Reduction in Ocular Hypotensive Eyedrops by Ab Interno Trabeculotomy Improves Not Only Ocular Surface Condition But Also Quality of Vision

Purpose. To investigate the effect of ab interno trabeculotomy using the Trabectome surgical system on tear film stability and functional visual acuity (FVA). Patients and Methods. Adult glaucoma patients who underwent Trabectome surgery alone or Trabectome surgery combined with phacoemulsification with intraocular lens insertion were included in this study. Corneal epithelial defects, tear film breakup time (TBUT), tear meniscus height, tear film spreading grade, tear interferometry grade, and FVA were assessed before and after surgery in addition to routine ophthalmic examinations. Changes in ocular surface conditions and visual acuity as a result of the Trabectome surgery were investigated. Results. Thirty eyes of 22 patients with a mean age of 72.2 ± 7.9 years, including 8 males and 14 females, were enrolled. The Trabectome surgery significantly reduced the intraocular pressure (IOP) from 20.3 ± 5.2 to 15.0 ± 3.3 mmHg (P<0.001) and the number of different types of ocular hypotensive eyedrops used from 3.2 ± 0.7 to 1.1 ± 0.7 types (P<0.001). The surgery significantly improved corneal epithelial defects, the tear spreading grade, the tear interferometry grade, and FVA. The surgery also improved the visual maintenance ratio among all enrolled patients, including those who underwent Trabectome surgery only. Conclusion. Trabectome surgery may be beneficial not only for IOP reduction but also for improving ocular surface conditions and FVA.

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Association among Blink Rate, Changes in Ocular Surface Temperature, Tear Film Stability, and Functional Visual Acuity in Patients after Cataract Surgery

Journal of Ophthalmology ◽

10.1155/2019/8189097 ◽

2019 ◽

Vol 2019 ◽

pp. 1-8 ◽

Cited By ~ 1

Author(s):

Takashi Itokawa ◽

Yukinobu Okajima ◽

Takashi Suzuki ◽

Tatsuhiko Kobayashi ◽

Yuto Tei ◽

...

Keyword(s):

Visual Acuity ◽

Regression Analysis ◽

Cataract Surgery ◽

Ocular Surface ◽

Tear Film ◽

Blink Rate ◽

Film Stability ◽

Tear Film Stability ◽

Functional Visual Acuity ◽

Film Group

Purpose. To investigate the association among the ocular surface temperature (OST), tear film stability, functional visual acuity (FVA), and blink rate in patients after cataract surgery. Methods. We recruited 98 eyes of 69 patients (mean age, 73.7 ± 5.2 years) 1 month after phacoemulsification with implantation of acrylic intraocular lenses and assessed slit-lamp microscopy, corrected distance VA, FVA, noninvasive tear breakup time (NIBUT), and OST. We defined the changes in the OST from 0 to 10 seconds after eye opening as the ΔOST. We measured the FVA and blink rate using the FVA measurement system. We divided the patients into two groups based on tear film stability: stable tear film (NIBUT, >5.0 seconds) and unstable tear film (NIBUT, ≤5.0 seconds). We evaluated the differences between the two groups and the association between the blink rate and other clinical parameters. Results. The unstable tear film group (56 eyes) had significantly (p<0.0001, unpaired t-test) shorter NIBUTs than the stable tear film group (42 eyes). The ΔOSTs and blink rates were significantly (p<0.0001) higher in the unstable tear film group than in the stable group. Linear single regression analysis showed that the ΔOST (r = −0.430, p<0.0001), NIBUT (r = −0.392, p<0.0001), and gender (r = −0.370, p=0.0002) were correlated significantly with the blink rate. Multiple regression analysis showed that the ΔOST independently contributed to the blink rate. Conclusions. The frequency of blinks is associated with tear film stability in patients after cataract surgery. The blink rate may be useful for evaluating the tear film stability in clinical practice. The ΔOST should be an important contributing factor to the blink rate. [This trial is registered with UMIN000026970].

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Effects of Aerobic Exercise on Tear Secretion and Tear Film Stability in Dry Eye Patients

10.21203/rs.3.rs-294144/v1 ◽

2021 ◽

Author(s):

Chao Sun ◽

Xiaofan Chen ◽

Yanming Huang ◽

Huan Zou ◽

Wei Fan ◽

...

