Brain Natriuretic Peptide for Predicting Contrast-Induced Acute Kidney Injury in Patients with Acute Coronary Syndrome Undergoing Coronary Angiography: A Systematic Review and Meta-Analysis

Objective. To assess the diagnostic value of B-type natriuretic peptide (BNP) or N-terminal pro-B-type natriuretic peptide (NT-proBNP) for contrast-induced acute kidney injury (CI-AKI) in patients with acute coronary syndrome (ACS) undergoing coronary angiography. Background. ACS remains a major cause of death worldwide. Patients with ACS undergoing coronary angiography are more likely to develop CI-AKI, which correlates highly with poor clinical outcomes. Early diagnosis of CI-AKI remains a challenge. Many recent studies have suggested that BNP or NT-proBNP may be a useful biomarker for the early diagnosis of CI-AKI. Methods. We searched databases (PubMed, EMBASE, and Cochrane Library) to identify eligible studies. Two authors independently screened the studies and extracted data. We used the Quality Assessment of Diagnostic Accuracy Studies 2 (QUADAS-2) criteria to assess the methodological quality of the included studies and STATA to perform all statistical analyses. Results. Nine studies including 2832 patients were identified. The pooled sensitivity of 0.73 (95% CI 0.65–0.79), specificity of 0.79 (95% CI 0.70–0.85), and area under the summary receiver operating characteristic curve of 0.81 (95% CI 0.77–0.84) suggested that BNP or NT-proBNP had a good diagnostic value for CI-AKI in patients with ACS undergoing coronary angiography. Conclusions. Our findings suggest that BNP or NT-proBNP may be an effective predictive marker for CI-AKI. However, additional high-quality studies are required to find the optimal cutoff value and the diagnostic value of BNP or NT-proBNP in combination with other biomarkers.

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Fenoldopam for prevention of Acute kidNey injury in patients with aCute coronarY syndrome undergoing coronary angiography and/or percutaneous coronary Intervention — The FANCY trial

IJC Metabolic & Endocrine ◽

10.1016/j.ijcme.2015.05.021 ◽

2015 ◽

Vol 7 ◽

pp. 10

Author(s):

Christian Pristipino ◽

Vincenzo Pasceri ◽

Antonino Granatelli ◽

Giulio Speciale ◽

Adriana Roncella ◽

...

Keyword(s):

Acute Kidney Injury ◽

Percutaneous Coronary Intervention ◽

Acute Coronary Syndrome ◽

Coronary Angiography ◽

Kidney Injury ◽

Coronary Intervention ◽

Coronary Syndrome ◽

Percutaneous Coronary

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TCT-129 Efficacy of Urinary Liver-type Fatty Acid-binding Protein Level for Patients with Acute Kidney Injury Following Coronary Angiography in Acute Coronary Syndrome

Journal of the American College of Cardiology ◽

10.1016/j.jacc.2018.08.1234 ◽

2018 ◽

Vol 72 (13) ◽

pp. B56

Author(s):

Keisuke Kojima ◽

Tadateru Takayama ◽

Nobuhiro Murata ◽

Naotaka Akutsu ◽

Mitsumasa Sudo ◽

...

Keyword(s):

Acute Kidney Injury ◽

Acute Coronary Syndrome ◽

Fatty Acid ◽

Coronary Angiography ◽

Protein Level ◽

Fatty Acid Binding Protein ◽

Kidney Injury ◽

Fatty Acid Binding ◽

Coronary Syndrome ◽

Acid Binding Protein

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Diagnostic and prognostic significance of aberrant miR-652-3p levels in patients with acute decompensated heart failure and acute kidney injury

Journal of International Medical Research ◽

10.1177/0300060520967829 ◽

2020 ◽

Vol 48 (11) ◽

pp. 030006052096782

Author(s):

Jiaolei Liu ◽

Hongmei Zhang ◽

Xin Li ◽

Lin Wang ◽

Huining Yu ◽

...

