scholarly journals Gastric Glomus Tumor: A Clinicopathologic and Immunohistochemical Study of 21 Cases

2020 ◽  
Vol 2020 ◽  
pp. 1-6 ◽  
Author(s):  
Jun Lin ◽  
Juan Shen ◽  
Hao Yue ◽  
Qiongqiong Li ◽  
Yuqing Cheng ◽  
...  
Keyword(s):  
Glomus Tumor ◽  
Smooth Muscle Actin ◽  
Treatment Method ◽  
Clinical Findings ◽  
Mesenchymal Tumors ◽  
Glomus Tumors ◽  
Common Location ◽  
Local Surgery ◽  
Nest Pattern ◽  
The Mean

Gastric glomus tumors (GGTs) are rare mesenchymal tumors. Most glomus tumors occur in the distal parts of the extremities. Here, we retrospectively analyzed the features of GGTs from two institutions. The histologic and clinical findings of all GGT cases from 2009 to 2018 were reviewed. The most common location was the antrum, the mean age of patients was 49.3 years, and the mean tumor size was 2.1 cm. Microscopically, small, round cell nodules surrounded the expansion of blood vessels in a nest pattern. Immunohistochemical assays for vimentin and smooth muscle actin (SMA) were positive, and assays for H-caldesmon and calponin were partially positive. GGT is rare and easily misdiagnosed before operation. However, immunohistochemistry is useful for the differential diagnosis. The majority of GGTs are benign, and local surgery achieving complete resection is the most effective treatment method.

scholarly journals Malignant Glomus Tumor of the Kidney: A Case Report and Review of the Literature

2021 ◽  
Vol 156 (Supplement_1) ◽  
pp. S73-S73
Author(s):  
J Nwanze ◽  
J Shih ◽  
N Rolf ◽  
S K Halat
Keyword(s):  
Case Report ◽  
Glomus Tumor ◽  
Motor Vehicle ◽  
Motor Vehicle Accident ◽  
Case Reports ◽  
Smooth Muscle Actin ◽  
Mitotic Figure ◽  
Arteriovenous Anastomosis ◽  
Posterior Aspect ◽  
Glomus Tumors

Abstract Introduction/Objective Glomus tumors are rare neoplasms arising from the glomus body which is a specialized arteriovenous anastomosis that has a role in temperature regulation of the skin. They account for less than 2% of soft tissue tumors and typically manifest as painful nodules in the extremities, most commonly in the subungual region of the fingers and dermis of the wrist, forearm, and foot. They rarely arise in visceral organs as they lack glomus bodies. There are rare case reports of benign glomus tumors arising in the kidney, and malignant renal glomus tumors are exceedingly rare. Methods/Case Report We present a case of a 32-year-old man who was found to have a right renal mass incidentally after being involved in a motor vehicle accident. Computed tomography of the abdomen revealed a 5.3 cm enhancing mass in the posterior aspect of the inferior pole of the right kidney. Histological examination revealed a solid neoplasm composed of a pleomorphic population of cells with densely eosinophilic to pale cytoplasm, centrally located round to oval nuclei with fine nuclear chromatin and relatively inconspicuous nucleoli. Prominent lymphovascular invasion and 1 mitotic figure per 10 high power fields were also present. Areas composed of necrosis, sclerosis, hemosiderin deposition and calcification were identified. Immunohistochemical stains revealed the neoplastic cells to be positive for CD34, vimentin, smooth muscle actin, caldesmon, with focal reticulin staining around the tumor cells. Cells were negative for desmin, high and low molecular weight cytokeratins, synaptophysin, chromogranin, PAX8, and GATA3. The morphology and immunoprofile of the mass are consistent with the diagnosis of glomus tumor. Results (if a Case Study enter NA) NA Conclusion Although very rare, the presence of prominent vascular invasion, increased mitotic activity as well as necrosis are consistent with malignant behavior and support the classification as a malignant glomus tumor.

Pediatric Malignant Glomus Tumor of the Cervical Paraspinal Tissue: Case Report and Review of the Literature

2020 ◽  
Author(s):  
Andrea Ziegler ◽  
Eric Thorpe
Keyword(s):  
Glomus Tumor ◽  
En Bloc Resection ◽  
Bloc Resection ◽  
The Body ◽  
Long Term Outcomes ◽  
Mesenchymal Tumors ◽  
En Bloc ◽  
Glomus Tumors ◽  
First Case

AbstractGlomus tumors are mesenchymal tumors that arise from glomus bodies and most frequently occur in the distal extremities. These tumors can occur throughout the body and are typically benign. However, a very small fraction of glomus tumors displays aggressive features and are considered atypical or malignant. We report on our experience and management of the first case in the literature of a malignant glomus tumor in a child originating in the paraspinal region with involvement of the cervical spine. Malignant glomus tumors tend to be locally aggressive, and en bloc resection is difficult, especially when the tumors occur in the head and neck. Additional studies on disease progression and adjuvant treatment outcomes are necessary to determine the best treatment approach and long-term outcomes in patients with malignant glomus tumors.

