Effects of Malania oleifera Chun Oil on the Improvement of Learning and Memory Function in Mice

Background. The fruits of Malania oleifera Chun & S. K. Lee have been highly sought after medically because its seeds have high oil content (>60%), especially the highest known proportion of nervonic acid (>55%). Objective of the Study. The objective was to explore the effects of different doses of Malania oleifera Chun oil (MOC oil) on the learning and memory of mice and to evaluate whether additional DHA algae oil and vitamin E could help MOC oil improve learning and memory and its possible mechanisms. Methods. After 30 days of oral administration of the relevant agents to mice, behavioral tests were conducted as well as detection of oxidative stress parameters (superoxide dismutase, malondialdehyde, and glutathione peroxidase) and biochemical indicators (acetylcholine, acetyl cholinesterase, and choline acetyltransferase) in the hippocampus. Results. Experimental results demonstrated that MOC oil treatment could markedly improve learning and memory of mouse models in behavioral experiments and increase the activity of GSH-PX in hippocampus and reduce the content of MDA, especially the dose of 46.27 mg/kg. The addition of DHA and VE could better assist MOC oil to improve the learning and memory, and its mechanism may be related to the inhibition of oxidative stress and restrain the activity of AChE and also increase the content of ACh. Conclusion. Our results demonstrated that MOC oil treatment could improve learning and memory impairments. Therefore, we suggest that MOC oil is a potentially important resource for the development of nervonic acid products.

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Learning and memory impairments associated to acetylcholinesterase inhibition and oxidative stress following glyphosate based-herbicide exposure in mice

Toxicology ◽

10.1016/j.tox.2019.01.010 ◽

2019 ◽

Vol 415 ◽

pp. 18-25 ◽

Cited By ~ 16

Author(s):

Yassine Ait Bali ◽

Nour-eddine Kaikai ◽

Saadia Ba-M’hamed ◽

Mohamed Bennis

Keyword(s):

Oxidative Stress ◽

Learning And Memory ◽

Acetylcholinesterase Inhibition ◽

Memory Impairments ◽

And Oxidative Stress ◽

Herbicide Exposure

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Subchronic neurotoxicity of diazinon in albino mice: Impact of oxidative stress, AChE activity, and gene expression disturbances in the cerebral cortex and hippocampus on mood, spatial learning, and memory function

Toxicology Reports ◽

10.1016/j.toxrep.2021.06.017 ◽

2021 ◽

Author(s):

Asieh Karimani ◽

Nasrin Ramezani ◽

Amir Afkhami Goli ◽

Mohammad Hossein Nazem Shirazi ◽

Hosein Nourani ◽

...

Keyword(s):

Oxidative Stress ◽

Gene Expression ◽

Cerebral Cortex ◽

Learning And Memory ◽

Spatial Learning ◽

Ache Activity ◽

Memory Function ◽

Spatial Learning And Memory ◽

Albino Mice

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Flavonoids ameliorate aluminum chloride-induced learning and memory impairments via suppression of apoptosis and oxidative stress in rats

Journal of Inorganic Biochemistry ◽

10.1016/j.jinorgbio.2020.111252 ◽

2020 ◽

Vol 212 ◽

pp. 111252

Author(s):

Shuling Li ◽

Qiongyao Zhang ◽

Yun Ding ◽

Xin Wang ◽

Ping Liu

Keyword(s):

Oxidative Stress ◽

Learning And Memory ◽

Aluminum Chloride ◽

Memory Impairments ◽

And Oxidative Stress

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Lemon Grass Tea Enhanced Memory Function and Attenuated Scopolamine-Induced Amnesia in Mice Via Inhibition of Oxidative Stress and Acetyl-Cholinesterase Activity

Journal of Herbs Spices & Medicinal Plants ◽

10.1080/10496475.2018.1520777 ◽

2018 ◽

Vol 24 (4) ◽

pp. 407-420 ◽

Cited By ~ 1

Author(s):

Solomon Umukoro ◽

Adeyinka Habeeb Adeola ◽

Benneth Ben-Azu ◽

Abayomi M. Ajayi

Keyword(s):

Oxidative Stress ◽

Cholinesterase Activity ◽

Memory Function ◽

Acetyl Cholinesterase ◽

Lemon Grass

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The possible protective mechanism of Hyperbaric oxygen (HBO) in memory impairments induced by Aβ25–35 in rats

Open Medicine ◽

10.2478/s11536-013-0163-8 ◽

2013 ◽

Vol 8 (4) ◽

pp. 468-475 ◽

Cited By ~ 2

Author(s):

XiaoQiang Tian ◽

LiDa Zhang ◽

JingMei Wang ◽

JianGuo Dai ◽

ShanShan Shen ◽

...

Keyword(s):

Oxidative Stress ◽

Protein Expression ◽

Learning And Memory ◽

Hyperbaric Oxygen ◽

Memory Impairment ◽

Protective Mechanism ◽

Aβ Peptides ◽

Memory Impairments ◽

Gene And Protein Expression ◽

Human Brains

AbstractAlzheimer’s disease is characterized by the accumulation and deposition of Aβ peptides in human brains. Aβ peptides are toxic to neurons by lots of mechanisms of which Aβ induced oxidative stress is one of the hypothesis. The present study aimed to determine the effect of Hyperbaric oxygen (HBO) on Aβ25–35 induced cognitive deficits and oxidative stress and apoptosis effects in rats. Rats were given an injection of aggregated Aβ25–35. After treatment with HBO for 20days, the learning and memory ability, hippocampus neuronal apoptosis, the activity of SOD, GSH content and the MDA level and mRNA and proteins expression of Bcl-2 and Bax were detected. Our results demonstrated that HBO could significantly improved the apoptosis hippocampus neuronal induced by Aβ25–35, involving the improvement of the learning and memory impairment, which accompanied of increasing the gene and protein expression of bcl-2 and enhancing the activity of SOD and GSH content. These findings suggest that treatment of HBO might prevent the Aβ25–35 induced learning and memory impairment by increasing the gene and protein expression of bcl-2 and enhancing the activity of SOD and GSH content to alleviate the apoptosis hippocampus neuronal. This suggests that HBO may be a potential therapeutic agent for AD.