Keyword(s):

Visual Acuity ◽

Aerobic Exercise ◽

Dry Eye ◽

Tear Film ◽

Normal Subjects ◽

Oxidative Stress Marker ◽

Film Stability ◽

Tear Secretion ◽

Tear Film Stability ◽

Before And After

Abstract Background: To study the effects of aerobic exercise (AE) on tear secretion and tear film stability in dry eye patients.Methods: Firstly we observed Schirmer Ⅰ test and 6 tear compositions detected by ELISA in 34 eyes of dry eye patients and 34 eyes of normal subjects before and after AE. Then we observed 30 eyes of dry eye patients and 30 eyes of normal subjects before and after AE, the evaluated variables included tear meniscus height (TMH), first and average non-invasive tear breakup time (F-NITBUT and A-NITBUT), lipid layer thickness (LLT), number of incomplete and complete blinks, partial blink rate (PBR) and visual acuity.Results: In dry eye group, compared with baseline, Schirmer Ⅰ test at 0 minutes after AE increased significantly (P < 0.001), F-NITBUT and A-NITBUT at every time point after AE prolonged significantly (P < 0.001, P = 0.007, P = 0.036; P < 0.001, P = 0.001, P = 0.044), number of incomplete blinks and PBR at 10 minutes after AE decreased significantly (P < 0.001; P < 0.001) while number of complete blinks increased significantly (P < 0.001), visual acuity at 10 and 20 minutes after AE improved significantly (P = 0.017, P = 0.021). The overall oxidative stress marker 8-hydroxy-2’-deoxyguanosine at 0 minutes after AE decreased significantly compared with baseline (P = 0.040).Conclusion: AE promotes tear secretion and improves tear film stability in dry eye patients. AE may be a potential treatment for dry eye.Trial registration: Chinese Clinical Trial Registry, ChiCTR2000038673. Registered 27 September 2020, http://www.chictr.org.cn/showproj.aspx?proj=57282

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Prevalence of Ocular Demodicosis and Ocular Surface Conditions in Patients Selected for Cataract Surgery

Journal of Clinical Medicine ◽

10.3390/jcm9103069 ◽

2020 ◽

Vol 9 (10) ◽

pp. 3069

Author(s):

Katarzyna Nowomiejska ◽

Piotr Lukasik ◽

Agnieszka Brzozowska ◽

Mario Damiano Toro ◽

Aleksandra Sedzikowska ◽

...

Keyword(s):

Cataract Surgery ◽

Ocular Surface ◽

Anterior Segment ◽

Tear Film ◽

Test Results ◽

Conjunctival Hyperemia ◽

Surface Conditions ◽

Demodex Folliculorum ◽

Before And After ◽

Demodex Mites

The aim of the study was to analyze the prevalence of ocular demodicosis and ocular surface conditions in patients selected for cataract surgery. Eyelashes from 73 patients selected for cataract surgery were evaluated at ×40 and ×100 magnification using light microscopy. The anterior segment was assessed with the slit lamp. Additionally, Schirmer I and break up time (BUT) tests were carried out before surgery and 1 and 3 months postoperatively. A specially designed questionnaire containing e.g., information about chronic skin and eye diseases, previous ophthalmic surgeries, and patient’s hygiene habits was used to assess the demographic variables. A majority of patients were at the age of 70–79 years, and there were more females (83%) in the study group. Demodex folliculorum was found in 48% of the patients. There was a correlation between the number of parasites and the presence of blepharitis, discharge at eyelid margins, and conjunctival hyperemia. Schirmer I and BUT test results were lower in patients with Demodex infestation before and after cataract surgery. The higher number of mites was correlated with lower Schirmer I test results postoperatively. The presence of Demodex mites influences the conjunctiva and lid margins leading to inflammation. The higher number of Demodex mites disturbs the tear film over time after cataract surgery.

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The ocular surface in children: A review of current knowledge and meta-analysis of tear film stability and tear secretion in children

The Ocular Surface ◽

10.1016/j.jtos.2018.09.006 ◽

2019 ◽

Vol 17 (1) ◽

pp. 28-39 ◽

Cited By ~ 3

Author(s):

Ngozi Charity Chidi-Egboka ◽

Nancy E. Briggs ◽

Isabelle Jalbert ◽

Blanka Golebiowski

Keyword(s):

Ocular Surface ◽

Current Knowledge ◽

Meta Analysis ◽

Tear Film ◽

Film Stability ◽

Tear Secretion ◽

Tear Film Stability

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Association Between Ocular Surface Temperature and Tear Film Stability in Soft Contact Lens Wearers

Investigative Opthalmology & Visual Science ◽

10.1167/iovs.17-23173 ◽

2018 ◽

Vol 59 (2) ◽

pp. 771 ◽

Cited By ~ 4

Author(s):

Takashi Itokawa ◽

Yukinobu Okajima ◽

Takashi Suzuki ◽

Koji Kakisu ◽

Hiroko Iwashita ◽

...

