scholarly journals College Students’ Psychological Health Analysis Based on Multitask Gaussian Graphical Models

Complexity ◽  
2021 ◽  
Vol 2021 ◽  
pp. 1-17
Author(s):  
Qiang Tian ◽  
Rui Wang ◽  
Shijie Li ◽  
Wenjun Wang ◽  
Ou Wu ◽  
...  
Keyword(s):  
College Students ◽  
Complex Networks ◽  
Graphical Models ◽  
Psychological Health ◽  
Large Scale ◽  
Graphical Model ◽  
Small Sample Size ◽  
Small Sample ◽  
Gaussian Graphical Model ◽  
Factors Affecting

Understanding and solving the psychological health problems of college students have become a focus of social attention. Complex networks have become important tools to study the factors affecting psychological health, and the Gaussian graphical model is often used to estimate psychological networks. However, previous studies leave some gaps to overcome, including the following aspects. (1) When studying networks of subpopulations, the estimation neglects the intrinsic relationships among subpopulations, leading to a large difference between the estimated network and the real network. (2) Because of the high cost, previous psychological surveys often have a small sample size, and the psychological description is insufficient. Here, the intrinsic connections among multiple tasks are used, and multitask machine learning is applied to develop a multitask Gaussian graphical model. The psychological networks of the population and subpopulations are estimated based on psychological questionnaire data. This study is the first to apply a psychological network to such a large-scale college student psychological analysis, and we obtain some interesting results. The model presented here is a dynamic model based on complex networks which predicts individual behavior and provides insight into the intrinsic links among various symptoms.

scholarly journals Combining Bayesian Approaches and Evolutionary Techniques for the Inference of Breast Cancer Networks

2017 ◽  
Author(s):  
Stefano Beretta ◽  
Mauro Castelli ◽  
Ivo Gonçalves ◽  
Ivan Merelli ◽  
Daniele Ramazzotti
Keyword(s):  
Breast Cancer ◽  
Graphical Models ◽  
Protein Interactions ◽  
Large Scale ◽  
Small Sample Size ◽  
Small Sample ◽  
Cancer Data ◽  
Correlation Networks ◽  
Model Complex ◽  
Cancer Networks

AbstractGene and protein networks are very important to model complex large-scale systems in molecular biology. Inferring or reverseengineering such networks can be defined as the process of identifying gene/protein interactions from experimental data through computational analysis. However, this task is typically complicated by the enormously large scale of the unknowns in a rather small sample size. Furthermore, when the goal is to study causal relationships within the network, tools capable of overcoming the limitations of correlation networks are required. In this work, we make use of Bayesian Graphical Models to attach this problem and, specifically, we perform a comparative study of different state-of-the-art heuristics, analyzing their performance in inferring the structure of the Bayesian Network from breast cancer data.

CONTRIBUTION OF DNA COPY-NUMBER VARIATION (CNV) TO CANCER SUSCEPTIBILITY AND LARGE-SCALE GENOME ALTERATIONS IN OSTEOSARCOMA (OS)

2008 ◽  
Vol 31 (4) ◽  
pp. 19
Author(s):  
I Pasic ◽  
A Shlien ◽  
A Novokmet ◽  
C Zhang ◽  
U Tabori ◽  
...  
Keyword(s):  
Genomic Instability ◽  
Large Scale ◽  
Structural Variation ◽  
Age Of Onset ◽  
Cancer Susceptibility ◽  
Small Sample Size ◽  
Snp Array ◽  
Tumour Suppressor Gene ◽  
Small Sample ◽  
International Hapmap Project

