scholarly journals Characteristics of Lumbar Bone Density in Middle-Aged and Elderly Subjects: A Correlation Study between T-Scores Determined by the DEXA Scan and Hounsfield Units from CT

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Dejian Zhang ◽  
Yao Wu ◽  
Shengfei Luo ◽  
Fangyong Wang ◽  
Lizhuo Li
Keyword(s):  
Lumbar Spine ◽  
Bone Density ◽  
Elderly Subjects ◽  
Vertebral Compression Fractures ◽  
Strong Positive Correlation ◽  
Middle Aged ◽  
Mineral Density ◽  
Multislice Spiral Ct ◽  
Ct Value ◽  
Lumbar Bone Density

Purpose. To describe the characteristics of lumbar bone density in middle-aged and elderly subjects and explore whether there is a correlation between computed tomography (CT) values and the bone mineral density (BMD) T-scores of the lumbar vertebral cancellous bone. Methods. Forty-two subjects, including 25 males and 17 females, with a mean age of 56 years, who underwent BMD measurement and lumbar multislice spiral CT scan at the China Rehabilitation Research Center from January 2019 to December 2019 were selected. Dual-energy X-ray absorptiometry (DEXA) was applied to obtain the total BMD T-scores of the lumbar L1–L4 vertebrae. Results. The CT values decreased from L1 to L4 and were 145.91 ± 8.686 HU, 143.18 ± 8.598 HU, 137.39 ± 8.276 HU, and 135.23 ± 8.219 HU, respectively. The total CT value of L1–L4 was 140.43 ± 4.199 HU. The mean total BMD T-score of L1–L4 was −0.94. The CT values of the L1–L4 vertebrae were positively correlated with the total BMD T-scores of L1–L4 (r = 0.349, P < 0.001 ). The CT value of the left third of the same vertebrae was the highest, and there was a strong positive correlation between the regional CT value of the lumbar spine and the entire vertebra CT values (r > 0.7). Conclusion. The CT values of the lumbar spine can assist the measurement of the T-scores of lumbar BMD, which could aid in early opportunistic screening for osteopenia and preventing osteoporosis and vertebral compression fractures in middle-aged and elderly subjects. This trial is registered with ChiCTR2100049571.

scholarly journals BONE DENSITY OF THE LUMBAR SPINE L1-L4 AND FEMUR NECK ON CHILDBEARING AGE WOMAN WHO ARE IMPLANT AND NON HORMONAL CONTRACEPTIVES ACCEPTORS.

2018 ◽  
Vol 3 (1) ◽  
pp. 25
Author(s):  
Kuswati Kuswati ◽  
Rohmi Handayani
Keyword(s):  
Lumbar Spine ◽  
Bone Density ◽  
T Test ◽  
Hormonal Contraceptives ◽  
Mineral Density ◽  
Childbearing Age ◽  
T Score ◽  
Femur Neck ◽  
Estrogen Production ◽  
Significant Difference

mplant contraception is one type of contraceptive in the form of an implant made of silastik rubber containing the progestin hormone (levonogestrel) attached to the upper arm. This contraceptives are effective enough to prevent pregnancy in long-term with a lifetime of 3 years for 2 sticks and 1 stick implant. The main principle of levonorgestrel implants was to inhibite the ovulation resulting suppression of estrogen production. Estrogen is one of the important factors in bone remodeling. This becomes our concerns about the effect of implant use on the bone health status of the acceptors. The objective of this study is to determine mean difference of bone mineral density of the Lumbar Spine L1-L4 and Femur Neck on childbearing age woman who are implant acceptors and non hormonal family planning acceptors.This study was analytic survey with cross sectional design. The population in this study were all childbearing age woman in the work area of South Klaten Public Health Center. The sample were 30 people using purposive sampling. Data analysis was performed using Unpaired T-test with p ≤ 0,05. The result of examination on implant acceptor group totaling 15 people shown that the average of T-Score Lumbar Spine L1-L4 bone density was 0,51 and T-score of Femur neck bone was 0,1. While the results of bone density examination in the group of acceptor non hormonal totaling 15 people shown that the average value of T-score Lumbar Spine L1-L4 was 0.72, whereas the mean value of T-score of femur neck bone was 0.06. Unpaired T-Test statistic test for difference of bumble density of Lumbar Spine L1-L4 and Femur Neck between the two groups obtained P value  0.611 and 0.889 (P> 0,05). So there is no statistically significant difference between Lumbar spine L1-L4 and Femur neck bone density on childbearing age woman who are non-hormonal and implant acceptors. Keyword: Bone density, Lumbar Spine L1-L4, Femur neck, Implant, non hormonal Contraceptive  

