and have a negligible incidence of metastasis. Treatment is complete surgical resection, ideally by Mohs micrographic surgery, to ensure adequate clear margins. Cutaneous VC predominantly occurs on the plantar surface of the foot and rarely occurs in multiple sites. This case study describes the fourth reported occurrence of bilateral VC of the feet in a woman with chronic diabetic foot ulcers. The case provides further support for persistent wounds contributing to the development of this lesion and describes their role in the characteristic delay in diagnosis of VC.

scholarly journals Optimal treatment for penile verrucous carcinoma: a systematic literature review

BMC Urology ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Dong In Jo ◽  
Song Hyun Han ◽  
Soon Heum Kim ◽  
Hye Young Kim ◽  
Hong Chung ◽  
...  
Keyword(s):  
Local Excision ◽  
Verrucous Carcinoma ◽  
Surgical Excision ◽  
Metastatic Potential ◽  
Biological Behavior ◽  
Publication Date ◽  
Low Grade ◽  
Clinical Prognosis ◽  
Impact Function ◽  
Well Differentiated

Abstract Background Verrucous carcinoma, a rare low-grade well-differentiated squamous cell carcinoma, is known for its favorable biological behavior and lack of metastatic potential. However, aggressive resection is problematic in terms of compromised function and aesthetics. Hence, more conservative treatments are needed. Methods: To identify the up-to-date general biological behavior, diagnosis, and treatment trends, we searched PubMed using the keyword “penile verrucous carcinoma” without restrictions on publication date. Results: Current treatments for penile verrucous carcinoma include wide surgical excision, seldom preventive lymphadenectomy, and conservative chemotherapy without surgery or local excision with safe margins. Despite the advent of partial penectomy to minimally impact function and aesthetics, affected patients experience psychosexual problems. Local excision can be used to save the penile shaft and glans penis without preventive lymphadenectomy or adjuvant therapy and can achieve good clinical prognosis with rare recurrence. Conclusions: To preserve the functional and cosmetic aspects, we recommend local excision, especially for tumors measuring < 3 cm and classified as stage T1 according to the 2016 tumor node metastasis clinical and pathological classification for penile cancer.

scholarly journals Detection of Micro-invasion in Sudanese Oral Verrucous Carcinoma Samples Using Syndecan-1 Stain

2019 ◽  
Vol 11 ◽  
pp. 1179299X1986195
Author(s):  
AKB Elhassan ◽  
AM Suleiman ◽  
NIA El Dawi ◽  
Sofia B Mohamed
Keyword(s):  
Reference Group ◽  
Verrucous Carcinoma ◽  
Low Grade ◽  
Oral Epithelial Dysplasia ◽  
Normal Oral Mucosa ◽  
Cell Matrix ◽  
Paraffin Block ◽  
Hematoxylin And Eosin ◽  
Well Differentiated ◽  
Cell To Cell Adhesion

Aim: Verrucous carcinoma (VC) is a low-grade rare variant of squamous cell carcinoma (SCC). Syndecan-1 (CD138) is a heparan sulfate proteoglycan which participates in cell-to-cell adhesion and cell-matrix interaction. Being misled by the apparent non-aggressive nature of VC, some clinicians and pathologists believe that this tumor is not an aggressive tumor, not realizing the fact that some of these lesions may contain nests or foci of well-differentiated SCC. This study aimed to assess syndecan-1 expression of VC and detection of micro-invasion in VC using syndecan-1 immunohistochemical (IHC) stain. Methods: Observational analytical study of 34 paraffin block of VC cases and 24 cases of variable grades of oral epithelial dysplasia. Cases were stained by hematoxylin and eosin (H&E) and then IHC stain for syndecan-1 was applied. Nine paraffin blocks from specimens of normal oral mucosa were used as the reference group for syndecan-1 stain positivity. Results: In this study, we found that 32 (94.1%) out of 34 of verrucous carcinoma cases showed loss of syndecan-1 expression. Moreover, highly statistically significant association was found between the presence of suggestive micro-invasion in H&E and loss of syndecan-1 expression in micro-invasive area in the same case. Conclusions: In conclusion, syndecan-1 stain can be used as a biomarker in detection of micro-invasion in verrucous carcinoma.

scholarly journals Epitelioma cuniculatum: a propósito de un caso

2020 ◽  
Vol 31 (2) ◽  
Author(s):  
David Edoardo Torres-Guerrero ◽  
Alejandra Perera Sid ◽  
Cristina Eugenia Conde Ortiz ◽  
Ixtabay Ilizaliturri ◽  
María Elisa Vega Memije
Keyword(s):  
Key Words ◽  
Slow Growth ◽  
Low Grade ◽  
Squamous Cells ◽  
Plantar Wart ◽  
Epithelioma Cuniculatum ◽  
Well Differentiated

