scholarly journals Hepatic Failure following Metronidazole in Children with Cockayne Syndrome

2020 ◽  
Vol 2020 ◽  
pp. 1-3
Author(s):  
Pedram Ataee ◽  
Avat karimi ◽  
Kambiz Eftekhari
Keyword(s):  
Liver Failure ◽  
General Condition ◽  
Autosomal Recessive ◽  
Cockayne Syndrome ◽  
Premature Aging ◽  
Dental Infection ◽  
Abnormal Growth ◽  
First Case ◽  
Good General Condition ◽  
Very High

Cockayne syndrome is an uncommon autosomal recessive disease characterized by microcephaly, abnormal growth, and pathologic premature aging. The purpose of this report is to evaluate liver failure in children with Cockayne syndrome following metronidazole administration. The first case was a 2-year-old boy with Cockayne syndrome. He had been treated with metronidazole for gastroenteritis. 48 hours after treatment initiation, he was hospitalized due to jaundice, intractable vomiting, and agitation. Unfortunately, he died of acute liver failure. The second case was a 5-year-old boy with Cockayne syndrome as well, who had been treated with amoxicillin and metronidazole for a dental infection. He developed jaundice, drowsiness, lethargy, and anorexia after treatment. At hospital, the child received supportive treatment, and his general condition gradually improved. The liver enzyme levels decreased. He was finally discharged in good general condition. The mortality after metronidazole consumption in patients with Cockayne syndrome due to liver failure is very high. The awareness of the dangers of using metronidazole in these patients is valuable.

Small-Angle Electron Scattering (SAES) of Polymers

1985 ◽  
Vol 43 ◽  
pp. 78-79
Author(s):  
Ralph Oralor ◽  
Pamela Lloyd ◽  
Satish Kumar ◽  
W. W. Adams
Keyword(s):  
Electron Scattering ◽  
Small Angle ◽  
Angular Resolution ◽  
Structural Features ◽  
Objective Lens ◽  
High Angular Resolution ◽  
Push Button ◽  
First Case ◽  
Diffraction Mode ◽  
Very High

Small angle electron scattering (SAES) has been used to study structural features of up to several thousand angstroms in polymers, as well as in metals. SAES may be done either in (a) long camera mode by switching off the objective lens current or in (b) selected area diffraction mode. In the first case very high camera lengths (up to 7Ø meters on JEOL 1Ø ØCX) and high angular resolution can be obtained, while in the second case smaller camera lengths (approximately up to 3.6 meters on JEOL 1Ø ØCX) and lower angular resolution is obtainable. We conducted our SAES studies on JEOL 1ØØCX which can be switched to either mode with a push button as a standard feature.

scholarly journals Robotic-assisted proximal gastrectomy using the double-flap technique for early gastric cancer with situs inversus totalis: a case report

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Atsushi Takeno ◽  
Toru Masuzawa ◽  
Shinsuke Katsuyama ◽  
Kohei Murakami ◽  
Kenji Kawai ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Situs Inversus ◽  
Autosomal Recessive ◽  
Intraoperative Complications ◽  
Proximal Gastrectomy ◽  
Situs Inversus Totalis ◽  
Upper Body ◽  
Robot Assisted ◽  
Case Presentation ◽  
First Case

Abstract Background The robotic system has been applied in the treatment of gastric cancer (GC), and the procedure has been found to be safe and feasible. Situs inversus totalis (SIT) is a relatively rare autosomal recessive congenital anomaly. We successfully performed robot-assisted proximal gastrectomy (RAPG) and handsewn double-flap esophagogastrostomy for GC in a patient with SIT. Case presentation A 71-year-old woman was referred to us with an asymptomatic ulcerative lesion in the upper body of the stomach. Computed tomography revealed that she had SIT. She was diagnosed with cT1bN0M0, cStageIA gastric cancer. RAPG with lymph node dissection and handsewn double-flap esophagogastrostomy was performed. Robotic surgery enabled the surgeon to perform the surgery without changing his position and experiencing any confusion resulting from the patient’s reversed anatomy. It took 448 min, and no intraoperative complications occurred. Her postoperative course was uneventful; she was discharged on postoperative day 10. The final pathologic report showed pT1b1N0M0, pStage IA. Conclusions This is the first case describing RAPG with handsewn double-flap esophagogastrostomy for a SIT patient with early GC.