Keyword(s):

Surface Temperature ◽

Contact Lens ◽

Ocular Surface ◽

Tear Film ◽

Soft Contact ◽

Film Stability ◽

Soft Contact Lens ◽

Tear Film Stability

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Clinical manifestations of the dry eye syndrome for women in menopause

Pediatrician (St Petersburg) ◽

10.17816/ped5225-29 ◽

2014 ◽

Vol 5 (2) ◽

pp. 25-29

Author(s):

Nataliya Nikolayevna Sadovnikova ◽

Galiya Fettyakhovna Kutusheva

Keyword(s):

Dry Eye ◽

Ocular Surface ◽

Clinical Manifestations ◽

Tear Film ◽

Dry Eye Syndrome ◽

Menopausal Syndrome ◽

Film Stability ◽

Tear Film Stability ◽

Functional Features ◽

Subjective Discomfort

To assess the effect of menopausal syndrome manifestations in the manifestation of «dry eye» examined 63 women . All examined the condition of the ocular surface, tear film stability, severity of subjective discomfort . Revealed that the dry eye syndrome in postmenopausal women occurs predominantly in the mild and moderate forms, with the severity of clinical and functional features of dry eye syndrome significantly correlated with severity of menopausal symptoms .

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ASSESSMENT OF THE SURFACE CONDITIONS OF GAS-LUBRICATED FACE-SEAL SEALING RINGS

Tribologia ◽

10.5604/01.3001.0010.5893 ◽

2017 ◽

pp. 11-21

Author(s):

Jakub GACEK ◽

Łukasz NORYMBERCZYK ◽

Stanisław PŁONKA

Keyword(s):

Silicon Carbide ◽

Surface Condition ◽

Face Seal ◽

Roughness Parameters ◽

Surface Conditions ◽

Before And After ◽

The Face ◽

Almost All ◽

2D And 3D ◽

Sintered Silicon

The paper presents a study of surface condition of stationary and rotary rings of a gas-lubricated face seal before and after 25 hours of operation on a test bench, with 75 cycles of start-ups and stops of the drive. For evaluation of surface conditions, flatness deviation and a selected 2D and 3D roughness parameters were measured. Profiles of the roughness, material ratio curves, topography, and surface maps in colour before and after 25 hours of operations were presented. It has been found that wear of the end faces of the saling rings differs between sintered silicon carbide and carbon graphite. In the case of the stationary ring made of sintered silicon carbide with a hardness of 3000 HV, there is a slight increase in values of almost all (except Sp) measured 3D amplitude parameters: Sa, Sq, Sv, St. In the case of the rotary ring made of carbon graphite with hardness of about 115 HR a noticeable reduction in values of these parameters was found. Changes In 2D and 3D roughness parameters of end faces of the stationary and rotary rings allow confirming the al most contact-free character of the face seal operation.

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Why Chain Length of Hyaluronan in Eye Drops Matters

Diagnostics ◽

10.3390/diagnostics10080511 ◽

2020 ◽

Vol 10 (8) ◽

pp. 511 ◽

Cited By ~ 2

Author(s):

Wolfgang G.K. Müller-Lierheim

Keyword(s):

Molecular Weight ◽

Epithelial Cells ◽

Chain Length ◽

Ocular Surface ◽

Clinical Performance ◽

Average Molecular Weight ◽

Tear Film ◽

Eye Drops ◽

Zero Shear Viscosity ◽

Corneal Epithelial

The chain length of hyaluronan (HA) determines its physical as well as its physiological properties. Results of clinical research on HA eye drops are not comparable without this parameter. In this article methods for the assessment of the average molecular weight of HA in eye drops and a terminology for molecular weight ranges are proposed. The classification of HA eye drops according to their zero shear viscosity and viscosity at 1000 s−1 shear rate is presented. Based on the gradient of mucin MUC5AC concentration within the mucoaqueous layer of the tear film a hypothesis on the consequences of this gradient on the rheological properties of the tear film is provided. The mucoadhesive properties of HA and their dependence on chain length are explained. The ability of HA to bind to receptors on the ocular epithelial cells, and in particular the potential consequences of the interaction between HA and the receptor HARE, responsible for HA endocytosis by corneal epithelial cells is discussed. The physiological function of HA in the framework of ocular surface homeostasis and wound healing are outlined, and the influence of the chain length of HA on the clinical performance of HA eye drops is illustrated. The use of very high molecular weight HA (hylan A) eye drops as drug vehicle for the next generation of ophthalmic drugs with minimized side effects is proposed and its advantages elucidated. Consequences of the diagnosis and treatment of ocular surface disease are discussed.

