scholarly journals Role of Gender and Physical Activity Level on Cardiovascular Risk Factors and Biomarkers of Oxidative Stress in the Elderly

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Antoine Raberin ◽  
Philippe Connes ◽  
Jean-Claude Barthélémy ◽  
Pia Robert ◽  
Sébastien Celle ◽  
...  

Background. Cardiovascular diseases remain as the leading cause of morbidity and mortality in industrialized countries. Ageing and gender strongly modulate the risk to develop cardiovascular diseases but very few studies have investigated the impact of gender on cardiovascular diseases in the elderly, which represents a growing population. The purpose of this study was to test the impact of gender and physical activity level on several biochemical and clinical markers of cardiovascular risk in elderly individuals. Methods. Elderly individuals (318 women (75.8±1.2 years-old) and 227 men (75.8±1.1 years-old)) were recruited. Physical activity was measured by a questionnaire. Metabolic syndrome was defined using the National Cholesterol Education Program Expert Panel’s definition. Polysomnography and digital tonometry were used to detect obstructive sleep apnea and assess vascular reactivity, respectively. Blood was sampled to measure several oxidative stress markers and adhesion molecules. Results. The frequency of cardiovascular diseases was significantly higher in men (16.4%) than in women (6.1%) (p<0.001). Body mass index (25.0±4.3 vs. 25.8±3.13 kg.m−2) and glycaemia (94.9±16.5 vs. 101.5±22.6 mg.dL−1) were lower, and High Density Lipoprotein (HDL) (74.6±17.8 vs. 65.0±17.2 mg.dL−1) was higher in women compared to men (p<0.05). Oxidative stress was lower in women than in men (uric acid: 52.05±13.78 vs. 59.84±13.58, advanced oxidation protein products: 223±94 vs. 246±101 μmol.L−1, malondialdehyde: 22.44±6.81 vs. 23.88±9.74 nmol.L−1). Physical activity was not associated with lower cardiovascular risk factors in both genders. Multivariate analyses showed an independent effect of gender on acid uric (β=0.182; p=0.020), advanced oxidation protein products (β=0.257; p<0.001), and HDL concentration (β=−0.182; p=0.026). Conclusion. These findings suggest that biochemical cardiovascular risk factors are lower in women than men which could explain the lower cardiovascular disease proportion observed in women in the elderly.

Author(s):  
Lorena Ciumărnean ◽  
Mircea Vasile Milaciu ◽  
Vasile Negrean ◽  
Olga Hilda Orășan ◽  
Stefan Cristian Vesa ◽  
...  

Cardiovascular diseases create an important burden on the public health systems, especially in the elderly, mostly because this group of patients frequently suffer from multiple comorbidities. Accumulating cardiovascular risk factors during their lifetime has a detrimental effect on an older adult‘s health status. The modifiable and non-modifiable cardiovascular risk factors are very diverse, and are frequently in a close relationship with the metabolic comorbidities of the elderly, mainly obesity and Diabetes Mellitus. In this review, we aim to present the most important cardiovascular risk factors which link aging and cardiovascular diseases, starting from the pathophysiological links between these factors and the aging process. Next, we will further review the main interconnections between obesity and Diabetes Mellitus and cardiovascular diseases of the elderly. Lastly, we consider the most important aspects related to prevention through lifestyle changes and physical activity on the occurrence of cardiovascular diseases in the elderly.


2020 ◽  
Vol 8 (2) ◽  
Author(s):  
Febriani Fajar Ekawati ◽  
Tri Winarti Rahayu ◽  
Hendrig Joko Prasetyo