Laser-Induced Acoustic Waves for Measurement and Imaging

2000 ◽  
Author(s):  
Wen Li ◽  
Ronald A. Roy ◽  
Robin O. Cleveland ◽  
Lawrence J. Berg ◽  
Charles A. DiMarzio
Keyword(s):  
Acoustic Waves ◽  
Peak Power ◽  
Laser Light ◽  
Short Pulse ◽  
Laser Wavelength ◽  
Acoustic Imaging ◽  
Acoustic Energy ◽  
High Peak Power ◽  
First Case ◽  
Very High

Abstract A short pulse of laser light can act as a source of acoustic energy for acoustic imaging. Although there are a number of mechanisms by which the light pulse may generate sound, all require a pulse of high peak power density and short duration. In this work, we address examples where the material is highly absorbing at the laser wavelength, and the sound is generated near the surface. In these cases, there exist two different mechanisms which can convert the light to sound. The first is heating followed by expansion, and the second is generation of a plasma in the air above the surface. In the first case, sound generation occurs in the medium of interest and the energy efficiency can be very high, in the sense that no reflection losses occur. We present two applications from our own research.

Propranolol in Children: Safety-Toxicity

PEDIATRICS ◽  
1982 ◽  
Vol 70 (1) ◽  
pp. 30-31
Author(s):  
Michael Artman ◽  
Mitch Grayson ◽  
Robert C. Boerth
Keyword(s):  
Heart Rate Response ◽  
Plasma Concentrations ◽  
Caloric Intake ◽  
High Plasma ◽  
Intravenous Glucose ◽  
First Case ◽  
Acute Ingestion ◽  
Pharmacologic Effect ◽  
Propranolol Therapy ◽  
Very High

Four hours after acute ingestion of 400 to 1,200 mg of propranolol by a healthy, 3-year-old boy, his plasma concentration of propranolol was 2,289 ng/ml. The only pharmacologic effect observed was a diminished heart rate response to crying and activity. In a second case, a 4-year-old boy on chronic propranolol therapy for renovascular hypertension had a hypoglycemic seizure when solid food was refused for three days because of an oral wound. The hypoglycemia was easily managed with intravenous glucose, and there were no sequelae. The first case alludes to the safety of propranolol in a healthy child even with very high plasma concentrations. The second case suggests the necessity of anticipating and avoiding hypoglycemia that can develop in children on chronic propranolol therapy when caloric intake is impaired.

scholarly journals Microsurgical DREZ lesions for the control of cancer-related pain

2020 ◽  
Vol 3 (2) ◽  
pp. V14 ◽  
Author(s):  
Edoardo Mazzucchi ◽  
Andrei Brinzeu ◽  
Patrick Mertens ◽  
Marc Sindou
Keyword(s):  
General Condition ◽  
Dorsal Root ◽  
Lateral Part ◽  
Entry Zone ◽  
Dorsal Root Entry Zone ◽  
Patients With Cancer ◽  
Root Entry Zone ◽  
Refractory Pain ◽  
Pain Pathways ◽  
Good General Condition

Pain in patients with cancer is a major problem, and sometimes it is necessary to surgically interrupt pain pathways to effectively control refractory pain. Surgical lesion of the dorsal root entry zone (DREZ) was first performed in 1972 for the treatment of pain related to a Pancoast-Tobias tumor. The rationale of DREZotomy is to preferentially interrupt the nociceptive inputs in the lateral part of the DREZ and the ventrolateral (excitatory) part of the dorsal horn. Microsurgical DREZotomy is one technique for DREZ lesioning that is suited for tailored control of pain in patients in good general condition who are experiencing pain in a well-defined territory.The video can be found here: https://youtu.be/JtLQDP7gYSQ

CT and MRI of the Brain in Inherited Neurometabolic Disorders

1992 ◽  
Vol 7 (1_suppl) ◽  
pp. S112-S131 ◽  
Author(s):  
Jan Brismar
Keyword(s):  
World Literature ◽  
Autosomal Recessive ◽  
Wide Spectrum ◽  
Neurometabolic Disorder ◽  
Neurometabolic Disorders ◽  
Number Of Patients ◽  
Pediatric Neurologist ◽  
The Brain ◽  
Very High ◽  
Ct And Mri

The incidence of many autosomal recessive neurometabolic disorders is very high in Saudi Arabia, probably as a result of the frequency of consanguineous marriages. Because our hospital is the main referral center for the entire Kingdom, we examine a large number of patients who have a wide spectrum of neurometabolic disorders. We add our experience and review the world literature. Though a specific diagnosis is radiologically possible in a few disorders, the diagnosis must always be verified biochemically. When the patient is referred from a pediatric neurologist with the diagnosis of neurometabolic disorder, the aim of the neuroradiologist is to determine the amount of brain damage present and to follow the response to given therapy. When the patient is referred with a nonspecific diagnosis, such as delayed development, the aim is to suggest the possibility of a neurometabolic disorder and to initiate further evaluation including possible therapy and genetic counseling. (J Child Neurol 1992;7(Suppl):S112-S131.)

scholarly journals Acute Onset Polymyositis after Prolactinoma Extirpation

2014 ◽  
Vol 2014 ◽  
pp. 1-2
Author(s):  
Juan Jakez-Ocampo ◽  
Yemil Atisha-Fregoso ◽  
Luis Llorente
Keyword(s):  
Autoimmune Diseases ◽  
Muscle Biopsy ◽  
Steroid Therapy ◽  
Acute Onset ◽  
Pituitary Macroadenoma ◽  
Inflammatory Infiltration ◽  
Total Recovery ◽  
First Case ◽  
Very High

Hyperprolactinemia has been related to autoimmune diseases. Herein, we describe a case of a female with a prolactin producer pituitary macroadenoma who developed severe polymyositis one month after its removal. The patient had very high levels of CPK and muscle biopsy showed remarkable inflammatory infiltration. Steroid therapy was followed with total recovery. To the best of our knowledge, this is the first case reported of acute polymyositis after pituitary macroadenoma exeresis.

