scholarly journals Differences in Clinical Characteristics and Brain Activity between Patients with Low- and High-Frequency Tinnitus

2020 ◽  
Vol 2020 ◽  
pp. 1-12
Author(s):  
Jiajia Zhang ◽  
Zhen Zhang ◽  
Shujian Huang ◽  
Huiqun Zhou ◽  
Yanmei Feng ◽  
...  
Keyword(s):  
Hearing Loss ◽  
High Frequency ◽  
Clinical Characteristics ◽  
Brain Activity ◽  
Hearing Threshold ◽  
Posterior Cingulate Cortex ◽  
Angular Gyrus ◽  
Association Cortex ◽  
Band Frequency ◽  
Auditory Association Cortex

This study was aimed at delineating and comparing differences in clinical characteristics and brain activity between patients with low- and high-frequency tinnitus (LFT and HFT, respectively) using high-density electroencephalography (EEG). This study enrolled 3217 patients with subjective tinnitus who were divided into LFT (frequency<4000 Hz) and HFT (≥4000 Hz) groups. Data regarding medical history, Tinnitus Handicap Inventory, tinnitus matching, and hearing threshold were collected from all patients. Twenty tinnitus patients and 20 volunteers were subjected to 256-channel EEG, and neurophysiological differences were evaluated using standardized low-resolution brain electromagnetic tomography (sLORETA) source-localized EEG recordings. Significant differences in sex (p<0.001), age (p=0.022), laterality (p<0.001), intensity (p<0.001), tinnitus type (p<0.001), persistent tinnitus (p=0.04), average threshold (p<0.001), and hearing loss (p=0.028) were observed between LFT and HFT groups. The tinnitus pitch only appeared to be correlated with the threshold of the worst hearing loss in the HFT group. Compared with the controls, the LFT group exhibited increased gamma power (p<0.05), predominantly in the posterior cingulate cortex (PCC, BA31), whereas the HFT group had significantly decreased alpha1 power (p<0.05) in the angular gyrus (BA39) and auditory association cortex (BA22). Higher gamma linear connectivity between right BA39 and right BA41 was observed in the HFT group relative to controls (t=3.637, p=0.027). Significant changes associated with increased gamma in the LFT group and decreased alpha1 in the HFT group indicate that tinnitus pitch is crucial for matching between the tinnitus and control groups. Differences of band frequency energy in brain activity levels may contribute to the clinical characteristics and internal tinnitus “spectrum” differences.

scholarly journals Hearing threshold levels and hearing loss among people in Zhejiang, China: a population-based cross-sectional study

BMJ Open ◽  
2019 ◽  
Vol 9 (4) ◽  
pp. e027152 ◽  
Author(s):  
Dahui Wang ◽  
Huai Zhang ◽  
Haiyan Ma ◽  
Long Zhang ◽  
Lei Yang ◽  
...  
Keyword(s):  
Hearing Loss ◽  
High Frequency ◽  
Age Groups ◽  
Hearing Threshold ◽  
Population Based ◽  
Cross Sectional Study ◽  
Zhejiang Province ◽  
Sectional Study ◽  
Cross Sectional ◽  
High Frequency Hearing Loss

Hearing loss (≥26 dB threshold in the better ear), as a common chronic condition in humans, is increasingly gaining attention. Relevant research in China is relatively scarce, so we conduct a population-based study to investigate the prevalence of hearing loss among age groups, genders and ears in Zhejiang province, China, from September 2016 to June 2018.Study designPopulation-based cross-sectional studyParticipantsA total of 3754 participants aged 18–98 years and living in Zhejiang province, China.Outcome measuresPure-tone audiometric thresholds were measured at frequencies of 0.125–8 kHz for each subject. All participants were asked to complete a structured questionnaire, in the presence of a healthcare official.ResultsThe prevalence of speech-frequency and high-frequency hearing loss was 27.9% and 42.9%, respectively, in Zhejiang. There were significant differences in auditory thresholds at most frequencies among the age groups, genders (male vs female: 31.6%vs24.1% at speech frequency; 48.9% vs 36.8% at high frequency) and ears. In addition to the common factors affecting both types of hearing loss, a significant correlation was found between personal income and speech-frequency hearing loss (OR=0.69, 95% CI 0.52 to 0.92), and between hyperlipidaemia and high-frequency hearing loss (OR=1.45, 95% CI 1.02 to 2.07).ConclusionThe prevalence of hearing loss was high among people living in Zhejiang, particularly males, and in the left ear. Moreover, hearing thresholds increased with age. Several lifestyle and environment factors, which can be influenced by awareness and education, were significantly associated with hearing loss.

scholarly journals Effects of Various Extents of High-Frequency Hearing Loss on Speech Recognition and Gap Detection at Low Frequencies in Patients with Sensorineural Hearing Loss