Introduction: OS, a common Li-Fraumeni syndrome (LFS)-associated neoplasm, is a common bone malignancy of children and adolescents. Sporadic OS is also characterized by young age of onset and high genomic instability, suggesting a genetic contribution to disease. This study examined the contribution of novel DNA structural variation elements, CNVs, to OS susceptibility. Given our finding of excessive constitutional DNA CNV in LFS patients, which often coincide with cancer-related genes, we hypothesized that constitutional CNV may also provide clues about the aetiology of LFS-related sporadic neoplasms like OS. Methods: CNV in blood DNA of 26 patients with sporadic OS was compared to that of 263 normal control samples from the International HapMap project, as well as 62 local controls. Analysis was performed on DNA hybridized to Affymetrix genome-wide human SNP array 6.0 by Partek Genomic Suite. Results: There was no detectable difference in average number of CNVs, CNV length, and total structural variation (product of average CNV number and length) between individuals with OS and controls. While this data is preliminary (small sample size), it argues against the presence of constitutional genomic instability in individuals with sporadic OS. Conclusion: We found that the majority of tumours from patients with sporadic OS show CN loss at chr3q13.31, raising the possibility that chr3q13.31 may represent a “driver” region in OS aetiology. In at least one OS tumour, which displays CN loss at chr3q13.31, we demonstrate decreased expression of a known tumour suppressor gene located at chr3q13.31. We are investigating the role ofchr3q13.31 in development of OS.

scholarly journals Review of the Studies in the Use of Biofeedback Therapy in Rehabilitation and Physiatrics of Neurological Patients

Doctor Ru ◽  
2021 ◽  
Vol 20 (9) ◽  
pp. 43-47
Author(s):  
E.Yu. Mozheyko ◽  
◽  
O.V. Petryaeva ◽  
◽  
◽  
...  
Keyword(s):  
Large Scale ◽  
Small Sample Size ◽  
Small Sample ◽  
Healthy Population ◽  
Biofeedback Therapy ◽  
Level Of Evidence ◽  
Double Blind ◽  
Key Points ◽  
Neurological Patients ◽  
Drug Free

Objective of the Review: To collect information, analyse and evaluate previous studies in the use of biofeedback in neurological patients. Key Points. Despite the wide practical application and a lot of available publications, the level of evidence of this method is low because of a small sample size and the challenges with biofeedback mechanism description. A review of various types of biocontrol, its mechanisms and developments shows that drug-free therapy using only patient’s resources (organic, psychological, emotional and volitional) can activate the mechanisms of neuroplasticity, which are poorly studied. Still, it does not prevent from using biocontrol for the therapy of patients and/or prevention of various diseases in healthy population. Conclusion. Biofeedback therapy has proven to be a safe, relatively efficient and easy-to-use method. However, organisation of a large-scale double blind randomized trial is one of the predominant directions in the future. Keywords: biofeedback, biocontrol, neurofeedback, biofeedback therapy.

Group-Based Interventions and Test-Taking Anxiety in Male College Students of Varied Ethnicities

2020 ◽  
Vol 12 (1) ◽  
pp. 13-27
Author(s):  
Sylvia Lindinger-Sternar ◽  
◽  
Chelsie Dollar ◽  
Sachin Jain ◽  
Jared Roberts
Keyword(s):  
College Students ◽  
Panic Disorder ◽  
Small Sample Size ◽  
Small Sample ◽  
Panic Attacks ◽  
Caffeine Intake ◽  
Test Taking ◽  
Male College ◽  
Preliminary Study

