scholarly journals Siwu Granules and Erythropoietin Synergistically Ameliorated Anemia in Adenine-Induced Chronic Renal Failure Rats

2019 ◽  
Vol 2019 ◽  
pp. 1-12
Author(s):  
Yansheng Wu ◽  
Qiang Wan ◽  
Liqiang Shi ◽  
Jiaoying Ou ◽  
YingQiao Li ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Renal Failure ◽  
Renal Function ◽  
Chronic Renal Failure ◽  
Combined Treatment ◽  
Inflammatory Factors ◽  
Control Group ◽  
Hemoglobin Content ◽  
End Stage

Objective. Renal anemia in patients with end-stage chronic kidney disease is closely related to the deterioration of cardiac function, renal function, and quality of life. This study involved adenine-induced renal anemic rat models and evaluated the treatment effect of Siwu granules and/or erythropoietin (EPO). Methods. Fifty SD rats were randomly divided into 5 groups: control, model, Siwu, EPO, and Siwu plus EPO groups. The expression levels of NO, MDA, SOD, CAT, IL-6, TNF-α, EPO, EPOR, α-SMA, and TGF-β1 were detected in rats after 8 weeks of treatment with Siwu granules and/or EPO. Results. After modeling, 47 rats entered the stage of treatment. Siwu plus EPO treatment significantly increased the rat hemoglobin content (p<0.05) and reduced blood urea nitrogen (p<0.05) and serum creatinine (p<0.001). Compared with the control group, the expression of EPO and EPOR in the kidney of rats with renal failure was significantly decreased (p<0.05). Moreover, the Siwu plus EPO group improved the level of oxidative stress in rats with chronic renal failure and reduced the expression of inflammatory factors. The expression of α-SMA and TGF-β1 in rats with renal failure was higher, but there was no expression in the control group. Conclusion. Combined treatment of Siwu granules with EPO increased the expression of EPO and EPOR in the renal tissues and inhibited oxidative stress and inflammatory factors, improving the renal function and anemia.

Oral and Maxillofacial Manifestations of Mineral and Bone Disorders Associated with Chronic Renal Failure

2017 ◽  
Vol 68 (6) ◽  
pp. 1325-1328
Author(s):  
Andrada Raluca Doscas ◽  
Mihail Balan ◽  
Mihai Liviu Ciofu ◽  
Doriana Agop Forna ◽  
Marius Cristian Martu ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Renal Failure ◽  
Renal Function ◽  
Chronic Renal Failure ◽  
Health Concern ◽  
Oral Manifestations ◽  
End Stage Renal Failure ◽  
Brown Tumors ◽  
The Mean ◽  
End Stage

Chronic kidney disease (CKD) is a multifactorial syndrome and a global health concern. As renal function declines, there is a progressive deterioration of mineral homeostasis. Starting from stage 3 of CKD oral manifestations of mineral disorders can occasionally appear and become more frequent and evident in stage 5. We retrospectively analysed 43 patients diagnosed with end stage renal failure undergoing dialysis, hospitalized in our clinic for different oral and maxillofacial pathologies. The mean dialysis period was 5.43 years. Radiographic alterations afecting the jaws were found in all patients. The most common feature was partial or total loss of lamina dura, followed by alterations of the bony trabeculae. 9 patients presented brown tumors which are considered the final stage of secondary hyperparathyroidism associated with renal failure.

Allantoin as a marker of oxidative stress in human erythrocytes

2008 ◽  
Vol 46 (9) ◽  
Author(s):  
Roman Kand'ár ◽  
Pavla Žáková
Keyword(s):  
Oxidative Stress ◽  
Renal Failure ◽  
Uric Acid ◽  
Chronic Renal Failure ◽  
Gradient Elution ◽  
Reversed Phase ◽  
Control Group ◽  
Uric Acid Concentration ◽  
Reversed Phase Hplc

Abstract: Uric acid is the final product of purine metabolism in humans. It was determined that this compound has important antioxidative properties and it may be oxidized to allantoin by various reactive oxygen species. Therefore, the measurement of allantoin may be useful for the determination of oxidative stress in humans.: We measured allantoin and uric acid in human plasma and erythrocytes obtained from patients with chronic renal failure before hemodialysis (n=30) and blood donors (n=30). We used a method based on selective isolation of allantoin from deproteinized plasma and erythrocyte lysate samples on AG 1-X8 resin and its derivatization to glyoxylate-2, 4-dinitrophenylhydrazone. Separation of glyoxylate-2, 4-dinitrophenylhydrazone from interfering substances was achieved on reversed phase HPLC with gradient elution and UV/VIS detection at 360 nm. Uric acid was determined by reversed phase HPLC with UV/VIS detection at 292 nm.: We found significant differences in allantoin and uric acid concentration between the patients with chronic renal failure and the control group both in plasma (20.5±6.5 μmol/L and 323.9±62.9 μmol/L vs. 2.1±1.1 μmol/L and 270.1±62.3 μmol/L, p<0.05) and erythrocytes [82.8±39.1 nmol/g hemoglobin (Hb) and 110.7±28.8 nmol/g Hb vs. 20.1±6.1 nmol/g Hb and 82.1±23.7 nmol/g Hb, p<0.05].: Significant higher levels of allantoin in both plasma and erythrocytes of patients with chronic renal failure indicate that allantoin may be used as a good marker of oxidative stress.Clin Chem Lab Med 2008;46:1270–4.