Malignant Glomus Tumor of the Urinary Bladder

2005 ◽  
Vol 129 (7) ◽  
pp. 940-942 ◽  
Author(s):  
Hyo Sub Shim ◽  
Young Deuk Choi ◽  
Nam Hoon Cho
Keyword(s):  
Smooth Muscle ◽  
Urinary Bladder ◽  
Basement Membrane ◽  
Glomus Tumor ◽  
Malignant Tumors ◽  
Smooth Muscle Actin ◽  
Pulmonary Nodules ◽  
Histochemical Staining ◽  
Muscle Actin ◽  
Glomus Tumors

Abstract We present a case of a malignant glomus tumor arising in the urinary bladder of a 57-year-old woman with metastatic pulmonary nodules who died 2 months later. Pathologically and clinically confirmed malignant glomus tumors are exceedingly rare, especially those that arise in the visceral organs. The present case retained its architectural similarity to a benign glomus tumor and consisted of sheets of highly malignant round cells showing cytoplasmic positivity for smooth muscle actin. On reticulin histochemical staining, we found that reticulum fibrils surrounded individual tumor cells, suggesting cellular investment by basement membrane. We discuss the concept of malignant glomus tumors and emphasize the criteria that distinguish them from other malignant tumors.

scholarly journals Glomangioma of the Kidney: A Rare Case of Glomus Tumor and Review of the Literature

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Ammar Almaghrabi ◽  
Nizar Almaghrabi ◽  
Haneen Al-Maghrabi
Keyword(s):  
Glomus Tumor ◽  
Histopathological Analysis ◽  
Kidney Tumors ◽  
Mesenchymal Tumors ◽  
Unique Case ◽  
Glomus Tumors ◽  
Extensive Search ◽  
One Year ◽  
Immunohistochemical Studies ◽  
Histopathology Examination

Background. Glomus tumors are rare mesenchymal tumors originating from glomus bodies in the skin. Glomus tumors of the kidney are rare tumors and only a few cases have been reported in the medical literature. An extensive search revealed a very limited number of primary renal glomus tumors. Although most of these cases were benign in nature, including a case with uncertain diagnosis of malignant potential, two were malignant. Case Report. We present a unique case of a 57-year-old male patient with an incidentally discovered 2 cm left renal mass. Histopathology examination and immunohistochemical studies confirm the diagnosis of glomangioma (a form of glomus tumor). The patient was followed for one year after partial nephrectomy and showed a benign course without any evidence of local recurrence or metastasis. Conclusion. To the best of our knowledge, this is the 16th case of primary benign renal glomus tumors. Primary renal glomus tumors are rare and may mimic other mesenchymal renal neoplasms radiologically. Proper investigation (including histopathological analysis and immunohistochemical staining) of kidney tumors is essential to make the diagnosis of glomus tumors, which usually show a benign clinical course following resection.

scholarly journals A Primary Pulmonary Glomus Tumor: A Case Report and Review of the Literature

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Yasushi Ariizumi ◽  
Hirotaka Koizumi ◽  
Masahiro Hoshikawa ◽  
Takuo Shinmyo ◽  
Kouji Ando ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Tumor Cells ◽  
Epithelial Membrane Antigen ◽  
Glomus Tumor ◽  
Lung Tumor ◽  
Smooth Muscle Actin ◽  
Relevant Literature ◽  
Sclerosing Hemangioma ◽  
Glomus Tumors ◽  
Clear Cytoplasm

A case of a glomus tumor originating from the lung is reported. A 43-year-old female had undergone resection of a right lung tumor following a clinical diagnosis of carcinoid, sclerosing hemangioma, or other sarcoma. Histologically, the tumor comprised uniform small round to oval cells with centrally located nucleus, a clear cytoplasm, and apparent cell borders. The tumor also showed a focally hemangiopericytomatous pattern with irregularly branching or dilated vessels. Electron microscopy revealed smooth muscle differentiation of the tumor cells. Immunostaining further revealed that the tumor cells expressed smooth muscle actin, h-caldesmon, muscle specific actin (HHF-35), but not cytokeratin, epithelial membrane antigen, synaptophysin, or chromogranin A. Based on these findings, a diagnosis of primary pulmonary glomus tumor was established. Glomus tumors of the lung are very rare and only 21 cases have been reported to date. The histological features of the present tumor and the relevant literature are discussed.