You are here: Home › Abstracts › Abstracts – Volume 12, Number 1, May 2020 › Group-Based Interventions and Test-Taking Anxiety in Male College Students of Varied Ethnicities doi 10.9769/EPJ.2020.12.1.SLS Sylvia Lindinger-Sternart, University of Providence, Great Falls,Montana, USA Chelsie Dollar, Great Falls, Montana, USA Sachin Jain, University of Providence, Montana, USA Jared Roberts, University of Providence, Montana, USA Abstract Purpose: Panic disorder is a disabling condition associated with reduced quality of life and impaired functioning. It is one of the most common mental health conditions in the United States and several European countries, and causes a significant burden of disease on impacted families. Typically, women have double the prevalence rate of anxiety-related disorders as compared to men. This preliminary study aimed to explore whether Emotional Freedom Techniques (EFT) offers potential as a treatment to reduce fear of future panic attacks in women who suffer from panic attacks. Eight women participated in the study. Outcomes were measured using the Subjective Units of Distress(SUD) scale and the Panic and Agoraphobia Scale(PAS). Results indicated reductions in both SUD and PAS scores at pre- and post-intervention, though not statistically significant, likely due to the small sample size. Nonetheless, the findings of this study support preliminary evidence that EFT may offer potential as a treatment for women with panic disorder. Further research to confirm statistical significance and long-term impacts of EFT needs to be conducted. Method: The current preliminary study adopted a one-group pre test, post test quasi-experimental A-B-A design, using the subjects themselves as their own control group. Results: The participants ranged from 35 to 53 years of age with a mean age of 43.75 years (SD 5.82) and median of 44 years, which is consistent with the literature that anxiety and panic encompasses all age brackets (Flint & Gagnon, 2003; Smoller et al., 2003; Yonkers, Bruce, Dyck, & Keller, 2003; Yonkers et al., 1998). Eight participants completed the demographic questionnaire, which included medications taken daily. Although all the participants were on medications, only five participants took medication for anxiety. Several different types of medicines or supplements were used by participants such as SSRIs, benzodiazepines, and magnesium, which is consistent with standards and guidelines for treating anxiety and panic disorders (Faria et al., 2012; Flint & Gagnon, 2003; Van Apeldoorn et al., 2014). Among the treatments besides medications, the most popular intervention was yoga and deep breathing. Participants reported an average caffeine intake of 1.125 cups per day (SD 1.13) with a range of 0 to 3 cups per day and median of 1 cup per day. Participants’ caffeine intake was similar to consumption patterns of the general population and can be eliminated as a variable that may influence this study’s results. This approach is consistent with the literature from the American Psychiatric Association (2013). Conclusion: To date, this is the first research study completed to determine whether EFT can assist with the reduction of fear of future panic attacks in women. The results showed a decrease in the PAS scores from the first day to the last day after four 60-minute sessions of group EFT. In addition, the SUD scores also showed a decrease not only from start of each session to end of each session but also from the first EFT session to the end of the last session, indicating the participants’ fear of having a future panic attack decreased from the first session to the last session. Statistically significant results were not obtained, however, likely due to the small sample size and high participant attrition rate. Nonetheless, this study offers preliminary support for the conducting of larger clinical trials to confirm the efficacy of EFT for treating fear of future panic attacks in women, as well as long-term impacts of EFT treatment on panic.

scholarly journals Copy number variation analysis of twin pairs discordant for cleft lip with or without cleft palate

2019 ◽  
Vol 33 ◽  
pp. 205873841985587
Author(s):  
Luca Scapoli ◽  
Francesco Carinci ◽  
Annalisa Palmieri ◽  
Francesca Cura ◽  
Alessandro Baj ◽  
...  
Keyword(s):  
Cleft Palate ◽  
Copy Number ◽  
Large Scale ◽  
Cleft Lip ◽  
Small Sample Size ◽  
Copy Number Variants ◽  
Monozygotic Twins ◽  
Monozygotic Twin ◽  
Small Sample ◽  
High Level

Non-syndromic cleft lip with or without cleft palate (nsCL/P) is a frequent orofacial malformation. The comparison of concordance rate observed in monozygotic and dizygotic twins supports high level of heritability and a strong genetic component. However, phenotype concordance for orofacial cleft in monozygotic twins is about 50%. The aim of the present investigation was to detect postzygotic events that may account for discordance in monozygotic twins. High-density SNP microarrays hybridization was used to genotype two pairs of monozygotic twins discordant for nsCL/P. Discordant SNP genotypes and copy number variants were analyzed to identify genetic differences responsible of phenotype discrepancy. A number of differences were observed, none involving known nsCL/P candidate genes or genomic regions. Considering the limitation of the study, related to the small sample size and to the large-scale investigation method, the results suggest that the detection of discordant events in other monozygotic twin pairs would be remarkable and warrant further investigations.

Facebook as a platform for co-creating music festival experiences

2016 ◽  
Vol 7 (2) ◽  
pp. 84-99 ◽  
Author(s):  
Emma Hoksbergen ◽  
Andrea Insch
Keyword(s):  
Young Adults ◽  
Large Scale ◽  
Small Sample Size ◽  
Small Sample ◽  
Survey Method ◽  
Future Research ◽  
Content Type ◽  
Music Festival ◽  
Alternative Means ◽  
On Line

