The Effect of Anesthesia on the Immune System in Colorectal Cancer Patients

Colorectal cancer (CRC) is the key leading cause of high morbidity and mortality worldwide. Surgical excision is the most effective treatment for CRC. However, stress caused by surgery response can destroy the body’s immunity and increase the likelihood of cancer dissemination and metastasis. Anesthesia is an effective way to control the stress response, and recent basic and clinical research has shown that anesthesia and related drugs can directly or indirectly affect the immune system of colorectal cancer patients during the perioperative period. Thus, these drugs may affect the prognosis of CRC surgery patients. This review is intended to summarize currently available data regarding the effects of anesthetics and related drugs on perioperative immune function and postoperative recurrence and metastasis in CRC patients. Determining the most suitable anesthesia for patients with CRC is of utmost importance.

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Copper-Zinc ratio and nutritional status in colorectal cancer patients during the perioperative period

Acta Cirurgica Brasileira ◽

10.1590/s0102-86502016001300006 ◽

2016 ◽

Vol 31 (suppl 1) ◽

pp. 24-28 ◽

Cited By ~ 8

Author(s):

Sofia Miranda de Figueiredo Ribeiro ◽

Amanda Maria Tomazini Munhoz Moya ◽

Camila Bitu Moreno Braga ◽

Fernanda Aparecida Domenici ◽

Marley Ribeiro Feitosa ◽

...

Keyword(s):

Colorectal Cancer ◽

Nutritional Status ◽

Cancer Patients ◽

Perioperative Period ◽

Copper Zinc ◽

Colorectal Cancer Patients

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The effect of supplementation with an amino acid that helps the body build protein (L-arginine) on change in the immune system of colorectal cancer patients

http://isrctn.com/ ◽

10.1186/isrctn61139514 ◽

2021 ◽

Author(s):

Jarosław Szefel ◽

Wiesław Kruszewski

Keyword(s):

Colorectal Cancer ◽

Immune System ◽

Amino Acid ◽

Cancer Patients ◽

The Body ◽

Protein L ◽

Body Build ◽

Colorectal Cancer Patients

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Gut bacteria identified in colorectal cancer patients promote tumourigenesis via butyrate secretion

Nature Communications ◽

10.1038/s41467-021-25965-x ◽

2021 ◽

Vol 12 (1) ◽

Author(s):

Shintaro Okumura ◽

Yusuke Konishi ◽

Megumi Narukawa ◽

Yuki Sugiura ◽

Shin Yoshimoto ◽

...

Keyword(s):

Colorectal Cancer ◽

Stress Response ◽

Gut Microbiota ◽

Cohort Studies ◽

Cancer Patients ◽

Colorectal Cancer Patients ◽

Inflammatory Phenotypes ◽

Colorectal Tumours ◽

Independent Cohort ◽

Oncogenic Stress

AbstractEmerging evidence is revealing that alterations in gut microbiota are associated with colorectal cancer (CRC). However, very little is currently known about whether and how gut microbiota alterations are causally associated with CRC development. Here we show that 12 faecal bacterial taxa are enriched in CRC patients in two independent cohort studies. Among them, 2 Porphyromonas species are capable of inducing cellular senescence, an oncogenic stress response, through the secretion of the bacterial metabolite, butyrate. Notably, the invasion of these bacteria is observed in the CRC tissues, coinciding with the elevation of butyrate levels and signs of senescence-associated inflammatory phenotypes. Moreover, although the administration of these bacteria into ApcΔ14/+ mice accelerate the onset of colorectal tumours, this is not the case when bacterial butyrate-synthesis genes are disrupted. These results suggest a causal relationship between Porphyromonas species overgrowth and colorectal tumourigenesis which may be due to butyrate-induced senescence.

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Circulation of tumor cells to destroy correlations in immune system of colorectal cancer patients.

Journal of Clinical Oncology ◽

10.1200/jco.2021.39.15_suppl.e15508 ◽

2021 ◽

Vol 39 (15_suppl) ◽

pp. e15508-e15508

Author(s):

Anastasia O. Sitkovskaya ◽

Elena Yu. Zlatnik ◽

Oleg I. Kit ◽

Inna A. Novikova ◽

Elena S. Bondarenko ◽

...

