scholarly journals Application of Acellular Tissue Matrix for Enhancement of Weak Abdominal Wall in Animal Model

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Minggang Wang ◽  
Shuo Yang ◽  
Zhen Cao ◽  
Sanyuan Hu
Keyword(s):  
Animal Model ◽  
Tensile Stress ◽  
Abdominal Wall ◽  
Polypropylene Mesh ◽  
Tensile Strain ◽  
Acellular Tissue ◽  
Motor Nerves ◽  
Abdominal Wall Muscle ◽  
Left And Right ◽  
Tissue Matrix

Background. Abdominal wall weakness occurs when the strength of muscle decreases due to physiological reason or iatrogenic injury. However, the treatment of this disease is complicated. Aim. To study the therapeutic effect of acellular tissue matrix (ACTM), compared with the polypropylene mesh. Methods. An abdominal wall weakness model was established in rabbits through motor nerves cutting. The polypropylene mesh and ACTM were implanted in the left and right abdomen sides, respectively. Mechanical testing of abdominal wall muscle and histology and scanning electron microscopy (SEM) evaluation of abdominal tissue explants were performed. Results. In animal model establishment, the abdominal length of healthy and weakened abdominal wall was 17.0 ± 0.7 cm and 19.0 ± 1.2 cm, respectively (P=0.022), and the weak abdominal wall group showed a significant decrease of 1.116 ± 0.221 MPa in tensile stress (P<0.001) and 9.126 ± 2.073% in tensile strain (P<0.001). In materials implantation experiment, compared with polypropylene group, ACTM group decreased 2.409 ± 0.806 MPa after 24 weeks (P<0.001) and 2.319 ± 0.486 MPa after 48 weeks (P<0.001) in tensile stress and increased 15.259% after 24 weeks (P<0.001) and 15.845% after 48 weeks (P<0.001) remarkably in tensile strain. Conclusion. The abdominal wall weakness model in rabbits was successfully established. ACTM is a promising biological material to be possibly further applied in clinical surgery in patients with abdominal wall weakness.

scholarly journals The optical analysis of the abdominal wall using the biospeckle after implants of polypropylene mesh in rats

2009 ◽  
Vol 24 (6) ◽  
pp. 442-448
Author(s):  
Tâmara Maria Nieri ◽  
Marco Antonio de Oliveira Peres ◽  
Emerson Rodrigo da Silva ◽  
Inácio Maria Dal Fabbro ◽  
Mikiya Muramatsu ◽  
...  
Keyword(s):  
Animal Model ◽  
Abdominal Wall ◽  
Polypropylene Mesh ◽  
Male Rats ◽  
Mesh Placement ◽  
Group 4 ◽  
Mesh Prosthesis ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

PURPOSE: To evaluate an experimental animal model to study the abdominal tissue activity considering its interaction with a polypropylene mesh, through the use of one of the optical phenomena of light Laser, the biospeckle. METHODS: Fifty Wistar male rats were divided into four groups: Group 1: ten animals not submitted to surgery; Group 2: ten animals submitted to surgery without polypropylene mesh; Group 3: 20 animals submitted to surgery followed by the mesh placement; Group 4: (sham) with ten animals. None of the animals presented post surgical complications being submitted to the optical tests at the 20th postoperative day. RESULTS: The analysis from the biospeckle tests, comparing the medians and standard deviations with T Student test, indicated that no significative difference was observed on the abdominal wall tissue activity in the four groups considered, with and without polypropylene mesh prosthesis implantation. CONCLUSION: The animal model is viable and the biospeckle open ways for a great number of experiments to be developed in evaluating tissue activity.

Stress-strain properties of aponeurotic suture in anterior abdominal wall after a midline laparotomy

2021 ◽  
Vol 2 (1) ◽  
Author(s):  
Sergey Vertyankin ◽  
Yana Vanzha ◽  
Rodion Mayorov ◽  
Izabella Turlykova ◽  
Anastasia Golyadkina ◽  
...  
Keyword(s):  
Tensile Stress ◽  
Abdominal Wall ◽  
Tensile Strain ◽  
Method Development ◽  
Anterior Abdominal Wall ◽  
Maximum Load ◽  
Stress Strain ◽  
Midline Laparotomy ◽  
Group 2 ◽  
Ventral Hernias