scholarly journals THE EFFECT OF SPIRITUAL BASED REIKI THERAPY (PRAYER) ON POSTTRAUMATIC GROWTH (PTG) AMONG CHRONIC RENAL FAILURE PATIENTS THROUGH HEMODIALYSIS

2021 ◽  
Vol 10 (2) ◽  
pp. 190-200
Author(s):  
Abdul Muhith ◽  
Nur Hidaayah ◽  
Rahayu Anggreani ◽  
Hartadi Hartadi
Keyword(s):  
Quality Of Life ◽  
Renal Failure ◽  
Chronic Renal Failure ◽  
Posttraumatic Growth ◽  
Intervention Group ◽  
Sampling Technique ◽  
Hospital Treatment ◽  
Control Group ◽  
Control Group Design

Background: Disease Chronic kidney failure can result in positive and negative implications as Posttraumatic Growth (PTG) and problems mental - psychological include self-concept, and the quality of life of patients.  Objectives: The research objective was to analyze the effect of spiritual based reiki therapy (prayer) on posttraumatic growth. Methods: The study design was Quasy-Experimental with pre-post test control group design and research conducted by a research assistant. The population was all chronic renal failure patients undergoing hemodialysis. Sample size 40, divided into 20 interventions and 20 controls. The sampling technique is purposive sampling. In the intervention group-based therapy reiki spiritual (prayer) for 45 - 75 minutes of 8-12 meetings (se whenever there are 3 sessions) performed 2 weeks. The control group was given action according to hospital standards. Test analysis Wilcoxon Signed Ranks Test and analysis uji depending Mann Whitney. Results: Results of analysis of test Wilcoxon Signed Ranks Test P no intervention group therapy reiki spiritually based (Prayer) no effect on posttraumatic growth p = 0.000. If the control group was given therapy according to hospital SOP, there was an effect on posttraumatic growth p = 0.025. And the results of the analysis using Mann Whitney found that  Results Posttraumatic Growth in the intervention group of the therapy reiki spiritually based (Prayer) - In the group controls are enforcedi according to SOP hospital treatment, the results are no different, p = 0.000.  Conclusion: Reiki therapy based spiritual (prayer) is very effective to decrease the Posttraumatic Growth, can improve quality of life and positive attitude in which respondents were willing to change his priorities and biases appreciate herself.

scholarly journals A comparative analysis of high-flux and low-flux dialysis in cervical cancer patients with obstructive renal failure showing no significantly improved renal function after catheterisation

2021 ◽  
Vol 37 (4) ◽  
Author(s):  
Chen-li Zhang ◽  
De-qiong Xie ◽  
Li-na Ao ◽  
Lei Zhu
Keyword(s):  
Cervical Cancer ◽  
Renal Failure ◽  
Renal Function ◽  
Cancer Patients ◽  
Cysteine Protease Inhibitor ◽  
Inflammatory Factors ◽  
Control Group ◽  
High Flux ◽  
Experimental Group ◽  
Obstructive Renal Failure

Objective: This study aims to compare the clinical application value of high-flux dialysis with low-flux dialysis in patients without significantly improved renal function after cervical cancer and obstructive renal failure catheterisation. Methods: This prospective randomised study was conducted from January 2018 to December 2019. Eighty cervical cancer patients with obstructive renal failure who showed no significant renal function improvement after catheterisation were randomised into two groups (n = 40 in each group) in the Second People’s Hospital of Yibin City. High-flux and low-flux dialysis were employed in the experimental group and the control group, respectively. Treatments in both groups were provided every other day, with the whole course lasting one week. Data were recorded before and after dialysis included inflammatory factors such as IL-6, CRP and TNF-a, large and moderate molecular toxins (e.g., β2 micro-globulin, parathyrin (PTH) and cysteine protease inhibitor). Renal function changes during the dialysis were also recorded. Afterwards, the two groups were compared regarding the overall efficacy. Results: Both the experimental group and the control group experienced a significant decrease in IL-6, CRP, TNF-a, β2 micro-globulin, PTH and cysteine protease inhibitor, with the decrease in the experimental group being more evident (p < 0.05). After dialysis was completed, the experimental group restored renal function indicators such as Cre, CysC and serum K+ levels more quickly than the control group (p < 0.05). The effective rate was 100% for the experimental group and 87.5% for the control group. The intragroup difference in the efficacy.was significant. Conclusions: High-flux dialysis appears to be more beneficial for cervical cancer patients with obstructive renal failure, showing no significant improvement in renal function after catheterisation. It restored renal function more quickly, had more radical draining of inflammatory factors and large and moderate molecular toxins, and had a higher overall effective rate. doi: https://doi.org/10.12669/pjms.37.4.3515 How to cite this:Zhang C, Xie DQ, Ao L, Zhu L. A comparative analysis of high-flux and low-flux dialysis in cervical cancer patients with obstructive renal failure showing no significantly improved renal function after catheterisation. Pak J Med Sci. 2021;37(4):---------.  doi: https://doi.org/10.12669/pjms.37.4.3515 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Pulsatile gonadotropin secretion in pubertal children with chronic renal failure

