scholarly journals Metagenomic Sequencing Analysis for Acne Using Machine Learning Methods Adapted to Single or Multiple Data

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Yu Wang ◽  
Mengru Sun ◽  
Yifan Duan
Keyword(s):  
Machine Learning ◽  
Principal Component Analysis ◽  
Principal Component ◽  
Component Analysis ◽  
Metagenomic Sequencing ◽  
Sequencing Data ◽  
Learning Methods ◽  
Machine Learning Methods ◽  
Three Samples ◽  
The Face

The human health status can be assessed by the means of research and analysis of the human microbiome. Acne is a common skin disease whose morbidity increases year by year. The lipids which influence acne to a large extent are studied by metagenomic methods in recent years. In this paper, machine learning methods are used to analyze metagenomic sequencing data of acne, i.e., all kinds of lipids in the face skin. Firstly, lipids data of the diseased skin (DS) samples and the healthy skin (HS) samples of acne patients and the normal control (NC) samples of healthy person are, respectively, analyzed by using principal component analysis (PCA) and kernel principal component analysis (KPCA). Then, the lipids which have main influence on each kind of sample are obtained. In addition, a multiset canonical correlation analysis (MCCA) is utilized to get lipids which can differentiate the face skins of the above three samples. The experimental results show the machine learning methods can effectively analyze metagenomic sequencing data of acne. According to the results, lipids which only influence one of the three samples or the lipids which simultaneously have different degree of influence on these three samples can be used as indicators to judge skin statuses.

Tropical principal component analysis on the space of phylogenetic trees

2020 ◽  
Vol 36 (17) ◽  
pp. 4590-4598
Author(s):  
Robert Page ◽  
Ruriko Yoshida ◽  
Leon Zhang
Keyword(s):  
Machine Learning ◽  
Principal Component Analysis ◽  
Phylogenetic Trees ◽  
Principal Component ◽  
Component Analysis ◽  
Fixed Number ◽  
Supplementary Information ◽  
Gene Trees ◽  
Learning Methods ◽  
Machine Learning Methods

Abstract Motivation Due to new technology for efficiently generating genome data, machine learning methods are urgently needed to analyze large sets of gene trees over the space of phylogenetic trees. However, the space of phylogenetic trees is not Euclidean, so ordinary machine learning methods cannot be directly applied. In 2019, Yoshida et al. introduced the notion of tropical principal component analysis (PCA), a statistical method for visualization and dimensionality reduction using a tropical polytope with a fixed number of vertices that minimizes the sum of tropical distances between each data point and its tropical projection. However, their work focused on the tropical projective space rather than the space of phylogenetic trees. We focus here on tropical PCA for dimension reduction and visualization over the space of phylogenetic trees. Results Our main results are 2-fold: (i) theoretical interpretations of the tropical principal components over the space of phylogenetic trees, namely, the existence of a tropical cell decomposition into regions of fixed tree topology; and (ii) the development of a stochastic optimization method to estimate tropical PCs over the space of phylogenetic trees using a Markov Chain Monte Carlo approach. This method performs well with simulation studies, and it is applied to three empirical datasets: Apicomplexa and African coelacanth genomes as well as sequences of hemagglutinin for influenza from New York. Availability and implementation Dataset: http://polytopes.net/Data.tar.gz. Code: http://polytopes.net/tropica_MCMC_codes.tar.gz. Supplementary information Supplementary data are available at Bioinformatics online.

Identifying Explosive Epidemiological Cases with Unsupervised Machine Learning (Preprint)

2020 ◽  
Author(s):  
Serge Dolgikh
Keyword(s):  
Machine Learning ◽  
Principal Component Analysis ◽  
Dimensionality Reduction ◽  
Local Time ◽  
Principal Component ◽  
Learning Methods ◽  
Unsupervised Machine Learning ◽  
Modeling Tool ◽  
Machine Learning Methods ◽  
Preventative Measures

UNSTRUCTURED An analysis of a combined dataset of Wave 1 and 2 cases, aligned at approximately Local Time Zero + 2 months with unsupervised machine learning methods such as Principal Component Analysis and deep autoencoder dimensionality reduction allows to clearly separate milder background cases from those with more rapid and aggressive onset of the epidemics. The analysis and findings of the study can be used in evaluation of possible epidemiological scenarios and as an effective modeling tool to design corrective and preventative measures to avoid developments with potentially heavy impact.

