scholarly journals Metabolomic Evaluation of Chronic Periodontal Disease in Older Adults

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Wellington F. Rodrigues ◽  
Camila B. Miguel ◽  
Ferdinando Agostinho ◽  
Gabriela V. da Silva ◽  
Javier E. Lazo-Chica ◽  
...  
Keyword(s):  
Older Adults ◽  
Periodontal Disease ◽  
Gas Chromatography Mass Spectrometry ◽  
Chronic Periodontal Disease ◽  
Diagnostic Power ◽  
High Concentrations ◽  
Crevicular Fluid ◽  
Inflammatory Molecules ◽  
Potential Biomarkers

Periodontal disease is an infectious inflammatory disease related to the destruction of supporting tissues of the teeth, leading to a functional loss of the teeth. Inflammatory molecules present in the exudate are catalyzed and form different metabolites that can be identified and quantified. Thus, we evaluated the inflammatory exudate present in crevicular fluid to identify metabolic biological markers for diagnosing chronic periodontal disease in older adults. Research participants were selected from long-term institutions in Brazil. Participants were individuals aged 65 years or older, healthy, or with chronic periodontal disease. Gas chromatography/mass spectrometry was used to evaluate potential biomarkers in 120 crevicular fluid samples. We identified 969 metabolites in the individuals. Of these, 15 metabolites showed a variable importance with projection   score > 1 and were associated with periodontal disease. Further analysis showed that among the 15 metabolites, two (5-aminovaleric acid and serine, 3TMS derivative) were found at higher concentrations in the crevicular fluid, indicating their potential diagnostic power for periodontal disease in older adults. Our findings indicated that some metabolites are present at high concentrations in the crevicular fluid in older adults with periodontal disease and can be used as biomarkers of periodontal disease.

Long-Term Exposure to Air Pollutants and Cognitive Function in Taiwanese Community-Dwelling Older Adults: A Four-Year Cohort Study

2021 ◽  
Author(s):  
Jen-Hau Chen ◽  
Tsung-Yu Kuo ◽  
Hwa-Lung Yu ◽  
Charlene Wu ◽  
Su-Ling Yeh ◽  
...  
Keyword(s):  
Older Adults ◽  
Cohort Study ◽  
Executive Function ◽  
Verbal Fluency ◽  
Air Pollutants ◽  
Community Dwelling ◽  
High Concentrations ◽  
High Level ◽  
Community Dwelling Older Adults

Background: Previous studies have assessed limited cognitive domains with relatively short exposure to air pollutants, and studies in Asia are limited. Objective: This study aims to explore the association between long-term exposure to air pollutants and cognition in community-dwelling older adults. Methods: This four-year prospective cohort study recruited 605 older adults at baseline (2011–2013) and 360 participants remained at four-year follow-up. Global and domain-specific cognition were assessed biennially. Data on PM2.5 (particulate matter ≤ 2.5 μm diameter, 2005–2015), PM10 (1993–2015), and nitrogen dioxide (NO2, 1993–2015) were obtained from Taiwan Environmental Protection Administration (TEPA). Bayesian Maximum Entropy was utilized to estimate the spatiotemporal distribution of levels of these pollutants. Results: Exposure to high-level PM2.5 (>29.98 μg/m3) was associated with an increased risk of global cognitive impairment (adjusted odds ratio = 4.56; β = −0.60). High-level PMcoarse exposure (>26.50 μg/m3) was associated with poor verbal fluency (β = −0.19). High-level PM10 exposure (>51.20 μg/m3) was associated with poor executive function (β = −0.24). Medium-level NO2 exposure (>28.62 ppb) was associated with better verbal fluency (β = 0.12). Co-exposure to high concentrations of PM2.5, PMcoarse or PM10 and high concentration of NO2 were associated with poor verbal fluency (PM2.5 and NO2: β = −0.17; PMcoarse and NO2: β = −0.23; PM10 and NO2: β = −0.21) and poor executive function (PM10 and NO2: β = −0.16). These associations became more evident in women, apolipoprotein ε4 non-carriers, and those with education > 12 years. Conclusion: Long-term exposure to PM2.5 (higher than TEPA guidelines), PM10 (lower than TEPA guidelines) or co-exposure to PMx and NO2 were associated with poor global, verbal fluency, and executive function over 4 years.

RP-HPLC assay of doxycycline in human saliva and gingival crevicular fluid in patients with chronic periodontal disease

2013 ◽  
Vol 78-79 ◽  
pp. 170-175 ◽  
Author(s):  
Marko S. Denić ◽  
Slavica M. Sunarić ◽  
Ljiljana G. Kesić ◽  
Ivan Z. Minić ◽  
Radmila R. Obradović ◽  
...  
Keyword(s):  
Periodontal Disease ◽  
Gingival Crevicular Fluid ◽  
Human Saliva ◽  
Hplc Assay ◽  
Rp Hplc ◽  
Chronic Periodontal Disease ◽  
Crevicular Fluid

scholarly journals Levels of prostaglandin E2 (PGE2) in gingival crevicular fluid from smokers and non-smokers with gingivitis and chronic periodontal disease

2015 ◽  
Vol 7 (5) ◽  
pp. 54-59 ◽  
Author(s):  
Alessandra da Cruz Galhardo Camargo Gabriela ◽  
Pereira dos Santos Marcelo ◽  
Linhares Coutinho Silva Natalia ◽  
Luisa Palhares de Miranda Ana ◽  
Luiz Mendonca Tributino Jorge
Keyword(s):  
Periodontal Disease ◽  
Prostaglandin E2 ◽  
Gingival Crevicular Fluid ◽  
Chronic Periodontal Disease ◽  
Crevicular Fluid

Chlorhexidine gluconate (corsodyl) mouthwash

1978 ◽  
Vol 16 (6) ◽  
pp. 23-24
Keyword(s):  
Periodontal Disease ◽  
Oral Candidiasis ◽  
Chlorhexidine Gluconate ◽  
Previous Article ◽  
Periodontal Surgery ◽  
Treatment And Prevention ◽  
Chronic Periodontal Disease ◽  
Aphthous Ulceration ◽  
Recurrent Aphthous Ulceration

When we reviewed chlorhexidine dental gel (Corsodyl - ICI) in the Bulletin1 we criticised the lack of evidence for its long-term efficacy for the treatment of chronic periodontal disease and suggested that it should not be used for this purpose. Now a chlorhexidine gluconate 0.2% mouthwash ‘Corsodyl’ (ICI) is being promoted as an aid in treatment and prevention of gingivitis, in the management of recurrent aphthous ulceration and oral candidiasis and to promote gingival healing following periodontal surgery.2 The pharmacology of this antiseptic was reviewed in a previous article on the gel.1

scholarly journals A pilot study of active enzyme levels in gingival crevicular fluid of patients with chronic periodontal disease

2016 ◽  
Vol 43 (8) ◽  
pp. 629-636 ◽  
Author(s):  
Sarhang S. Gul ◽  
Charles W. I. Douglas ◽  
Gareth S. Griffiths ◽  
Andrew Rawlinson
Keyword(s):  
Pilot Study ◽  
Periodontal Disease ◽  
Gingival Crevicular Fluid ◽  
Active Enzyme ◽  
Chronic Periodontal Disease ◽  
Crevicular Fluid
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