Glomus tumors of the upper extremity

2021 ◽  
Vol 53 (01) ◽  
pp. 72-75
Author(s):  
Hüseyin Bilgehan Çevik ◽  
Çagla Amutkan Çiçek ◽  
Sibel Kayahan ◽  
Seyit Ali Gümüstas ◽  
Gaye Taylan Filinte
Keyword(s):  
Upper Extremity ◽  
Glomus Tumor ◽  
Middle Finger ◽  
Clinical Findings ◽  
Long Term Outcomes ◽  
Glomus Tumors ◽  
Clinical Triad ◽  
Paroxysmal Pain

Abstract Background Glomus tumors are uncommon and painful benign perivascular neoplasms. They usually occur in the subungual region of phalanx, and present with a classic clinical triad of localized tenderness, cold hypersensitivity, and excruciating paroxysmal pain. The aim of this study was to review 45 cases of glomus tumor according to the clinical, radiological and therapeutic characteristics, and the clinical and functional outcomes of surgical treatment. Materials and methods A retrospective review was made of 45 glomus tumors of the upper extremity operated on between June 2005 and January 2019. Data were collected of demographic characteristics and the diagnostic, immunohistochemical, therapeutic and postoperative clinical findings. Results The patients comprised 69 % females and 31 % males with a median age of 41 years at the time of surgery. The most commonly affected anatomic location was the digits (87 %). Of the 39 cases with an affected digit, there was a predominance of the middle finger in 28 % and the peri-subungual area in 51 %. There was no recurrence or need for secondary surgical intervention in any patient in this study. The mean QuickDASH score was 1.47 at mean 66 months follow-up. Conclusions Glomus tumor, which is usually seen in the middle finger of middle-aged women, presents with excruciating paroxysmal pain out of proportion to the tumor size. The long-term outcomes after surgical loupe-assisted surgery with a transungual approach were seen to be good, without local recurrence and an acceptable rate of postoperative nail dystrophy.

scholarly journals Cytologic Analysis of a Glomus Tumor in the Left Second Toe: Case Report

2021 ◽  
Vol 156 (Supplement_1) ◽  
pp. S38-S38
Author(s):  
J Hwang ◽  
S McDowell ◽  
B Cole ◽  
A R Huber ◽  
C Reyes
Keyword(s):  
Case Report ◽  
Fine Needle Aspiration ◽  
Glomus Tumor ◽  
Case Reports ◽  
Smooth Muscle Actin ◽  
Needle Aspiration ◽  
Dorsal Margin ◽  
Glomus Tumors ◽  
Fine Needle ◽  
Second Toe

Abstract Introduction/Objective Glomus bodies reside in the stratum reticularis of the dermis as well as in visceral organs. Their functions involve temperature and blood pressure regulation. The incidence of glomus tumors is approximately 1.5%, occur more frequently in women, and generally manifest during the third to fifth decade of life. A majority of glomus tumors are diagnosed by biopsy and excision. At least 19 case reports exist in the literature where glomus tumors are diagnosed by fine-needle aspiration (FNA). We add to this growing literature by discussing a case report involving the cytologic findings of an FNA-diagnosed glomus tumor. Methods/Case Report A 66-year-old female presented with left second toe pain for 41 years but worsening in the past several months. Physical exam revealed 5/5 muscle strength in her toes without loss of sensation. There was no edema, erythema, nor ecchymosis. Pain was notably out of proportion when palpating her second nailbed. Magnetic resonance imaging (MRI) with contrast was performed revealing a 1.1 x 1.0 x 0.9 cm circumscribed, ovoid mass involving the dorsal aspect of the second toe distal phalanx along its dorsal margin (Figure 1). The patient underwent fine needle aspiration and biopsy. Cytologic findings included clusters of uniform cells with round to oval nuclei and scant cytoplasm. There was spindling of cells noted in some of the clusters. Cells were surrounded by thick wisps of magenta colored myxoid material reminiscent of a pleomorphic adenoma (Figure 2). Biopsy showed uniform cells surrounding capillaries. Immunohistochemistry performed on the biopsy showed that lesional cells were positive for alpha-smooth muscle actin (SMA). A diagnosis of glomus tumor was made. Amputation was performed with clear margins. Results (if a Case Study enter NA) NA Conclusion Glomus tumor is a rare tumor that is usually diagnosed on biopsy; however, it has distinct cytologic features that can aid in its diagnosis on fine needle aspirations.