2017 ◽  
Vol 2017 ◽  
pp. 1-9
Author(s):  
Bei Li ◽  
Yang Guo ◽  
Guang Yang ◽  
Yanmei Feng ◽  
Shankai Yin
Keyword(s):  
Hearing Loss ◽  
Speech Recognition ◽  
Sensorineural Hearing Loss ◽  
High Frequency ◽  
Hearing Threshold ◽  
Sensorineural Hearing ◽  
Gap Detection ◽  
Detection Thresholds ◽  
Low Frequencies ◽  
Compressed Speech

This study explored whether the time-compressed speech perception varied with the degree of hearing loss in high-frequency sensorineural hearing loss (HF SNHL) individuals. 65 HF SNHL individuals with different cutoff frequencies were recruited and further divided into mildly, moderately, and/or severely affected subgroups in terms of the averaged thresholds of all frequencies exhibiting hearing loss. Time-compressed speech recognition scores under both quiet and noisy conditions and gap detection thresholds within low frequencies that had normal thresholds were obtained from all patients and compared with data from 11 age-matched individuals with normal hearing threshold at all frequencies. Correlations of the time-compressed speech recognition scores with the extents of HF SNHL and with the 1 kHz gap detection thresholds were studied across all participants. We found that the time-compressed speech recognition scores were significantly affected by and correlated with the extents of HF SNHL. The time-compressed speech recognition scores also correlated with the 1 kHz gap detection thresholds except when the compression ratio of speech was 0.8 under quiet condition. Above all, the extents of HF SNHL were significantly correlated with the 1 kHz gap thresholds.

scholarly journals Investigation of Tinnitus Patients in Italy: Clinical and Audiological Characteristics

2010 ◽  
Vol 2010 ◽  
pp. 1-8 ◽  
Author(s):  
Francesco Martines ◽  
Daniela Bentivegna ◽  
Fabiola Di Piazza ◽  
Enrico Martines ◽  
Vincenzo Sciacca ◽  
...  
Keyword(s):  
Hearing Loss ◽  
High Frequency ◽  
Pure Tone ◽  
Hearing Threshold ◽  
Related Factors ◽  
High Frequencies ◽  
Tinnitus Severity ◽  
Hearing Status ◽  
Neural Connection ◽  
The Impact

Objective. 312 tinnitus sufferers were studied in order to analyze: the clinical characteristics of tinnitus; the presence of tinnitus-age correlation and tinnitus-hearing loss correlation; the impact of tinnitus on subjects' life and where possible the etiological/predisposing factors of tinnitus.Results. There is a slight predominance of males. The highest percentage of tinnitus results in the decades 61–70. Of the tinnitus sufferers, 197 (63.14%) have a hearing deficit (light hearing loss in 37.18% of cases). The hearing impairment results of sensorineural type in 74.62% and limited to the high frequencies in 58.50%. The tinnitus is referred as unilateral in 59.93%, a pure tone in 66.99% and 10 dB above the hearing threshold in 37.7%. It is limited to high frequencies in 72.10% of the patients with sensorineural hearing loss (SNHL) while the 88.37% of the patients with high-frequency SNHL have a high-pitched tinnitus ( ).Conclusion. Hearing status and age represent the principal tinnitus related factors; there is a statistically significant association between high-pitched tinnitus and high-frequency SNHL. There is no significant correlation between tinnitus severity and tinnitus loudness confirming the possibility that neural connection involved in evoking tinnitus-related negative reactions are governed by conditioned reflexes.

scholarly journals COVID-19-related sudden sensorineural hearing loss

2021 ◽  
Vol 2021 (3) ◽  
Author(s):  
Nada Khaleel Yaseen ◽  
Raid M. Al-Ani ◽  
Rasheed Ali Rashid
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Clinical Characteristics ◽  
Smoking Habit ◽  
Hearing Threshold ◽  
Treatment Protocol ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Unilateral Deafness ◽  
Nose And Throat

