scholarly journals Accurate Identification of Antioxidant Proteins Based on a Combination of Machine Learning Techniques and Hidden Markov Model Profiles

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Zhehan Shen ◽  
Taigang Liu ◽  
Ting Xu

Antioxidant proteins (AOPs) play important roles in the management and prevention of several human diseases due to their ability to neutralize excess free radicals. However, the identification of AOPs by using wet-lab experimental techniques is often time-consuming and expensive. In this study, we proposed an accurate computational model, called AOP-HMM, to predict AOPs by extracting discriminatory evolutionary features from hidden Markov model (HMM) profiles. First, auto cross-covariance (ACC) variables were applied to transform the HMM profiles into fixed-length feature vectors. Then, we performed the analysis of variance (ANOVA) method to reduce the dimensionality of the raw feature space. Finally, a support vector machine (SVM) classifier was adopted to conduct the prediction of AOPs. To comprehensively evaluate the performance of the proposed AOP-HMM model, the 10-fold cross-validation (CV), the jackknife CV, and the independent test were carried out on two widely used benchmark datasets. The experimental results demonstrated that AOP-HMM outperformed most of the existing methods and could be used to quickly annotate AOPs and guide the experimental process.

2021 ◽  
Vol 36 (1) ◽  
pp. 727-732
Author(s):  
M. Mohanambal ◽  
Dr.P. Vishnu Vardhan

Aim: The study aims to extract features from EEG signals and classify emotion using Support Vector Machine (SVM) and Hidden Markov Model (HMM) classifier. Materials and methods: The study was conducted using the Support Vector Machine (SVM) and Hidden Markov Model (HMM) programs to analyze and compare the recognition of emotions classified under EEG signals. The results were computed using the MATLAB algorithm. For each group, ten samples were used to compare the efficiency of SVM and HMM classifiers. Result: The study’s performance exhibits the HMM classifier’s accuracy over the SVM classifier and the emotion detection from EEG signals computed. The mean value of the HMM classifier is 52.2, and the SVM classifier is 22.4. The accuracy rate of 35% with the data features is found in HMM classifier. Conclusion: This study shows a higher accuracy level of 35% for the HMM classifier when compared with the SVM classifier. In the detection of emotions using the EEG signal. This result shows that the HMM classifier has a higher significant value of P=.001 < P=.005 than the SVM classifier.


2020 ◽  
Vol 1 (2) ◽  
Author(s):  
Ritika Sibal ◽  
Ding Zhang ◽  
Julie Rocho-Levine ◽  
K. Alex Shorter ◽  
Kira Barton

Abstract Behavior of animals living in the wild is often studied using visual observations made by trained experts. However, these observations tend to be used to classify behavior during discrete time periods and become more difficult when used to monitor multiple individuals for days or weeks. In this work, we present automatic tools to enable efficient behavior and dynamic state estimation/classification from data collected with animal borne bio-logging tags, without the need for statistical feature engineering. A combined framework of an long short-term memory (LSTM) network and a hidden Markov model (HMM) was developed to exploit sequential temporal information in raw motion data at two levels: within and between windows. Taking a moving window data segmentation approach, LSTM estimates the dynamic state corresponding to each window by parsing the contiguous raw data points within the window. HMM then links all of the individual window estimations and further improves the overall estimation. A case study with bottlenose dolphins was conducted to demonstrate the approach. The combined LSTM–HMM method achieved a 6% improvement over conventional methods such as K-nearest neighbor (KNN) and support vector machine (SVM), pushing the accuracy above 90%. In addition to performance improvements, the proposed method requires a similar amount of training data to traditional machine learning methods, making the method easily adaptable to new tasks.


2017 ◽  
Vol 4 (2) ◽  
pp. 94-98
Author(s):  
ShiJie Zhao ◽  
Toshihiko Sasama ◽  
Takao Kawamura ◽  
Kazunori Sugahara

We propose a human behavior detect method based on our development system of multifunctional outlet. This is a low-power sensor network system that can recognize human behavior without any wearable devices. In order to detect human regular daily behaviors, we setup various sensors in rooms and use them to record daily lives. In this paper we present a monitoring method of unusual behaviors, and it also can be used for healthcare and so on. We use Hidden Markov Model(HMM), and set two series HMM input to recognize irregular movement from daily lives, One is time sequential sensor data blocks whose sensor values are binarized and splitted by its response. And the other is time sequential labels using Support Vector Machine (SVM). In experiments, our developed sensor network system logged 34days data. HMM learns data of the first 34days that include only usual daily behaviors as training data, and then evaluates the last 8 days that include unusual behaviors. Index Terms—multifunctional outlet system; behavior detection; hidden markov model; sensor network; support vector machine. REFERENCES [1] T.Sasama, S.Iwasaki, and T.Okamoto, “Sensor Data Classification for Indoor Situation Using the Multifunctional Outlet”, The Institute of Electrinical Engineers of Japan, vol.134(7),2014,pp.949-995 [2] M.Anjali Manikannan, R.Jayarajan, “Wireless Sensor Netwrork For Lonely Elderly Perple Wellness”, International Journal of Advanced Computational Engineering and Networking, ISSN: 2320-2106, vol. 3, 2015, pp.41-45 [3] Nagender Kumar Suryadevara, “Wireless Sensor Network Based Home Monitoring System for Wellness Determination of Elderly”, IEEE SENSORS JOURNAL, VOL. 12, NO. 6, JUNE 2012, pp. 1965-1972. [4] iTec Co., safety confirmation system: Mimamorou, http://www.minamoro.biz/. [6] Alexander Schliep's group for bioinformatics, The General Hidden Markov Model library(GHMM), http://ghmm.sourceforge.net/. [7] Jr Joe H.Ward, Joumal of the American Statistical Association, vol58(301), 1963, pp236-244 [5] SOLXYZ Co., status monitoring system:Ima-Irumo, http://www.imairumo.com/.


Sign in / Sign up

Export Citation Format

Share Document