Purpose The purpose of this paper is to address the need to understand how younger music festival-goers use and engage with a music festival’s Facebook page, and how they perceive this social networking service (SNS) as a potential on-line platform for value co-creation. Design/methodology/approach Face-to-face in-depth interviews were conducted with 16 young adults who attended an annual New Year’s Eve music festival, Rhythm and Vines, in Gisborne, New Zealand. Findings Analysis of the interview data revealed that the majority of participants did not actively engage with this platform and could be categorised as passive viewers or information-seekers. In addition, participants perceived five types of value from using this SNS: functional, social, emotional, interactive and aesthetic value. Even though participants were not segmented due to the small sample size, patterns in their levels of engagement with Facebook, attendance status, reasons for attending the festival and the combinations of forms of value that they perceived were identified. Research limitations/implications Future research should use a large-scale survey method to obtain a representative sample that is generalisable to a specific population of music festival-goers. Practical implications Dominance of features on Facebook providing festival-goers with functional value suggests they prefer a passive or co-optation approach to value co-creation in this context. Due to the limited extent of participants actively co-creating value on this platform, alternative means of encouraging interaction to co-create value with festival-goers should be investigated. Originality/value This study demonstrates that this SNS provides this group of young adults with a means to connect their real-time festival experience, with their on-line Facebook social network during the year.

Cortical Circuitry Implementing Graphical Models

2009 ◽  
Vol 21 (11) ◽  
pp. 3010-3056 ◽  
Author(s):  
Shai Litvak ◽  
Shimon Ullman
Keyword(s):  
Graphical Models ◽  
Large Scale ◽  
Graphical Model ◽  
Current Model ◽  
Building Blocks ◽  
Population Based ◽  
Spiking Neurons ◽  
Inhibitory Neurons ◽  
Basket Cells ◽  
Local Circuitry

In this letter, we develop and simulate a large-scale network of spiking neurons that approximates the inference computations performed by graphical models. Unlike previous related schemes, which used sum and product operations in either the log or linear domains, the current model uses an inference scheme based on the sum and maximization operations in the log domain. Simulations show that using these operations, a large-scale circuit, which combines populations of spiking neurons as basic building blocks, is capable of finding close approximations to the full mathematical computations performed by graphical models within a few hundred milliseconds. The circuit is general in the sense that it can be wired for any graph structure, it supports multistate variables, and it uses standard leaky integrate-and-fire neuronal units. Following previous work, which proposed relations between graphical models and the large-scale cortical anatomy, we focus on the cortical microcircuitry and propose how anatomical and physiological aspects of the local circuitry may map onto elements of the graphical model implementation. We discuss in particular the roles of three major types of inhibitory neurons (small fast-spiking basket cells, large layer 2/3 basket cells, and double-bouquet neurons), subpopulations of strongly interconnected neurons with their unique connectivity patterns in different cortical layers, and the possible role of minicolumns in the realization of the population-based maximum operation.

scholarly journals Sectoral Evaluation for Economic and Financial Development in Dubai and rest of UAE

2017 ◽  
Vol 1 (1) ◽  
pp. 1-29
Author(s):  
Sumaiyya Wahid Shaikh ◽  
Genanew B Worku ◽  
Ananth Rao
Keyword(s):  
Financial Development ◽  
United Arab Emirates ◽  
Small Sample Size ◽  
Core Competencies ◽  
Business Environment ◽  
Small Sample ◽  
Factors Affecting ◽  
Relative Contribution ◽  
Level Data ◽  
Start Ups

The paper examines sector specific characteristics to analyse the factors affecting the sustainability of the economies of Dubai and rest of the United Arab Emirates (UAE). The study applies system design to analyse the research questions. Consequently, Zellner’s seemingly unrelated regressions (SURE) technique is used to examine the relative contribution of sectors to the economies Dubai, as an individual Emirate, and the rest of UAE as a group of Emirates using time series sectoral level data for 2001–2015. The study shows that there exists positive interdependencies between Dubai and rest of UAE economies. This signifies that the core competencies across various sectors in Dubai and rest of UAE economies need to be promoted further to have overall diversified impact on UAE economy. The positive sizable impact of the finance sector in Dubai and negative sizable impact in the rest of the UAE provide many opportunities for designing diversification programs for sustained economic development of the entire UAE economy. The small sample size, non-availability of detailed sectoral data in four of the seven emirates constrained the scope of the study for generalization to other economies in the middle east.   The study findings are very crucial for identifying structural reforms, to strengthen competitiveness and accelerate private sector-led job creation for nationals, potential on further opening up foreign direct investment (FDI), improving selected areas of the business environment, and easing access to finance for start-ups and SMEs in both the economies. There are very few studies, which have researched the sector specific characteristics to explain the factors affecting the sustainability of the economies of Dubai and the rest of UAE. The study provides insights to the UAE policy makers, for enhancement of policies through development of the key sectors that influence the performance of the two economies. Despite being independent entities though, the seven emirates of the UAE are economically interdependent. Studies on such interactions add unique value to the literature. Keywords: SURE, GDP, Dubai, UAE, Sectoral Evaluation, Financial development.

