scholarly journals A Rare Complication of Noncompliance Status Post-Transhiatal Esophagectomy and Esophago-Gastroanastomosis

2020 ◽  
Vol 2020 ◽  
pp. 1-4
Author(s):  
Daniel Ramirez ◽  
Graham Appelbe ◽  
Venkatramana Vattipally ◽  
Justin Miller
Keyword(s):  
Rare Complication ◽  
Fistulous Tract ◽  
Tension Pneumothorax ◽  
Transhiatal Esophagectomy ◽  
Gastric Ulcers ◽  
Peptic Ulcers ◽  
Orogastric Tube ◽  
Presenting Symptoms ◽  
Tube Output ◽  
Gastropleural Fistula

Gastropleural fistulas are a complication of peptic ulcers in hiatal hernias, trauma, infections, surgical complications, and malignancy. Presenting symptoms may include gastric and chest pain with respiratory failure in the setting of pneumonitis, hydropneumothorax, or tension pneumothorax. We describe a 57-year-old male with a history of transhiatal esophagectomy and esophago-gastroanastomosis who presented in the setting of dyspnea and dark orogastric tube output. Upper endoscopy revealed multiple gastric ulcers with a dominant ulceration communicating with an adjacent space, and a fistulous tract was demonstrated on computed tomography chest, confirming a gastropleural fistula, a rare life-threatening condition.

scholarly journals Gastropleural fistula: a rare complication of a perforated gastric ulcer in a hiatus hernia

2021 ◽  
Vol 14 (7) ◽  
pp. e241315
Author(s):  
Samantha Ann Pellegrino ◽  
Henry RE Drysdale ◽  
George Kalogeropoulos
Keyword(s):  
Gastric Ulcer ◽  
Hiatus Hernia ◽  
Rare Complication ◽  
Perforated Gastric Ulcer ◽  
Gastropleural Fistula

scholarly journals Incidence of Duodenal Ulcers and Gastric Ulcers in a Western Population: Back to Where It Started

2009 ◽  
Vol 23 (9) ◽  
pp. 604-608 ◽  
Author(s):  
Marcel JM Groenen ◽  
Ernst J Kuipers ◽  
Bettina E Hansen ◽  
Rob J Th Ouwendijk
Keyword(s):  
Gastric Ulcers ◽  
Bleeding Complications ◽  
Upper Gastrointestinal Endoscopy ◽  
Peptic Ulcers ◽  
Duodenal Ulcers ◽  
Ulcer Disease ◽  
Treatment Regimens ◽  
H Pylori ◽  
Upper Gastrointestinal ◽  
Over Time

BACKGROUND/OBJECTIVES: As recently as 40 years ago, a decline in the incidence of peptic ulcers was observed. The discovery of Helicobacter pylori had a further major impact on the incidence of ulcer disease. Our aim was to evaluate the trends in the incidence and bleeding complications of ulcer disease in the Netherlands.METHODS: From a computerized endoscopy database of a district hospital, the data of all patients who underwent upper gastrointestinal endoscopy from 1996 to 2005 were analyzed. The incidence of duodenal and gastric ulcers, with and without complications, were compared over time.RESULTS: Overall, 20,006 upper gastrointestinal endoscopies were performed. Duodenal ulcers were diagnosed in 696 (3.5%) cases, with signs of bleeding in 158 (22.7%). Forty-five (6.5%) of these ulcers were classified as Forrest I and 113 (16.2%) as Forrest II. Gastric ulcers were diagnosed in 487 cases (2.4%), with signs of bleeding in 60 (12.3%). A Forrest 1 designation was diagnosed in 19 patients (3.9%) and Forrest 2 in 41 patients (8.4%). The incidence of gastric ulcers was stable over time, while the incidence of duodenal ulcers declined.CONCLUSIONS: The incidence of duodenal ulcer disease in the Dutch population is steadily decreasing over time. Test and treatment regimens for H pylori have possibly contributed to this decline. With a further decline in the prevalence of H pylori, the incidence of gastric ulcers is likely to exceed the incidence of duodenal ulcers in the very near future, revisiting a similar situation that was present at the beginning of the previous century.

scholarly journals Subcutaneous Emphysema Secondary to Tonsillectomy

2015 ◽  
Vol 7 (2) ◽  
pp. 78-80
Author(s):  
Vivek Sasindran ◽  
Vijay Stephen ◽  
Lakshana Deve
Keyword(s):  
Case Report ◽  
Surgical Procedures ◽  
Subcutaneous Emphysema ◽  
Subcutaneous Tissue ◽  
Rare Complication ◽  
Tension Pneumothorax ◽  
Tonsillar Fossa ◽  
Superior Constrictor ◽  
History Of ◽  
Fatal Complications

