scholarly journals Interleukin-18 Is a Prognostic Marker and Plays a Tumor Suppressive Role in Colon Cancer

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Xiaodong Feng ◽  
Zhijun Zhang ◽  
Peng Sun ◽  
Guanghui Song ◽  
Lu Wang ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Patients ◽  
Colon Cancer Cell ◽  
Cancer Cell Proliferation ◽  
Interleukin 18 ◽  
Potential Therapeutic Target ◽  
Ajcc Stage ◽  
Regulatory Cytokine ◽  
Protein Expressions ◽  
And Function

Interleukin-18 (IL-18) belongs to the IL-1 family and is an essential proinflammatory and immune regulatory cytokine. The present study was designed to investigate the expression and function of IL-18 in colon cancer. In clinical analyses, mRNA and protein expressions of IL-18 were decreased in tissues of colon cancer patients. This decreased expression of IL-18 was significantly correlated with the tumor size ( P = 0.001 ) and American Joint Committee on Cancer (AJCC) stage ( P = 0.013 ). Patients with IL-18-positive tumors had a better survival rate than patients with IL-18-negative tumors. Moreover, upregulation of IL-18 inhibited colon cancer cell proliferation. Our data suggest that the decreased expression of IL-18 in colon cancer was associated with prognosis and tumor proliferation. IL-18 may be considered a novel tumor suppressor and a potential therapeutic target for colon cancer patients.

NF-κB regulates colon cancer cell proliferation and tumorigenicity

2001 ◽  
Vol 120 (5) ◽  
pp. A615-A615
Author(s):  
S KUWADA ◽  
C SCAIFE ◽  
J KUANG ◽  
R DAYNES
Keyword(s):  
Colon Cancer ◽  
Cell Proliferation ◽  
Cancer Cell ◽  
Colon Cancer Cell ◽  
Cancer Cell Proliferation

Cellular mechanisms involved in the melatonin inhibition of HT-29 human colon cancer cell proliferation in culture

2007 ◽  
Vol 43 (2) ◽  
pp. 195-205 ◽  
Author(s):  
Ana García-Navarro ◽  
Cristina González-Puga ◽  
Germaine Escames ◽  
Luis C. López ◽  
Ana López ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cell Proliferation ◽  
Cancer Cell ◽  
Human Colon ◽  
Colon Cancer Cell ◽  
Cancer Cell Proliferation ◽  
Human Colon Cancer Cell ◽  
Cellular Mechanisms ◽  
Human Colon Cancer ◽  
Ht 29

scholarly journals Isoalvaxanthone inhibits colon cancer cell proliferation, migration and invasion through inactivating Rac1 and AP-1

2009 ◽  
Vol 127 (5) ◽  
pp. 1220-1229 ◽  
Author(s):  
Lei Wang ◽  
Lisha Kuang ◽  
Xinhua Pan ◽  
Junchen Liu ◽  
Qian Wang ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cell Proliferation ◽  
Cancer Cell ◽  
Colon Cancer Cell ◽  
Migration And Invasion ◽  
Cancer Cell Proliferation

scholarly journals miR-4262 inhibits colon cancer cell proliferation via targeting of GALNT4

2017 ◽  
Vol 16 (4) ◽  
pp. 3731-3736 ◽  
Author(s):  
Jian-Jun Qu ◽  
Xiang-Yang Qu ◽  
De-Zhen Zhou
Keyword(s):  
Colon Cancer ◽  
Cell Proliferation ◽  
Cancer Cell ◽  
Colon Cancer Cell ◽  
Cancer Cell Proliferation
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