Kinematics of the lumbar spine in elderly subjects with decreased bone mineral density

2009 ◽  
Vol 47 (7) ◽  
pp. 783-789 ◽  
Author(s):  
Heather Ting Ma ◽  
James F. Griffith ◽  
Zhengyi Yang ◽  
Anthony Wai Leung Kwok ◽  
Ping Chung Leung ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Lumbar Spine ◽  
Bone Mineral ◽  
Elderly Subjects ◽  
Mineral Density

Bone Mineral Density Changes In Patients with Paraproteinemia After Treatment with Bortezomib

Blood ◽  
2010 ◽  
Vol 116 (21) ◽  
pp. 4989-4989
Author(s):  
Tamara Berno ◽  
Kenneth Boucher ◽  
Fenghuang Zhan ◽  
Guido J. Tricot ◽  
Benjamin Mughal ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Lumbar Spine ◽  
Bone Density ◽  
Femoral Neck ◽  
Bone Mineral ◽  
Bone Disease ◽  
Proteasome Inhibitor ◽  
Mineral Density ◽  
T Score ◽  
The Mean

Abstract Abstract 4989 Background: Bone disease is present at diagnosis in almost all patients with multiple myeloma (MM) and can impact substantially on patient morbidity and quality of life. Decreased bone mineral density is also observed not only in MM but also in patients with monoclonal gammopathy of undetermined significance (MGUS). The pathogenesis of bone disease in MM is complex. The activity of proteasome inhibitor bortezomib has been linked to increased bone formation and osteoblastic activation. Evidence from the available clinical data indicates that bortezomib has a positive impact on bone health in MM and demonstrates a bone anabolic effect. Methods: We analyzed retrospectively 53 patients with MM and 16 with MGUS who have completed bone density at least at diagnosis. 21 patients have completed two bone density (3 MGUS and 18 MM). The bone density was obtained in all patients at baseline and in 16 patients repeated after bortezomib treatement with a median time of bortezomib exposure of 6 months. We analyzed T-score values at lumbar spine and at femoral neck. Results: With a median age of 66 years, 41 male and 28 female were analyzed. At baseline the mean lumbar spine T-score of all subjects and of 16 MM treated with bortezomib was -0.50 and -0.76 respectively. At baseline the mean femoral neck T-score for all subjects and for 16 MM treated with Bortezomib was -1.56 and -1.31 respectively. The baseline mean lumbar spine T-score for MGUS and MM was -0.71 and -0.43 respectively. The baseline mean femoral neck T-score of MGUS and MM was -1.61 and -1.54 respectively. In the group of 16 patients treated with Bortezomib we observed from baseline a change in lumbar bone mineral density T-score of 0.36 and at femoral neck bone density T-score of 0.25. Conclusion: These data show that patients treated with proteasome inhibitor showed moderate increment in bone mineral density at lumbar spine and at femoral neck. Disclosures: No relevant conflicts of interest to declare.

scholarly journals Comparative studies of bone density by quantitative ultrasound (QUS) with dual-energy X-ray absorptiometry (DEXA) scan

2019 ◽  
Vol 9 (1) ◽  
pp. 8-12
Author(s):  
Alark Devkota Rajouria ◽  
Madur Dev Bhattarai ◽  
Manil Ratna Bajracharya ◽  
Buddha Bahadur Karki
Keyword(s):  
Bone Mineral Density ◽  
Lumbar Spine ◽  
Bone Density ◽  
Femoral Neck ◽  
Quantitative Ultrasound ◽  
Screening Tool ◽  
Dual Energy ◽  
Mineral Density ◽  
X Ray ◽  
T Score

Background: The aim of the study was to establish the correlation quantitative ultrasound (QUS) between and dual-energy X-ray absorp­tiometry (DEXA) and to assess the ability of QUS as a screening tool for osteoporosis. Methods: The study was conducted on 115 patients. All the patients underwent QUS of radius using Sunlight MiniOmni bone sonometer and DEXA screening for measurement of bone mineral density (BMD) at lumbar spine, total left & femoral neck and radius. Results: Significant correlations were observed between QUS and DEXA T score. Conclusions: QUS is a sensitive screening tool to detect changes in the bone mass and risk of osteoporosis.

scholarly journals Degenerative Spondylolisthesis Is Associated with Low Spinal Bone Density: A Comparative Study between Spinal Stenosis and Degenerative Spondylolisthesis