ABSTRACT Background Tonsillectomy is one of the most common surgical procedures performed worldwide. However, it can potentially be associated with several complications. One of the very rare complications post-tonsillectomy in adults is subcutaneous emphysema, as in our case here. Although, most reported cases are resolved spontaneously, it may lead to fatal complications, like tension pneumothorax. Case report Tonsillectomy was performed on an adult patient with history of frequent tonsillitis. The patient developed facial subcutaneous emphysema 48 hours after the surgery (evident by clinical and radiological examination) that resolved within 2 days without further complications. Conclusion Tonsil should be removed along with tonsilar capsule. If tonsillectomy causes deeper than usual mucosal tear up to the level of the muscles, then air might pass into the subcutaneous tissue through the tonsillar fossa and superior constrictor muscle into fascial layers of neck. Emphysema can then spread to parapharyngeal, retropharyngeal spaces and mediastinum with its related morbidity. Though a rare complication, all otorhinolaryngologists must be aware of this complication and its management. How to cite this article Abraham SS, Stephen V, Deve L, Kurien M. Subcutaneous Emphysema Secondary to Tonsillectomy. Int J Otorhinolaryngol Clin 2015;7(2):78-80.

scholarly journals Pengaruh Kecepatan Pembentukan Tukak Lambung Terhadap Pemberian Berbagai Golongan NSAID Pada Tikus Jantan

2019 ◽  
Vol 1 (2) ◽  
pp. 8-17
Author(s):  
Parhan Parhan ◽  
Aliman Yafarugi Gulo
Keyword(s):  
Gastric Ulcer ◽  
Diclofenac Sodium ◽  
Gastric Ulcers ◽  
Dominant Factor ◽  
Epithelial Tissue ◽  
Peptic Ulcers ◽  
Epithelial Layer ◽  
Gastrointestinal Mucosa ◽  
Mucosal Layer ◽  
The Difference

Background : Gastric ulcer is wound to the mucosal layer (epithelial layer) of the stomach and mucosal irritation of 5 mm or more in diameter with depth down to submucosa. The basic pathogenesis of gastric ulcers in when there is an imbalance of aggressive factor enhancement. Non-steroidal antiinflammantory drug can cause stomach ulcers in two ways, either directly or topical irritation of the epithelial tissue and inhibit the endogeneous system of gastrointestinal mucosa of prostaglandins. In this case inhibition of prostaglandin systhesis is the dominant factor of peptic ulcers by NSAIDs. Objectives : The purpose of this study was to determine the effct of NSAID drug administration on the formation of peptic ulcers and to know the difference in the rate of formation of peptic ulcers from each class. Method : Sampel method mice performed surgery on the stomach is done in Pharmacology Laboratory of Pharmacy Institute Deli Husada Deli Tua. Results : The results of this study indicate that faster drugs cause gastric ulcers with a degree of redness are Aspirin 4.03 mm, 2.01 mm mefenamat and 1.02 mm Diclofenac Sodium while Ibuprofen mwdication does not cause peptic ulcers. Conclusion : The results of this study it can be concluded that Aspirin administration with doses of 21 mg/kg faster causes gastric ulcers from other NSAID groups such as Mefenamat with a dose of 21 mg/kg BW, Diclofenac sodium at a dose of 2 mg/kg while administration, Ibuprofen for ten days does not couse ulcers in the stomach of experimetal animals.

Vocal Fold Immobility Following Vaccination

2020 ◽  
pp. 000348942096563
Author(s):  
Guy Talmor ◽  
Brandon Nguyen ◽  
Corina Din-Lovinescu ◽  
Boris Paskhover ◽  
Rachel Kaye
Keyword(s):  
Adverse Event ◽  
Adverse Events ◽  
Symptom Onset ◽  
Vocal Fold ◽  
Rare Complication ◽  
Adverse Event Reporting System ◽  
Vaccine Administration ◽  
Presenting Symptoms ◽  
Vocal Fold Immobility ◽  
The Relationship