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The Influence of Overnight Orthokeratology on Ocular Surface and Meibomian Gland Dysfunction in Teenagers with Myopia

Journal of Ophthalmology ◽

10.1155/2019/5142628 ◽

2019 ◽

Vol 2019 ◽

pp. 1-6

Author(s):

Xiu Wang ◽

Jing Li ◽

Rui Zhang ◽

Na Li ◽

Yi Pang ◽

...

Keyword(s):

Ocular Surface ◽

Tear Film ◽

Meibomian Gland ◽

Meibomian Gland Dysfunction ◽

Ocular Surface Disease Index ◽

Time Points ◽

Meniscus Height ◽

Significant Difference ◽

Before And After

Purpose. The aim of this study was to investigate the effect of overnight orthokeratology (OOK) on ocular surface and meibomian gland dysfunction in teenagers with myopia. Methods. A total of 59 subjects were recruited in this prospective study. The following tests were performed before and after 1, 3, 6, 12, and 24 months of OOK lens wear, including ocular surface disease index (OSDI) questionnaire, slit-lamp examination, and Keratograph 5M. Results. No infectious keratitis occurred during the study. OSDI scores increased gradually and reached the maximum at 6 months of OOK wear (P<0.001). The meniscus height was significantly increased at 1 and 3 months after the initiation of OOK (P=0.006, P=0.035). The corneal fluorescein staining at 1, 3, 6, 12, and 24 months after wearing OOK were all increased than the prewearing level with significant difference (P=0.014, P=0.036, P<0.001, P<0.001, and P=0.008, respectively). The first and the average tear film NIKBUT were all higher than the prewearing level, but there was no significant difference between every follow-up time points (P>0.05). The lid margin abnormalities were significantly increased (P=0.003, P=0.038, and P=0.015) at 6, 12, and 24 months after the initiation of OOK. There was no significant difference in the meibomian gland orifice scores at each follow-up time points compared to the prewearing level (P>0.05). The meibomian gland lipid secretion scores after wearing OOK were higher than those of the prewearing level, however, without statistically significant difference (P>0.05). No significant differences of the degree of difficulty of lipid excretions were detected after the initiation of OOK (P>0.05). There was no significant difference in meibomian gland dropout scores between all follow-up time points and the prewearing level (P=1.000). Conclusion. OOK increased the symptoms of dry eye and decreased the function of tear film by affecting the meniscus height and BUT. OOK did not affect the function of meibomian glands.Clinical Study registration number: ChiCTR18000185708.

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Impact of pterygium on the ocular surface and meibomian glands

10.1101/569772 ◽

2019 ◽

Author(s):

Ana Cláudia Viana Wanzeler ◽

Italo Antunes França Barbosa ◽

Bruna Duarte ◽

Eduardo Buzolin Barbosa ◽

Daniel Almeida Borges ◽

...

Keyword(s):

Ocular Surface ◽

Tear Film ◽

Lower Eyelid ◽

Meibomian Gland ◽

Conjunctival Hyperemia ◽

Upper Eyelid ◽

Film Stability ◽

Surface Parameters ◽

Meibomian Glands ◽

The Impact

AbstractPurposeTo analyze how ocular surface parameters correlate to pterygium and investigate the possible impact on tear film and meibomian glands.Methodswe investigated objective parameters of the ocular surface such as conjunctival hyperemia, tear film stability and volume, meibomian gland dysfunction, dry eye disease, corneal topography comparing healthy individuals and correlating with the pterygium clinical presentation.ResultsA total of 83 patients were included. Corneal astigmatism induction was 2.65 ± 2.52 D (0.4-11.8). The impact of pterygium on the ocular surface parameters compared to matched controls was seen in: conjunctival hyperemia (control 1.55±0.39/pterygium 2.14±0.69; p=0.0001), tear meniscus height (control 0.24±0.05 mm/pterygium 0.36±0.14mm; p 0.0002), meiboscore lower eyelid (control 0.29±0.64/pterygium 1.38±0.95; p 0.0001) and meiboscore upper eyelid (control 0.53±0.62/pterygium 0.98±0.75; p=0.0083). We found a high number of pterygium patients (88%) presented meibomian gland alterations. Interestingly, meibomian gland loss was coincident to the localization of the pterygium in 54% of the upper and 77% lower lids.ConclusionPterygium greatly impacts on ocular surface by inducing direct alterations in the pattern of meibomian glands besides corneal irregularities, conjunctival hyperemia and lacrimal film alterations, inducing significant symptoms and potential signs of dysfunction.

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