Background: Sudden sensorineural hearing loss (SSNHL) can be a feature of COVID-19. It may present alone or with other symptoms of the disease. However, there is little written in the literature about its occurrence. We aimed to evaluate the socio-clinical characteristics and outcome of confirmed mild- to moderate COVID-19 cases with SSNHL in Tikrit city, Iraq. Materials and Methods: This descriptive study was conducted at the Otolaryngology Department, Tikrit General Hospital, Tikrit city, Iraq. The period of the study was from December 1, 2020 to June 30, 2021.Mild and moderate COVID-19 subjects confirmed by real-time polymerase reaction were included in the study. Detailed demographic (age, gender, and smoking habit) and clinical characteristics (onset and duration of deafness, side, severity, associated ear, nose, and throat symptoms, and comorbidity) were recorded for every patient. Outcomes following the steroid treatment protocol were also registered. Results: SSNHL was identified in 26 patients, of whom 20 (76.9%) were women, 20 (76.9%) were in the age group ≥ 30 years, and 21 (80.8%) were non-smokers. Around three-quarters of the subjects were identified within the first week of deafness occurrence. Bilateral (18/26) was more common than unilateral deafness (8/26); therefore, the total number of deaf ears was 44. Besides, bilateral symmetrical deafness (13/18) outnumbered the asymmetrical type (5/18). Around three-quarters were of moderate severity. The most common otological symptom was tinnitus (25/26). The most common nose and throat symptom was anosmia (6/26). The mean hearing threshold before and after treatment with oral steroids ± intratympanic steroids was 50.91 ± 11.777 dB and 40.24 ± 15.693, respectively. One patient with bilateral SSNHL was lost to follow-up; the remaining number of deaf ears was 42, and half of them were partially improved. The outcome of the treatment showed no statistically significant relation with the duration, side, and severity of SSNHL (p>0.05). Conclusion: The majority of COVID-19-related SSNHL cases presented within one week of onset, with bilateral outnumbering unilateral cases. Tinnitus was the most common associated symptom. Treatment with steroids achieved partial improvement in half of the cases, and this outcome was not affected by the duration, side, and severity of deafness.

Noise-Induced Hearing Loss in Professional Orchestral Musicians

2013 ◽  
Vol 38 (2) ◽  
pp. 223-234 ◽  
Author(s):  
Małgorzata Pawlaczyk-Łuszczyńska ◽  
Małgorzata Zamojska ◽  
Adam Dudarewicz ◽  
Kamil Zaborowski
Keyword(s):  
Hearing Loss ◽  
High Frequency ◽  
Noise Exposure ◽  
Hearing Threshold ◽  
Noise Induced Hearing Loss ◽  
Occupational Risk Factors ◽  
Threshold Levels ◽  
Exposed Population ◽  
Orchestral Musicians ◽  
The Impact

Abstract The overall purpose of this study was to assess hearing status in professional orchestral musicians. Standard pure-tone audiometry (PTA) and transient-evoked otoacoustic emissions (TEOAEs) were per- formed in 126 orchestral musicians. Occupational and non-occupational risk factors for noise-induced hearing loss (NIHL) were identified in questionnaire inquiry. Data on sound pressure levels produced by various groups of instruments were also collected and analyzed. Measured hearing threshold levels (HTLs) were compared with the theoretical predictions calculated according to ISO 1999 (1990). Musicians were exposed to excessive sound at weekly noise exposure levels of for 81-100 dB (mean: 86.6±4.0 dB) for 5-48 years (mean: 24.0±10.7 years). Most of them (95%) had hearing corresponds to grade 0 of hearing impairment (mean hearing threshold level at 500, 1000, 2000 and 4000 Hz lower than 25 dB). However, high frequency notched audiograms typical for noise-induced hearing loss were found in 35% of cases. Simultaneously, about 35% of audiograms showed typical for NIHL high frequency notches (mainly occurring at 6000 Hz). When analyzing the impact of age, gender and noise exposure on hearing test results both PTA and TEOAE consistently showed better hearing in females vs. males, younger vs. older musicians. But higher exposure to orchestral noise was not associated with poorer hearing tests results. The musician’s audiometric hearing threshold levels were poorer than equivalent non-noise-exposed population and better (at 3000 and 4000 Hz) than expected for noise-exposed population according to ISO 1999 (1990). Thus, music impairs hearing of orchestral musicians, but less than expected from noise exposure.

Mutations in the MYO15A Gene Are a Significant Cause of Nonsyndromic Hearing Loss

2015 ◽  
Vol 124 (1_suppl) ◽  
pp. 158S-168S ◽  
Author(s):  
Maiko Miyagawa ◽  
Shin-ya Nishio ◽  
Mitsuru Hattori ◽  
Hideaki Moteki ◽  
Yumiko Kobayashi ◽  
...  
Keyword(s):  
Hearing Loss ◽  
High Frequency ◽  
Clinical Characteristics ◽  
Age At Onset ◽  
Massively Parallel ◽  
Nonsyndromic Hearing Loss ◽  
Congenital Hearing Loss ◽  
Progressive Hearing Loss ◽  
High Frequency Hearing Loss ◽  
Massively Parallel Dna Sequencing

Objectives: Screening for MYO15A mutations was carried out using a large cohort to clarify the frequency and clinical characteristics of patients with MYO15A (DFNB3) mutations in a hearing loss population. Methods: Genetic analysis of 63 previously reported deafness genes based on massively parallel DNA sequencing (MPS) in 1120 Japanese hearing loss patients from 53 otorhinolaryngology departments was performed. Detailed clinical features of the patients with MYO15A mutations were then collected and analyzed. Results: Eleven patients from 10 families were found to have compound heterozygosity for MYO15A. Audiograms showed profound or high frequency hearing loss, with some patients showing progressive hearing loss. Age at onset was found to vary from 0 to 14 years, which seemed to be associated with the mutation. Four children underwent bilateral cochlear implantation for congenital hearing loss, with all showing good results. Conclusion: Mutations in the MYO15A gene are a notable cause of nonsyndromic hearing loss. MPS technology successfully detected mutations in relatively rare deafness genes such as MYO15A.