scholarly journals System and Neural Network Analysis of Economic and Financial Development – A case study of Dubai and rest of UAE

2018 ◽  
Vol 1 (1) ◽  
pp. 51-67
Author(s):  
Genanew B Worku ◽  
Ananth Rao
Keyword(s):  
Neural Network ◽  
Financial Development ◽  
Small Sample Size ◽  
Core Competencies ◽  
Business Environment ◽  
Small Sample ◽  
Factors Affecting ◽  
Jel C32 ◽  
Using Data ◽  
Start Ups

The study examines the factors affecting the economic and financial development by applying Zellner’s seemingly unrelated regressions (SURE) and Neural Network techniques. It applies multivariate and neural network frameworks for analysing the GDP of Dubai and rest of UAE using data for 2001–2015. The study shows that there exists positive interdependencies between Dubai and rest of UAE economies. This signifies that the core competencies across various sectors in Dubai and rest of UAE economies need to be promoted further to have overall diversified impact on UAE economy. The positive sizable impact of the finance sector in Dubai and negative sizable impact in the rest of the UAE provide many opportunities for designing diversification programs for sustained economic development of the entire UAE economy. The small sample size, non-availability of detailed sectoral data in four of the seven emirates constrained the scope of the study for generalization to other economies in the Middle East. The study findings are crucial for identifying structural reforms, to strengthen competitiveness and accelerate private sector-led job creation for nationals, potential on further opening up foreign direct investment (FDI), improving selected areas of the business environment, and easing access to finance for start-ups and SMEs in both the economies. JEL: C32, C52, D85, N15, N25

scholarly journals Pattern of Coronary Artery Stenosis among Ischaemic Heart Disease Cases in Chittagong

2017 ◽  
Vol 28 (1) ◽  
pp. 30-31
Author(s):  
Abu Tarek Iqbal ◽  
Jalal Uddin ◽  
Dhiman Banik ◽  
Salehuddin ◽  
Hasan Mamun ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Sample Size ◽  
Large Scale ◽  
Resource Constraints ◽  
Coronary Artery Stenosis ◽  
Small Sample Size ◽  
Sampling Technique ◽  
Small Sample ◽  
Artery Stenosis ◽  
Study Results

Many studies were conducted on the topic over the whole world but there is none in Chittagong, Bangladesh. To know the pattern of coronary artery stenosis in Chittagong we have conducted the study because it is important for effective case management. It was an observational study. Convenient sampling technique was used and sample size was fixed to 110 considering resource constraints. All the cases were diagnosed on the basis of history, clinical features and laboratory investigations. Coronary artery angiogram was methodically conducted. All relevant data had been recorded and were managed manually. The findings were validated statistically. Discussion was made with updated literature review and finally conclusion was drawn. Total 110 cases were studied. Stenosis was found in 77(70%) cases. Among them 83% were male and 17% were female. Age range was 30-80 years but 76% cases were of 40-60 years age group. Among the stenosed cases SVD 29%, DVD 20% and TVD 20% only. Only 01% was LMCA. Commonest stenosed vessel was LAD 71%. RCA 60%, LCX 58% and LMCA 6%. 47% of stenosed cases were found with normal ECG. Ejection fraction of 57% stenosed cases was >55%. Study results are not significantly apart from studies in home and abroad. The limitation is small sample size. So, a multicenter study on a large scale cases is hereby advocated for a conclusive opinionMedicine Today 2016 Vol.28(1): 30-31

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