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Thomas Andersen ◽  
Finn B. Christensen ◽  
Bente L. Langdahl ◽  
Carsten Ernst ◽  
Søren Fruensgaard ◽  
...  
Keyword(s):  
Lumbar Spine ◽  
Bone Density ◽  
Spinal Stenosis ◽  
Rating Scale ◽  
Degenerative Spondylolisthesis ◽  
Mineral Density ◽  
Fusion Procedure ◽  
One Year ◽  
Lumbar Spinal ◽  
Vertebral Wedging

Spinal stenosis and degenerative spondylolisthesis share many symptoms and the same treatment, but their causes remain unclear. Bone mineral density has been suggested to play a role. The aim of this study was to investigate differences in spinal bone density between spinal stenosis and degenerative spondylolisthesis patients. 81 patients older than 60 years, who underwent DXA-scanning of their lumbar spine one year after a lumbar spinal fusion procedure, were included. Radiographs were assessed for disc height, vertebral wedging, and osteophytosis. Pain was assessed using the Low Back Pain Rating Scale pain index.T-score of the lumbar spine was significantly lower among degenerative spondylolisthesis patients compared with spinal stenosis patients (−1.52 versus −0.52,P=0.04). Thirty-nine percent of degenerative spondylolisthesis patients were classified as osteoporotic and further 30% osteopenic compared to only 9% of spinal stenosis patients being osteoporotic and 30% osteopenic (P=0.01). Pain levels tended to increase with poorer bone status (P=0.06). Patients treated surgically for symptomatic degenerative spondylolisthesis have much lower bone mass than patients of similar age treated surgically for spinal stenosis. Low BMD might play a role in the development of the degenerative spondylolisthesis, further studies are needed to clarify this.

scholarly journals Bone Mineral Recovery after Parathyroidectomy in Patients with Primary and Renal Hyperparathyroidism

1998 ◽  
Vol 83 (11) ◽  
pp. 3845-3851 ◽  
Author(s):  
Mohamed Abdelhadi ◽  
Jörgen Nordenström
Keyword(s):  
Bone Mineral Density ◽  
Lumbar Spine ◽  
Renal Transplant ◽  
Bone Density ◽  
Femoral Neck ◽  
Bone Mass ◽  
Distal Radius ◽  
Bone Mineral ◽  
Mineral Density ◽  
Total Body

Patients with hyperparathyroidism (HPT) generally display reduced bone mass due to excessive PTH activity. The effect of parathyroidectomy on bone mass changes in different types of HPT, however, is not well understood. Bone mineral density (BMD) was measured in the distal radius, total body, femoral neck, and lumbar spine by dual energy x-ray absorptiometry in four groups of patients with different hyperparathyroid conditions: primary symptomatic HPT (n = 54), primary asymptomatic (mild) HPT (n = 24), HPT associated with hemodialysis (n = 20), and HPT associated with renal transplant (n = 30). Subsets of patients with primary symptomatic HPT (n= 52), HPT associated with hemodialysis (n = 19), and HPT associated with renal transplant (n = 15) underwent parathyroidectomy, and bone density was measured longitudinally for 3 yr. Patients with primary asymptomatic (mild) HPT did not undergo surgery and were followed prospectively. Before surgery, all groups showed a greater reduction of bone mineral density in cortical bone (distal radius) than in predominantly trabecular bone (lumbar spine). In primary symptomatic HPT, the BMD z-score of the distal radius was −1.80 ± 0.21 (±sem), and the corresponding figures for the total body, femoral neck, and lumbar spine were −0.60 ± 0.15, −0.54 ± 0.14, and −0.53 ± 0.18 compared with those of an age- and sex-matched reference group. In renal HPT BMD z-scores were −2.51± 0.38 (hemodialysis patients) and −2.83 ± 0.43 (renal transplant patients) for the distal radius and between −0.81 and− 1.46 for the other measured sites. After parathyroidectomy, BMD increased by 1–8% at all sites in patients with primary symptomatic HPT and HPT associated with renal transplant. The largest increase in bone mass was observed in patients with HPT associated with hemodialysis, in whom the improvement amounted to 7–23%. In patients with primary HPT and HPT associated with hemodialysis, this increase in bone density resulted in virtual recovery from their preoperative bone loss. The majority of patients with asymptomatic primary HPT disease (n = 21) maintained their bone density during the follow-up period and have not shown evidence of increases in serum calcium or PTH levels, but three patients followed conservatively underwent parathyroidectomy due to progressive deterioration of BMD. We conclude that, regardless of the etiology, a large proportion of HPT patients show reduced bone density. In patients with primary symptomatic HPT and patients with HPT associated with hemodialysis, bone density increases after parathyroidectomy to an extent that largely restores the preoperative bone loss. However, no anabolic effect of parathyroidectomy on bone mass was observed in patients with HPT associated with renal transplant, probably because of their immunosuppressive therapy.

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