Clinical Features of Hepatitis C Virus-Related Acute-On-Chronic Liver Failure in a Korean Population

2021 ◽  
Author(s):  
Jung Woo Choi ◽  
Jin-Kyu Cho ◽  
Sang Soo Lee ◽  
Jae Heon Kim ◽  
Hankyu Jeon ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Hepatitis B Virus ◽  
Liver Failure ◽  
Chronic Liver ◽  
Chronic Liver Failure ◽  
Short Term ◽  
B Virus ◽  
Short Term Mortality ◽  
Very High

Abstract Background Acute-on-chronic liver failure (ACLF) is a widely recognized concept in which acute decompensation (AD) in patients with cirrhosis results in organ failures and high short-term mortality. However, few studies reflecting the various etiologies of cirrhosis are available. We aimed to investigate the clinical features of patients with hepatitis C virus (HCV)-related ACLF. Methods Between January 2005 and December 2018, 109 HCV-related cirrhosis patients who were hospitalized for AD (ascites, hepatic encephalopathy, gastrointestinal hemorrhage, and/or bacterial infection) were enrolled for ACLF defined by European Association for the Study of the Liver (EASL). Results ACLF developed in 35 patients (32.1%) on admission. Eight patients had ACLF grade 1, eight had ACLF grade 2, and 19 had ACLF grade 3. The 28-day and 90-day mortality rates were very low (2.7% and 5.4%, respectively) in patients without ACLF and very high (60.0% and 74.3%, respectively) in those with ACLF. In patients with HCV-related ACLF, the prevalence of liver failure was very low (17.1%), whereas that of kidney failure was very high (71.4%) compared to previous studies on hepatitis B virus-related ACLF and alcohol-related ACLF. Compared with all other prognostic scores, Chronic liver failure Consortium Organ Failure score most accurately predicted 90-day mortality, with an area under the receiver operator characteristic of 0.921. Conclusions HCV-related ACLF has unique clinical characteristics that are distinct from hepatitis B virus-related and alcohol-related ACLF. ACLF defined by EASL can be useful in predicting short-term mortality in HCV-related cirrhosis.

scholarly journals New size record for Snapping Turtle (Chelydra serpentina) in southern Quebec, Canada

2019 ◽  
Vol 132 (4) ◽  
pp. 378-381
Author(s):  
Patrick Galois ◽  
Ève-Lyne Grenier ◽  
Martin Ouellet
Keyword(s):  
Population Structure ◽  
Adult Male ◽  
General Condition ◽  
Carapace Length ◽  
Maximum Size ◽  
Chelydra Serpentina ◽  
Snapping Turtle ◽  
Good General Condition ◽  
Turtle Population ◽  
Local Habitat

We report a new size record for a Snapping Turtle (Chelydra serpentina) in Quebec, Canada. We captured an adult male in good general condition in the Rivière du Sud in the southern Montérégie region. Its straight midline carapace length was 43.2 cm (maximum carapace length 45.1 cm), and it weighed 19.8 kg. This record contributes to our understanding of the maximum size of this species at the northeastern part of its range. More intensive effort will be necessary to document the Snapping Turtle population structure in Quebec to allow for sound comparisons with other populations, as well as a better understanding of the effects of elevation, latitude, and local habitat on Snapping Turtle growth and size.

scholarly journals A case of Shwachman-Diamond syndrome distinguished from celiac disease

2012 ◽  
Vol 4 (3) ◽  
pp. 30 ◽  
Author(s):  
Shin-ichiro Hagiwara ◽  
Arata Watanabe
Keyword(s):  
Bone Marrow ◽  
Celiac Disease ◽  
Autosomal Recessive ◽  
Autosomal Recessive Disease ◽  
First Case ◽  
Pancreatic Dysfunction ◽  
Shwachman Diamond Syndrome

Shwachman-Diamond syndrome (SDS) is a rare, inherited, autosomal recessive disease characterized by exocrine pancreatic dysfunction, skeletal problems and varying degrees of cytopenias resulting in bone marrow dysfunction. We report the first case of SDS that was difficult to distinguish from celiac disease because this is a valuable example of the variety in SDS presentation.

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