Noncommunicable Diseases (NCDs) merupakan salah satu penyebab kematian utama di dunia. Kurangnya aktivitas fisik dapat meningkatkan risiko penyakit ini. Meskipun telah banyak penelitian yang menyelidiki tentang hubungan aktivitas fisik dan faktor risiko penyakit kardiovaskuler, hanya terdapat beberapa penelitian di Indonesia yang menelaah tentang peran aktivitas fisik dalam perkembangan penyakit kardiovaskuler. Penelitian ini bertujuan untuk mendeskripsikan tentang tingkat aktivitas fisik dan menyelidiki hubungannya dengan faktor risiko penyakit kardiovaskuler pada karyawan kantor di lingkungan Universitas Sebelas Maret (UNS). Penelitian ini menggunakan desain penelitian potong lintang, dengan jumlah sampel sebanyak 44 orang. Data level aktivitas fisik diperoleh dari International Physical Activity Questionnaire (IPAQ). Sedangkan faktor-faktor risiko penyakit kardiovaskuler (gula darah, kolesterol, tekanan darah, lingkar pinggang, dan IMT) diukur dengan menggunakan alat ukur yang sesuai. Hasil penelitian menunjukkan bahwa level aktivitas fisik karyawan berkategori Rendah sebesar 6.82%, Sedang sebesar 72.73%, dan Tinggi sebesar 20.45%. Berdasarkan uji Pearson Correlation, tekanan darah baik sistolik dan diastolik mempunyai hubungan yang signifikan dengan level aktivitas fisik. Tidak ada hubungan yang signifikan antara level aktivitas fisik dengan faktor risiko lainnya dalam penelitian ini. Secara umum penelitian ini menunjukkan bahwa level aktivitas fisik karyawan di lingkungan UNS adalah berkategori sedang, dan tekanan darah mempunyai hubungan yang signifikan dengan aktivitas fisik. Physical activity level and cardiovascular risk factors among university employees AbstractNoncommunicable Diseases (NCDs) are one of the leading deaths in the world. Insufficiency of physical activity (PA) escalate the risk of NCDs. Although the reports of the studies investigating the relationship between PA and cardiovascular risk factors are abundance, only a few studies in Indonesia examined the role of PA in the development of cardiovascular diseases. The aim of this study was to describe the level of PA and investigate the relationships between PA and cardiovascular risk factors among UNS employees. This was a cross sectional study with a sample of 44 university employees. PA level was assessed using IPAQ. Meanwhile cardiovascular risk factors such as plasma glucose, cholesterol, blood pressure, waist circumference, and BMI were measured using an appropriate tool for each measure. The results revealed that participants with low level of PA (6.82%), moderate category (72.73%), and high category (20.45%). Pearson Correlation analysis showed blood pressure both systolic and diastolic had a significant association with PA level. There was no a significant association between PA level and others cardiovascular risk factors in this research. Generally, this study exhibited the level of PA among UNS employees in the moderate category, and blood pressure had a significant association with PA.


2018 ◽  
Vol 2018 ◽  
pp. 1-11 ◽  
Author(s):  
Agata Stanek ◽  
Armand Cholewka ◽  
Tomasz Wielkoszyński ◽  
Ewa Romuk ◽  
Aleksander Sieroń

Objective. The aim of the study was to estimate the impact of whole-body cryotherapy (WBC) on cardiovascular risk factors in patients with ankylosing spondylitis (AS). Material and Methods. We investigated the effect of WBC with subsequent kinesiotherapy on markers of inflammation, oxidative stress, lipid profile, and atherosclerosis plaque in male AS patients (WBC group). To assess the disease activity, the BASDAI and BASFI were also calculated. The results from the WBC group were compared with results from the kinesiotherapy (KT) group. Results. The results showed that in the WBC group, the plasma hsCRP level decreased without change to the IL-6 level. The ICAM-1 level showed a decreasing tendency. The CER concentration, as well as the BASDAI and BASFI, decreased in both groups, but the index changes of disease activity were higher in the WBC than KT patients. Additionally, in the WBC group, we observed a decrease in oxidative stress markers, changes in the activity of some antioxidant enzymes and nonenzymatic antioxidant parameters. In both groups, the total cholesterol and LDL cholesterol, triglycerides, sCD40L, PAPP-A, and PLGF levels decreased, but the parameter changes were higher in the WBC group. Conclusion. WBC appears to be a useful method of atherosclerosis prevention in AS patients.


2022 ◽  
Vol 22 (1) ◽  
Author(s):  
Zsolt Bagyura ◽  
Angéla Takács ◽  
Loretta Kiss ◽  
Edit Dósa ◽  
Réka Vadas ◽  
...  

