scholarly journals Peripheral Oxidation Markers in Down Syndrome Patients: The Better and the Worse

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Dominik Szwajgier ◽  
Ewa Baranowska-Wójcik ◽  
Joanna Grzelczyk ◽  
Wioletta Żukiewicz-Sobczak
Keyword(s):  
Oxidative Stress ◽  
Down Syndrome ◽  
Matched Control ◽  
Dietary Supplementation ◽  
Dose Effect ◽  
Control Groups ◽  
Markers Of Oxidative Stress ◽  
Nutritional Studies ◽  
Peripheral Markers ◽  
Healthy Persons

Oxidative stress plays an important role in Down syndrome (DS) pathology since the gene dose effect leads to abnormal levels of certain enzymes and metabolites. In this review, we focused on relatively easy-to-obtain, peripheral markers of oxidative stress and inflammation, in order to compare the levels of these markers in DS patients and chromosomally healthy persons. Studies taking into account age- and sex-matched control groups were of particular interest in this context. We analyzed the factors that influence the levels of said markers in both groups (i.e., the usefulness of the markers), including the age of DS patients, occurrence of regular trisomy 21 or mosaicism, physical activity of patients, and the onset of Alzheimer’s disease in DS. This paper was conceived as a handbook—to help for selecting suitable, easy-to-obtain markers for monitoring of the health status of DS patients (e.g., in nutritional studies and during dietary supplementation).

Peripheral markers of oxidative stress in Parkinson’s disease. the role of L-DOPA

1999 ◽  
Vol 27 (3-4) ◽  
pp. 428-437 ◽  
Author(s):  
E Martignoni ◽  
F Blandini ◽  
L Godi ◽  
S Desideri ◽  
C Pacchetti ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Markers Of Oxidative Stress ◽  
Peripheral Markers

scholarly journals Peripheral markers of oxidative stress in chronic mercuric chloride intoxication

2006 ◽  
Vol 39 (6) ◽  
pp. 767-772 ◽  
Author(s):  
L.L.P. Gutierrez ◽  
N.G. Mazzotti ◽  
A.S.R. Araújo ◽  
R.B. Klipel ◽  
T.R.G. Fernandes ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Mercuric Chloride ◽  
Markers Of Oxidative Stress ◽  
Peripheral Markers

Peripheral markers of oxidative stress and antioxidative defense in euthymia of bipolar disorder—Gender and obesity effects

2015 ◽  
Vol 172 ◽  
pp. 367-374 ◽  
Author(s):  
S.A. Bengesser ◽  
N. Lackner ◽  
A. Birner ◽  
F.T. Fellendorf ◽  
M. Platzer ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Bipolar Disorder ◽  
Antioxidative Defense ◽  
Markers Of Oxidative Stress ◽  
Peripheral Markers

scholarly journals Indices of oxidative stress under intranasal administration of deicing reagent solutions in rats

2021 ◽  
Vol 99 (12) ◽  
pp. 1446-1453
Author(s):  
Lyudmila V. Khripach ◽  
Mariia A. Vodyanova ◽  
Tatiana D. Knyazeva ◽  
Zoya I. Koganova ◽  
Anna K. Makovetskaya ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Tap Water ◽  
Indirect Evidence ◽  
Dose Effect ◽  
Effective Measure ◽  
Male Wistar Rats ◽  
Markers Of Oxidative Stress ◽  
Mda Content ◽  
Dose Dependent Increase ◽  
Dose Dependent

Introduction. The use of road deicing reagents (RDR) is an effective measure to reduce winter traumatism and requires enhancement of methods for evaluation of deicers safety. The aim of investigation: to study markers of oxidative stress in rat blood samples during intranasal (i/n) administration of RDR solutions, as a model of intake under natural conditions, using liquid commercial RDR (22% CaCl2; 6% NaCl). Material and methods. Male Wistar rats (10 rats per group) were daily injected into the nasal cavity with 100 μl of RDR solutions in concentrations (C) 0; 0.75; 7.5 and 75 ml per liter of tap water. 5 and 28 days after the start of the experiment, the content of malondialdehyde (MDA), GSH, the activity of SOD, catalase, glutathione peroxidase (GPO) and glutathione reductase (GR) in the hemolysates were determined. Logarithmic transformation x=lg(C+0.01)+2 was used for regression analysis of dose - effect relations. Results. 5 days after the start of the experiment, adaptive dose-dependent changes in activities of SOD (R = -0.504; p=0.001); GR (R = 0.548; p<0,001) and catalase (R=0.725; p<0,001) were revealed, and after 28 days these effects were replaced by dose-dependent increase in MDA content (R=0.617; p<0,001) and GPO activity (R=0.326; p=0.04). The revealed effects, apparently, are due to the presence of additional RDR components (such as detergents, corrosion inhibitors, etc.), since significant differences with corresponding control groups were found also during administration of 0.75 ml RDR per liter (CNa+ 200 times lower than in saline solution; CCa2+ equivalent to its serum content). In particular, sharp increase in catalase activity after 5 days may be indirect evidence of anticorrosive formates metabolism (commonly used anti-corrosive additive) in the conditions of their entry bypassing the portal vein. Conclusion. I/n administration of the studied RDR solutions (0.75-75 ml/L) gave distinct dose-dependent signs of compensated (5 days) and decompensated (28 days) oxidative stress, presumably due to the presence of additional components besides of basic chlorides.