Classification of Observations through Combination of the Dimension Reduction and the Cluster Analysis

2017 ◽  
Vol 7 (8) ◽  
pp. 30
Author(s):  
Hyeuk Kim
Keyword(s):  
Machine Learning ◽  
Principal Component Analysis ◽  
Cluster Analysis ◽  
Unsupervised Learning ◽  
Principal Component ◽  
Component Analysis ◽  
Baseball Players ◽  
Partitioning Around Medoids ◽  
Different Characteristics

Unsupervised learning in machine learning divides data into several groups. The observations in the same group have similar characteristics and the observations in the different groups have the different characteristics. In the paper, we classify data by partitioning around medoids which have some advantages over the k-means clustering. We apply it to baseball players in Korea Baseball League. We also apply the principal component analysis to data and draw the graph using two components for axis. We interpret the meaning of the clustering graphically through the procedure. The combination of the partitioning around medoids and the principal component analysis can be used to any other data and the approach makes us to figure out the characteristics easily.

Analysis of the Bath Motion in the MM-SQC Dynamics Using Unsupervised Machine Learning Dimensionality Reduction Approaches: Principal Component Analysis

2020 ◽  
Author(s):  
Jiawei Peng ◽  
Yu Xie ◽  
Deping Hu ◽  
Zhenggang Lan
Keyword(s):  
Machine Learning ◽  
Principal Component Analysis ◽  
Collective Motion ◽  
Principal Component ◽  
Component Analysis ◽  
Nonadiabatic Dynamics ◽  
Trajectory Data ◽  
Unsupervised Machine Learning ◽  
Physical Knowledge ◽  
Vibronic Couplings

The system-plus-bath model is an important tool to understand nonadiabatic dynamics for large molecular systems. The understanding of the collective motion of a huge number of bath modes is essential to reveal their key roles in the overall dynamics. We apply the principal component analysis (PCA) to investigate the bath motion based on the massive data generated from the MM-SQC (symmetrical quasi-classical dynamics method based on the Meyer-Miller mapping Hamiltonian) nonadiabatic dynamics of the excited-state energy transfer dynamics of Frenkel-exciton model. The PCA method clearly clarifies that two types of bath modes, which either display the strong vibronic couplings or have the frequencies close to electronic transition, are very important to the nonadiabatic dynamics. These observations are fully consistent with the physical insights. This conclusion is obtained purely based on the PCA understanding of the trajectory data, without the large involvement of pre-defined physical knowledge. The results show that the PCA approach, one of the simplest unsupervised machine learning methods, is very powerful to analyze the complicated nonadiabatic dynamics in condensed phase involving many degrees of freedom.

scholarly journals Detecting selection in low-coverage high-throughput sequencing data using principal component analysis

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Jonas Meisner ◽  
Anders Albrechtsen ◽  
Kristian Hanghøj
Keyword(s):  
Principal Component Analysis ◽  
High Throughput ◽  
East Asian ◽  
Principal Component ◽  
Component Analysis ◽  
Human Populations ◽  
Population Genetic Study ◽  
Sequencing Data ◽  
High Quality ◽  
Low Coverage

Abstract Background Identification of selection signatures between populations is often an important part of a population genetic study. Leveraging high-throughput DNA sequencing larger sample sizes of populations with similar ancestries has become increasingly common. This has led to the need of methods capable of identifying signals of selection in populations with a continuous cline of genetic differentiation. Individuals from continuous populations are inherently challenging to group into meaningful units which is why existing methods rely on principal components analysis for inference of the selection signals. These existing methods require called genotypes as input which is problematic for studies based on low-coverage sequencing data. Materials and methods We have extended two principal component analysis based selection statistics to genotype likelihood data and applied them to low-coverage sequencing data from the 1000 Genomes Project for populations with European and East Asian ancestry to detect signals of selection in samples with continuous population structure. Results Here, we present two selections statistics which we have implemented in the framework. These methods account for genotype uncertainty, opening for the opportunity to conduct selection scans in continuous populations from low and/or variable coverage sequencing data. To illustrate their use, we applied the methods to low-coverage sequencing data from human populations of East Asian and European ancestries and show that the implemented selection statistics can control the false positive rate and that they identify the same signatures of selection from low-coverage sequencing data as state-of-the-art software using high quality called genotypes. Conclusion We show that selection scans of low-coverage sequencing data of populations with similar ancestry perform on par with that obtained from high quality genotype data. Moreover, we demonstrate that outperform selection statistics obtained from called genotypes from low-coverage sequencing data without the need for ad-hoc filtering.