Abstract Background Oxidative stress is an important factor in the pathomechanism of atherosclerosis. Advanced oxidation protein products (AOPPs) are considered markers of oxidative stress. Thickening of the carotid intima-media layers indicates subclinical atherosclerosis and can be detected by carotid ultrasound. Objective Our aim was to examine the association between carotid intima-media thickness (CIMT) and the level of AOPPs. Methods Carotid duplex scans and measurements of AOPPs were performed on 476 participants of a cardiovascular population study. The presence of conventional cardiovascular risk factors was investigated with a questionnaire, physical examination, and laboratory tests. Results There was a positive correlation between maximum CIMT and the level of AOPPs only in the male population (r = 0.219, p = 0.033). Multivariate analysis has revealed that the association between AOPPs and mean or maximum CIMT was independent of cardiovascular risk factors (OR = 1.458, p = 0.004, and OR = 2.038, p < 0.001). Conclusions Among males, the elevated level of AOPPs as a marker of oxidative stress may signal the existence of early atherosclerotic alterations.


2018 ◽  
Vol 12 (1) ◽  
pp. 1-8
Author(s):  
Zuraini Zulkepli ◽  
Nur Zakiah Moh ◽  
Nor Farah Moha ◽  
Siti Aishah Han ◽  
Noraziah Md. Zin

2014 ◽  
Vol 54 (4) ◽  
pp. 265-273 ◽  
Author(s):  
Venla Lohi ◽  
Samuli Hannula ◽  
Pasi Ohtonen ◽  
Martti Sorri ◽  
Elina Mäki-Torkko

2011 ◽  
Vol 5 (10) ◽  
pp. 2374
Author(s):  
Adriana Arruda Barbosa ◽  
Giselle Pinheiro Lima Aires Gomes ◽  
Ivandra Mari Roieski ◽  
Elizângela Sofia Ribeiro Rodrigues ◽  
Sávia Denise Silva Carlotto Herrera

ABSTRACTObjective: to verify the prevalence of cardiovascular risk factors in hypertensive military police officers. Method: this is a transversal, descriptive, and exploratory research, approved by the Research Ethics Committee of Centro Universitario Unirg under the Protocol 0142/2010, in which the 22 military police officers identified as hypertensive subjects underwent the assessment of vital signs and anthropometric measurements. After this, they answered to the questionnaires on physical activity level, smoking habit, pattern of alcohol intake, inventory of stress symptoms, and dietary interview. The data underwent a statistical analysis using the chi-square test with Yates' correction. Results: with regard to the body mass index (BMI), only 5% were normal. In the waist/hip ratio (WHR), it was found that 36.36% presented cardiac risk factors. In the physical activity level, 22.73% were sedentary, and 36.36% were insufficiently active. Considering the smoking habit, only 9.09% were smokers. In the pattern of alcohol intake, 4.55% fit into the zone III and 9.09% fit into the zone IV. Through the stress questionnaire it was found that 54.55% did not fit into any phase. In the feeding pattern assessment, 40.91% had the adequate number of daily meals and only 18.18% consumed adequate amounts of macronutrients. Conclusion: the cardiovascular risk factors evaluated, such as WHR, smoking habit, stress, and alcohol intake, presented a low prevalence among military police officers, however, with regard to BMI, those evaluated were mostly classified as subjects with overweight or obesity, insufficiently active or sedentary, and with a reduced number of daily meals. Descriptors: hypertension; cardiovascular diseases; prevalence.RESUMOObjetivo: verificar a prevalência dos fatores de risco cardiovasculares em policiais militares hipertensos. Método: trata-se de pesquisa transversal, descritiva e exploratória, aprovada pelo Comitê de Ética em Pesquisa do Centro Universitário Unirg sob o Protocolo n. 0142/2010, na qual os 22 policiais militares identificados como hipertensos foram submetidos à aferição dos sinais vitais e das medidas antropométricas. Após isso, responderam aos questionários sobre nível de atividade física, hábito tabagístico, padrão do uso do álcool, inventário de sintomas de stress e inquérito dietético. Os dados foram submetidos à análise estatística utilizando o teste de Qui-quadrado com correção de Yates. Resultados: em se tratando do índice de massa corpórea (IMC), apenas 5% encontrava-se dentro da normalidade. Na relação cintura-quadril (RCQ), constatou-se que 36,36% apresentavam fatores de risco cardíaco. No nível de atividade física, 22,73% eram sedentários e 36,36% insuficientemente ativos. Sobre hábito tabagístico, apenas 9,09% eram fumantes. No padrão do uso de álcool, 4,55% encontravam-se na zona III e 9,09% na zona IV. Por meio do questionário de estresse constatou-se 54,55% não estavam em nenhuma fase. Na avaliação do hábito alimentar, 40,91% faziam o número adequado de refeições diárias e apenas 18,18% alimentavam-se com quantidades adequadas de macronutrientes. Conclusão: os fatores de riscos cardiovasculares avaliados, como RCQ, hábito tabagístico, estresse e ingestão de álcool, apresentaram baixa prevalência nos policiais militares, porém, em relação ao IMC, os avaliados foram classificados, em sua maioria, com sobrepeso ou obesidade, insuficientemente ativos ou sedentários e com número reduzido de refeições diárias. Descritores: hipertensão; doenças cardiovasculares; prevalência.RESUMEN Objetivo: verificar la prevalencia de los factores de riesgo cardiovasculares en policías militares hipertensos. Método: esta investigación fue transversal, descriptiva y exploratoria y aprobado por el  Comité de Ética en Investigación del Centro Universitario Unirg bajo Protocolo nº 0142/2010, en el que 22 policías militares identificados como hipertensos se sometieron al contraste de signos vitales y a medidas antropométricas. Tras ello, respondieron a los cuestionarios sobre nivel de actividad física, hábitos tabaquistas, estándar de empleo de alcohol, inventario de síntomas de estrés y hábitos dietéticos. Los datos se sometieron a un análisis estadístico empleando el test de qui-cuadrado con corrección de Yates. Resultados: tratándose del índice de masa corporal (IMC), apenas el 5% se encontraba dentro de la normalidad. En la relación cintura-caderas (RCC), se constató que el 36,36% presentaban riesgo cardíaco. En el nivel de actividad física, el 22,73% eran sedentarios y el 36,36% insuficientemente activos. Sobre hábitos tabaquistas, apenas el 9,09% eran fumadores. En el estándar de consumo de alcohol, el 4,55% se encontraba en la zona III y el 9,09% en la zona IV. Por medio de cuestionario de estrés se constató que un 54,4% no estaba en ninguna fase. En la evaluación de hábitos alimenticios, el 40,91% efectuaba el número adecuado de comidas diarias y apenas el 18,18% se alimentaba con cantidades adecuadas de macro-nutrientes. Conclusión: los factores de riesgo cardiovasculares evaluados, como RCC, hábitos tabaquistas, estrés e consumo de alcohol, estos presentaron baja prevalencia en los policías militares, aunque en relación al IMC, los evaluados se clasificaron, en su mayoría, con sobrepeso y obesidad, insuficientemente activos o sedentarios y con número reducido de comidas diarias. Descriptores: hipertensión; enfermedades cardiovasculares; prevalencia.