1989 ◽  
Vol 120 (1) ◽  
pp. 14-19 ◽  
Author(s):  
F. Schaefer ◽  
R. Stanhope ◽  
H. Scheil ◽  
D. Schönberg ◽  
M. A. Preece ◽  
...  
Keyword(s):  
Renal Failure ◽  
Renal Function ◽  
Chronic Renal Failure ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Gonadotropin Secretion ◽  
Pubertal Maturation ◽  
Stage Renal Disease ◽  
End Stage ◽  
Nocturnal Rise

Abstract. We have examined physiological nocturnal secretion of gonadotropins in 6 boys and 2 girls with end-stage renal disease, who had either delayed or disturbed puberty. The 5 patients treated by dialysis had reduced gonadotropin pulsatility for their stage of pubertal maturation, whereas the 3 patients with successful kidney grafts demonstrated a higher nocturnal rise and increased amplitude of gonadotropin pulsatility. It is suggested that the improved gonadotropin pulsatility of transplanted patients is due to their restored renal function.

scholarly journals Lipoprotein(a) in Chronic Renal Failure

2009 ◽  
Vol 28 (2) ◽  
pp. 82-88
Author(s):  
Velibor Čabarkapa ◽  
Mirjana Đerić ◽  
Zoran Stošić ◽  
Vladimir Sakač ◽  
Sunčica Kojić-Damjanov ◽  
...  
Keyword(s):  
Renal Failure ◽  
Renal Function ◽  
Chronic Renal Failure ◽  
Serum Concentration ◽  
Elevated Serum ◽  
Serum Levels ◽  
Chronic Hemodialysis ◽  
Control Group ◽  
Elevated Concentration ◽  
Lipoprotein A

Lipoprotein(a) in Chronic Renal Failure Cardiovascular diseases are the leading cause of mortality in patients with chronic renal failure. Among the parameters contributing to cardiovascular disease development is the elevated serum concentration of lipoprotein(a) diagnosed in these patients, especially in the terminal stage of CRF. However, an elevated concentration of lipoprotein(a) could influence the renal failure progression. The objective of this study is to examine the lipoprotein(a) serum levels in chronic renal failure, and to establish the relation between the stage of renal function preservation and the level of this lipoprotein. In this study 127 subjects were included, divided into three groups. The first group contained 42 subjects (15 females and 27 males) in different CRF stages, the second group contained 32 subjects (7 females and 25 males) on a chronic hemodialysis program, and the control group contained 53 subjects (22 females and 31 males) with regular renal function. The results obtained point to significantly higher frequency of hyper-Lp(a) lipoproteinaemia in dialysed patients compared to the control group, as well as significantly higher Lp(a) values in both groups of patients compared to the control group. It can be concluded that for the risk assessment of premature atherosclerotic changes, but also renal failure progression in patients with CRF, determination of the Lp(a) serum concentration is recommendable.

scholarly journals Chronic Kidney Disease Associated with Pruritus And Nursing Care

2020 ◽  
Author(s):  
Neşe Altınok Ersoy ◽  
İmatullah Akyar
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Nursing Care ◽  
Negative Impact ◽  
Life Assessment ◽  
Pathophysiological Mechanism ◽  
Unpleasant Sensation ◽  
Stage Renal Disease ◽  
End Stage

Pruritus is defined as an unpleasant sensation and there are many diseases in the etiopathogenesis. Among these systemic diseases, chronic renal failure associated with pruritus is seen with a prevalence of 10-70% in end stage renal disease patients. Although there are many hypotheses about the pathophysiological mechanism of chronic renal failure associated pruritus, it is still unclear and adversely affects the patients’ life. Patients have insomnia with itching at night, fatigue, itching scratching with discomfort and social isolation problems. The negative impact of the quality of life of the patients makes assessment of the itch important and the assessment is done by both subjective and objective measurement methods and scales. While pharmacological and non-pharmacological options are included in the treatment, nursing care includes skin care precautions and practices on chronic renal failure associated pruritus. In nursing care, prevention, early detection and assessment with written and verbal scales of pruritus with record of chronic renal failure pruritus. In this review, chronic renal failure associated pruritus and prevalence, classification, pathophysiological hypothesis, impact on patients' life, assessment, treatment and nursing care will be mentioned.ce, classification, pathophysiological hypothesis, impact on patients' life, assessment, treatment and nursing care will be mentioned.