Objective: method development for preventing postoperative ventral hernias based on experimental assessment of the stress-strain properties of aponeurosis in various types of a midline laparotomy. Materials and methods. We evaluated 42 fascia muscular aponeurotic complexes of the anterior abdominal wall. Based on the technique for dissecting the aponeurosis and its suturing, the complexes were divided into two groups (each containing 21 samples): Group 1 with a bypass of the umbilical ring on the left, and Group 2 with umbilical ring dissection. Results. Fascia aponeurotic complexes dissected and sutured through the umbilical ring (Group 2) had, on the average, higher values of mechanical characteristics. E.g., mean values of tensile stress (S), tensile stress at a maximum load (Smax), Young’s modulus (E), aponeurotic tensile strain (D), aponeurotic tensile strain at a maximum load (Dmax), and maximum load level (Load) were higher in Group 2 by 35.4; 39.8; 14.9; 34.6; 30.2 and 40.2 (%), respectively. Conclusion. We conducted the development, experimental application and evaluation of a novel method for preventing postoperative ventral hernias after a midline laparotomy based on the assessment of the stress-strain properties of aponeurosis.

scholarly journals Ureteral reconstruction with abdominal wall muscle flap: experimental study in rabbits

2014 ◽  
Vol 41 (6) ◽  
pp. 455-456
Author(s):  
Nelson Alfred Smith ◽  
Paulo Cesar Silva ◽  
Manoel Luiz Ferreira ◽  
Alberto Schanaider
Keyword(s):  
Experimental Study ◽  
Surgical Technique ◽  
Abdominal Wall ◽  
Muscle Flap ◽  
Experimental Development ◽  
Preliminary Results ◽  
Ureteral Reconstruction ◽  
Abdominal Wall Muscle ◽  
Tubular Shape

The authors detail the experimental development of a technique for the reconstruction of the ureter using a tubular shape, muscle flap of the abdominal wall. the preliminary results indicate the feasibility of this surgical technique.

scholarly journals Evaluation of peritoneal adhesions formation and tissue response to polypropylene - poli (2-hydroxyethyl methacrylate)-(polyHEMA) implant on rats' abdominal wall

2010 ◽  
Vol 25 (4) ◽  
pp. 337-341 ◽  
Author(s):  
Neusa Margarida Paulo ◽  
Sonia Maria Malmonge ◽  
Liliana Borges de Menezes ◽  
Flávia Gontijo de Lima ◽  
Aline de Moraes Faria ◽  
...  
Keyword(s):  
Abdominal Wall ◽  
Polypropylene Mesh ◽  
Histopathological Examination ◽  
Adhesion Formation ◽  
Foreign Body Response ◽  
Tissue Response ◽  
Female Rats ◽  
Hydroxyethyl Methacrylate ◽  
Peritoneal Adhesions ◽  
Body Response

PURPOSE: To verify if the composit poli (2-hydroxyethyl methacrylate)-PolyHEMA/polypropylene mesh implanted in the female rat's abdominal wall could be suitable for the prevention of peritoneal adhesions, and for the evaluation of the tecidual response produced by this biomaterial. METHODS: Polypropylene meshes (Group PP, n=20) and polypropylene meshes coated with a layer of poli (2-hydroxyethyl methacrylate)-PolyHEMA (Group PH, n=20) were implanted on the abdominal wall of Wistar female rats. Ten animals from each group were submitted to euthanasia at 15 and 30 days of the postoperative period. RESULTS: The animals from the group PP presented visceral adhesions on the mesh surface, which was not observed in the ones from group PH. At the histopathological examination foreign body response was observed in both groups, whilst there was a greater intensity of inflammatory response in group PH on both moments. CONCLUSION: The poli (2-hydroxyethyl methacrylate) polyHEMA hydrogel associated to polypropylene mesh reduces visceral adhesion formation in rats, although it may be associated to greater inflammatory reaction.