Objective: Vocal fold immobility (VFI) may severely affect quality of life due to dysphonia and respiratory distress. Many etiologies of this disorder have been evaluated, however the relationship between VFI and vaccination has yet to be explored. The objective of this study was to identify the relationship between VFI and vaccine administration. Methods: The Vaccine Adverse Event Reporting System (VAERS) database was queried for patients exhibiting symptoms of VFI following vaccination. Patient demographics and clinical information including presenting symptoms, time of symptom onset, laterality, outcomes, and adverse events were documented. Results: Twenty-two patients were found to have VFI following vaccination. Of those reported, 13 patients were female (59.1%) and 8 were male (36.4%) with an average age of 48.4 years. Vaccinations for influenza, shingles, pneumococcus, and hepatitis B were reported. A majority of these cases were unilateral in nature (73.3%). Mean lag time from vaccination to symptom onset was 6.3 days (range 0-45 days). Five adverse events were reported, with 4 patients requiring intubation and tracheostomy. Conclusion: Vaccine administration may be associated with VFI and physicians should be cognizant of this potential adverse event. This is a rare complication with less reported cases than other post-vaccination cranial neuropathies. The difficulty in establishing an initial diagnosis and need for specialized evaluation by an otolaryngologist may result in under-reporting of such events. Further research is needed to delineate the exact pathophysiology of this complication and determine whether a causal relationship exists.

Endothelin-1, an ulcer inducer, promotes gastric ulcer healing via mobilizing gastric myofibroblasts and stimulates production of stroma-derived factors

2006 ◽  
Vol 290 (5) ◽  
pp. G1041-G1050 ◽  
Author(s):  
Tsutomu Nishida ◽  
Shingo Tsuji ◽  
Arata Kimura ◽  
Masahiko Tsujii ◽  
Syuji Ishii ◽  
...  
Keyword(s):  
Gastric Ulcer ◽  
Ulcer Healing ◽  
Angiogenic Factors ◽  
Gastric Epithelium ◽  
Gastric Ulcers ◽  
Ulcer Formation ◽  
Peptic Ulcers ◽  
Converting Enzyme ◽  
Potent Inducer ◽  
Gastric Ulcer Healing

Endothelin (ET)-1 is a potent inducer of peptic ulcers. The roles of ET-1 in ulcer healing, however, have remained unclear, and these were investigated in mice. Gastric ulcers were induced in mice by serosal application of acetic acid. Three days later, mice were given a neutralizing ET-1 antibody or nonimmunized serum. The ulcer size, amount of fibrosis and myofibroblasts, and localization of ET-1 and ETA/B receptors were analyzed. To elucidate the mechanisms underlying the effects of ET-1, we examined the proliferation, migration, and release of growth and angiogenic factors in gastric myofibroblasts with or without ET-1. The expression of prepro-ET-1 (an ET-1 precursor) and ET-converting enzyme-1 was examined in gastric myofibroblasts using RT-PCR. Immunoneutralization of ET-1 delayed gastric ulcer healing. The areas of fibrosis and myofibroblasts were smaller in the anti-ET-1 antibody group than in the control. ET-1 was expressed in the gastric epithelium, myofibroblasts, and other cell types. ETA receptors, but not ETB receptors, were present in myofibroblasts. ET-1 increased proliferation and migration of gastric myofibroblasts. ET-1 stimulated the release of hepatocyte growth factor, VEGF, PGE2, and IL-6 from gastric myofibroblasts. mRNA for prepro-ET-1 and ET-converting enzyme-1 was also expressed. ET-1 promotes the accumulation of gastric myofibroblasts and collagen fibrils at gastric ulcers. ET-1 also stimulates migration and proliferation of gastric myofibroblasts and enhances the release of growth factors, angiogenic factors, and PGE2. Thus ET-1 has important roles not only in ulcer formation but also in ulcer healing via mobilizing myofibroblasts and inducing production of stroma-derived factors.

Chronic gastroduodenal ulcers in patients with diabetes mellitus

2003 ◽  
Vol 49 (1) ◽  
pp. 5-10
Author(s):  
Yu. L. Fedorchenko
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Clinical Course ◽  
Gastrin Level ◽  
Gastric Ulcers ◽  
Peptic Ulcers ◽  
Duodenal Ulcers ◽  
Patients With Diabetes ◽  
H Pylori

The clinical picture, course, and treatment of gastroduodenal ul­cers (GDU) in diabetics were studied. A total of 395 diabetics were examined; GDU were detected in 36. The incidence of gas­tric and duodenal ulcers was similar in patients with insulin-de­pendent diabetes mellitus, while in patients with non-insulin-de- pendent diabetes gastric ulcers predominated. The clinical pic­ture of the disease, gastric acid production, Helicobacter pylori infection, and blood gastrin levels were studied in all patients with ulcers. The efficiency of GDU treatment with quamatel, raniti­dine, and antacids was evaluated. The clinical course of GDU in diabetics was asymptomatic. The highest incidence of H. pylori, infection was observed in patients with type 1 diabetes with con­comitant peptic ulcers. Serum gastrin levels were more frequently increased in patients with type 1 diabetes and duodenal ulcers and normal in patients with type 2 diabetes. Quamatel therapy was highly effective in diabetics with GDU. Ulcers healed in 85% patients and blood gastrin level significantly decreased after 3- week therapy. GDU in diabetics are characterized by specific lo­cation, clinical course, laboratory and instrumental features, which allows a differentiated approach to therapy of these pa­tients.