Melatonin ameliorates oxidative stress, inflammation, proteinuria, and progression of renal damage in rats with renal mass reduction

2008 ◽  
Vol 294 (2) ◽  
pp. F336-F344 ◽  
Author(s):  
Yasmir Quiroz ◽  
Atilio Ferrebuz ◽  
Freddy Romero ◽  
Nosratola D. Vaziri ◽  
Bernardo Rodriguez-Iturbe
Keyword(s):  
Oxidative Stress ◽  
Renal Failure ◽  
Renal Function ◽  
Chronic Renal Failure ◽  
Renal Mass ◽  
Mass Reduction ◽  
Melatonin Treatment ◽  
Melatonin Administration ◽  
Renal Ablation ◽  
Remnant Kidney

The progressive deterioration of renal function and structure resulting from renal mass reduction are mediated by a variety of mechanisms, including oxidative stress and inflammation. Melatonin, the major product of the pineal gland, has potent_antioxidant and anti-inflammatory properties, and its production is impaired in chronic renal failure. We therefore investigated if melatonin treatment would modify the course of chronic renal failure in the remnant kidney model. We studied rats followed 12 wk after renal ablation untreated (Nx group, n = 7) and treated with melatonin administered in the drinking water (10 mg/100 ml) (Nx + MEL group, n = 8). Sham-operated rats ( n = 10) were used as controls. Melatonin administration increased 13–15 times the endogenous hormone levels. Rats in the Nx + MEL group had reduced oxidative stress (malondialdehyde levels in plasma and in the remnant kidney as well as nitrotyrosine renal abundance) and renal inflammation (p65 nuclear factor-κB-positive renal interstitial cells and infiltration of lymphocytes and macrophages). Collagen, α-smooth muscle actin, and transforming growth factor-β renal abundance were all increased in the remnant kidney of the untreated rats and were reduced significantly by melatonin treatment. Deterioration of renal function (plasma creatinine and proteinuria) and structure (glomerulosclerosis and tubulointerstitial damage) resulting from renal ablation were ameliorated significantly with melatonin treatment. In conclusion, melatonin administration improves the course of chronic renal failure in rats with renal mass reduction. Further studies are necessary to define the potential usefulness of this treatment in other animal models and in patients with chronic renal disease.

FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN KUALITAS TIDUR PADA PASIEN GAGAL GINJAL KRONIK YANG MENJALANI HEMODIALISIS DI RUMAH SAKIT TARAKAN JAKARTA

2019 ◽  
Vol 3 (1) ◽  
Author(s):  
Enggus Subarman Pius ◽  
Santi Herlina
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Sleep Disorders ◽  
Psychological Stress ◽  
Quality Of Sleep ◽  
Quality Sleep ◽  
Average Patient ◽  
Stress Environment ◽  
End Stage

Sleep is an activity that involves the arrangement of the central nervous, endocrine, cardiovascular peripheral nervous, respiratory and Musculoskeletal, sleep disorders often occur in patients with end-stage renal failure. Problems with sleep disorders experienced by about 5080% of patients who undergo the therapy Hemodialisis. The average patient undergoing chronic renal failure Hemodialisis having problems on the quality of sleep. With increasing numbers semakian kejdian renal failure it will be growing patients undergoing therapy Hemodialisis. From the results of a survey conducted by researchers at the hospital tarakan terdapa chronic renal failure patient 90 undergoing Hemodialisis, this number is calculated from December 2013February 2014. Researchers want to know the relationship of companion ailments, psychological stress, environment and kelelahaan with the quality of sleep in patients with chronic renal failure undergoing Hemodialisis in Jakarta Tarakan hospital Hemodialisis. Methods used is descriptive with sample 40 respondents taking with total sampling techniques and observation guided by kuessioner as instruments. A research done in earn comorbidities such 79,3 %, psychological stress 92,3 %, environment 91,7 %, and fatigue 100 %. Disease penuerta, psychological stress, environment and fatigue very influential on quality sleep patient kidney failure chronicle underwent Hemodialisis. The high influence of companion ailments, psychological stress, the environment, and the fatigue of sleep quality chronic renal failure patients undergoing Hemodialisis, hence the need for a serious handling of the health care personnel to be able to minimize the faktor that can affect the quality of sleep is chronic renal failure patients undergoing Hemodialisis at Jakarta Tarakan hospital

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