RESUMENEl término carcinoma verrugoso (epitelioma cuniculatum [EC]) se atribuye a Ackerman, y corresponde a una de las tres formas inusuales de carcinoma espinocelular o de células escamosas, el cual se caracteriza por ser una neoformación bien diferenciada, de bajo grado de malignidad y con poco potencial metastásico. Las otras dos formas corresponden al tumor de Buschke-Löwenstein y en la cavidad oral, al tumor de Ackerman. Se presenta el caso de un hombre de 61 años de edad con una neoformación exofítica de aspecto verrugoso en planta del pie derecho, de 20 años de evolución, la cual fue traumatizada durante ese tiempo, de manera constante y repetitiva mediante medios mecánicos y químicos.Palabras Clave: Epitelioma Cuniculatum, Carcinoma Verrugoso plantar, Carcinoma Espinocelular. ABSTRACTThe Epithelioma Cuniculatum (EC), is one of three rare forms of low grade squamous cells carcinoma, where the topography in which it is presented is the foot, which is characterized for being a well differentiated carcinoma, it has a slow growth and a low metastasis potential. We present a 61 year old man with an exophytic lesion with a warty appearance on right foot sole, 20 years of evolution, which during that time was diagnosed as a plantar wart and it was treated and traumatized with mechanical and chemical means with de purpose of eliminate it, without success. Key Words: Cuniculatum Epithelioma, Verrucous Plantar Carcinoma, Squamous Cells Carcinoma.

scholarly journals Verrucous Carcinoma of the Foot - Report of Two Cases

2016 ◽  
Vol 8 (3) ◽  
pp. 155-160
Author(s):  
Jovan Lalošević ◽  
Branislav Lekić ◽  
Mirjana Gajić-Veljić ◽  
Dušan Škiljević ◽  
Katarina Đukić ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Verrucous Carcinoma ◽  
Histopathological Diagnosis ◽  
Low Grade ◽  
X Rays ◽  
Clinical Center ◽  
Partial Amputation ◽  
Well Differentiated

Abstract Verrucous carcinoma (VC) is a rare variant of a well-differentiated squamous cell carcinoma (SCC) with a low grade of malignancy. Epithelioma cuniculatum (EC) is a subtype of VC, usually found on the sole of the foot. Two patients, a 55-year-old female, and a 77-year-old male, with VC were treated at the Clinic of Dermatology and Venereology, Clinical Center of Serbia, from 2002 to 2011. Both patients presented with a tumor on the foot. Incisional biopsies showed a well differentiated squamous cell carcinoma. Foot x-rays showed bone involvement in one case. One patient underwent surgical amputation of the lower extremity, while the other had a partial amputation of the affected foot. In the initial stage of the disease, it is difficult to distinguish pseudoepitheliomatous hyperplasia from verrucous carcinoma. The superficial biopsy of EC lesion may mislead to a histopathological diagnosis of warts or condylomas. Multiple deep biopsies are necessary for accurate and timely diagnosis of verrucous carcinoma.

Immunotherapy and potential predictive biomarkers in the treatment of neuroendocrine neoplasia

2020 ◽  
Author(s):  
Guanghui Xu ◽  
Yuhao Wang ◽  
Hushan Zhang ◽  
Xueke She ◽  
Jianjun Yang
Keyword(s):  
Current Knowledge ◽  
Checkpoint Inhibitors ◽  
Treatment Options ◽  
Predictive Biomarkers ◽  
The Body ◽  
Low Grade ◽  
Ablative Therapies ◽  
Cancer Types ◽  
New Treatment ◽  
Well Differentiated

Neuroendocrine neoplasias (NENs) are a heterogeneous group of rare tumors scattered throughout the body. Surgery, locoregional or ablative therapies as well as maintenance treatments are applied in well-differentiated, low-grade NENs, whereas cytotoxic chemotherapy is usually applied in high-grade neuroendocrine carcinomas. However, treatment options for patients with advanced or metastatic NENs are limited. Immunotherapy has provided new treatment approaches for many cancer types, including neuroendocrine tumors, but predictive biomarkers of immune checkpoint inhibitors (ICIs) in the treatment of NENs have not been fully reported. By reviewing the literature and international congress abstracts, we summarize the current knowledge of ICIs, potential predicative biomarkers in the treatment of NENs, implications and efficacy of ICIs as well as biomarkers for NENs of gastroenteropancreatic system, lung NENs and Merkel cell carcinoma in clinical practice.