Stress Analysis and Microstructure Evolution of Titanium Alloy Pipe during Flattening Processing

2019 ◽  
Vol 944 ◽  
pp. 1088-1093
Author(s):  
Jun Chen ◽  
She Wei Xin ◽  
Wei Zhou ◽  
Qian Li ◽  
Si Yuan Zhang ◽  
...  
Keyword(s):  
Titanium Alloy ◽  
Tensile Stress ◽  
Compressive Stress ◽  
Outer Layer ◽  
Contact Stage ◽  
Straight Wall ◽  
Vertical Part ◽  
Left And Right ◽  
Titanium Alloy Tube ◽  
Flattening Process

TA24 titanium alloy pipe with 638mm diameter and 19mm wall thickness is carried out continuous load flatten test, and the stress of internal and external pipe wall during flatten process is studied in this paper. The results show that the TA24 titanium alloy tube has good flattening performance, and the flattening process has experienced original stage, flattened oblate stage, flattened straight wall stage, flattened depressed stage, flattened concave contact stage. During the flattening process, the outer layer of the upper and lower wall of the tube is subjected to compressive stress, and the inner layer material is subjected to tensile stress. The tensile and compressive forces cause the vertical part of the upper and lower walls to be concave. The outer layer of the left and right circular arc parts is subjected to tensile stress and the inner layer is subjected to tensile stress. The compressive stress also causes the radius of the arc to decrease due to the combined force of the tensile and compressive forces, that is, the flattening occurs. With the decrease of and pressing distance under continuous loading condition, the metal on the left and right sides of the pipe gathers toward the middle depression, which aggravates the deformation of the upper and lower walls until the upper and lower walls contact, and the arc radius of the left and right walls decreases until the outer surface cracks. The pipe microstructure changes significantly into elongated deformation structure during the flattening process. The most severe part of the deformation is the left and right end arc of the pipe, followed by the upper and lower end depression.

scholarly journals A Case of a Ventral Hernia due to Rupture of the Abdominal Wall Muscle in a Patient with SLE on Long-term Steroid Therapy

2015 ◽  
Vol 76 (3) ◽  
pp. 626-630
Author(s):  
Masahiro FUKADA ◽  
Nobuhisa MATSUHASHI ◽  
Takao TAKAHASHI ◽  
Kazuya YAMAGUCHI ◽  
Shinji OSADA ◽  
...  
Keyword(s):  
Abdominal Wall ◽  
Ventral Hernia ◽  
Steroid Therapy ◽  
Abdominal Wall Muscle

scholarly journals O50 ALTERATIONS IN THE ABDOMINAL WALL MUSCULATURE AFTER ENDOSCOPIC ANTERIOR AND OPEN POSTERIOR COMPONENT SEPARATION

2021 ◽  
Vol 108 (Supplement_8) ◽  
Author(s):  
Erling Oma ◽  
Jan Kim Christensen ◽  
Jorge Daes ◽  
Lars Nannestad Jorgensen
Keyword(s):  
Abdominal Wall ◽  
Case Series ◽  
Muscle Thickness ◽  
Component Separation ◽  
Fascial Closure ◽  
Lateral Abdominal Wall ◽  
Transverse Abdominis ◽  
Abdominal Wall Muscle ◽  
Anterior Component Separation

Abstract Aim Effects of component separation (CS) on abdominal wall musculature have only been investigated in smaller case series. The study aimed to compare abdominal wall alterations following endoscopic anterior component separation (EACS) or transverse abdominis release (TAR). Material and Methods Computed tomography scans were evaluated in patients who underwent open ventral hernia repair with TAR or EACS. Lateral abdominal wall muscle thickness and displacement were compared with preoperative images after bilateral CS and the undivided side postoperatively after unilateral CS. Results In total, 105 patients were included. The mean defect width was 12.2 cm. Fifty-five (52%) and 15 (14%) underwent bilateral and unilateral EACS, respectively. Five (5%) and 14 (13%) underwent bilateral and unilateral TAR, respectively. Sixteen (15%) underwent unilateral EACS and contralateral TAR. Complete fascial closure was achieved in 103 (98%) patients. The external oblique and transverse abdominis muscles were significantly laterally displaced with a mean of 2.74 cm (95% CI 2.29-3.19 cm) and 0.82 cm (0.07-1.57 cm) after EACS and TAR, respectively. The combined thickness of the lateral muscles was significantly decreased after EACS (mean decrease 10.5% [5.8-15.6%]) and insignificantly decreased after TAR (mean decrease 2.6% [-4.8-9.5%]), mean reduction difference EACS versus TAR 0.22 cm (-0.01-0.46 cm). One (1%) patient developed an iatrogenic linea semilunaris hernia after EACS. The recurrence rate was 19% after mean 1.7 years follow-up. Conclusions The divided muscle was significantly more laterally displaced after EACS compared with TAR. The thickness of the lateral muscles was slightly decreased after EACS and unchanged after TAR.

Sign in / Sign up

Export Citation Format

Share Document