Differences in clinical characteristics and prognosis of sudden low- and high-frequency hearing loss

2016 ◽  
Vol 127 (8) ◽  
pp. 1878-1884 ◽  
Author(s):  
Oak-Sung Choo ◽  
Suk Min Yang ◽  
Hun Yi Park ◽  
Jong Bin Lee ◽  
Jeong Hun Jang ◽  
...  
Keyword(s):  
Hearing Loss ◽  
High Frequency ◽  
Clinical Characteristics ◽  
High Frequency Hearing Loss

scholarly journals Hearing Loss in Agricultural Workers Exposed to Pesticides and Noise

2019 ◽  
Vol 63 (7) ◽  
pp. 707-718 ◽  
Author(s):  
Nattagorn Choochouy ◽  
Pornpimol Kongtip ◽  
Suttinun Chantanakul ◽  
Noppanun Nankongnab ◽  
Dusit Sujirarat ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Frequency Band ◽  
High Frequency ◽  
Noise Exposure ◽  
Hearing Threshold ◽  
Agricultural Workers ◽  
Agricultural Machinery ◽  
High Frequency Band ◽  
Full Cohort ◽  
Increased Risk

AbstractAgricultural workers who have concurrent exposure to pesticides and noise are at increased risk of hearing loss. We recruited 163 Thai conventional and 172 organic farmers to answer our questionnaires about personal demographics, agricultural activities, and pesticide and agricultural machinery use. This information was used to calculate the years of conventional (pesticide use) farming and the years of agricultural noise exposure, and to estimate semiquantitative metrics for pesticide exposure (cumulative intensity score-years) and cumulative noise exposure (dB(A)-years) for each conventional farmer. All participants underwent pure tone audiometric testing. The mean hearing threshold in the low-frequency band (0.5–2 kHz) and high-frequency band (3–6 kHz) were used for analysis. Years involved in conventional farming and years using agricultural machinery were associated with an increase in the average hearing threshold for the high-frequency band after controlling for age, ever exposed to industrial noise and cigarette smoking. The highest category of cumulative insecticide exposure (score-years), cumulative organophosphates exposure (score-years) and cumulative noise exposure (dB(A)-years) were also associated with an increased high-frequency band hearing threshold among conventional farmers. Results from the full cohort and the subcohort of conventional farmers support each other and the hypothesis that pesticide and noise have an additive effect on hearing, since no model interactions were significant.

scholarly journals Musical hallucination associated with hearing loss

2011 ◽  
Vol 69 (2b) ◽  
pp. 395-400 ◽  
Author(s):  
T G Sanchez ◽  
S C M Rocha ◽  
K A B Knobel ◽  
M A Kii ◽  
R M R Santos ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Hearing Aids ◽  
Auditory Hallucination ◽  
Sensory Deprivation ◽  
Auditory Memory ◽  
Association Cortex ◽  
Auditory Information ◽  
Nerve Lesion ◽  
Musical Hallucination ◽  
Auditory Association Cortex

In spite of the fact that musical hallucination have a significant impact on patients' lives, they have received very little attention of experts. Some researchers agree on a combination of peripheral and central dysfunctions as the mechanism that causes hallucination. The most accepted physiopathology of musical hallucination associated to hearing loss (caused by cochlear lesion, cochlear nerve lesion or by interruption of mesencephalon or pontine auditory information) is the disinhibition of auditory memory circuits due to sensory deprivation. Concerning the cortical area involved in musical hallucination, there is evidence that the excitatory mechanism of the superior temporal gyrus, as in epilepsies, is responsible for musical hallucination. In musical release hallucination there is also activation of the auditory association cortex. Finally, considering the laterality, functional studies with musical perception and imagery in normal individuals showed that songs with words cause bilateral temporal activation and melodies activate only the right lobe. The effect of hearing aids on the improvement of musical hallucination as a result of the hearing loss improvement is well documented. It happens because auditory hallucination may be influenced by the external acoustical environment. Neuroleptics, antidepressants and anticonvulsants have been used in the treatment of musical hallucination. Cases of improvement with the administration of carbamazepine, meclobemide and donepezil were reported, but the results obtained were not consistent.

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