scholarly journals MDM2 Amplified Sarcomas: A Literature Review

Diagnostics ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 496
Author(s):  
Raf Sciot
Keyword(s):  
Suppressor Gene ◽  
Negative Regulator ◽  
Low Grade ◽  
P53 Mutations ◽  
Lipomatous Tumor ◽  
Double Minute ◽  
Genetic Features ◽  
Murine Double Minute ◽  
Well Differentiated ◽  
Mdm2 Amplification

Murine Double Minute Clone 2, located at 12q15, is an oncogene that codes for an oncoprotein of which the association with p53 was discovered 30 years ago. The most important function of MDM2 is to control p53 activity; it is in fact the best documented negative regulator of p53. Mutations of the tumor suppressor gene p53 represent the most frequent genetic change in human cancers. By overexpressing MDM2, cancer cells have another means to block p53. The sarcomas in which MDM2 amplification is a hallmark are well-differentiated liposarcoma/atypical lipomatous tumor, dedifferentiated liposarcoma, intimal sarcoma, and low-grade osteosarcoma. The purpose of this review is to summarize the typical clinical, histopathological, immunohistochemical, and genetic features of these tumors.

scholarly journals Impact of Pathological Stratification on the Clinical Outcomes of Advanced Well-Differentiated/Dedifferentiated Liposarcoma Treated with Trabectedin

Cancers ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1453
Author(s):  
Chiara Fabbroni ◽  
Giovanni Fucà ◽  
Francesca Ligorio ◽  
Elena Fumagalli ◽  
Marta Barisella ◽  
...  
Keyword(s):  
Clinical Outcomes ◽  
Proportional Hazards ◽  
Case Series ◽  
Progression Free Survival ◽  
Cox Proportional Hazards ◽  
Low Grade ◽  
High Grade ◽  
Retrospective Case ◽  
Well Differentiated ◽  
The Impact

Background. We previously showed that grading can prognosticate the outcome of retroperitoneal liposarcoma (LPS). In the present study, we aimed to explore the impact of pathological stratification using grading on the clinical outcomes of patients with advanced well-differentiated LPS (WDLPS) and dedifferentiated LPS (DDLPS) treated with trabectedin. Patients: We included patients with advanced WDLPS and DDLPS treated with trabectedin at the Fondazione IRCCS Istituto Nazionale dei Tumori between April 2003 and November 2019. Tumors were categorized in WDLPS, low-grade DDLPS, and high-grade DDLPS according to the 2020 WHO classification. Patients were divided in two cohorts: Low-grade (WDLPS/low-grade DDLPS) and high-grade (high-grade DDLPS). Results: A total of 49 patients were included: 17 (35%) in the low-grade cohort and 32 (65%) in the high-grade cohort. Response rate was 47% in the low-grade cohort versus 9.4% in the high-grade cohort (logistic regression p = 0.006). Median progression-free survival (PFS) was 13.7 months in the low-grade cohort and 3.2 months in the high-grade cohort. Grading was confirmed as an independent predictor of PFS in the Cox proportional-hazards regression multivariable model (adjusted hazard ratio low-grade vs. high-grade: 0.45, 95% confidence interval: 0.22–0.94; adjusted p = 0.035). Conclusions: In this retrospective case series, sensitivity to trabectedin was higher in WDLPS/low-grade DDLPS than in high-grade DDLPS. If confirmed in larger series, grading could represent an effective tool to personalize the treatment with trabectedin in patients with advanced LPS.

Aggressive verrucous carcinoma of the paranasal sinuses invading the orbit: case report and literature review

2009 ◽  
Vol 123 (11) ◽  
Author(s):  
J Yiotakis ◽  
T Vamvakidis ◽  
E Iakovou ◽  
L Manolopoulos
Keyword(s):  
Case Report ◽  
Paranasal Sinuses ◽  
Verrucous Carcinoma ◽  
Transnasal Approach ◽  
Early Management ◽  
Combined Radiochemotherapy ◽  
Endoscopic Transnasal Approach ◽  
Well Differentiated ◽  
Orbital Invasion ◽  
Histological Result

AbstractIntroduction:Verrucous carcinoma is a variant of well differentiated squamous cell carcinoma characterised by an exophytic, warty growth which is slowly but locally invasive and which can cause extensive local destruction if left untreated.Case report:We report the first known case of veruccous carcinoma of the paranasal sinuses with rapid orbital invasion. A 58-year-old man presented with right-sided nasal obstruction, a huge right intranasal lesion, intractable dacryocystitis and cutaneous involvement of the nasolacrimal sac region. The tumour was partially removed using an endoscopic transnasal approach. Post-operatively, and while waiting for the histological result, the patient developed signs of rapid invasion of the orbit, with uniocular visual acuity deficit. He underwent combined radiochemotherapy, with a moderate response.Conclusion:Knowledge of the potentially aggressive nature of verrucous carcinoma may be helpful in early management of intraorbital invasion and salvaging of the eye.

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