scholarly journals An Unusual Case of Mandibular Squamous Cell Carcinoma in Intimacy with an Impacted Wisdom Tooth

2019 ◽  
Vol 2019 ◽  
pp. 1-6
Author(s):  
Johnson Cheung ◽  
Ayham Al Afif ◽  
Martin Joseph Bullock ◽  
Chad Robertson ◽  
Robert Hart ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Clinical Signs ◽  
Third Molar ◽  
Surgical Removal ◽  
Histopathological Analysis ◽  
Diagnostic Challenge ◽  
Oral Mucosal Lesion ◽  
Facial Swelling

Squamous cell carcinoma is the most common head and neck malignancy. It can occur in the mandible or maxilla without a preexisting oral mucosal lesion. Often, the clinical and radiographic presentation of SCC directs the clinician to favour malignancy over other pathological conditions. However, SCC may also mimic an infectious condition and therefore can pose a diagnostic challenge even for the most experienced clinicians. Herein, we report a case of mandibular squamous cell carcinoma in a 53-year-old male who presented with symptoms of right facial swelling, trismus, pain, and right-sided lip paresthesia. The patient underwent a surgical removal of the presumed infected third molar of the right mandible, but histopathological analysis of the associated soft tissue unexpectedly yielded squamous cell carcinoma. Given the biopsy-proven diagnosis, the patient received a mandibular resection of the tumor followed by primary reconstruction with a fibular free flap. Patients presenting with symptoms mimicking odontogenic infections should receive vigilant attention by clinicians with regard to the disease history, clinical signs, radiographic evidence, and decision for histopathological analysis. This is especially true in the context of impacted dentition, where malignancy must be considered when formulating a differential diagnosis.

scholarly journals Local Chemotherapy as an Adjuvant Treatment in Unresectable Squamous Cell Carcinoma: What Do We Know So Far?

2021 ◽  
Vol 28 (4) ◽  
pp. 2317-2325
Author(s):  
Luigi Bennardo ◽  
Francesco Bennardo ◽  
Amerigo Giudice ◽  
Maria Passante ◽  
Stefano Dastoli ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Gold Standard ◽  
Systemic Chemotherapy ◽  
Standard Treatment ◽  
Case Reports ◽  
Case Series ◽  
Surgical Removal ◽  
Local Chemotherapy

Background: Squamous cell carcinoma (SCC) is one of the most common cancers involving skin and oral mucosa. Although this condition’s gold-standard treatment is the surgical removal of the lesions, the physician must propose alternative treatments in some cases due to the patient’s ineligibility for surgery. Among the available alternative therapies, local chemotherapy may represent an initial treatment in combination with radiotherapy or systemic chemotherapy due to the low frequency of side-effects and the lack of necessity for expensive devices. Methods: In this paper, we review all available literature in various databases (PubMed, Scopus-Embase, Web of Science), proposing local chemotherapy as a treatment for cutaneous and oral SCC. Exclusion criteria included ocular lesions (where topical treatments are common), non-English language, and non-human studies. Results: We included 14 studies in this review. The majority were case reports and case series describing the treatment of non-resectable localized SCC with either imiquimod or 5-fluorouracil. We also analyzed small studies proposing combination treatments. Almost all studies reported an excellent clinical outcome, with a low risk of relapses in time. Conclusions: Resection of the lesion remains the gold-standard treatment for SCC. When this approach is not feasible, local chemotherapy may represent a treatment alternative, and it may also be associated with radiotherapy or systemic chemotherapy.

scholarly journals Squamous cell carcinoma of the breast as a clinical diagnostic challenge

2018 ◽  
Author(s):  
Katarzyna Jakubowska ◽  
Luiza Kańczuga‑Koda ◽  
Wojciech Kisielewski ◽  
Mariusz Koda ◽  
Waldemar Famulski
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Diagnostic Challenge ◽  
Carcinoma Of The Breast ◽  
Clinical Diagnostic

scholarly journals Pinnal squamous cell carcinoma in cats and the effectiveness of treatment with radical pinnectomy

2012 ◽  
Vol 57 (No. 8) ◽  
pp. 420-429 ◽  
Author(s):  
A. Demirutku ◽  
K. Ozer ◽  
Y. Devecioglu ◽  
Z. Mutlu ◽  
O. Duzgun ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Veterinary Medicine ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Postoperative Period ◽  
Blood Analysis ◽  
Histopathological Analysis ◽  
Operative Techniques ◽  
Carcinoma Lesion ◽  
Biochemical Blood Analysis