Peptic Ulcers After the Hanshin-Awaji Earthquake: Increased Incidence of Bleeding Gastric Ulcers

1998 ◽  
Vol 93 (3) ◽  
pp. 311-316 ◽  
Author(s):  
Nobuo Aoyama ◽  
Yoshikazu Kinoshita ◽  
Sotaro Fujimoto ◽  
Seiichi Himeno ◽  
Akio Todo ◽  
...  
Keyword(s):  
Gastric Ulcers ◽  
Peptic Ulcers

scholarly journals Subdural Hematoma Following Spinal Cord Stimulator Implant

2008 ◽  
Vol 1;11 (1;1) ◽  
pp. 97-101
Author(s):  
Srinivas Chiravuri
Keyword(s):  
Spinal Cord ◽  
Subdural Hematoma ◽  
Dural Puncture ◽  
Rare Complication ◽  
Delayed Diagnosis ◽  
Secondary Process ◽  
Spinal Cord Stimulator ◽  
Diagnostic Challenge ◽  
Treatment Change ◽  
Presenting Symptoms

Headache following interventional procedures is a diagnostic challenge due to the multitude of possible etiologies involved. Presentation can be simple (PDPH alone) or complex (exacerbation of pre-existing chronic headache along with PDPH) or headache associated with a new onset intracranial process. Subdural hematoma is a rare complication of cranio-spinal trauma. Cranial subdural hematoma may present in an acute, sub-acute, or chronic fashion. Diagnosis of a subdural hematoma in the wake of a PDPH is difficult, requiring a high level of suspicion. Delayed diagnosis of subdural hematoma is usually related to failure to consider it in the differential diagnosis. Thorough history, assessment of the evolution of symptoms, and imaging studies may identify the possible cause and help direct treatment. Change in the character of initial presenting symptoms may be a sign of resolution of the headache or the onset of a secondary process. We report a case of acute intracranial subdural hematoma secondary to unintentional dural puncture during placement of a permanent spinal cord stimulator lead for refractory angina. There is need for careful follow-up of patients with a known post-dural tear. Failure to identify uncommon adverse events in patients with complicated spinal cord stimulator implantation may lead to permanent injury. Key words: Subdural, post-dural puncture, headache, spinal cord stimulation

scholarly journals Clinical and Endoscopic Features in Helicobacter Pylori Infection: Literature Review

2021 ◽  
Vol 22 (1) ◽  
pp. 66-72
Author(s):  
Ghina Tsuraya Salsabila Budiman ◽  
Muhammad Begawan Bestari ◽  
Sri Suryanti
Keyword(s):  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
Functional Dyspepsia ◽  
Epigastric Pain ◽  
False Negative ◽  
Clinical Manifestations ◽  
Helicobacter Pylori Infection ◽  
Gastric Ulcers ◽  
Common Symptom ◽  
Peptic Ulcers

Helicobacter pylori is a common infection worldwide and can cause functional dyspepsia, gastritis, and peptic ulcers, leading to gastric cancer. The very diverse clinical outcomes and symptoms of this infection are difficult to distinguish from one another. Endoscopy is one of the methods used to detect Helicobacter pylori infection. Still, it has various endoscopic features, has the possibility of false-negative results, and requires skill to get the maximum results.This study found that infection can cause various clinical manifestations due to different virulence factors of Helicobacter pylori bacteria. In functional dyspepsia, the patient's most common symptoms are epigastric pain, nausea, and vomiting. In gastritis, Helicobacter pylori infection often causes chronic gastritis with topographic features of pangastritis, and endoscopic features that are usually found are redness, swelling, and regular arrangement of collecting venules (RAC). The most common symptom in peptic ulcers is pain that occurs after eating or at night, and this infection can cause duodenal and gastric ulcers. Currently, the relationship between Helicobacter pylori infection and gastroesophageal reflux disease (GERD) is controversial. In gastric cancer, the most common symptoms are weight loss and repeated vomiting. This infection is more likely to causes intestinal-type gastric cancer.

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