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Antiamnesic and Neuroprotective Effects of an Aqueous Extract of Ziziphus jujuba Mill. (Rhamnaceae) on Scopolamine-Induced Cognitive Impairments in Rats

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2021/5577163 ◽

2021 ◽

Vol 2021 ◽

pp. 1-15

Author(s):

Etienne Djeuzong ◽

Antoine K. Kandeda ◽

Séfirin Djiogue ◽

Lewale Stéphanie ◽

Danide Nguedia ◽

...

Keyword(s):

Oxidative Stress ◽

Learning And Memory ◽

Water Maze ◽

Cognitive Impairments ◽

Control Group ◽

Distilled Water ◽

Neuroprotective Effects ◽

Memory Impairments ◽

Y Maze ◽

Ziziphus Jujuba

Background. Alzheimer's disease is a neurological condition that affects about 44 million people worldwide. The available treatments target symptoms rather than the underlying causes. Ziziphus jujuba (Rhamnaceae) is widely used in traditional Cameroonian medicine to treat diabetes, pain, infections, and dementia. Previous studies reported that Z. jujuba aqueous macerate improves working memory impairment, but no study on the antiamnesic effect of a concoction of Z. jujuba in rats has been performed. Therefore, this study aimed to assess the antiamnesic and neuroprotective effects of an aqueous extract of Z. jujuba on scopolamine-induced cognitive impairments in rats. Methods. Learning and memory impairments were induced in rats by administering scopolamine (1 mg/kg, i.p.) to 58 rats for 15 days. Rats that developed learning and memory impairments in Morris water maze and Y-maze paradigms were divided into 7 groups (8 rats each) and treated daily for 15 days as follows: the normal control group received distilled water (10 ml/kg, p.o.), the negative control group received distilled water (10 ml/kg, p.o.), positive control groups either received donepezil (1.2 mg/kg, p.o.) or tacrine (10 mg/kg, p.o.), and the three test groups were given the extract (29, 57, and 114 mg/kg, p.o.). At the end of treatments, learning and memory impairments were determined using the same paradigms. Animals were then euthanized, and biochemical parameters of oxidative stress, inflammation, and apoptosis were analyzed in the hippocampus and prefrontal cortex. Results. On the 4th day of the acquisition phase in the Morris water maze, Z. jujuba (29 and 114 mg/kg) reduced ( p < 0.001 ) the latency to reach the platform, while in the retention phase, Z. jujuba (57 and 114 mg/kg) decreased ( p < 0.001 ) the time to reach the platform and increased the time in the target quadrant ( p < 0.05 ) compared to control. Surprisingly, the extract failed to affect spontaneous alternations in the Y-maze. Furthermore, the extract (29, 57, and 114 mg/kg) reversed ( p < 0.001 ) scopolamine-induced oxidative stress, inflammation, and apoptosis. This was supported by the reduction of neuronal alterations in the hippocampus and prefrontal cortex. Conclusions. Compared to donepezil, a standard drug against Alzheimer’s disease, these findings suggest that Z. jujuba extract possesses antiamnesic and neuroprotective effects, and these effects are mediated in part through antioxidant, anti-inflammatory, and antiapoptotic activities. These findings help to explain its use in treating psychiatric disorders in Cameroon’s folk medicine.

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Fraction n-Butanol of Radix Notoginseng Protects PC12 Cells from Aβ25–35-Induced Cytotoxicity and Alleviates Cognitive Deficits in SAMP8 Mice by Attenuating Oxidative Stress and Aβ Accumulation

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2017/8469754 ◽

2017 ◽

Vol 2017 ◽

pp. 1-10 ◽

Cited By ~ 1

Author(s):

Jin-Lan Huang ◽

Ying-Qin Feng ◽

Li-Ru Bai ◽

Mei-Chun Qin ◽

Zhe-Hao Xu ◽

...

Keyword(s):

Oxidative Stress ◽

Chinese Medicine ◽

Learning And Memory ◽

Pc12 Cells ◽

Spatial Learning ◽

Spatial Learning And Memory ◽

Memory Impairments ◽

Low Toxicity ◽

Samp8 Mice

Chinese medicine has been used for Alzheimer’s disease (AD) treatment for thousands of years with more effective and fewer side effects. Therefore, developing effective potential candidates from Chinese medicine against AD would be considered as critical and efficient therapy for AD treatment. This study was designed to evaluate the neuronal protective effect of fraction n-butanol (NB) of Radix Notoginseng on Aβ25–35-induced PC12 cells, explore the effect of the tested fraction on spatial learning and memory, and characterize the impacts of fraction NB on antioxidant enzymes, Aβ production, and APP and BACE1 expressions. The results revealed that fraction NB could promote proliferation of PC12 cells and protect and rescue PC12 cells from Aβ25–35-induced cell death. Moreover, fraction NB could improve spatial learning and memory impairments of senescence-accelerated prone8 (SAMP8) mice and attenuate oxidative stress and reduce the production of Aβ by inhibiting the expressions of APP and BACE1 in the brains of SAMP8 mice. The result of single dose acute toxicity assay showed that fraction NB had a mild toxicity in vivo. The pronounced actions against AD and in vivo low toxicity of fraction NB suggest that fraction NB may be a useful alternative to the current AD treatment.

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