  The aim of this study was to observe the effectiveness of treatment with radical pinnectomy and investigate postoperative relapse cases in pinnal squamous cell carcinoma in cats. Twelve cats which were brought to surgery clinic of Istanbul University, Faculty of Veterinary Medicine were used. Biopsies were taken from the cases in which squamous cell carcinoma was suspected following anamnesis and the clinical examination of patients that were brought to our clinic. The patients were diagnosed on the basis of histopathological analysis of biopsy samples. Haemogram and biochemical blood analysis were performed and thoracic radiographs were taken as routine in cases that a decision was made to operate. After the area was prepared for operation radical pinnectomy or total external acoustic canal ablation along with radical pinnectomy were performed in the patients that were eligible for operation. Relapses seen in the postoperative period were re-operated with the techniques selected according to invasion status. Periodic controls of the patients were made after the operations and the cats were examined for relapse. In seven out of 12 cases, only squamous cell carcinoma; in three cases, actinic dermatitis actinic dermatitis in addition to squamous cell carcinoma, and in two cases, only actinic dermatitis lesions were detected. In the postoperative period, relapse was observed in the cases in which the squamous cell carcinoma lesion reached the lower half of the pinna or the external acoustic canal while relapse was not observed in cases with actinic dermatitis lesions or when the squamous cell carcinoma lesion was on the top part of the pinna. Relapse cases were re-operated using different operative techniques. It is concluded that performing radical pinnectomy on actinic dermatitis lesions detected on the pinna before development into squamous cell carcinoma, and removing the tumour according to its localization with radical pinnectomy or total external acoustic canal ablation alongside radical pinnectomy is the most reliable treatment option in terms of relapse in cases of pinnal squamous cell carcinoma.  

scholarly journals Two different clinical forms of squamous cell carcinoma (SCC) in the perineum and vulva of two mares

2020 ◽  
Vol 16 (1) ◽  
Author(s):  
Andrzej Raś ◽  
Iwona Otrocka-Domagała ◽  
Małgorzata Raś-Noryńska
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Ultrasound Examination ◽  
Histopathological Examination ◽  
Reproductive Organs ◽  
Malignant Neoplasms ◽  
Surgical Removal ◽  
Chemotherapy Treatment ◽  
Case Presentation

Abstract Background Genital malignant neoplasms in mares are relatively rare. The treatment involve surgical removal of the tumour masses, chemotherapy or both. Case presentation Two elderly warmblood mares, aged 16 and 20 were presented in University Clinic with the lumpy lesions at the region of perineum and left labia. Surgical removals of tumour masses were performed on standing animals. Removed tissues were subjected to histopathological examination which confirmed SCC. Conclusions Clinical and ultrasound examination of reproductive organs in both mares showed no inflammatory or neoplastic changes. Both mares healed within 2 weeks after surgery and showed no signs of tumour recurrence for the following year despite no chemotherapy treatment.

scholarly journals A surgical approach to squamous cell carcinoma of penis that also resolved the psychological dysfunction of the patient

2020 ◽  
Vol 92 (1) ◽  
pp. 58-60
Author(s):  
Napoleon Moulavasilis ◽  
Konstantina Yiannopoulou ◽  
Marios Frangoulis ◽  
Ioannis Katafigiotis ◽  
Georgios Liapis ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Histopathological Analysis ◽  
Depression And Anxiety ◽  
Subjective Memory ◽  
Memory Decline ◽  
Psychological Dysfunction ◽  
Poorly Differentiated

In this case study, we present an unusual case with squamous cell carcinoma surrounding the penis involving foreskin and glans of penis. In addition, multiple satellite nodules were noted in the pubis. A 57-year-old circumcised heterosexual male patient presented with a penile lesion existing for 10 years. At the same time, he was referred to an outpatient memory clinic because of persistent subjective memory complaints associated with depression and anxiety. The patient was operated under general anaesthesia. The lesion was resected circumferentially with macroscopic clearance, resulting in complete degloving of the penile shaft. Neurovascular bundles were preserved. Histopathological analysis of the lesion revealed an invasive and poorly differentiated squamous cell carcinoma, and the surgical margins were free from tumour. The patient was followed for 18 months. He did not have voiding difficulty. Pelvic tomographic and physical examination findings did not reveal any episode of recurrence or metastasis. Treatment of carcinoma resulted in a simultaneous full recovery of his memory decline and he remained free of depression and anxiety symptoms over time.