scholarly journals Anise Hyssop Agastache foeniculum Increases Lifespan, Stress Resistance, and Metabolism by Affecting Free Radical Processes in Drosophila

2020 ◽  
Vol 11 ◽  
Author(s):  
Olha M. Strilbytska ◽  
Alina Zayachkivska ◽  
Alexander Koliada ◽  
Fabio Galeotti ◽  
Nicola Volpi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Free Radical ◽  
Antioxidant Properties ◽  
Dietary Supplementation ◽  
Egg Laying ◽  
Independent Manner ◽  
Metabolic Traits ◽  
Elevated Protein ◽  
Markers Of Oxidative Stress ◽  
Leaf Powder

Anise hyssop, Agastache foeniculum, is a widely used medicinal herb with known antioxidant properties. We studied how dietary supplementation with dried A. foeniculum leaf powder affected physiological and metabolic traits as well as activities of antioxidant enzymes and markers of oxidative stress in Drosophila melanogaster. Dietary hyssop extended the lifespan in a sex and genotype independent manner over a broad range of concentrations up to 30 mg/ml. Dietary supplementation with the herb significantly increased fecundity, resistance to oxidative stress and starvation. Higher transcript levels of Drosophila insulin-like peptide (dilp2) and decreased dilp3 and dilp6 transcripts together with increased levels of glycogen and triacylglycerols support an alteration of insulin signaling by the plant extract. Increased enzymatic activities of superoxide dismutase and aconitase as well as elevated protein and low molecular mass thiols also supported an alteration of free radical process in flies treated with dietary A. foeniculum leaf powder. Thus, physiological and metabolic traits as well as free radical processed may be affected by active compounds detected in extracts of anise hyssop leaves and contribute to the increased lifespan and reproductive (egg-laying) activity observed.

Markers of oxidative stress in children with Down syndrome

2006 ◽  
Vol 44 (3) ◽  
Author(s):  
Ingrid Žitňanová ◽  
Peter Korytár ◽  
Hana Sobotová ◽  
L'ubica Horáková ◽  
Mária Šustrová ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Down Syndrome ◽  
Children With Down Syndrome ◽  
Markers Of Oxidative Stress

Abstract

The effects of tirofiban on peripheral markers of oxidative stress and endothelial dysfunction in patients with acute coronary syndromes

2007 ◽  
Vol 119 (2) ◽  
pp. 167-174 ◽  
Author(s):  
Efstathios K. Iliodromitis ◽  
Ioanna Andreadou ◽  
Sophia Markantonis-Kyroudis ◽  
Kalliopi Mademli ◽  
Stamatis Kyrzopoulos ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Endothelial Dysfunction ◽  
Acute Coronary Syndromes ◽  
Markers Of Oxidative Stress ◽  
Coronary Syndromes ◽  
Peripheral Markers

scholarly journals Peripheral biomarkers of oxidative stress in aging and Alzheimer's disease

2008 ◽  
Vol 2 (1) ◽  
pp. 2-8 ◽  
Author(s):  
Tania Marcourakis ◽  
Rosana Camarini ◽  
Elisa Mitiko Kawamoto ◽  
Leandro Rodrigues Scorsi ◽  
Cristoforo Scavone
Keyword(s):  
Oxidative Stress ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Neurodegenerative Disorders ◽  
Stress Markers ◽  
Markers Of Oxidative Stress ◽  
The Central Nervous System ◽  
Peripheral Markers ◽  
Lateral Sclerosis ◽  
Biomarkers Of Oxidative Stress

Abstract Aging is associated with a greatly increased incidence of a number of neurodegenerative disorders, including Alzheimer's disease (AD), Parkinson's disease (PD) and amyotrophic lateral sclerosis (ALS). These conditions are associated with chronic inflammation, which generates oxygen reactive species, ultimately responsible for a process known as oxidative stress. It is well established that this process is the culprit of neurodegeneration, and there are also mounting evidences that it is not restricted to the central nervous system. Indeed, several studies, including some by our group, have demonstrated that increased peripheral oxidative stress markers are associated to aging and, more specifically, to AD. Therefore, it is very instigating to regard aging and AD as systemic conditions that might be determined by studying peripheral markers of oxidative stress.

Peripheral markers of oxidative stress in probable Alzheimer patients

1999 ◽  
Vol 29 (7) ◽  
pp. 643-649 ◽  
Author(s):  
Repetto ◽  
Reides ◽  
Evelson ◽  
Kohan ◽  
De Lustig ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Markers Of Oxidative Stress ◽  
Peripheral Markers
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