scholarly journals Glomus Tumor of the Kidney: Case report

2018 ◽  
Vol 64 (3) ◽  
pp. 126-129
Author(s):  
Edith Dee ◽  
Andrada Loghin ◽  
Tamas Toth ◽  
Adrian Năznean ◽  
Angela Borda
Keyword(s):  
Case Report ◽  
Soft Tissues ◽  
Glomus Tumor ◽  
Smooth Muscle Actin ◽  
Soft Tissue Tumors ◽  
Renal Neoplasm ◽  
Microscopic Appearance ◽  
Glomus Tumors ◽  
Eosinophilic Cytoplasm ◽  
Fibrous Tumor

AbstractIntroduction: Glomus tumors are rare benign mesenchymal neoplasms accounting for only 2% of all types of soft tissue tumors. Commonly located in the peripheral soft tissues, they are most frequently encountered in the subungual areas of fingers and toes, and very rarely in visceral organs due to the absence of glomus bodies. To date, 22 cases of primary renal glomus tumors have been described in the literature, of which 17 benign, with no evidence of recurrence or metastasis, three cases of malignant glomus tumor, and two cases with uncertain malignant potential. Case report: We report the 18th case of a benign glomus tumor of the kidney in a 49-year-old female patient, presenting the microscopic appearance (round, uniform cells with indistinct borders, scant finely granular eosinophilic cytoplasm, round nuclei lacking prominent nucleoli, arranged in solid sheets, accompanied by slit-like vascular spaces), the immunohistochemical profile (tumor cells showed immunoreactivity for smooth muscle actin, vimentin, as well as for CD34; they were negative for AE1/AE3, desmin, HMB-45, S-100 protein, renin, and chromogranin), and the differential diagnosis of this rare entity (juxtaglomerular tumor, angiomyolipoma, hemangioma, epithelioid leyomioma, solitary fibrous tumor, carcinoid tumor, and paraganglioma). Conclusion: Primary renal glomus tumors are rare tumors that radiologically can mimic other mesenchymal renal neoplasm. Accurate diagnosis is based on the microscopic appearance and especially the characteristic immunophenotype.

Glomangiomyoma (Glomus Tumor) of the Kidney

2005 ◽  
Vol 129 (9) ◽  
pp. 1172-1174 ◽  
Author(s):  
Noman H. Siddiqui ◽  
Agnieszka Rogalska ◽  
Indu S. Basil
Keyword(s):  
Electron Microscopy ◽  
Smooth Muscle ◽  
Glomus Tumor ◽  
Smooth Muscle Actin ◽  
Muscle Actin ◽  
Thin Filaments ◽  
Glomus Tumors ◽  
Computed Tomographic ◽  
Dense Bodies ◽  
Computed Tomographic Scan

Abstract We report herein a case of glomus tumor arising in the kidney of a 55-year-old woman, which was found incidentally on a computed tomographic scan. Partial nephrectomy revealed a 2-cm encapsulated mass that was architecturally similar to glomus tumor. Immunohistochemistry showed positivity of tumor cells for vimentin and smooth muscle actin. On electron microscopy, cytoplasmic thin filaments and dense bodies were seen, confirming the smooth muscle nature of the tumor. Glomus tumors arising in visceral organs are rare, and those arising in kidney are exceedingly rare.

Atypical Presentation of a Glomus Tumor in the Rearfoot: A Case Report

2020 ◽  
Vol 110 (6) ◽  
Author(s):  
Erin M. Kunz ◽  
Bebu Ram
Keyword(s):  
Case Report ◽  
Soft Tissue ◽  
Glomus Tumor ◽  
Excisional Biopsy ◽  
Clinical Findings ◽  
Cold Sensitivity ◽  
Atypical Presentation ◽  
Glomus Tumors ◽  
Clinical Appearance ◽  
Soft Tissue Masses

Glomus tumors are rare and benign vascular soft-tissue masses commonly found subungually in the foot. A glomus tumor typically manifests with a classic triad of pain, point tenderness, and cold sensitivity. This case report describes an atypical presentation of a glomus tumor in the soft tissue of the rearfoot in a 77-year-old man in the setting of urosepsis. The mass had enlarged progressively for 6 months. Originally misdiagnosed as a hemangioma based on magnetic resonance imaging and clinical appearance, an excisional biopsy was performed. The lesion was subsequently diagnosed histopathologically as a glomus tumor. This article discusses the statistics of glomus tumor and discusses the importance of the need to recognize the symptoms and clinical findings of both typical and atypical presentation of this abnormality in differentiation and differential treatment and risk management of benign and malignant soft-tissue masses.

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