Invasive squamous cell carcinoma originating from a giant penile condyloma

2016 ◽  
Vol 28 (6) ◽  
pp. 619-622 ◽  
Author(s):  
Emin Sir ◽  
Melike Gungor ◽  
Oktay Ucer ◽  
Tulu Kebat
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Condyloma Acuminata ◽  
Split Thickness Skin Graft ◽  
Histopathological Analysis ◽  
Invasive Squamous Cell Carcinoma ◽  
Giant Condyloma ◽  
First Case ◽  
Giant Condyloma Acuminata

In this case study, we present an unusual case with squamous cell carcinoma originating from a giant condyloma acuminata completely surrounding the penis. A 57-year-old circumcised heterosexual male patient presented with a penile lesion existing for 20 years. Incisional biopsy revealed acanthosis of the squamous epithelium. The patient was operated on under spinal anaesthesia. The lesion was resected circumferentially with macroscopic clearance, resulting in complete degloving of the penile shaft. Neurovascular bundles were preserved. The penile skin was constructed with a split thickness skin graft. Histopathological analysis of the lesion revealed an invasive and well-differentiated squamous cell carcinoma arising on a condyloma, and the surgical margins were free from tumour. The patient was staged as G2 T1 N0 M0 and was followed for one year. He did not have any erectile dysfunction and could engage in intercourse. Pelvic tomographic and physical examination findings did not reveal any episode of recurrence or metastasis. When encountering patients with giant condyloma acuminata, it should not be forgotten that it may be accompanied by squamous cell carcinoma. In addition, tissue excision should be as extensive as possible while keeping in mind the importance of the function. This is the first case of a penile-degloving surgery for giant penile condyloma, supporting conservative and preserving penile surgery for such tumours.

Squamous Cell Carcinoma of the Penis with Pulmonary Metastasis and Paraneoplastic Hypertrophic Osteopathy in a Dog

2017 ◽  
Vol 53 (5) ◽  
pp. 277-280
Author(s):  
Victoria Jenkins ◽  
Carlos Henrique de Mello Souza ◽  
Louis-Phillippe de Lorimier ◽  
Evandro de Toledo-Piza
Keyword(s):  
Squamous Cell Carcinoma ◽  
Case Report ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Complete Resolution ◽  
Poor Prognosis ◽  
Palliative Treatment ◽  
Clinical Signs ◽  
Incisional Biopsy ◽  
Intact Male

ABSTRACT Squamous cell carcinoma of the penis was diagnosed by incisional biopsy of a penile mass in a 12 yr old intact male beagle dog presenting with hemorrhagic discharge from the prepuce. Penile amputation, orchiectomy with scrotal ablation, and scrotal urethrostomy were performed. Hypertrophic osteopathy secondary to pulmonary metastatic disease occurred 10 mo after the surgery. Palliative treatment with piroxicam was administered and led to complete resolution of the clinical signs of the pain. Sixteen months following surgery, the dog presented with significant dyspnea and anorexia and was euthanized due to poor prognosis. This case report describes a rare penile tumor, squamous cell carcinoma. Consequent paraneoplastic hypertrophic osteopathy and its palliative treatment are also reviewed.

scholarly journals Pyoderma gangrenosum–like ulceration of the lower extremity secondary to sunitinib therapy: a case report

2018 ◽  
Vol 6 ◽  
pp. 2050313X1878304 ◽  
Author(s):  
Mildred Lopez Pineiro ◽  
Eric Willis ◽  
Chen Yao ◽  
Susan Y Chon
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lower Extremity ◽  
Cell Carcinoma ◽  
Pyoderma Gangrenosum ◽  
Squamous Cell ◽  
Kinase Inhibitor ◽  
Wound Care ◽  
Diagnostic Challenge ◽  
Recurrent Squamous Cell Carcinoma ◽  
Grade 3

Sunitinib is a multi-targeted receptor tyrosine kinase inhibitor used for the treatment of multiple different types of malignancies. Serious grade 3–4 adverse events occur in <10% of the patient population and usually improve with dose reduction. One of the more rarely reported side effects of sunitinib therapy is the development of pyoderma gangrenosum–like ulcerations in the lower extremities. These pyoderma gangrenosum–like ulcerations are difficult to treat and distinguish from similar-appearing dermatological diagnoses. We present a patient with refractory lung carcinoma and a past medical history of squamous cell carcinoma of the lower extremity, who developed a non-healing ulceration at the previous site of her skin cancer while undergoing therapy with sunitinib. At the time of the initial evaluation, the ulceration mimicked recurrent squamous cell carcinoma, posing a diagnostic challenge. Histopathological findings showed epidermal hyperplasia, ulceration, and dense acute inflammation. Despite meticulous wound care and treatment of infection, the ulcer only improved with cessation of sunitinib.

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