Keyword(s):

Colorectal Cancer ◽

Immune System ◽

Cancer Patients ◽

Tumor Cells ◽

Tumor Stage ◽

Cell Mediated Immunity ◽

Ki 67 ◽

Immunologic Factors ◽

Activated T Lymphocytes ◽

Colorectal Cancer Patients

e15508 Background: The most important stages of metastatic cascade are extravasation and invasion of malignant cells and their surviving in blood. The vast majority of circulating tumor cells (CTC) is destroyed by immune cells. The role of immune system which is able to play not only antitumor but also prooncogenic role is manifested both on local and systemic levels. We studied correlations between lymphocyte subsets` content in blood and in tumor of colorectal cancer patients (II, III, IV stages) with and without CTC. Methods: 60 colorectal cancer patients with II (n = 20), III (n = 20) and IV (n = 20) stages underwent surgery without previous chemotherapy. CTC were measured in blood by CellSearchSystem™ (JanssenDiagnostics, LLC), cell-mediated immunity was assessed in blood by flow cytometry (BD Canto II) and in tissue after surgery by immunohistochemistry; some markers of proliferation and epithelial-mesenchimal transition (EMT) in tumor cells (Ki-67, E- and N-cadherins) were also studied. Criteria of CTC-positive and CTC-negative samples were > 3 and ≤3 respectively. Correlative analysis was performed between the data of the patients with and without CTC in each stage, r was counted. Results: In CTC-positive patients with all the stages the number of strong and moderate correlations between system immunologic factors involving CD8+ appeared to be fewer than in CTC-negative ones (7 vs 19). On the contrary, the number of correlations with T regs in CTC-positive was increased: 5 vs 3 in CTC-negative patients. In patients with CTC > 3 fewer correlations were noted between factors of local and systemic immunity than in CTC-negative ones (9 vs 4 in II stage) and total disruption of all the correlations between system immunologic factors and proliferating tumor cells in III and IV stages was established. Some pathologic correlations appeared in CTC-positive patients like moderate direct one between activated T-lymphocytes` amount and Ki-67+ tumor cells. The number of correlations between intratumoral lymphocytes and tumor cells expressing proliferation and EMT markers in CTC-positive patients was decreased in comparison with CTC-negative ones (4 vs 10 in II stage, 1 vs 9 in III, 2 vs 9 in IV stage). Conclusions: The presence of CTC in colorectal cancer patients rather than tumor stage is associated with imbalance of their systemic and local immunologic factors. This provides some evidence that disruption of interactions in the immune system is at least partly due to CTC.

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Simultaneous LC-MS/MS-Based Quantification of Free 3-Nitro-l-tyrosine, 3-Chloro-l-tyrosine, and 3-Bromo-l-tyrosine in Plasma of Colorectal Cancer Patients during Early Postoperative Period

Molecules ◽

10.3390/molecules25215158 ◽

2020 ◽

Vol 25 (21) ◽

pp. 5158

Author(s):

Mariusz G. Fleszar ◽

Paulina Fortuna ◽

Marek Zawadzki ◽

Bogna Kosyk ◽

Małgorzata Krzystek-Korpacka

Keyword(s):

Colorectal Cancer ◽

Cancer Patients ◽

Postoperative Period ◽

Solid Phase ◽

Surgical Site Infections ◽

Perioperative Period ◽

Early Postoperative Period ◽

Specificity And Sensitivity ◽

Liquid Chromatography Tandem Mass ◽

Colorectal Cancer Patients

Quantification with satisfactory specificity and sensitivity of free 3-Nitro-l-tyrosine (3-NT), 3-Chloro-l-tyrosine (3-CT), and 3-Bromo-l-tyrosine (3-BT) in biological samples as potential inflammation, oxidative stress, and cancer biomarkers is analytically challenging. We aimed at developing a liquid chromatography–tandem mass spectrometry (LC-MS/MS)-based method for their simultaneous analysis without an extract purification step by solid-phase extraction. Validation of the developed method yielded the following limits of detection (LOD) and quantification (LOQ) for 3-NT, 3-BT, and 3-CT: 0.030, 0.026, 0.030 ng/mL (LODs) and 0.100, 0.096, 0.098 ng/mL (LOQs). Coefficients of variation for all metabolites and tested concentrations were <10% and accuracy was within 95–105%. Method applicability was tested on colorectal cancer patients during the perioperative period. All metabolites were significantly higher in cancer patients than healthy controls. The 3-NT was significantly lower in advanced cancer and 3-BT showed a similar tendency. Dynamics of 3-BT in the early postoperative period were affected by type of surgery and presence of surgical site infections. In conclusion, a sensitive and specific LC-MS/MS method for simultaneous quantification of free 3-NT, 3-BT, and 3-CT in human plasma has been developed.

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