Author(s):  
Priscila Cristina dos Santos ◽  
Luiz Rodrigo Augustemak de Lima ◽  
Bruno Gonçalves Galdino da Costa ◽  
Cilene Rebolho Martins ◽  
Giseli Minatto ◽  
...  

Abstract The association of moderate to vigorous physical activity and sedentary behavior performed in the school context with cardiovascular risk factors is unclear. Thus, the purpose of this study was to evaluate whether MVPA and SB during school time are associated with single and clustered cardiovascular risk factors in 10- to 16-year-old school students. This study used the baseline data from a non-randomized controlled clinical trial (“MEXA-SE”) conducted on 6th to 9th-grade students from schools in Florianopolis, Brazil. Skinfolds, resting blood pressure, 20-m shuttle-run test, fasting glucose, triglycerides, total cholesterol, high-density lipoprotein cholesterol, and white blood cell counts were obtained. MVPA and SB were objectively measured with accelerometers. A minimum of 180 minutes was considered valid school-time for analysis. Multiple linear regression adjusted for age, sex and habitual physical activity was used. School-time MVPA was positively associated with the peak VO2 (β = 0.17 ml.kg.min-1), and inversely associated with sum of four skinfolds (β = -0.96 mm), diastolic blood pressure (β = -0.36 mmHg), systolic blood pressure (β = -0.301 mmHg); triglycerides (β = -1.49 mg.dL-1), and clustered cardiovascular risk factors (β = -0.123). School-time SB was positively associated with clustered cardiovascular risk factors (β = 0.033). In conclusion, independently of habitual physical activity level, school-time MVPA and a lower time in SB were associated to single and clustered cardiovascular risk factors. Thus, the promotion of strategies aimed increase MVPA and reduce SB at school may prevent the onset and early accumulation of cardiovascular risk factors in adolescence.


Sign in / Sign up

Export Citation Format

Share Document