scholarly journals Criteria for choosing the number of dimensions in a principal component analysis: An empirical assessment

2020 ◽  
Author(s):  
Renata Silva ◽  
Daniel Oliveira ◽  
Davi Pereira Santos ◽  
Lucio F.D. Santos ◽  
Rodrigo Erthal Wilson ◽  
...  
Keyword(s):  
Machine Learning ◽  
Principal Component Analysis ◽  
Hypothesis Test ◽  
Feature Learning ◽  
Principal Component ◽  
Component Analysis ◽  
Scree Plot ◽  
Open Issue ◽  
Chained Tasks ◽  
High Dimensional Datasets

Principal component analysis (PCA) is an efficient model for the optimization problem of finding d' axes of a subspace Rd' ⊆ Rd so that the mean squared distances from a given set R of points to the axes are minimal. Despite being steadily employed since 1901 in different scenarios, e.g., mechanics, PCA has become an important link in machine learning chained tasks, such as feature learning and AutoML designs. A frequent yet open issue that arises from supervised-based problems is how many PCA axes are required for the performance of machine learning constructs to be tuned. Accordingly, we investigate the behavior of six independent and uncoupled criteria for estimating the number of PCA axes, namely Scree-Plot %, Scree Plot Gap, Kaiser-Guttman, Broken-Stick, p-Score, and 2D. In total, we evaluate the performance of those approaches in 20 high dimensional datasets by using (i) four different classifiers, and (ii) a hypothesis test upon the reported F-Measures. Results indicate Broken-Stick and Scree-Plot % criteria consistently outperformed the competitors regarding supervised-based tasks, whereas estimators Kaiser-Guttman and Scree-Plot Gap delivered poor performances in the same scenarios.

scholarly journals Differentially Expressed Genes Extracted by the Tensor Robust Principal Component Analysis (TRPCA) Method

Complexity ◽  
2019 ◽  
Vol 2019 ◽  
pp. 1-13 ◽  
Author(s):  
Yue Hu ◽  
Jin-Xing Liu ◽  
Ying-Lian Gao ◽  
Sheng-Jun Li ◽  
Juan Wang
Keyword(s):  
Principal Component Analysis ◽  
Differentially Expressed Genes ◽  
Principal Component ◽  
Component Analysis ◽  
Differentially Expressed ◽  
Low Rank ◽  
Cancer Gene ◽  
Sequencing Data ◽  
Robust Principal Component Analysis ◽  
The Matrix

In the big data era, sequencing technology has produced a large number of biological sequencing data. Different views of the cancer genome data provide sufficient complementary information to explore genetic activity. The identification of differentially expressed genes from multiview cancer gene data is of great importance in cancer diagnosis and treatment. In this paper, we propose a novel method for identifying differentially expressed genes based on tensor robust principal component analysis (TRPCA), which extends the matrix method to the processing of multiway data. To identify differentially expressed genes, the plan is carried out as follows. First, multiview data containing cancer gene expression data from different sources are prepared. Second, the original tensor is decomposed into a sum of a low-rank tensor and a sparse tensor using TRPCA. Third, the differentially expressed genes are considered to be sparse perturbed signals and then identified based on the sparse tensor. Fourth, the differentially expressed genes are evaluated using Gene Ontology and Gene Cards tools. The validity of the TRPCA method was tested using two sets of multiview data. The experimental results showed that our method is superior to the representative methods in efficiency and accuracy aspects.

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