Keyword(s):

Heart Failure ◽

Acute Kidney Injury ◽

Early Diagnosis ◽

Diagnostic Performance ◽

Acute Decompensated Heart Failure ◽

Characteristic Curve ◽

Prognostic Significance ◽

Kidney Injury ◽

Decompensated Heart Failure ◽

Diagnostic Value

Objective This study aimed to examine a novel microRNA (miR-652-3p) biomarker to improve early diagnosis of acute kidney injury (AKI) in patients with acute decompensated heart failure (ADHF) and to evaluate the survival predictive value of miR-652-3p. Methods We retrospectively analyzed the data of 196 patients with ADHF, including 65 who developed AKI during hospitalization. Neutrophil gelatinase-associated lipocalin (NGAL) levels were measured in serum and urine samples. Real-time quantitative PCR was applied to evaluate miR-652-3p mRNA expression. The diagnostic performance of miR-652-3p was examined using receiver operating characteristic curve analysis. The prognostic value of miR-652-3p was also analyzed. Results Serum and urinary NGAL and miR-652-3p levels were elevated in patients with ADHF and AKI. Serum and urinary miR-652-3p expression had diagnostic value in predicting AKI onset in patients with ADHF, and it had improved diagnostic performance when used with NGAL. Patients with AKI and high miR-652-3p levels had a high failure rate of renal recovery and poor 180-day survival. Conclusion Serum and urinary miR-652-3p may be a candidate biomarker for early diagnosis of AKI in patients with ADHF and for predicting the prognosis of AKI. The combination of NGAL and miR-652-3p may accurately predict AKI onset in ADHF.

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Сontrast-induced acute kidney injury in patients with acute coronary syndrome without ST-segment elevation after diagnostic coronary angiography

Nephrology and Dialysis ◽

10.28996/2618-9801-2021-2-213-218 ◽

2021 ◽

Vol 23 (2) ◽

pp. 213-218

Author(s):

L.V. Mikhailova ◽

◽

D.O. Sheleg ◽

F.G. Yunusova ◽

K.G. Shcherbanev ◽

...

Keyword(s):

Acute Kidney Injury ◽

Acute Coronary Syndrome ◽

Coronary Angiography ◽

Kidney Injury ◽

St Segment Elevation ◽

Coronary Syndrome ◽

St Segment ◽

Diagnostic Coronary Angiography

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Definition of acute kidney injury impacts prevalence and prognosis in ACS patients undergoing coronary angiography

BMC Cardiovascular Disorders ◽

10.1186/s12872-021-01985-9 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Maren Weferling ◽

Christoph Liebetrau ◽

Daniel Kraus ◽

Philipp Zierentz ◽

Beatrice von Jeinsen ◽

...

Keyword(s):

Acute Kidney Injury ◽

Acute Coronary Syndrome ◽

Coronary Angiography ◽

Mortality Risk ◽

Outcome Measure ◽

Kidney Injury ◽

Coronary Syndrome ◽

Strong Risk Factor ◽

All Cause Mortality ◽

Definition Of

Abstract Background Development of acute kidney injury (AKI) in invasively managed patients with acute coronary syndrome (ACS) is associated with a markedly increased mortality risk. Different definitions of AKI are in use, leading to varying prevalence and outcome measurements. The aim of the present study is to analyze an ACS population undergoing coronary angiography for differences in AKI prevalence and outcome using four established AKI definitions. Methods 944 patients (30% female) were enrolled in a prospective registry between 2003 and 2005 with 6-month all-cause mortality as outcome measure. Four established AKI definitions were used: an increase in serum creatinine (sCR) ≥ 1.5 fold, ≥ 0.3 mg/dl, and ≥ 0.5 mg/dl and a decrease in eGFR > 25% from baseline (AKIN 1, AKIN 2, CIN, and RIFLE definition groups, respectively). Results AKI rates varied widely between the different groups. Using the CIN definition, AKI frequency was lowest (4.4%), whereas it was highest if the RIFLE definition was applied (13.2%). AKIN 2 displayed a twofold higher AKI prevalence compared with AKIN 1 (10.2% vs. 5.3% (p < 0.001)). AKI was a strong risk factor for mid-term mortality, with distinctive variability between the definitions. The lowest mortality risk was found in the RIFLE group (HR 6.0; 95% CI 3.7–10.0; p < 0.001), whereas CIN revealed the highest risk (HR 16.7; 95% CI 9.9–28.1; p < 0.001). Conclusion Prevalence and outcome in ACS patients varied considerably depending on the AKI definition applied. To define patients with highest renal function-associated mortality risk, use of the CIN definition seems to have the highest prognostic relevance.

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